Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells (472 views)
Proteomics (ISSN: 1615-9853), 2016; 16(4): 674-688.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.041, 5-year impact factor: 3.825
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958599044&partnerID=40&md5=d2fc9d5afd628336694404863fad71c4
Keywords: Biomedicine, Cytokines Profiling, Multiplexed Immunoassay, Neuro-Glial Differentiation, Secretome, Stem Cells,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Napoli, Italy
Istituto di Genetica e Biofisica 'Adriano Buzzati Traverso' IGB, CNR, Napoli, Italy
Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy
Istituto di Biostrutture e Bioimmagini, IBB, CNR, Napoli, Italy
IRCCS, Multimedica, Milano, Italy
References:
Klimanskaya, I., Rosenthal, N., Lanza, R., Derive and conquer: sourcing and differentiating stem cells for therapeutic applications (2008) Nat. Rev. Drug Discov., 7, pp. 131-14
Salgado, A.J., Gimble, J.M., Special section: the mesenchymal stem cell secretome in regenerative medicine (2013) Biochimie, 95, pp. 2195-2464
Franci, G., Casalino, L., Petraglia, F., Miceli, M., The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells (2013) Biol. Open, 2, pp. 1070-1077
Makridakis, M., Roubelakis, M.G., Vlahou, A., Stem cells: insights into the secretome (2013) Biochim. Biophys. Acta, 1834, pp. 2380-2384
Tran, C., Damaser, M.S., Stem cells as drug delivery methods: application of stem cell secretome for regeneration (2014) Adv. Drug Deliv. Rev., 82-83, pp. 1-11
Skalnikova, H., Motlik, J., Gadher, S.J., Kovarova, H., Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines (2011) Proteomics, 11, pp. 691-708
Baglio, S.R., Pegtel, D.M., Baldini, N., Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy (2012) Front. Physiol., 3, pp. 1-11
Kyurkchiev, D., Bochev, I., Ivanova-Todorova, E., Mourdjeva, M., Secretion of immunoregulatory cytokines by mesenchymal stem cells (2014) World J. Stem Cells, 6, pp. 552-570
Jacobs, S.A., Roobrouck, V.D., Verfaillie, C.M., Van Gool, S.W., Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells (2013) Immunol. Cell Biol., 91, pp. 32-39
Nardi Beyer, N., da Silva Meirelles, L., Mesenchymal stem cells: isolation, in vitro expansion and characterization (2006) Handb. Exp. Pharmacol., 174, pp. 249-282
Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Multilineage potential of adult human mesenchymal stem cells (1999) Science, 284, pp. 143-147
Wang, Y., Chen, X., Cao, W., Shi, Y., Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications (2014) Nat. Immunol., 15, pp. 1009-1016
Mosna, F., Sensebe, L., Krampera, M., Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide (2010) Stem Cells Dev., 19, pp. 1449-1470
Prockop, D.J., Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms (2009) Mol. Ther., 17, pp. 939-946
Keating, A., Mesenchymal stromal cells: new directions (2012) Cell Stem Cell, 10, pp. 709-716
Choi, Y.A., Lim, J., Kim, K.M., Acharya, B., Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation (2010) J. Proteome Res., 9, pp. 2946-2956
Kim, J.M., Kim, J., Kim, Y.H., Kim, K.T., Comparative secretome analysis of human bone marrow-derived mesenchymal stem cells during osteogenesis (2013) J. Cell Physiol., 228, pp. 216-224
Sarojini, H., Estrada, R., Lu, H., Dekova, S., PEDF from mouse mesenchymal stem cell secretome attracts fibroblasts (2008) J. Cell Biochem., 104, pp. 1793-1802
Estrada, R., Li, N., Sarojini, H., An, J., Secretome from mesenchymal stem cells induces angiogenesis via Cyr61 (2009) J. Cell Physiol., 219, pp. 563-571
Mirabella, T., Cilli, M., Carlone, S., Cancedda, R., Gentili, C., Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model (2011) Biomaterials, 32, pp. 3689-3699
Mirabella, T., Hartinger, J., Lorandi, C., Gentili, C., Proangiogenic soluble factors from amniotic fluid stem cells mediate the recruitment of endothelial progenitors in a model of ischemic fasciocutaneous flap (2012) Stem Cells Dev., 21, pp. 2179-2188
Zagoura, D.S., Roubelakis, M.G., Bitsika, V., Trohatou, O., Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure (2012) Gut, 61, pp. 894-906
Berardis, S., Lombard, C., Evraerts, J., El Taghdouini, A., Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells (2014) Plos One, 9
Miceli, M., Franci, G., Dell'Aversana, C., Ricciardiello, F., MePR: a novel human mesenchymal progenitor model with characteristics of pluripotency (2013) Stem Cells Dev., 22, pp. 2368-2383
Severino, V., Alessio, N., Farina, A., Sandomenico, A., Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (2013) Cell Death Dis., 4, p. e911
Severino, V., Farina, A., Colucci-D'Amato, L., Reccia, M.G., Secretome profiling of differentiated neural mes-c-myc A1 cell line endowed with stem cell properties (2013) Biochim. Biophys. Acta, 1834, pp. 2385-2395
Xia, J., Benner, M.J., Hancock, R.E., NetworkAnalyst-integrative approaches for protein-protein interaction network analysis and visual exploration (2014) Nucleic Acids Res., 42, pp. W167-W174
Liu, X.S., Zhang, Z.G., Zhang, R.L., Gregg, S.R., Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke (2007) J. Neurosci. Res., 85, pp. 2120-2125
Lawrence, D.M., Seth, P., Durham, L., Diaz, F., Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells (2006) Glia, 53, pp. 81-91
Gordon, R.J., Mehrabi, N.F., Maucksch, C., Connor, B., Chemokines influence the migration and fate of neural precursor cells from the young adult and middle-aged rat subventricular zone (2012) Exp. Neurol., 233, pp. 587-594
Turbic, A., Leong, S.Y., Turnley, A.M., Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation (2011) PLoS One, 6, p. e25406
Severino, V., Malorni, L., Cicatiello, A.E., D'Esposito, V., An integrated approach based on multiplexed protein array and iTRAQ labeling for in-depth identification of pathways associated to IVF outcome (2013) PLoS One, 8, p. e77303
Herold, S., Jagasia, R., Merz, K., Wassmer, K., Lie, D.C., CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis (2011) Mol. Cell Neurosci., 46, pp. 79-88
Finkbeiner, S., CREB couples neurotrophin signals to survival messages (2000) Neuron, 25, pp. 11-14
Harada, T., Morooka, T., Ogawa, S., Nishida, E., ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 (2001) Nat. Cell Biol., 3, pp. 453-459
Park, C.W., Kim, K.S., Bae, S., Son, H.K., Cytokine secretion profiling of human mesenchymal stem cells by antibody array (2009) Int. J. Stem Cells, 2, pp. 59-68
Bernardo, M.E., Fibbe, W.E., Mesenchymal stromal cells: sensors and switchers of inflammation (2013) Cell Stem Cell, 13, pp. 392-402
Mathieu, P., Battista, D., Depino, A., Roca, V., The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain (2010) J. Neurochem., 112, pp. 1368-1385
Breton, J., Mao-Draayer, Y., Impact of cytokines on neural stem/progenitor cell fate (2011) J. Neurol. Neurophysiol. S4
Takei, Y., Laskey, R., Interpreting crosstalk between TNF-alpha and NGF: potential implications for disease (2008) Trends Mol. Med., 14, pp. 381-388
Bernardino, L., Agasse, F., Silva, B., Ferreira, R., Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures (2008) Stem Cells, 26, pp. 2361-2371
Iosif, R.E., Ahlenius, H., Ekdahl, C.T., Darsalia, V., Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1 (2008) J. Cereb. Blood Flow Metab., 28, pp. 1574-1587
Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis (2006) J. Neurosci., 26, pp. 9703-9712
Egea, V., von Baumgarten, L., Schichor, C., Berninger, B., TNF-alpha respecifies human mesenchymal stem cells to a neural fate and promotes migration toward experimental glioma (2011) Cell Death Differ., 18, pp. 853-863
Li, L., Walker, T.L., Zhang, Y., Mackay, E.W., Bartlett, P.F., Endogenous interferon gamma directly regulates neural precursors in the non-inflammatory brain (2010) J. Neurosci., 30, pp. 9038-9050
Hong, Y.R., Lee, H., Park, M.H., Lee, J.K., CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice (2015) J. Vet. Med. Sci., 77, pp. 693-699
Suyama, T., Furuya, M., Nishiyama, M., Kasuya, Y., Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma (2005) Cancer, 103, pp. 258-267
Owens, T., Babcock, A.A., Millward, J.M., Toft-Hansen, H., Cytokine and chemokine inter-regulation in the inflamed or injured CNS (2005) Brain Res. Brain Res. Rev., 48, pp. 178-184
Croitoru-Lamoury, J., Guillemin, G.J., Boussin, F.D., Mognetti, B., Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation (2003) Glia, 41, pp. 354-370
Belmadani, A., Tran, P.B., Ren, D., Miller, R.J., Chemokines regulate the migration of neural progenitors to sites of neuroinflammation (2006) J. Neurosci., 26, pp. 3182-3191
Zhou, Y., Day, A., Haykal, S., Keating, A., Waddell, T.K., Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway (2013) Cytotherapy, 15, pp. 1195-1207
Meirelles Lda, S., Fontes, A.M., Covas, D.T., Caplan, A.I., Mechanisms involved in the therapeutic properties of mesenchymal stem cells (2009) Cytokine Growth Factor Rev., 20, pp. 419-427
Boomsma, R.A., Geenen, D.L., Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis (2012) PLoS One, 7, p. e35685
Lee, H.J., Ko, J.H., Jeong, H.J., Ko, A.Y., Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells (2015) J. Immunol., 194, pp. 3634-3645
Molloy, A.P., Martin, F.T., Dwyer, R.M., Griffin, T.P., Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells (2009) Int. J. Cancer, 124, pp. 326-332
Goodman, H., (2009) Basic Medical Endocrinology, , 4th Edition, Elsevier Academic press, Amsterdam
Watson, M.L., Chemokines-linking receptors to response (2002) Immunology, 105, pp. 121-124
Proteomics (ISSN: 1615-9853), 2016; 16(4): 674-688.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.041, 5-year impact factor: 3.825
Url: https://www2.scopus.com/inward/record.uri?eid=2-s2.0-84958599044&partnerID=40&md5=d2fc9d5afd628336694404863fad71c4
Keywords: Biomedicine, Cytokines Profiling, Multiplexed Immunoassay, Neuro-Glial Differentiation, Secretome, Stem Cells,
Affiliations:
*** IBB - CNR ***
Dipartimento di Biochimica, Biofisica e Patologia Generale, Seconda Università di Napoli, Napoli, Italy
Istituto di Genetica e Biofisica 'Adriano Buzzati Traverso' IGB, CNR, Napoli, Italy
Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Seconda Università degli Studi di Napoli, Caserta, Italy
Istituto di Biostrutture e Bioimmagini, IBB, CNR, Napoli, Italy
IRCCS, Multimedica, Milano, Italy
References:
Klimanskaya, I., Rosenthal, N., Lanza, R., Derive and conquer: sourcing and differentiating stem cells for therapeutic applications (2008) Nat. Rev. Drug Discov., 7, pp. 131-14
Salgado, A.J., Gimble, J.M., Special section: the mesenchymal stem cell secretome in regenerative medicine (2013) Biochimie, 95, pp. 2195-2464
Franci, G., Casalino, L., Petraglia, F., Miceli, M., The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells (2013) Biol. Open, 2, pp. 1070-1077
Makridakis, M., Roubelakis, M.G., Vlahou, A., Stem cells: insights into the secretome (2013) Biochim. Biophys. Acta, 1834, pp. 2380-2384
Tran, C., Damaser, M.S., Stem cells as drug delivery methods: application of stem cell secretome for regeneration (2014) Adv. Drug Deliv. Rev., 82-83, pp. 1-11
Skalnikova, H., Motlik, J., Gadher, S.J., Kovarova, H., Mapping of the secretome of primary isolates of mammalian cells, stem cells and derived cell lines (2011) Proteomics, 11, pp. 691-708
Baglio, S.R., Pegtel, D.M., Baldini, N., Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy (2012) Front. Physiol., 3, pp. 1-11
Kyurkchiev, D., Bochev, I., Ivanova-Todorova, E., Mourdjeva, M., Secretion of immunoregulatory cytokines by mesenchymal stem cells (2014) World J. Stem Cells, 6, pp. 552-570
Jacobs, S.A., Roobrouck, V.D., Verfaillie, C.M., Van Gool, S.W., Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells (2013) Immunol. Cell Biol., 91, pp. 32-39
Nardi Beyer, N., da Silva Meirelles, L., Mesenchymal stem cells: isolation, in vitro expansion and characterization (2006) Handb. Exp. Pharmacol., 174, pp. 249-282
Pittenger, M.F., Mackay, A.M., Beck, S.C., Jaiswal, R.K., Multilineage potential of adult human mesenchymal stem cells (1999) Science, 284, pp. 143-147
Wang, Y., Chen, X., Cao, W., Shi, Y., Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications (2014) Nat. Immunol., 15, pp. 1009-1016
Mosna, F., Sensebe, L., Krampera, M., Human bone marrow and adipose tissue mesenchymal stem cells: a user's guide (2010) Stem Cells Dev., 19, pp. 1449-1470
Prockop, D.J., Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms (2009) Mol. Ther., 17, pp. 939-946
Keating, A., Mesenchymal stromal cells: new directions (2012) Cell Stem Cell, 10, pp. 709-716
Choi, Y.A., Lim, J., Kim, K.M., Acharya, B., Secretome analysis of human BMSCs and identification of SMOC1 as an important ECM protein in osteoblast differentiation (2010) J. Proteome Res., 9, pp. 2946-2956
Kim, J.M., Kim, J., Kim, Y.H., Kim, K.T., Comparative secretome analysis of human bone marrow-derived mesenchymal stem cells during osteogenesis (2013) J. Cell Physiol., 228, pp. 216-224
Sarojini, H., Estrada, R., Lu, H., Dekova, S., PEDF from mouse mesenchymal stem cell secretome attracts fibroblasts (2008) J. Cell Biochem., 104, pp. 1793-1802
Estrada, R., Li, N., Sarojini, H., An, J., Secretome from mesenchymal stem cells induces angiogenesis via Cyr61 (2009) J. Cell Physiol., 219, pp. 563-571
Mirabella, T., Cilli, M., Carlone, S., Cancedda, R., Gentili, C., Amniotic liquid derived stem cells as reservoir of secreted angiogenic factors capable of stimulating neo-arteriogenesis in an ischemic model (2011) Biomaterials, 32, pp. 3689-3699
Mirabella, T., Hartinger, J., Lorandi, C., Gentili, C., Proangiogenic soluble factors from amniotic fluid stem cells mediate the recruitment of endothelial progenitors in a model of ischemic fasciocutaneous flap (2012) Stem Cells Dev., 21, pp. 2179-2188
Zagoura, D.S., Roubelakis, M.G., Bitsika, V., Trohatou, O., Therapeutic potential of a distinct population of human amniotic fluid mesenchymal stem cells and their secreted molecules in mice with acute hepatic failure (2012) Gut, 61, pp. 894-906
Berardis, S., Lombard, C., Evraerts, J., El Taghdouini, A., Gene expression profiling and secretome analysis differentiate adult-derived human liver stem/progenitor cells and human hepatic stellate cells (2014) Plos One, 9
Miceli, M., Franci, G., Dell'Aversana, C., Ricciardiello, F., MePR: a novel human mesenchymal progenitor model with characteristics of pluripotency (2013) Stem Cells Dev., 22, pp. 2368-2383
Severino, V., Alessio, N., Farina, A., Sandomenico, A., Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (2013) Cell Death Dis., 4, p. e911
Severino, V., Farina, A., Colucci-D'Amato, L., Reccia, M.G., Secretome profiling of differentiated neural mes-c-myc A1 cell line endowed with stem cell properties (2013) Biochim. Biophys. Acta, 1834, pp. 2385-2395
Xia, J., Benner, M.J., Hancock, R.E., NetworkAnalyst-integrative approaches for protein-protein interaction network analysis and visual exploration (2014) Nucleic Acids Res., 42, pp. W167-W174
Liu, X.S., Zhang, Z.G., Zhang, R.L., Gregg, S.R., Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke (2007) J. Neurosci. Res., 85, pp. 2120-2125
Lawrence, D.M., Seth, P., Durham, L., Diaz, F., Astrocyte differentiation selectively upregulates CCL2/monocyte chemoattractant protein-1 in cultured human brain-derived progenitor cells (2006) Glia, 53, pp. 81-91
Gordon, R.J., Mehrabi, N.F., Maucksch, C., Connor, B., Chemokines influence the migration and fate of neural precursor cells from the young adult and middle-aged rat subventricular zone (2012) Exp. Neurol., 233, pp. 587-594
Turbic, A., Leong, S.Y., Turnley, A.M., Chemokines and inflammatory mediators interact to regulate adult murine neural precursor cell proliferation, survival and differentiation (2011) PLoS One, 6, p. e25406
Severino, V., Malorni, L., Cicatiello, A.E., D'Esposito, V., An integrated approach based on multiplexed protein array and iTRAQ labeling for in-depth identification of pathways associated to IVF outcome (2013) PLoS One, 8, p. e77303
Herold, S., Jagasia, R., Merz, K., Wassmer, K., Lie, D.C., CREB signalling regulates early survival, neuronal gene expression and morphological development in adult subventricular zone neurogenesis (2011) Mol. Cell Neurosci., 46, pp. 79-88
Finkbeiner, S., CREB couples neurotrophin signals to survival messages (2000) Neuron, 25, pp. 11-14
Harada, T., Morooka, T., Ogawa, S., Nishida, E., ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 (2001) Nat. Cell Biol., 3, pp. 453-459
Park, C.W., Kim, K.S., Bae, S., Son, H.K., Cytokine secretion profiling of human mesenchymal stem cells by antibody array (2009) Int. J. Stem Cells, 2, pp. 59-68
Bernardo, M.E., Fibbe, W.E., Mesenchymal stromal cells: sensors and switchers of inflammation (2013) Cell Stem Cell, 13, pp. 392-402
Mathieu, P., Battista, D., Depino, A., Roca, V., The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain (2010) J. Neurochem., 112, pp. 1368-1385
Breton, J., Mao-Draayer, Y., Impact of cytokines on neural stem/progenitor cell fate (2011) J. Neurol. Neurophysiol. S4
Takei, Y., Laskey, R., Interpreting crosstalk between TNF-alpha and NGF: potential implications for disease (2008) Trends Mol. Med., 14, pp. 381-388
Bernardino, L., Agasse, F., Silva, B., Ferreira, R., Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures (2008) Stem Cells, 26, pp. 2361-2371
Iosif, R.E., Ahlenius, H., Ekdahl, C.T., Darsalia, V., Suppression of stroke-induced progenitor proliferation in adult subventricular zone by tumor necrosis factor receptor 1 (2008) J. Cereb. Blood Flow Metab., 28, pp. 1574-1587
Iosif, R.E., Ekdahl, C.T., Ahlenius, H., Pronk, C.J., Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis (2006) J. Neurosci., 26, pp. 9703-9712
Egea, V., von Baumgarten, L., Schichor, C., Berninger, B., TNF-alpha respecifies human mesenchymal stem cells to a neural fate and promotes migration toward experimental glioma (2011) Cell Death Differ., 18, pp. 853-863
Li, L., Walker, T.L., Zhang, Y., Mackay, E.W., Bartlett, P.F., Endogenous interferon gamma directly regulates neural precursors in the non-inflammatory brain (2010) J. Neurosci., 30, pp. 9038-9050
Hong, Y.R., Lee, H., Park, M.H., Lee, J.K., CCL2 induces neural stem cell proliferation and neuronal differentiation in Niemann-Pick type C mice (2015) J. Vet. Med. Sci., 77, pp. 693-699
Suyama, T., Furuya, M., Nishiyama, M., Kasuya, Y., Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma (2005) Cancer, 103, pp. 258-267
Owens, T., Babcock, A.A., Millward, J.M., Toft-Hansen, H., Cytokine and chemokine inter-regulation in the inflamed or injured CNS (2005) Brain Res. Brain Res. Rev., 48, pp. 178-184
Croitoru-Lamoury, J., Guillemin, G.J., Boussin, F.D., Mognetti, B., Expression of chemokines and their receptors in human and simian astrocytes: evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation (2003) Glia, 41, pp. 354-370
Belmadani, A., Tran, P.B., Ren, D., Miller, R.J., Chemokines regulate the migration of neural progenitors to sites of neuroinflammation (2006) J. Neurosci., 26, pp. 3182-3191
Zhou, Y., Day, A., Haykal, S., Keating, A., Waddell, T.K., Mesenchymal stromal cells augment CD4+ and CD8+ T-cell proliferation through a CCL2 pathway (2013) Cytotherapy, 15, pp. 1195-1207
Meirelles Lda, S., Fontes, A.M., Covas, D.T., Caplan, A.I., Mechanisms involved in the therapeutic properties of mesenchymal stem cells (2009) Cytokine Growth Factor Rev., 20, pp. 419-427
Boomsma, R.A., Geenen, D.L., Mesenchymal stem cells secrete multiple cytokines that promote angiogenesis and have contrasting effects on chemotaxis and apoptosis (2012) PLoS One, 7, p. e35685
Lee, H.J., Ko, J.H., Jeong, H.J., Ko, A.Y., Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells (2015) J. Immunol., 194, pp. 3634-3645
Molloy, A.P., Martin, F.T., Dwyer, R.M., Griffin, T.P., Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells (2009) Int. J. Cancer, 124, pp. 326-332
Goodman, H., (2009) Basic Medical Endocrinology, , 4th Edition, Elsevier Academic press, Amsterdam
Watson, M.L., Chemokines-linking receptors to response (2002) Immunology, 105, pp. 121-124
Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells
Secreted cytokines and growth factors play a key role in the modulation of stem cell proliferation, differentiation and survival. To investigate the interplay between the changes in their expression levels, we used the newly characterized human amniotic fluid derived-mesenchymal progenitor MePR-2B cell line differentiated to a neuro-glial phenotype and exploited the very high sensitivity and versatility of magnetic beads-based immunoassays. We found that a sub-set of proteins, including the cytokines IL-6, TNFα, IL-15, IFNγ, IL-8, IL-1ra, MCP-1/CCL2, RANTES and the growth factor PDGFbb, underwent a significant down-regulation following neuro-glial differentiation, whereas the expression levels of IL-12 p70, IL-5, IL-7, bFGF, VEGF and G-CSF were increased. The role of MCP-1/CCL2, previously identified as a regulator of neural progenitor stem cell differentiation, has been further investigated at transcriptional level, revealing that both the chemokine and its receptor are co-expressed in MePR-2B cells and that are regulated upon differentiation, suggesting the presence of an autocrine and paracrine loop in differentiating cells. Moreover, we demonstrated that exogenous CCL2 is capable to affect neuro-glial differentiation in MePR-2B cells, thus providing novel evidences for the potential involvement of chemokine-mediated signaling in progenitor/stem cells differentiation processes and fate specification. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Secreted cytokines and growth factors play a key role in the modulation of stem cell proliferation, differentiation and survival. To investigate the interplay between the changes in their expression levels, we used the newly characterized human amniotic fluid derived-mesenchymal progenitor MePR-2B cell line differentiated to a neuro-glial phenotype and exploited the very high sensitivity and versatility of magnetic beads-based immunoassays. We found that a sub-set of proteins, including the cytokines IL-6, TNFα, IL-15, IFNγ, IL-8, IL-1ra, MCP-1/CCL2, RANTES and the growth factor PDGFbb, underwent a significant down-regulation following neuro-glial differentiation, whereas the expression levels of IL-12 p70, IL-5, IL-7, bFGF, VEGF and G-CSF were increased. The role of MCP-1/CCL2, previously identified as a regulator of neural progenitor stem cell differentiation, has been further investigated at transcriptional level, revealing that both the chemokine and its receptor are co-expressed in MePR-2B cells and that are regulated upon differentiation, suggesting the presence of an autocrine and paracrine loop in differentiating cells. Moreover, we demonstrated that exogenous CCL2 is capable to affect neuro-glial differentiation in MePR-2B cells, thus providing novel evidences for the potential involvement of chemokine-mediated signaling in progenitor/stem cells differentiation processes and fate specification. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells
Secretome profiling of cytokines and growth factors reveals that neuro-glial differentiation is associated with the down-regulation of Chemokine Ligand 2 (MCP-1/CCL2) in amniotic fluid derived-mesenchymal progenitor cells
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Ngoc B, Vu Hoa T, N , Palumbo R, Rinaldo P, Fagoonee S, Phuc V
* Stem cell-derived exosomes for wound healing: current status and promising directions (61 views)
Minerva Med, 2021 Jun; 112(3): 384-400.
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Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A
* Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage (11 views)
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Impact Factor: 5.611
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Saccu G, Menchise V, Giordano C, Delli Castelli D, Dastrù W, Pellicano R, Tolosano E, Van Pham P, Altruda F, Fagoonee S
* Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries (12 views)
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Impact Factor: 4.241
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Zannetti A, Benga G, Brunetti A, Napolitano F, Avallone L, Pelagalli A
* Role of Aquaporins in the Physiological Functions of Mesenchymal Stem Cells (54 views) (PDF 15 views)
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Impact Factor: 4.366
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Hill BS, Sarnella A, D'Avino G, Zannetti A
* Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer (220 views) (PDF 47 views)
Semin Cancer Biol (ISSN: 1044-579xlinking), 2020 Feb; 60: 202-213.
Impact Factor: 11.09
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Famulari ES, Navarro-tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F
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Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jan 21; 10 (1 ): 887-887.
Impact Factor: 5.078
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Guerriero I, De Angelis MT, D'Angelo F, Leveque R, Savignano E, Roberto L, Lucci V, Mazzone P, Laurino S, Storto G, Nardelli A, Sgambato A, Ceccarelli M, De Felice M, Amendola E, Falco G
* Exploring the Molecular Crosstalk between Pancreatic Bud and Mesenchyme in Embryogenesis: Novel Signals Involved (202 views)
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Impact Factor: 4.183
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Zambrano G, Ruggiero E, Malafronte A, Chino M, Maglio O, Pavone V, Nastri F, Lombardi A
* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (264 views)
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Impact Factor: 3.687
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De Chiara L, Famulari ES, Fagoonee S, Van Daalen SKM, Buttiglieri S, Revelli A, Tolosano E, Silengo L, Van Pelt AMM, Altruda F
* Characterization of Human Mesenchymal Stem Cells Isolated from the Testis (247 views)
Stem Cells Int (ISSN: 1687-966xprint, 1687-9678electronic), 2018 Sep 3; 2018: 4910304-4910304.
Impact Factor: 3.989
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Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (568 views)
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Impact Factor: 8.29
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Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (723 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
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De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
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Maglio O, Costanzo S, Cercola R, Zambrano G, Mauro M, Battaglia R, Ferrini G, Nastri F, Pavone V, Lombardi A
* A Quartz Crystal Microbalance Immunosensor for Stem Cell Selection and Extraction (1114 views) (PDF 151 views)
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Impact Factor: 2.475
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Hill BS, Pelagalli A, Passaro N, Zannetti A
* Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (316 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Sep 22; 8(42): 73296-73311.
Impact Factor: 5.168
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Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (697 views) (PDF 210 views)
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Impact Factor: 8.537
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Filippi M, Boido M, Terreno E
* Imaging of MSC transplantation in neuroscience (207 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 14; 8(7): 10781-10782.
Impact Factor: 5.008
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Fagoonee S, De Chiara L, Famulari ES, Silengo L, Altruda F
* Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury (130 views)
Kidney Transpl Bioeng And Regen (ISSN: 9780-1280183619780128017340), 2017; N/D: 1109-1115.
Impact Factor: 0
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Fagoonee S, Famulari ES, Silengo L, Camussi G, Altruda F
* Prospects for Adult Stem Cells in the Treatment of Liver Diseases (212 views)
Stem Cells Dev (ISSN: 1547-3287, 1547-3287linking), 2016 Sep 7; 25(20): 1471-1482.
Impact Factor: 3.562
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Pelagalli A, Nardelli A, Fontanella R, Zannetti A
* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (427 views) (PDF 311 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Jul 11; 17(7): N/D-N/D.
Impact Factor: 4.556
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
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Fagoonee S, Famulari ES, Silengo L, Tolosano E, Altruda F
* Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells (214 views)
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Impact Factor: 3.057
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Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
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Impact Factor: 4.079
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De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (943 views)
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Impact Factor: 5.177
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Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (432 views) (PDF 242 views)
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Impact Factor: 5.333
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Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
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Impact Factor: 11.089
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Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
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Impact Factor: 3.914
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Riccio A, Cubellis MV
* Gain of function in CDKN1C (512 views)
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Impact Factor: 35.209
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Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (462 views)
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
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Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (585 views)
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
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* Stem cell-derived exosomes for wound healing: current status and promising directions (61 views)
Minerva Med, 2021 Jun; 112(3): 384-400.
Impact Factor: 4.806
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Di Giovannantonio LG, Acampora D, Omodei D, Nigro V, Barba P, Barbieri E, Chambers I, Simeone A
* Direct repression of Nanog and Oct4 by OTX2 modulates the contribution of epiblast-derived cells to germline and somatic lineage (11 views)
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Impact Factor: 5.611
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Saccu G, Menchise V, Giordano C, Delli Castelli D, Dastrù W, Pellicano R, Tolosano E, Van Pham P, Altruda F, Fagoonee S
* Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries (12 views)
J Clin Med (ISSN: 2077-0383electronic, 2077-0383linking), 2021 Jan 16; 10(2): N/D-N/D.
Impact Factor: 4.241
View Export to BibTeX Export to EndNote
Zannetti A, Benga G, Brunetti A, Napolitano F, Avallone L, Pelagalli A
* Role of Aquaporins in the Physiological Functions of Mesenchymal Stem Cells (54 views) (PDF 15 views)
Cells (ISSN: 2073-4409linking, 2073-4409electronic), 2020 Dec 13; 9(12): N/D-N/D.
Impact Factor: 4.366
View Export to BibTeX Export to EndNote
Hill BS, Sarnella A, D'Avino G, Zannetti A
* Recruitment of stromal cells into tumour microenvironment promote the metastatic spread of breast cancer (220 views) (PDF 47 views)
Semin Cancer Biol (ISSN: 1044-579xlinking), 2020 Feb; 60: 202-213.
Impact Factor: 11.09
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Famulari ES, Navarro-tableros V, Herrera Sanchez MB, Bortolussi G, Gai M, Conti L, Silengo L, Tolosano E, Tetta C, Muro AF, Camussi G, Fagoonee S, Altruda F
* Human liver stem cells express UGT1A1 and improve phenotype of immunocompromised Crigler Najjar syndrome type I mice (152 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2020 Jan 21; 10 (1 ): 887-887.
Impact Factor: 5.078
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Guerriero I, De Angelis MT, D'Angelo F, Leveque R, Savignano E, Roberto L, Lucci V, Mazzone P, Laurino S, Storto G, Nardelli A, Sgambato A, Ceccarelli M, De Felice M, Amendola E, Falco G
* Exploring the Molecular Crosstalk between Pancreatic Bud and Mesenchyme in Embryogenesis: Novel Signals Involved (202 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1661-6596, 1422-0067electronic), 2019 Oct 3; 20(19): N/D-N/D.
Impact Factor: 4.183
View Export to BibTeX Export to EndNote
Zambrano G, Ruggiero E, Malafronte A, Chino M, Maglio O, Pavone V, Nastri F, Lombardi A
* Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (264 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Impact Factor: 3.687
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De Chiara L, Famulari ES, Fagoonee S, Van Daalen SKM, Buttiglieri S, Revelli A, Tolosano E, Silengo L, Van Pelt AMM, Altruda F
* Characterization of Human Mesenchymal Stem Cells Isolated from the Testis (247 views)
Stem Cells Int (ISSN: 1687-966xprint, 1687-9678electronic), 2018 Sep 3; 2018: 4910304-4910304.
Impact Factor: 3.989
View Export to BibTeX Export to EndNote
Supuran CT, Alterio V, Di Fiore A, D'Ambrosio K, Carta F, Monti SM, De Simone G
* Inhibition of carbonic anhydrase IX targets primary tumors, metastases, and cancer stem cells: Three for the price of one (568 views)
Med Res Rev (ISSN: 1098-1128electronic, 0198-6325linking), 2018 Sep; 38(6): 1799-1836.
Impact Factor: 8.29
View Export to BibTeX Export to EndNote
Pelagalli A, Nardelli A, Lucarelli E, Zannetti A, Brunetti A
* Autocrine signals increase Ovine Mesenchymal Stem Cells migration through Aquaporin-1 and CXCR4 overexpression (723 views)
J Cell Physiol (ISSN: 1097-4652electronic, 0021-9541linking), 2018 Jan 18; 233(8): 6241-6249.
Impact Factor: 5.546
View Export to BibTeX Export to EndNote
De Rosa L, Di Stasi R, D'Andrea LD
* Pro-angiogenic peptides in biomedicine (481 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 2018; 660: 72-86.
Impact Factor: 3.118
View Export to BibTeX Export to EndNote
Maglio O, Costanzo S, Cercola R, Zambrano G, Mauro M, Battaglia R, Ferrini G, Nastri F, Pavone V, Lombardi A
* A Quartz Crystal Microbalance Immunosensor for Stem Cell Selection and Extraction (1114 views) (PDF 151 views)
Sensors (ISSN: 1424-8220, 1424-3210, 1424-8220linking), 2017 Nov 28; 17(12): N/D-N/D.
Impact Factor: 2.475
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Hill BS, Pelagalli A, Passaro N, Zannetti A
* Tumor-educated mesenchymal stem cells promote pro-metastatic phenotype (316 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Sep 22; 8(42): 73296-73311.
Impact Factor: 5.168
View Export to BibTeX Export to EndNote
Camorani S, Hill BS, Fontanella R, Greco A, Gramanzini M, Auletta L, Gargiulo S, Albanese S, Lucarelli E, Cerchia L, Zannetti A
* Inhibition of Bone Marrow-Derived Mesenchymal Stem Cells Homing Towards Triple-Negative Breast Cancer Microenvironment Using an Anti-PDGFRbeta Aptamer (697 views) (PDF 210 views)
Theranostics (ISSN: 1838-7640, 1838-7640electronic), 2017 Aug 22; 7(14): 3595-3607.
Impact Factor: 8.537
View Export to BibTeX Export to EndNote
Filippi M, Boido M, Terreno E
* Imaging of MSC transplantation in neuroscience (207 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2017 Feb 14; 8(7): 10781-10782.
Impact Factor: 5.008
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Fagoonee S, De Chiara L, Famulari ES, Silengo L, Altruda F
* Renal Cells From Spermatogonial Germline Stem Cells for Protection Against Kidney Injury (130 views)
Kidney Transpl Bioeng And Regen (ISSN: 9780-1280183619780128017340), 2017; N/D: 1109-1115.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Fagoonee S, Famulari ES, Silengo L, Camussi G, Altruda F
* Prospects for Adult Stem Cells in the Treatment of Liver Diseases (212 views)
Stem Cells Dev (ISSN: 1547-3287, 1547-3287linking), 2016 Sep 7; 25(20): 1471-1482.
Impact Factor: 3.562
View Export to BibTeX Export to EndNote
Pelagalli A, Nardelli A, Fontanella R, Zannetti A
* Inhibition of AQP1 Hampers Osteosarcoma and Hepatocellular Carcinoma Progression Mediated by Bone Marrow-Derived Mesenchymal Stem Cells (427 views) (PDF 311 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Jul 11; 17(7): N/D-N/D.
Impact Factor: 4.556
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Fontanella R, Pelagalli A, Nardelli A, D'Alterio C, Ierano C, Cerchia L, Lucarelli E, Scala S, Zannetti A
* A novel antagonist of CXCR4 prevents bone marrow-derived mesenchymal stem cell-mediated osteosarcoma and hepatocellular carcinoma cell migration and invasion (931 views) (PDF 283 views)
Cancer Lett (ISSN: 0304-3835), 2015 Oct 27; 370(1): 100-107.
Impact Factor: 7.36
View Export to BibTeX Export to EndNote
Fagoonee S, Famulari ES, Silengo L, Tolosano E, Altruda F
* Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells (214 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2015 Aug 31; 10(8): e0136762-e0136762.
Impact Factor: 3.057
View Export to BibTeX Export to EndNote
Colucci-D'Amato L, Cicatiello AE, Reccia MG, Volpicelli F, Severino V, Russo R, Sandomenico A, Doti N, D'Esposito V, Formisano P, Chambery A
* A targeted secretome profiling by multiplexed immunoassay revealed that secreted chemokine ligand 2 (MCP-1/CCL2) affects neural differentiation in mesencephalic neural progenitor cells (588 views)
Proteomics (ISSN: 1615-9853), 2015 Feb; 15(4): 714-724.
Impact Factor: 4.079
View Export to BibTeX Export to EndNote
De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (354 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
View Export to BibTeX Export to EndNote
Severino V, Alessio N, Farina A, Sandomenico A, Cipollaro M, Peluso G, Galderisi U, Chambery A
* Insulin-like growth factor binding proteins 4 and 7 released by senescent cells promote premature senescence in mesenchymal stem cells (943 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Nov 7; 4(11): e911-e911.
Impact Factor: 5.177
View Export to BibTeX Export to EndNote
Romano S, Staibano S, Greco A, Brunetti A, Nappo G, Ilardi G, Martinelli R, Sorrentino A, Di Pace A, Mascolo M, Bisogni R, Scalvenzi M, Alfano B, Romano M
* FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential (432 views) (PDF 242 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2013 Apr 4; 4(6): e578-e578.
Impact Factor: 5.333
View Export to BibTeX Export to EndNote
Galasso G, De Rosa R, Ciccarelli M, Sorriento D, Del Giudice C, Strisciuglio T, De Biase C, Luciano R, Piccolo R, Pierri A, Di Gioia G, Prevete N, Trimarco B, Piscione F, Iaccarino G
* β2-adrenergic receptor stimulation improves endothelial progenitor cell-mediated ischemic neoangiogenesis (473 views)
Circ Res (ISSN: 0009-7330, 1524-4571electronic, 0009-7330linking), 2013; 112(7): 1026-1034.
Impact Factor: 11.089
View Export to BibTeX Export to EndNote
Roviello GN, Musumeci D, Bucci EM, Pedone C
* Synthesis of a diaminopropanoic acid-based nucleoamino acid and assembly of cationic nucleopeptides for biomedical applications (444 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2012 Dec; 43(6): 2537-2543.
Impact Factor: 3.914
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (512 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G
* A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation, and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease (775 views)
Stem Cells (ISSN: 1066-5099), 2010 Sep; 28(8): 1326-1337.
Impact Factor: 7.871
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Kelly SE, Di Benedetto A, Greco A, Howard CM, Sollars VE, Primerano DA, Valluri JV, Claudio PP
* Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic Implications (462 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2010 Apr 8; 5(4): N/D-N/D.
Impact Factor: 4.411
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Garzia L, Andolfo I, Cusanelli E, Marino N, Petrosino G, De Martino D, Esposito V, Galeone A, Navas L, Esposito S, Gargiulo S, Fattet S, Donofrio V, Cinalli G, Brunetti A, Del Vecchio L, Northcott PA, Delattre O, Taylor MD, Iolascon A, Zollo M
* MicroRNA-199b-5p Impairs Cancer Stem Cells through Negative Regulation of HES1 in Medulloblastoma (442 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Mar 24; 4(3): e4998-e4998.
Impact Factor: 4.351
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Roviello GN, Musumeci D, Moccia M, Castiglione M, Cesarani A, Bucci EM, Saviano M, Pedone C, Benedetti E
* Evidences Of Complex Formation Between Daba-Based Nucleo-Gamma-Peptides With Alternate Configuration Backbone (431 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2009 Mar; 15(3): 147-154.
Impact Factor: 1.807
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Chambery A, Vissers JPC, Langridge JI, Lonardo E, Minchiotti G, Ruvo M, Parente A
* Qualitative and quantitative proteomic profiling of cripto-1- embryonic stem cells by means of accurate mass LC-MS analysis (1031 views)
J Proteome Res (ISSN: 1535-3893), 2009; 8(2): 1047-1058.
Impact Factor: 5.132
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (585 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Esposito L, Sica F, Sorrentino G, Berisio R, Carotenuto L, Giordano A, Raia CA, Rossi M, Lamzin VS, Wilson KS, Zagari A
Protein crystal growth in the advanced protein crystallization facility on the LMS mission: A comparison of Sulfolobus solfataricus alcohol dehydrogenase crystals grown on the ground and in microgravity (433 views)
Acta Crystallogr D Biol Crystallogr (ISSN: 0907-4449, 0907-4449linking), 1998; 54(3): 386-390.
Impact Factor: 2.244
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36 Records (30 excluding Abstracts).
Total impact factor: 211.112 (179.44 excluding Abstracts).
Total 5 year impact factor: 167.012 (134.17 excluding Abstracts).
Total impact factor: 211.112 (179.44 excluding Abstracts).
Total 5 year impact factor: 167.012 (134.17 excluding Abstracts).
472 views. Last view on Saturday 27 May 2023, 11:54:53
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