The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders
The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders(369 views) Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Keywords: Alzheimer, S Disease, Major Depressive Disorders, Metabotropic Glutamate Receptors, Neurodegeneration, Parkinson, Schizophrenia, Alzheimer Disease Drug Therapy Metabolism
, Animals
, Drug Delivery Systems Trends
, Drug Discovery Trends
, Excitatory Amino Acid Agonists Administration, Dosage Metabolism
, Excitatory Amino Acid Antagonists Administration, Humans
, Mental Disorders Drug Therapy Metabolism
, Nervous System Diseases Drug Therapy Metabolism
, Neuroprotective Agents Administration, Parkinson Disease Drug Therapy Metabolism
, Metabotropic Glutamate Agonists Antagonists, Inhibitors Metabolism
, Schizophrenia Drug Therapy Metabolism
, Alzhiemer’s Disease
, Parkinson’s Disease,
Affiliations: *** IBB - CNR ***
Department of Physiology and Pharmacology, University Sapienza, 00185 Rome, Italy; I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy. Electronic address: valeria.bruno@uniroma1.it., Department of Drug Sciences, University of Catania, 95125 Catania, Italy; I.R.C.C.S. Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy., Department of Drug Sciences, University of Catania, 95125 Catania, Italy; National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), 95126 Catania, Italy., Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, USA.,
I.R.C.C.S. Neuromed, 86077 Pozzilli, Italy. Electronic address: valeria.bruno@uniroma1.it.
Department of Drug Sciences, University of Catania, 95125 Catania, Italy
I.R.C.C.S. Associazione Oasi Maria S.S., Institute for Research on Mental Retardation and Brain Aging, 94018 Troina, Italy.
National Research Council, Institute of Biostructure and Bioimaging (IBB-CNR), 95126 Catania, Italy.
Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, USA.
References: Not available.
The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders
Metabotropic glutamate (mGlu) receptor ligands are under clinical development for the treatment of CNS disorders with high social and economic burden, such as schizophrenia, major depressive disorder (MDD), and Parkinson's disease (PD), and are promising drug candidates for the treatment of Alzheimer's disease (AD). So far, clinical studies have shown symptomatic effects of mGlu receptor ligands, but it is unknown whether these drugs act as disease modifiers or, at the opposite end, they accelerate disease progression by enhancing neurodegeneration. This is a fundamental issue in the treatment of PD and AD, and is also an emerging theme in the treatment of schizophrenia and MDD, in which neurodegeneration is also present and contribute to disease progression. Moving from in vitro data and preclinical studies, we discuss the potential impact of drugs targeting mGlu2, mGlu3, mGlu4 and mGlu5 receptor ligands on active neurodegeneration associated with AD, PD, schizophrenia, and MDD. We wish to highlight that our final comments on the best drug candidates are not influenced by commercial interests or by previous or ongoing collaborations with drug companies. This article is part of the Special Issue entitled 'Metabotropic Glutamate Receptors, 5 years on'.
The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders
The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders