Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model (441 views) (PDF restricted 96 views)
Dent Mater (ISSN: 0109-5641, 0109-5641linking), 2016 Jun; 32(6): 794-806.
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Paper type: Journal Article,
Impact factor: 4.07, 5-year impact factor: 5.155
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969234313&doi=10.1016%2fj.dental.2016.03.025&partnerID=40&md5=024078f340dbde6c191b42be91a25f76
Keywords: Dental Implant, Histomorphometry, Insertion Torque, Minipig Model, Resonance Frequency Analysis, Muct, Animals, Dental Implantation, Endosseous, Humans, Osseointegration, Pilot Projects, Reproducibility Of Results, Swine, Miniature, X-Ray Microtomography, μct,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: matteo.gramanzini@ibb.cnr.it., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: sara.gargiulo@ibb.cnr.it., Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University "Federico II", Via Pansini 5, 80131 Naples, Italy. Electronic address: fernandozarone@mac.com., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy. Electronic address: rosario.megna@ibb.cnr.it., Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: antonio.apicella@unina2.it., Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: raffaella.aversa@unina2.it., IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy. Electronic address: marsalva@unina.it., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy. Electronic address: marcello.mancini@ibb.cnr.it., Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University "Federico II", Via Pansini 5, 80131 Naples, Italy; Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: errestino@libero.it., Department of Advanced Medical Sciences, University "Federico II", Via Pansini 5, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: brunetti@unina.it.,
CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: matteo.gramanzini@ibb.cnr.it.
Department of Neuroscien
References:
Not available.
Dent Mater (ISSN: 0109-5641, 0109-5641linking), 2016 Jun; 32(6): 794-806.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.07, 5-year impact factor: 5.155
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969234313&doi=10.1016%2fj.dental.2016.03.025&partnerID=40&md5=024078f340dbde6c191b42be91a25f76
Keywords: Dental Implant, Histomorphometry, Insertion Torque, Minipig Model, Resonance Frequency Analysis, Muct, Animals, Dental Implantation, Endosseous, Humans, Osseointegration, Pilot Projects, Reproducibility Of Results, Swine, Miniature, X-Ray Microtomography, μct,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: matteo.gramanzini@ibb.cnr.it., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: sara.gargiulo@ibb.cnr.it., Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University "Federico II", Via Pansini 5, 80131 Naples, Italy. Electronic address: fernandozarone@mac.com., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy. Electronic address: rosario.megna@ibb.cnr.it., Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: antonio.apicella@unina2.it., Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: raffaella.aversa@unina2.it., IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy. Electronic address: marsalva@unina.it., Institute of Biostructure and Bioimaging, National Research Council, Via T. De Amicis 95, 80145 Naples, Italy. Electronic address: marcello.mancini@ibb.cnr.it., Department of Neurosciences, Reproductive and Odontostomatological Sciences, School of Medicine, University "Federico II", Via Pansini 5, 80131 Naples, Italy; Department of Architecture and Industrial Design, Second University of Naples, Borgo San Lorenzo, 81031 Aversa, Italy. Electronic address: errestino@libero.it., Department of Advanced Medical Sciences, University "Federico II", Via Pansini 5, 80145 Naples, Italy; CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: brunetti@unina.it.,
CEINGE scarl, Via G. Salvatore 486, 80145 Naples, Italy. Electronic address: matteo.gramanzini@ibb.cnr.it.
Department of Neuroscien
References:
Not available.
Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model
OBJECTIVES: To present a practical approach that combines biomechanical tests, microcomputed tomography (μCT) and histomorphometry, providing quantitative results on bone structure and mechanical properties in a minipig model, in order to investigate the specific response to an innovative dental biomaterial. METHODS: Titanium implants with innovative three-dimensional scaffolds were inserted in the tibias of 4 minipigs. Primary stability and osseointegration were investigated by means of insertion torque (IT) values, resonance frequency analysis (RFA), bone-to-implant contact (BIC), bone mineral density (BMD) and stereological measures of trabecular bone. RESULTS: A significant positive correlation was found between IT and RFA (r=0.980, p=0.0001). BMD at the implant sites was 18% less than the reference values (p=0.0156). Peri-implant Tb.Th was 50% higher, while Tb.N was 50% lower than the reference zone (p<0.003) and they were negatively correlated (r=-0.897, p=0.006). SIGNIFICANCE: μCT increases evaluation throughput and offers the possibility for qualitative three-dimensional recording of the bone-implant system as well as for non-destructive evaluation of bone architecture and mineral density, in combination with conventional analysis methods. The proposed multimodal approach allows to improve accuracy and reproducibility for peri-implant bone measurements and could support future investigations.
OBJECTIVES: To present a practical approach that combines biomechanical tests, microcomputed tomography (μCT) and histomorphometry, providing quantitative results on bone structure and mechanical properties in a minipig model, in order to investigate the specific response to an innovative dental biomaterial. METHODS: Titanium implants with innovative three-dimensional scaffolds were inserted in the tibias of 4 minipigs. Primary stability and osseointegration were investigated by means of insertion torque (IT) values, resonance frequency analysis (RFA), bone-to-implant contact (BIC), bone mineral density (BMD) and stereological measures of trabecular bone. RESULTS: A significant positive correlation was found between IT and RFA (r=0.980, p=0.0001). BMD at the implant sites was 18% less than the reference values (p=0.0156). Peri-implant Tb.Th was 50% higher, while Tb.N was 50% lower than the reference zone (p<0.003) and they were negatively correlated (r=-0.897, p=0.006). SIGNIFICANCE: μCT increases evaluation throughput and offers the possibility for qualitative three-dimensional recording of the bone-implant system as well as for non-destructive evaluation of bone architecture and mineral density, in combination with conventional analysis methods. The proposed multimodal approach allows to improve accuracy and reproducibility for peri-implant bone measurements and could support future investigations.
Combined microcomputed tomography, biomechanical and histomorphometric analysis of the peri-implant bone: a pilot study in minipig model
| ▼ Complementary use of preclinical imaging in minipig model studies |
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