Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease
CNR Ibb | back to homepage
CNR Ibb | back to homepage

Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease (443 views)

Sarappa C, Salvatore E, Filla A, Cocozza S, Russo CV, Sacca F, Brunetti A, De Michele G, Quarantelli M

Brain Imaging Behav (ISSN: 1931-7557, 1931-7557linking), 2017 Oct; 11(5): 1459-1469.

Export to BibTeX    Export to EndNote

Paper type: Journal Article

Impact factor: 3.719, 5-year impact factor: 4.21

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041996376&doi=10.1007%2fs11682-016-9630-6&partnerID=40&md5=95ba20813da9b897d3c8c68e048d18f5

Keywords: Amplitude Of Low-Frequency Fluctuations, Huntington, S Disease, Local Functional Connectivity, Regional Homogeneity, Resting-State Fmri, Spontaneous Neuronal Activity, Adolescent , Adult , Aged , Brain Diagnostic Imaging Physiopathology , Brain Mapping , Cerebrovascular Circulation Physiology , Female , Functional Laterality , Heterozygote , Humans , Huntingtin Protein Genetics , Huntington Disease Diagnostic Imaging Genetics Physiopathology , Magnetic Resonance Imaging , Middle Aged , Oxygen Blood , Prodromal Symptoms , Severity Of Illness Index , Young Adult, Huntington’s Disease

Affiliations:
*** IBB - CNR ***

Department of Advanced Biomedical Sciences, University "Federico II", Edificio 10, Via S. Pansini 5, 80131, Naples, Italy., Department of Neurosciences, Reproductive and Odontostomatological Sciences, University "Federico II", Edificio 17, Via S. Pansini 5, 80131, Naples, Italy., Biostructure and Bioimaging Institute, National Research Council, Via T. De Amicis 95, 80145, Naples, Italy. quarante@unina.it.,


References:
Not available.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

The fractional Amplitude of Low Frequency Fluctuations (fALFF) and the degree of local synchronization (Regional Homogeneity - ReHo) of resting-state BOLD signal have been suggested to map spontaneous neuronal activity and local functional connectivity, respectively. We compared voxelwise, independent of atrophy, the fALFF and ReHo patterns of 11 presymptomatic (ps-HD) and 28 symptomatic (sHD) Huntington's disease mutation carriers, with those of 40 normal volunteers, and tested their possible correlations with the motor and cognitive subscores of the Unified Huntington's Disease Rating Scale. In sHD patients, fALFF was mainly reduced bilaterally in parietal lobes (right precuneus being already affected in psHD), and in superior frontal gyri, and increased bilaterally in cerebellar lobules VI, VIII and IX, as well as in the right inferior temporal gyrus. In sHD, and to a lesser extent in psHD, ReHo was bilaterally reduced in putamina, cerebellar lobules III to VI, and superior medial frontal gyri, and increased in both psHD and sHD in fronto-basal cortices, and in the right temporal lobe. fALFF correlated inversely with cognitive scores in lobule IX of the cerebellum (mainly with total Stroop score, p < 0.0001), and in the medial portions of both thalami. These results are consistent with a reduced neuronal activity in the cortical components of the executive networks, known to be affected in Huntington's Disease, and with reduced local functional integration in subcortical and cerebellar components of the sensori-motor network. Cerebellar clusters of significant correlation of fALFF with executive function scores may be related to compensatory mechanisms.
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

▼    Characterization of neurotoxic and neuroprotective factors by using computational methodologies
Functional MRI signal fluctuations highlight altered resting brain activity in Huntington's disease

Filter those results▼
Query:  [X]
Options:
   Extended  
   IBB affiliation
 
Authors:  [X]
Paper type:  [X]
Start date:  [X]
End date:  [X]
Site:
[Clear form]
Select the year: 
Other filter: ([btitle,keywords] "Amplitude Of Low-Fre ...

Sort by:   date ▼▲   title ▲ ▼   journal ▲ ▼   authors ▲ ▼   I.F. ▲ ▼
Mazio F, Aloj G, Pastorino GMG, Perillo T, Russo C, Riccio MP, Covelli EM, Parasole R, Tedeschi E, Ugga L, D’amico A, Quarantelli M
* Default-Mode Network Connectivity Changes Correlate with Attention Deficits in ALL Long-Term Survivors Treated with Radio- and/or Chemotherapy (120 views)
Biology (ISSN: 2079-7737electronic, 2079-7737linking), 2022 Mar 24; 11 (4 ): N/D-N/D.
Impact Factor:
View    Export to BibTeX    Export to EndNote

Pepe G, Calce E, Verdoliva V, Saviano M, Maglione V, Di Pardo A, De Luca S
* Curcumin-Loaded Nanoparticles Based on Amphiphilic Hyaluronan-Conjugate Explored as Targeting Delivery System for Neurodegenerative Disorders (196 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Nov 23; 21(22): 1-13.
Impact Factor: 4.556
View    Export to BibTeX    Export to EndNote

Assante R, Salvatore E, Nappi C, Peluso S, De Simini G, Di Maio L, Palmieri GR, Ferrara IP, Roca A, De Michele G, Cuocolo A, Pappata S, De Rosa A
* Autonomic disorders and myocardial 123I-metaiodobenzylguanidine scintigraphy in Huntington's disease (121 views)
J Nucl Cardiol (ISSN: 1071-3581linking, 1532-6551electronic), 2020 Aug 16; N/D: N/D-N/D.
Impact Factor: 3.847
View    Export to BibTeX    Export to EndNote

Cocozza S, Pontillo G, Quarantelli M, Sacca F, Riccio E, Costabile T, Olivo G, Brescia Morra V, Pisani A, Brunetti A, Tedeschi E
* Default mode network modifications in Fabry disease: A resting-state fMRI study with structural correlations (643 views)
Hum Brain Mapp (ISSN: 1097-0193electronic, 1065-9471linking), 2018 Jan 09; 39(4): 1755-1764.
Impact Factor: 5.88
View    Export to BibTeX    Export to EndNote

Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (1021 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View    Export to BibTeX    Export to EndNote

Aiello M, Salvatore E, Cachia A, Pappata S, Cavaliere C, Prinster A, Nicolai E, Salvatore M, Baron JC, Quarantelli M
* Relationship between simultaneously acquired resting-state regional cerebral glucose metabolism and functional MRI: a PET/MR hybrid scanner study (476 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2015 Jun; 113: 111-121.
Impact Factor: 5.463
View    Export to BibTeX    Export to EndNote

Salvatore E, Quarantelli M, Russo C, Giorgio SM, Cervo A, Cocozza S, Di Maio L, Brunetti A, Filla A, De Michele G
* Default-Mode Network Alterations In Huntington'S Disease (453 views)
Second Joint Limpe / Dismov Sin Meeting Rome, 2013 Nov; N/D: N/D-N/D.
Impact Factor: 0
View    Export to BibTeX    Export to EndNote

Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (1260 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
View    Export to BibTeX    Export to EndNote

Esmaeilzadeh M, Farde L, Karlsson P, Varrone A, Halldin C, Waters S, Tedroff J
* Extrastriatal dopamine D 2 receptor binding in Huntington's disease (803 views)
Hum Brain Mapp (ISSN: 1065-9471, 1097-0193electronic, 1065-9471linking), 2011 Oct; 32(10): 1626-1636.
Impact Factor: 5.88
View    Export to BibTeX    Export to EndNote

Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (755 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View    Export to BibTeX    Export to EndNote

Esmaeilzadeh M, Kullingsjo J, Ullman H, Varrone A, Tedroff J
* Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with huntington disease (480 views)
Clin Neuropharmacol (ISSN: 0362-5664), 2011 May; 34(3): 95-100.
Impact Factor: 2.166
View    Export to BibTeX    Export to EndNote

Varrone A, Halldin C
Molecular imaging of the dopamine transporter (669 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
View    Export to BibTeX    Export to EndNote

Salvatore E, Di Maio L, Filla A, Ferrara AM, Rinaldi C, Sacca F, Peluso S, Macchia PE, Pappata S, De Michele G
* Benign hereditary chorea: Clinical and neuroimaging features in an Italian family (459 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2010 Jul 30; 25(10): 1491-1496.
Impact Factor: 4.48
View    Export to BibTeX    Export to EndNote

Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (1712 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View    Export to BibTeX    Export to EndNote

Coppola G, Fortunato D, Auricchio G, Mainolfi C, Operto FF, Signoriello G, Pascotto A, Salvatore M
* Bone mineral density in children, adolescents, and young adults with epilepsy (714 views)
Epilepsia (ISSN: 1528-1167, 0013-9580), 2009 Sep; 50(9): 2140-2146.
Impact Factor: 4.052
View    Export to BibTeX    Export to EndNote

Palladino P, Ronga L, Benedetti E, Rossi F, Ragone R
* Peptide Fragment Approach to Prion Misfolding: The Alpha-2 Domain (523 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2009 Sep; 15(3): 165-176.
Impact Factor: 0.869
View    Export to BibTeX    Export to EndNote

Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1258 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View    Export to BibTeX    Export to EndNote

17 Records (15 excluding Abstracts).
Total impact factor: 92.928 (89.394 excluding Abstracts).
Total 5 year impact factor: 94.597 (90.582 excluding Abstracts).

Last modified by Marco Comerci on Monday 27 May 2024, 11:16:08
443 views. Last view on Wednesday 11 December 2024, 16:08:50