Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme (BN), Telese Terme, Italy., Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini, 5, -80131, Naples, Italy., SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy., Department of Cardiology, Fatebenefratelli Hospital, Naples, Italy., Institute of Biostructures and Bioimages of the National Council of Research, Naples, Italy., Division of Imaging, Radiotherapy, Neuroradiology, and Medical Physics, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy., Division of Cardiology, Ospedale Medico-Chirurgico Accreditato Villa dei Fiori, Acerra, Naples, Italy., Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy., Division of Geriatrics, Department of Translational Medical Sciences, University of Naples Federico II, Via Sergio Pansini, 5, -80131, Naples, Italy. dleosco@unina.it.,
References: Not available.
Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure
PURPOSE: Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and there is conflicting evidence on cardiac 123I-mIBG uptake in healthy elderly subjects compared to adults. However, little data are available on the impact of ageing on cardiac sympathetic nerve activity assessed by 123I-mIBG scintigraphy, in patients with HF. METHODS AND RESULTS: We studied 180 HF patients (age = 66.1 +/- 10.5 years [yrs]), left ventricular ejection fraction (LVEF = 30.6 +/- 6.3 %) undergoing cardiac 123I-mIBG imaging. Early and late heart to mediastinum (H/M) ratios and washout rate were calculated in all patients. Demographic, clinical, and echocardiographic data were also collected. Our study population consisted of 53 patients aged >75 years (age = 77.7 +/- 4.0 year), 67 patients aged 62-72 years (age = 67.9 +/- 3.2 years) and 60 patients aged
Impact of aging on cardiac sympathetic innervation measured by 123I-mIBG imaging in patients with systolic heart failure
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G * Adrenergic Receptors(338 views) Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315. Impact Factor:0 ViewExport to BibTeXExport to EndNote
Santulli G, Cipolletta E, Sorriento D, Del Giudice C, Anastasio A, Monaco S, Maione AS, Condorelli G, Puca A, Trimarco B, Illario M, Iaccarino G * CaMK4 gene deletion induces hypertension(413 views) J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2012; 1(4): N/D-N/D. Impact Factor:2.882 ViewExport to BibTeXExport to EndNote