Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage(455 views) Monti DM, De Simone G, Langella E, Supuran CT, Di Fiore A, Monti SM
a Department of Chemical Sciences , University of Naples Federico II , Naples , Italy., b Institute of Biostructures and Bioimaging, CNR , Naples , Italy., c Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Universita degli Studi di Firenze , Florence , Italy.,
b Institute of Biostructures and Bioimaging, CNR , Naples , Italy.
c Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Florence , Italy.
References: Not available.
Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage
Carbonic anhydrases (CAs) III and VII are two cytosolic isoforms of the alpha-CA family which catalyze the physiological reaction of carbon dioxide hydration to bicarbonate and proton. Despite these two enzymes share a 49% sequence identity and present a very similar three-dimensional structure, they show profound differences when comparing the specific activity for CO2 hydration reaction, with CA VII being much more active than CA III. Recently, CA III and CA VII have been proposed to play a new role as scavenger enzymes in cells where oxidative damage occurs. Here, we will examine functional and structural features of these two isoforms giving insights into their newly proposed protective role against oxidative stress.
Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage
No results.
Insights into the role of reactive sulfhydryl groups of Carbonic Anhydrase III and VII during oxidative damage
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