Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study(368 views) Cocozza S, Canna A, Lanzillo R, Russo C, Postiglione E, Liuzzi R, Vastola M, Brunetti A, Salvatore M, Brescia Morra V, Palma G, Tedeschi E
The British Institute Of Radiology, 2016 Jun; N/D: N/D-N/D.
Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study
Objective:
We
aimed to evaluate the presence of venous stenosis and blood flow
abnormalities in the neck vessels of patients with multiple sclerosis
(MS), in respect to a group of age- and sex-matched healthy controls
(HC), and their possible relations with clinical variables using a
semi-automated quantitative MRI method.
Methods:
45
patients with relapsing remitting MS and 40 HC were enrolled in this
study. Flow rates and cross-sectional areas of arterial and venous neck
vessels were assessed by phase-contrast MRI at two different neck levels
(C2–C3 and C6–C7), and differences between groups were evaluated with
an unpaired
t
-test. Correlation between blood flow variables and clinical parameters was analyzed with Spearman's test.
Results:
A
significant internal jugular vein (IJV) stenosis was found in 23/45
(51.1%) patients with MS and 18/40 (45.0%) HC. No differences were
observed between patients with MS and HC for any of the flow measures
obtained. No correlations were found between MRI measures and any of the
tested clinical variables.
Conclusion:
No
differences in the IJV area emerged at quantitative MRI evaluation,
suggesting that stenosis of the extracranial veins is unrelated to MS.
Furthermore, no flow differences in the neck vessels were found between
patients with MS and HC in any of the tested flow measures, with no
correlation with clinical variables. Our results confirm that the
hypothesis of the presence of extracranial venous abnormalities in MS,
both in terms of stenosis or flow measures, is not suitable.
Advances in knowledge:
Neck
venous drainage abnormalities have been claimed to be associated with
MS. Conversely, our quantitative MRI analysis seems to exclude that
extracranial venous alterations are related to the disease.
Lack of correlation between extracranial venous abnormalities and multiple sclerosis: a quantitative MRI study
Hesse B, Tagil K, Cuocolo A, Anagnostopoulos C, Bardies M, Bax J, Bengel F, Busemann Sokole E, Davies G, Dondi M, Edenbrandt L, Franken P, Kjaer A, Knuuti J, Lassmann M, Ljungberg M, Marcassa C, Marie PY, Mckiddie F, O'connor M, Prvuolovich E, Underwood R * 3. 0 T perfusion MR imaging(879 views) Rivista Di Neuroradiologia (ISSN: 1120-9976), 2004; 17(6): 807-812. Impact Factor:0.023 ViewExport to BibTeXExport to EndNote