Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties(829 views) Musumeci D, Roviello GN, Rigione G, Capasso D, Di Gaetano S, Riccardi C, Roviello V, Montesarchio D
Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties
Notwithstanding the wide variety of applications of benzodifuran derivatives, especially in the field of innovative organic materials with particular properties, the biological activity of this class of compounds has been scarcely investigated. Aiming at further exploring the properties and bioactivity of benzodifurans, we here synthesized three compounds belonging to this class, and characterized them using spectroscopic and spectrometric techniques, also using SEM and thermogravimetric analysis. The obtained compounds showed interesting antiproliferative activity on different human cancer cells, while no relevant cytotoxic effect was observed on healthy cells used as control. In order to explore the possible mechanism of action of the benzodifuran molecules, we investigated their ability to bind DNA ‒ studying their interaction with various DNA model systems ‒ and evaluated their aggregation properties and ability to bind biologically relevant metal ions.
Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L * Combined HAT/EZH2 modulation leads to cancer-selective cell death(616 views) Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646. Impact Factor:5.008 ViewExport to BibTeXExport to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease(992 views) Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026. Impact Factor:0.913 ViewExport to BibTeXExport to EndNote
226 Records (206 excluding Abstracts). Total impact factor: 744.694 (688.31 excluding Abstracts). Total 5 year impact factor: 771.403 (700.278 excluding Abstracts).