Altered functional connectivity of interoception in illness anxiety disorder (340 views)
Cortex (ISSN: 0010-9452, 0010-9452linking), 2017 Jan; 86: 22-32.
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Paper type: Journal Article
Impact factor: 4.907, 5-year impact factor: 4.97
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996557480&doi=10.1016%2fj.cortex.2016.10.018&partnerID=40&md5=ab6f7b3e30e5892cfda0ade12dc3cbaa
Keywords: Emotion, Functional Connectivity, Illness Anxiety Disorder, Interoception, Rs-Fmri, Adult , Aged , Anxiety Disorders Diagnostic Imaging Physiopathology , Awareness Physiology , Brain Diagnostic Imaging Physiopathology , Emotions Physiology , Female , Humans , Interoception Physiology , Magnetic Resonance Imaging , Middle Aged , Nerve Net Diagnostic Imaging Physiopathology , Young Adult
Affiliations:
*** IBB - CNR ***
Department of Psychology, Second University of Naples, Italy., Department of Psychology, Second University of Naples, Italy. Electronic address: mariachiara.longarzo@unina2.it., Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy., Department of Neuroscience Reproductive Sciences and Odontostomatology, University Federico II, Naples, Italy., IRCCS SDN, Naples, Italy., Center for Psychosomatic Psychotherapy, Naples, Italy.,
References:
Not available.
Cortex (ISSN: 0010-9452, 0010-9452linking), 2017 Jan; 86: 22-32.
Export to BibTeX Export to EndNote
Paper type: Journal Article
Impact factor: 4.907, 5-year impact factor: 4.97
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84996557480&doi=10.1016%2fj.cortex.2016.10.018&partnerID=40&md5=ab6f7b3e30e5892cfda0ade12dc3cbaa
Keywords: Emotion, Functional Connectivity, Illness Anxiety Disorder, Interoception, Rs-Fmri, Adult , Aged , Anxiety Disorders Diagnostic Imaging Physiopathology , Awareness Physiology , Brain Diagnostic Imaging Physiopathology , Emotions Physiology , Female , Humans , Interoception Physiology , Magnetic Resonance Imaging , Middle Aged , Nerve Net Diagnostic Imaging Physiopathology , Young Adult
Affiliations:
*** IBB - CNR ***
Department of Psychology, Second University of Naples, Italy., Department of Psychology, Second University of Naples, Italy. Electronic address: mariachiara.longarzo@unina2.it., Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy., Department of Neuroscience Reproductive Sciences and Odontostomatology, University Federico II, Naples, Italy., IRCCS SDN, Naples, Italy., Center for Psychosomatic Psychotherapy, Naples, Italy.,
References:
Not available.
Altered functional connectivity of interoception in illness anxiety disorder
Interoception collects all information coming from the body and is sustained by several brain areas such as insula and cingulate cortex. Here, we used resting-state functional magnetic resonance imaging to investigate functional connectivity (FC) of networks implied in interoception in patients with Illness anxiety disorders (IADs). We observed significantly reduced FC between the left extrastriate body area (EBA) and the paracentral lobule compared to healthy controls. Moreover, the correlation analysis between behavioural questionnaires and ROI to ROI FC showed that higher levels of illness anxiety were related to hyper-connectivity between EBA and amygdala and hippocampus. Scores on a questionnaire for interoceptive awareness were significantly correlated with higher FC between right hippocampus and nucleus accumbens bilaterally, and with higher connectivity between left anterior cingulate cortex (ACC) and left orbitofrontal cortex (OFC). Last, patients showed increased interoceptive awareness, measured by Self-Awareness Questionnaire (SAQ), and reduced capability in recognizing emotions, indicating inverse correlation between interoception and emotional awareness. Taken together our results suggested that, in absence of structural and micro-structural changes, patients with IADs show functional alteration in the neural network involved in the self-body representation; such functional alteration might be the target of possible treatments.
Interoception collects all information coming from the body and is sustained by several brain areas such as insula and cingulate cortex. Here, we used resting-state functional magnetic resonance imaging to investigate functional connectivity (FC) of networks implied in interoception in patients with Illness anxiety disorders (IADs). We observed significantly reduced FC between the left extrastriate body area (EBA) and the paracentral lobule compared to healthy controls. Moreover, the correlation analysis between behavioural questionnaires and ROI to ROI FC showed that higher levels of illness anxiety were related to hyper-connectivity between EBA and amygdala and hippocampus. Scores on a questionnaire for interoceptive awareness were significantly correlated with higher FC between right hippocampus and nucleus accumbens bilaterally, and with higher connectivity between left anterior cingulate cortex (ACC) and left orbitofrontal cortex (OFC). Last, patients showed increased interoceptive awareness, measured by Self-Awareness Questionnaire (SAQ), and reduced capability in recognizing emotions, indicating inverse correlation between interoception and emotional awareness. Taken together our results suggested that, in absence of structural and micro-structural changes, patients with IADs show functional alteration in the neural network involved in the self-body representation; such functional alteration might be the target of possible treatments.
Altered functional connectivity of interoception in illness anxiety disorder
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Altered functional connectivity of interoception in illness anxiety disorder
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 4.907
View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.534
View Export to BibTeX Export to EndNote
18 Records (17 excluding Abstracts).
Total impact factor: 77.077 (73.543 excluding Abstracts).
Total 5 year impact factor: 71.32 (67.305 excluding Abstracts).
Total impact factor: 77.077 (73.543 excluding Abstracts).
Total 5 year impact factor: 71.32 (67.305 excluding Abstracts).
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