Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations (593 views)
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2017 Feb; 24(1): 103-107.
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Paper type: Journal Article,
Impact factor: 4.011, 5-year impact factor: 3.456
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949524716&doi=10.1007%2fs12350-015-0332-z&partnerID=40&md5=7e8356ae97c03fb7f47ebf68fbbc27b5
Keywords: 123i-Metaiodobenzylguanidine Myocardial Scintigraphy, Parkinson, S Disease, Parkin Gene,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Via Pansini 5, 80131, Naples, Italy. anna_derosa@libero.it., Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy., Center for Neurodegenerative Disease, University of Salerno-CEMAND, Salerno, Italy., Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.,
References:
Not available.
J Nucl Cardiol (ISSN: 1071-3581, 1532-6551, 1532-6551electronic), 2017 Feb; 24(1): 103-107.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.011, 5-year impact factor: 3.456
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84949524716&doi=10.1007%2fs12350-015-0332-z&partnerID=40&md5=7e8356ae97c03fb7f47ebf68fbbc27b5
Keywords: 123i-Metaiodobenzylguanidine Myocardial Scintigraphy, Parkinson, S Disease, Parkin Gene,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Via Pansini 5, 80131, Naples, Italy. anna_derosa@libero.it., Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy., Center for Neurodegenerative Disease, University of Salerno-CEMAND, Salerno, Italy., Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy.,
References:
Not available.
Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations
BACKGROUND: PARK2 is an autosomal recessive parkinsonism caused by parkin gene mutations. Several Parkinson's Disease (PD) cases harbor single parkin mutations, raising a debate about the pathogenic meaning of heterozygous mutations. Here, we evaluate cardiac autonomic innervation in patients with either two or one parkin mutations compared to patients with idiopathic PD (IPD). PATIENTS AND METHODS: Myocardial 123I-metaiodobenzylguanidine (MIBG) scintigraphy was performed in six PD patients with single parkin mutations (HET), four with two mutations (PARK2), and eight with IPD. RESULTS: In comparison to control group, IPD patients showed lower early and late heart-to-mediastinum (H/M) ratios and higher washout rates, whereas HET patients had only lower early H/M ratio, and PARK2 patients were not different for any parameter. At individual level, MIBG findings were abnormal in 7/8 IPD, in 4/6 HET and in 1/4 PARK2 patients. CONCLUSIONS: Preserved cardiac 123I-MIBG uptake confirms that PARK2 pathogenic mechanism, at least partially, differs from that responsible for IPD. HET subjects show intermediate findings, suggesting possible heterogeneity.
BACKGROUND: PARK2 is an autosomal recessive parkinsonism caused by parkin gene mutations. Several Parkinson's Disease (PD) cases harbor single parkin mutations, raising a debate about the pathogenic meaning of heterozygous mutations. Here, we evaluate cardiac autonomic innervation in patients with either two or one parkin mutations compared to patients with idiopathic PD (IPD). PATIENTS AND METHODS: Myocardial 123I-metaiodobenzylguanidine (MIBG) scintigraphy was performed in six PD patients with single parkin mutations (HET), four with two mutations (PARK2), and eight with IPD. RESULTS: In comparison to control group, IPD patients showed lower early and late heart-to-mediastinum (H/M) ratios and higher washout rates, whereas HET patients had only lower early H/M ratio, and PARK2 patients were not different for any parameter. At individual level, MIBG findings were abnormal in 7/8 IPD, in 4/6 HET and in 1/4 PARK2 patients. CONCLUSIONS: Preserved cardiac 123I-MIBG uptake confirms that PARK2 pathogenic mechanism, at least partially, differs from that responsible for IPD. HET subjects show intermediate findings, suggesting possible heterogeneity.
Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations
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Myocardial 123I-metaiodobenzylguanidine scintigraphy in patients with homozygous and heterozygous parkin mutations
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De Rosa A, Pellegrino T, Pappata S, Lieto M, Bonifati V, Palma V, Topa A, Santoro L, Bilo L, Cuocolo A, De Michele G
* Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism (580 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2016 Feb; 23: 102-105.
Impact Factor: 4.484
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* Non-motor symptoms and cardiac innervation in SYNJ1-related parkinsonism (580 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2016 Feb; 23: 102-105.
Impact Factor: 4.484
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 4.484 (4.484 excluding Abstracts).
Total 5 year impact factor: 4.38 (4.38 excluding Abstracts).
Total impact factor: 4.484 (4.484 excluding Abstracts).
Total 5 year impact factor: 4.38 (4.38 excluding Abstracts).
593 views. Last view on Wednesday 19 March 2025, 15:13:00
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