Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers (483 views) (PDF public 223 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 20; 7: 46659-46659.
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Paper type: Journal Article,
Impact factor: 4.122, 5-year impact factor: 4.609
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030992723&doi=10.1038%2fsrep46659&partnerID=40&md5=c70828c6b219fa6cd79a0487dfcab7d0
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore" (IEOS), Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini 5, 80131 Naples, Italy., Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via T. De Amicis 95, 80145 Naples, Italy.,
Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore” (IEOS), Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini 5, Naples, 80131, Italy
References:
Dent, R., Triple-negative breast cancer: Clinical features and patterns of recurrence (2007) Clin. Cancer Res., 13, pp. 4429-443
Lehmann, B.D., Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies (2011) J. Clin. Invest., 121, pp. 2750-2767
Mayer, I.A., Abramson, V.G., Lehmann, B.D., Pietenpol, J.A., New strategies for triple-negative breast cancer–deciphering the heterogeneity (2014) Clin. Cancer Res., 20, pp. 782-790
Masuda, H., Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes (2013) Clin. Cancer Res., 19, pp. 5533-5540
Schneider, B.P., Triple-negative breast cancer: Risk factors to potential targets (2008) Clin. Cancer Res., 14, pp. 8010-8018
Carey, L.A., The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes (2007) Clin. Cancer Res., 13, pp. 2329-2334
Liu, T.J., CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer (2013) Oncogene, 32, pp. 544-553
Plantamura, I., PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells (2014) Mol. Oncol., 8, pp. 968-981
Wagenblast, E., A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis (2015) Nature, 520, pp. 358-362
Kirschmann, D.A., Seftor, E.A., Hardy, K.M., Seftor, R.E., Hendrix, M.J., Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications (2012) Clin. Cancer Res., 18, pp. 2726-2732
Masuda, H., Role of epidermal growth factor receptor in breast cancer (2012) Breast Cancer Res. Treat., 136, pp. 331-345
Park, H.S., High EGFR gene copy number predicts poor outcome in triple-negative breast cancer (2014) Mod. Pathol., 27, pp. 1212-1222
Corkery, B., Crown, J., Clynes, M., O’Donovan, N., Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer (2009) Ann. Oncol., 20, pp. 862-867
Von Minckwitz, G., A multicentre phase II study on gefitinib in taxane- And anthracycline-pretreated metastatic breast cancer (2005) Breast Cancer Res. Treat., 89, pp. 165-172
Baselga, J., Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer (2005) J. Clin. Oncol., 23, pp. 5323-5333
Dickler, M.N., Cobleigh, M.A., Miller, K.D., Klein, P.M., Winer, E.P., Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer (2009) Breast Cancer Res. Treat., 115, pp. 115-121
Cowherd, S., A phase II clinical trial of weekly paclitaxel and carboplatin in combination with panitumumab in metastatic triple negative breast cancer (2015) Cancer Biol. Ther., 16, pp. 678-683
Seguin, L., An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition (2014) Nat. Cell Biol., 16, pp. 457-468
Lee, M.J., Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks (2012) Cell, 149, pp. 780-794
Cerchia, L., De Franciscis, V., Targeting cancer cells with nucleic acid aptamers (2010) Trends Biotechnol., 28, pp. 517-525
Keefe, A.D., Pai, S., Ellington, A., Aptamers as therapeutics (2010) Nat. Rev. Drug Discov., 9, pp. 537-550
Thiel, K.W., Giangrande, P.H., Intracellular delivery of RNA-based therapeutics using aptamers (2010) Ther. Deliv., 1, pp. 849-861
Wang, A.Z., Langer, R., Farokhzad, O.C., Nanoparticle delivery of cancer drugs (2012) Annu. Rev. Med., 63, pp. 185-198
Esposito, C.L., A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death (2011) Plos One, 6, p. e24071
Camorani, S., Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer (2014) Mol. Ther., 22, pp. 828-841
Camorani, S., Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells (2015) Oncotarget, 6, pp. 37570-37587
Shu, D., Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology (2015) ACS Nano, 9, pp. 9731-9740
Kim, Y., Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity (2012) Genes Dev, 26, pp. 1247-1262
D’ Ippolito, E., MiR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016) Cancer Res., 76, pp. 5562-5572
Ruf, W., Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry (2003) Cancer Res., 63, pp. 5381-5399
Amiano, N.O., Anti-tumor effect of SLPI on mammary but not colon tumor growth (2013) J. Cell Physiol., 228, pp. 469-475
Fayard, B., The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression (2009) Cancer Res., 69, pp. 5690-5698
Desgrosellier, J.S., Cheresh, D.A., Integrins in cancer: Biological implications and therapeutic opportunities (2010) Nat. Rev. Cancer, 10, pp. 9-22
Niu, G., Chen, X., Why integrin as a primary target for imaging and therapy (2011) Theranostics, 1, pp. 30-47
Huttenlocher, A., Horwitz, A.R., Integrins in cell migration (2011) Cold Spring Harb. Perspect Biol., 3, p. a005074
Vartanian, A., Melanoma vasculogenic mimicry capillary-like structure formation depends on integrin and calcium signaling (2011) Microcirculation, 18, pp. 390-399
Soung, Y.H., Clifford, J.L., Chung, J., Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression (2010) BMB Rep., 43, pp. 311-318
Das, R., Mahabeleshwar, G.H., Kundu, G.C., Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells (2004) J. Biol. Chem., 279, pp. 11051-11064
Liu, Z., EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis (2016) Oncotarget, 7, pp. 4680-4694
Moro, L., Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines (2002) J. Biol. Chem., 277, pp. 9405-9414
Carlson, T.R., Feng, Y., Maisonpierre, P.C., Mrksich, M., Morla, A.O., Direct cell adhesion to the angiopoietins mediated by integrins (2001) J. Biol. Chem., 276, pp. 26516-26525
Baselga, J., Randomized phase II study of the anti-epidermal growth factor receptor monoclonal antibody cetuximab with cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer (2013) J. Clin. Oncol., 31, pp. 2586-2592
Rudek, M.A., Chau, C.H., Figg, W., McLeod, H.L., (2014) Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, pp. 599-602. , Springer-Verlag, New York
Qiao, L., Advanced research on vasculogenic mimicry in cancer (2015) J. Cell Mol. Med., 19, pp. 315-326
Nguyen, L.V., DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts (2014) Nat. Commun., 5, p. 5871
Blick, T., Epithelial mesenchymal transition traits in human breast cancer cell lines (2008) Clin. Exp. Metastasis, 25, pp. 629-642
Betapudi, V., Licate, L.S., Egelhoff, T.T., Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration (2006) Cancer Res., 66, pp. 4725-4733
Han, H.J., Russo, J., Kohwi, Y., Kohwi-Shigematsu, T., SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis (2008) Nature, 452, pp. 187-193
Hendrix, M.J., Seftor, E.A., Hess, A.R., Seftor, R.E., Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma (2003) Nat. Rev. Cancer, 3, pp. 411-421
Yarden, Y., Biology of HER2 and its importance in breast cancer (2001) Oncology, 61, pp. 1-13
Moore, K.M., Therapeutic targeting of integrin αvβ6 in breast cancer (2014) J. Natl. Cancer Inst., p. 106
De Franceschi, N., Hamidi, H., Alanko, J., Sahgal, P., Ivaska, J., Integrin traffic - The update (2015) J. Cell. Sci., 128, pp. 839-852
Muharram, G., Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells (2014) Dev. Cell., 29, pp. 421-436
Borges, E., Jan, Y., Ruoslahti, E., Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain (2000) J. Biol. Chem., 275, pp. 39867-43973
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Apr 20; 7: 46659-46659.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.122, 5-year impact factor: 4.609
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030992723&doi=10.1038%2fsrep46659&partnerID=40&md5=c70828c6b219fa6cd79a0487dfcab7d0
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Istituto per l'Endocrinologia e l'Oncologia Sperimentale "G. Salvatore" (IEOS), Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini 5, 80131 Naples, Italy., Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via T. De Amicis 95, 80145 Naples, Italy.,
Istituto per l’Endocrinologia e l’Oncologia Sperimentale “G. Salvatore” (IEOS), Consiglio Nazionale delle Ricerche (CNR), Via S. Pansini 5, Naples, 80131, Italy
References:
Dent, R., Triple-negative breast cancer: Clinical features and patterns of recurrence (2007) Clin. Cancer Res., 13, pp. 4429-443
Lehmann, B.D., Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies (2011) J. Clin. Invest., 121, pp. 2750-2767
Mayer, I.A., Abramson, V.G., Lehmann, B.D., Pietenpol, J.A., New strategies for triple-negative breast cancer–deciphering the heterogeneity (2014) Clin. Cancer Res., 20, pp. 782-790
Masuda, H., Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes (2013) Clin. Cancer Res., 19, pp. 5533-5540
Schneider, B.P., Triple-negative breast cancer: Risk factors to potential targets (2008) Clin. Cancer Res., 14, pp. 8010-8018
Carey, L.A., The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes (2007) Clin. Cancer Res., 13, pp. 2329-2334
Liu, T.J., CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancer (2013) Oncogene, 32, pp. 544-553
Plantamura, I., PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells (2014) Mol. Oncol., 8, pp. 968-981
Wagenblast, E., A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis (2015) Nature, 520, pp. 358-362
Kirschmann, D.A., Seftor, E.A., Hardy, K.M., Seftor, R.E., Hendrix, M.J., Molecular pathways: Vasculogenic mimicry in tumor cells: Diagnostic and therapeutic implications (2012) Clin. Cancer Res., 18, pp. 2726-2732
Masuda, H., Role of epidermal growth factor receptor in breast cancer (2012) Breast Cancer Res. Treat., 136, pp. 331-345
Park, H.S., High EGFR gene copy number predicts poor outcome in triple-negative breast cancer (2014) Mod. Pathol., 27, pp. 1212-1222
Corkery, B., Crown, J., Clynes, M., O’Donovan, N., Epidermal growth factor receptor as a potential therapeutic target in triple-negative breast cancer (2009) Ann. Oncol., 20, pp. 862-867
Von Minckwitz, G., A multicentre phase II study on gefitinib in taxane- And anthracycline-pretreated metastatic breast cancer (2005) Breast Cancer Res. Treat., 89, pp. 165-172
Baselga, J., Phase II and tumor pharmacodynamic study of gefitinib in patients with advanced breast cancer (2005) J. Clin. Oncol., 23, pp. 5323-5333
Dickler, M.N., Cobleigh, M.A., Miller, K.D., Klein, P.M., Winer, E.P., Efficacy and safety of erlotinib in patients with locally advanced or metastatic breast cancer (2009) Breast Cancer Res. Treat., 115, pp. 115-121
Cowherd, S., A phase II clinical trial of weekly paclitaxel and carboplatin in combination with panitumumab in metastatic triple negative breast cancer (2015) Cancer Biol. Ther., 16, pp. 678-683
Seguin, L., An integrin β3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition (2014) Nat. Cell Biol., 16, pp. 457-468
Lee, M.J., Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks (2012) Cell, 149, pp. 780-794
Cerchia, L., De Franciscis, V., Targeting cancer cells with nucleic acid aptamers (2010) Trends Biotechnol., 28, pp. 517-525
Keefe, A.D., Pai, S., Ellington, A., Aptamers as therapeutics (2010) Nat. Rev. Drug Discov., 9, pp. 537-550
Thiel, K.W., Giangrande, P.H., Intracellular delivery of RNA-based therapeutics using aptamers (2010) Ther. Deliv., 1, pp. 849-861
Wang, A.Z., Langer, R., Farokhzad, O.C., Nanoparticle delivery of cancer drugs (2012) Annu. Rev. Med., 63, pp. 185-198
Esposito, C.L., A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death (2011) Plos One, 6, p. e24071
Camorani, S., Inhibition of receptor signaling and of glioblastoma-derived tumor growth by a novel PDGFRβ aptamer (2014) Mol. Ther., 22, pp. 828-841
Camorani, S., Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells (2015) Oncotarget, 6, pp. 37570-37587
Shu, D., Systemic Delivery of Anti-miRNA for Suppression of Triple Negative Breast Cancer Utilizing RNA Nanotechnology (2015) ACS Nano, 9, pp. 9731-9740
Kim, Y., Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity (2012) Genes Dev, 26, pp. 1247-1262
D’ Ippolito, E., MiR-9 and miR-200 Regulate PDGFRβ-Mediated Endothelial Differentiation of Tumor Cells in Triple-Negative Breast Cancer (2016) Cancer Res., 76, pp. 5562-5572
Ruf, W., Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry (2003) Cancer Res., 63, pp. 5381-5399
Amiano, N.O., Anti-tumor effect of SLPI on mammary but not colon tumor growth (2013) J. Cell Physiol., 228, pp. 469-475
Fayard, B., The serine protease inhibitor protease nexin-1 controls mammary cancer metastasis through LRP-1-mediated MMP-9 expression (2009) Cancer Res., 69, pp. 5690-5698
Desgrosellier, J.S., Cheresh, D.A., Integrins in cancer: Biological implications and therapeutic opportunities (2010) Nat. Rev. Cancer, 10, pp. 9-22
Niu, G., Chen, X., Why integrin as a primary target for imaging and therapy (2011) Theranostics, 1, pp. 30-47
Huttenlocher, A., Horwitz, A.R., Integrins in cell migration (2011) Cold Spring Harb. Perspect Biol., 3, p. a005074
Vartanian, A., Melanoma vasculogenic mimicry capillary-like structure formation depends on integrin and calcium signaling (2011) Microcirculation, 18, pp. 390-399
Soung, Y.H., Clifford, J.L., Chung, J., Crosstalk between integrin and receptor tyrosine kinase signaling in breast carcinoma progression (2010) BMB Rep., 43, pp. 311-318
Das, R., Mahabeleshwar, G.H., Kundu, G.C., Osteopontin induces AP-1-mediated secretion of urokinase-type plasminogen activator through c-Src-dependent epidermal growth factor receptor transactivation in breast cancer cells (2004) J. Biol. Chem., 279, pp. 11051-11064
Liu, Z., EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis (2016) Oncotarget, 7, pp. 4680-4694
Moro, L., Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines (2002) J. Biol. Chem., 277, pp. 9405-9414
Carlson, T.R., Feng, Y., Maisonpierre, P.C., Mrksich, M., Morla, A.O., Direct cell adhesion to the angiopoietins mediated by integrins (2001) J. Biol. Chem., 276, pp. 26516-26525
Baselga, J., Randomized phase II study of the anti-epidermal growth factor receptor monoclonal antibody cetuximab with cisplatin versus cisplatin alone in patients with metastatic triple-negative breast cancer (2013) J. Clin. Oncol., 31, pp. 2586-2592
Rudek, M.A., Chau, C.H., Figg, W., McLeod, H.L., (2014) Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, pp. 599-602. , Springer-Verlag, New York
Qiao, L., Advanced research on vasculogenic mimicry in cancer (2015) J. Cell Mol. Med., 19, pp. 315-326
Nguyen, L.V., DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts (2014) Nat. Commun., 5, p. 5871
Blick, T., Epithelial mesenchymal transition traits in human breast cancer cell lines (2008) Clin. Exp. Metastasis, 25, pp. 629-642
Betapudi, V., Licate, L.S., Egelhoff, T.T., Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migration (2006) Cancer Res., 66, pp. 4725-4733
Han, H.J., Russo, J., Kohwi, Y., Kohwi-Shigematsu, T., SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis (2008) Nature, 452, pp. 187-193
Hendrix, M.J., Seftor, E.A., Hess, A.R., Seftor, R.E., Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma (2003) Nat. Rev. Cancer, 3, pp. 411-421
Yarden, Y., Biology of HER2 and its importance in breast cancer (2001) Oncology, 61, pp. 1-13
Moore, K.M., Therapeutic targeting of integrin αvβ6 in breast cancer (2014) J. Natl. Cancer Inst., p. 106
De Franceschi, N., Hamidi, H., Alanko, J., Sahgal, P., Ivaska, J., Integrin traffic - The update (2015) J. Cell. Sci., 128, pp. 839-852
Muharram, G., Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells (2014) Dev. Cell., 29, pp. 421-436
Borges, E., Jan, Y., Ruoslahti, E., Platelet-derived growth factor receptor beta and vascular endothelial growth factor receptor 2 bind to the beta 3 integrin through its extracellular domain (2000) J. Biol. Chem., 275, pp. 39867-43973
Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers
Current treatment options for triple-negative breast cancers (TNBCs) is limited by the absence of well-defined biomarkers, excluding a targeted therapy. Notably, epidermal growth factor receptor (EGFR) is overexpressed in a great proportion of TNBCs and is a negative prognostic factor. In clinical trials, however, existing EGFR inhibitors showed disappointing outcome. Oligonucleotide aptamers are a valid alternative to antibodies for diagnostic and therapeutic uses. Here, we prove that, when applied to aggressive TNBC cell lines with unique stem-like plasticity, the anti-EGFR CL4 aptamer, but not erlotinib or cetuximab, prevents the vasculogenic mimicry (VM) capability of the cells and destroys previously formed channels in three-dimensional culture. Notably, we found that CL4 impairs the matrix-induced integrin αvβ3 interaction with EGFR and integrin αvβ3-dependent cell adhesion. Consistently, the aptamer strongly inhibits VM and tumor growth in a xenograft TNBC model. These data suggest that in TNBC cells, EGFR may cooperate with integrin αvβ3 to regulate integrin binding to extracellular ligands required for VM, and EGFR-targeting by CL4 aptamer may counteract this event. Overall, we demonstrate a novel mechanism of action for CL4 related with integrin αvβ3-EGFR interaction, that may help to develop new oligonucleotide-based strategy addressing unmet need for TNBCs therapy. © The Author(s) 2017
Current treatment options for triple-negative breast cancers (TNBCs) is limited by the absence of well-defined biomarkers, excluding a targeted therapy. Notably, epidermal growth factor receptor (EGFR) is overexpressed in a great proportion of TNBCs and is a negative prognostic factor. In clinical trials, however, existing EGFR inhibitors showed disappointing outcome. Oligonucleotide aptamers are a valid alternative to antibodies for diagnostic and therapeutic uses. Here, we prove that, when applied to aggressive TNBC cell lines with unique stem-like plasticity, the anti-EGFR CL4 aptamer, but not erlotinib or cetuximab, prevents the vasculogenic mimicry (VM) capability of the cells and destroys previously formed channels in three-dimensional culture. Notably, we found that CL4 impairs the matrix-induced integrin αvβ3 interaction with EGFR and integrin αvβ3-dependent cell adhesion. Consistently, the aptamer strongly inhibits VM and tumor growth in a xenograft TNBC model. These data suggest that in TNBC cells, EGFR may cooperate with integrin αvβ3 to regulate integrin binding to extracellular ligands required for VM, and EGFR-targeting by CL4 aptamer may counteract this event. Overall, we demonstrate a novel mechanism of action for CL4 related with integrin αvβ3-EGFR interaction, that may help to develop new oligonucleotide-based strategy addressing unmet need for TNBCs therapy. © The Author(s) 2017
Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers
Aptamer-mediated impairment of EGFR-integrin alphavbeta3 complex inhibits vasculogenic mimicry and growth of triple-negative breast cancers
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Impact Factor: 4.48
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Lanzillo R, Chiodi A, Carotenuto A, Magri V, Napolitano A, Liuzzi R, Costabile T, Rainone N, Freda MF, Valerio P, Brescia Morra V
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Impact Factor: 2.013
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
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Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
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Impact Factor: 2.559
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
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Impact Factor: 2.526
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
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Impact Factor: 2.884
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Bilo L, Peluso S, Antenora A, De Rosa A, Auletta G, Pappata S, De Michele G
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Impact Factor: 3.972
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
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Impact Factor: 4.922
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
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Impact Factor: 1.045
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
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Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
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Impact Factor: 7.895
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Bastianello S, Giugni E, Amato MP, Tola MR, Trojano M, Galletti S, Luccichenti G, Quarantelli M, Picconi O, Patti F, COGIMUS
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Impact Factor: 2.167
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Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P
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Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
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Impact Factor: 3.474
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Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
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Impact Factor: 5.036
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (395 views)
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Impact Factor: 3.042
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
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Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
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Impact Factor: 6.747
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
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De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
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Impact Factor: 2.02
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
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Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
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Impact Factor: 0.193
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
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Impact Factor: 5.115
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Pappata S, Varrone A, Milan G, Sansone V, Iavarone A, Panico M, Quarantelli M, Mollica C, De Falco C, Lore E, Postiglione A, Salvatore M
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
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Impact Factor: 2.296
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
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Impact Factor: 5.778
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Varrone A, Pappata S, Lore E, Sansone V, Iavarone A, Carlomagno S, Brunetti A, Postiglione A, Salvatore M
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Impact Factor: 3.935
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Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
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Impact Factor: 3.935
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* Voxel-based analysis of gray matter relaxation rates shows different correlation patterns for cognitive impairment and physical disability in relapsing-remitting multiple sclerosis (186 views)
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Impact Factor: 2.526
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Megna R, Alfano B, Lanzillo R, Costabile T, Comerci M, Vacca G, Carotenuto A, Moccia M, Servillo G, Prinster A, Brescia Morra V, Quarantelli M
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Impact Factor: 3.853
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Hill BS, Sarnella A, Capasso D, Comegna D, Del Gatto A, Gramanzini M, Albanese S, Saviano M, Zaccaro L, Zannetti A
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Bolzati C, Salvarese N, Carpanese D, Seraglia R, Melendez-alafort L, Rosato A, Capasso D, Saviano M, Del Gatto A, Comegna D, Zaccaro L
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Ciarmiello A, Tartaglione A, Giovannini E, Riondato M, Giovacchini G, Ferrando O, De Biasi M, Passera C, Carabelli E, Mannironi A, Foppiano F, Alfano B, Mansi L
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Impact Factor: 7.704
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Marchitelli R, Aiello M, Cachia A, Quarantelli M, Cavaliere C, Postiglione A, Tedeschi G, Montella P, Milan G, Salvatore M, Salvatore E, Baron JC, Pappata S
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Comegna D, Zannetti A, Del Gatto A, De Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L
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Impact Factor: 6.253
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Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML
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Carecchio M, Picillo M, Valletta L, Elia AE, Haack TB, Cozzolino A, Vitale A, Garavaglia B, Iuso A, Bagella CF, Pappata S, Barone P, Prokisch H, Romito L, Tiranti V
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Leggio GM, Catania MV, Puzzo D, Spatuzza M, Pellitteri R, Gulisano W, Torrisi SA, Giurdanella G, Piazza C, Impellizzeri AR, Gozzo L, Navarria A, Bucolo C, Nicoletti F, Palmeri A, Salomone S, Copani A, Caraci F, Drago F
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Impact Factor: 4.48
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Lanzillo R, Chiodi A, Carotenuto A, Magri V, Napolitano A, Liuzzi R, Costabile T, Rainone N, Freda MF, Valerio P, Brescia Morra V
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Impact Factor: 2.013
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Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
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Impact Factor: 4.609
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Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
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Impact Factor: 2.559
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
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Impact Factor: 2.526
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Olgiati S, De Rosa A, Quadri M, Criscuolo C, Breedveld GJ, Picillo M, Pappata S, Quarantelli M, Barone P, De Michele G, Bonifati V
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Impact Factor: 2.884
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Bilo L, Peluso S, Antenora A, De Rosa A, Auletta G, Pappata S, De Michele G
* Parkinsonism may be part of the symptom complex of DOOR syndrome (260 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1353-8020print), 2014 Apr; 20(4): 463-465.
Impact Factor: 3.972
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Nold-Petry CA, Rudloff I, Baumer Y, Ruvo M, Marasco D, Botti P, Farkas L, Cho SX, Zepp JA, Azam T, Dinkel H, Palmer BE, Boisvert WA, Cool CD, Taraseviciene-Stewart L, Heinhuis B, Joosten LA, Dinarello CA, Voelkel NF, Nold MF
* IL-32 Promotes Angiogenesis (708 views)
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Impact Factor: 4.922
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Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
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Impact Factor: 1.045
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D'Angelo D, Borbone E, Palmieri D, Uboldi S, Esposito F, Frapolli R, Pacelli R, D'Incalci M, Fusco A
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Impact Factor: 4.819
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Santulli G, Lombardi A, Sorriento D, Anastasio A, Del Giudice C, Formisano P, Béguinot F, Trimarco B, Miele C, Iaccarino G
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Impact Factor: 7.895
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Bastianello S, Giugni E, Amato MP, Tola MR, Trojano M, Galletti S, Luccichenti G, Quarantelli M, Picconi O, Patti F, COGIMUS
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Impact Factor: 2.167
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Pappata S, Santangelo G, Aarsland D, Vicidomini C, Longo K, Bronnick K, Amboni M, Erro R, Vitale C, Caprio MG, Pellecchia MT, Brunetti A, De Michele G, Salvatore M, Barone P
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Impact Factor: 8.312
View Export to BibTeX Export to EndNote
Santulli G, Basilicata MF, De Simone M, Del Giudice C, Anastasio A, Sorriento D, Saviano M, Del Gatto A, Trimarco B, Pedone C, Zaccaro L, Iaccarino G
* Evaluation of the anti-angiogenic properties of the new selective alphaVbeta3 integrin antagonist RGDechiHCit (481 views)
J Transl Med (ISSN: 1479-5876electronic), 2011 Jan 13; 9: 7-7.
Impact Factor: 3.474
View Export to BibTeX Export to EndNote
Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (500 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin binds the antiatherogenic protein apolipoprotein e - Impairment of apolipoprotein e stimulation of both lecithin: Cholesterol acyltransferase activity and cholesterol uptake by hepatocytes (395 views)
Febs J (ISSN: 1742-464x), 2009 Nov; 276(21): 6158-6171.
Impact Factor: 3.042
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of alpha(v)beta(3) expression by a bifunctional chimeric RGD peptide not cross-reacting with alpha(v)beta(5) (479 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (860 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Carriero MV, Longanesi-cattani I, Bifulco K, Maglio O, Lista L, Barbieri A, Votta G, Masucci MT, Arra C, Franco R, De Rosa M, Stoppelli MP, Pavone V
* Structure-based design of an urokinase-type plasminogen activator receptor-derived peptide inhibiting cell migration and lung metastasis (487 views)
Mol Cancer Ther (ISSN: 1535-7163, 1538-8514electronic, 1535-7163linking), 2009 Sep; 8(9): 2708-2717.
Impact Factor: 4.953
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De Luca S, Del Gatto A, Ruvo M, Panico M, Zannetti A, Del Vecchio S, Salvatore M, Pedone C, Saviano M, Zaccaro L
* A new and selective radiolabeled alpha(V)beta(3) peptide antagonist as tracer in tumor diagnosis (439 views)
Adv Exp Med Biol (ISSN: 0065-2598, 0065-2598print), 2009; 611: 439-440.
Impact Factor: 2.02
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Cigliano L, Pugliese CR, Spagnuolo MS, Palumbo R, Abrescia P
* Haptoglobin Binds The Anti-Atherogenic Protein Apolipoprotein E: Impairment Of The Apolipoprotein E Stimulation On Both The Enzyme Lecithin-Cholesterol Acyl-Transferase Activity And The Cholesterol Uptake By Hepatocytes (274 views)
Febs J, 2009; 276: 6158-6171.
Impact Factor: 3.986
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Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (606 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (618 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Pappata S, Varrone A, Milan G, Sansone V, Iavarone A, Panico M, Quarantelli M, Mollica C, De Falco C, Lore E, Postiglione A, Salvatore M
* SPECT study of GABAA/BZD receptors and cerebral blood flow in mild cognitive impairment (MCI) (351 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2006; 31: N/D-N/D.
Impact Factor: 5.559
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Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (794 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
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Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M, Lombardi G
* The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: An observational, case-control study (283 views)
J Clin Endocrinol Metab (ISSN: 0021-972x), 2004 Dec; 89(12): 5998-6004.
Impact Factor: 5.778
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Varrone A, Pappata S, Lore E, Sansone V, Iavarone A, Carlomagno S, Brunetti A, Postiglione A, Salvatore M
* Changes of regional cerebral blood flow in mild cognitive impairment studied with [99mTc]HMPAO SPET (381 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
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Varrone A, Pappata S, Quarantelli M, Sansone V, Mollica C, Lore E, Carlomagno S, Iavarone A, Postiglione A, Alfano B, Salvatore M
* Partial volume effect correction of rCBF SPET studies in mild cognitive impairment and Alzheimer's disease (356 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2004 Sep; 31: N/D-N/D.
Impact Factor: 3.935
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39 Records (34 excluding Abstracts).
Total impact factor: 171.175 (153.02 excluding Abstracts).
Total 5 year impact factor: 161.69 (140.283 excluding Abstracts).
Total impact factor: 171.175 (153.02 excluding Abstracts).
Total 5 year impact factor: 161.69 (140.283 excluding Abstracts).
483 views. Last view on Friday 27 January 2023, 16:39:54
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