Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity (567 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
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Paper type: Journal Article,
Impact factor: 4.816, 5-year impact factor: 4.527
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018381943&doi=10.1016%2fj.ejmech.2017.04.060&partnerID=40&md5=943ce04c402fb0aa28bfbda96332b1b1
Keywords: Antiglycating Effect, Aβ Aggregation, Carnosine, Copper Complexes, Trehalose, Acrolein Antagonists, Inhibitors Toxicity , Amyloid Beta-Peptides Antagonists, Inhibitors Metabolism , Antioxidants Chemical Synthesis Chemistry Pharmacology , Carnosine Chemistry Pharmacology , Copper Chemistry Pharmacology , Dose-Response Relationship, Drug , Humans , Molecular Structure , Organometallic Compounds Chemical Synthesis Chemistry Pharmacology , Protein Aggregates Drug Effects , Structure-Activity Relationship , Trehalose Chemistry Pharmacology,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, Catania, Italy
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, Italy
References:
Not available.
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jul 28; 135: 447-457.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.816, 5-year impact factor: 4.527
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018381943&doi=10.1016%2fj.ejmech.2017.04.060&partnerID=40&md5=943ce04c402fb0aa28bfbda96332b1b1
Keywords: Antiglycating Effect, Aβ Aggregation, Carnosine, Copper Complexes, Trehalose, Acrolein Antagonists, Inhibitors Toxicity , Amyloid Beta-Peptides Antagonists, Inhibitors Metabolism , Antioxidants Chemical Synthesis Chemistry Pharmacology , Carnosine Chemistry Pharmacology , Copper Chemistry Pharmacology , Dose-Response Relationship, Drug , Humans , Molecular Structure , Organometallic Compounds Chemical Synthesis Chemistry Pharmacology , Protein Aggregates Drug Effects , Structure-Activity Relationship , Trehalose Chemistry Pharmacology,
Affiliations:
*** IBB - CNR ***
Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, Catania, Italy
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, Italy
References:
Not available.
Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity
Increasing evidence is accumulating, showing that neurodegenerative disorders are somehow associated with the toxicity of amyloid aggregates, metal ion dyshomeostasis as well as with products generated by oxidative stress. Within the biological oxidation products, acrolein does have a prominent role. A promising strategy to deal with the above neurogenerative disorders is to use multi-functions bio-molecules. Herein, we show how a class of bio-conjugates takes advantage of the antiaggregating, antioxidant and antiglycating properties of trehalose and carnosine. Their ability to sequester acrolein and to inhibit both self- and metal-induced aggregation is here reported. The copper(II) coordination properties of a new trehalose-carnosine conjugate and the relative antioxidant effects have also been investigated. © 2017 Elsevier Masson SAS
Increasing evidence is accumulating, showing that neurodegenerative disorders are somehow associated with the toxicity of amyloid aggregates, metal ion dyshomeostasis as well as with products generated by oxidative stress. Within the biological oxidation products, acrolein does have a prominent role. A promising strategy to deal with the above neurogenerative disorders is to use multi-functions bio-molecules. Herein, we show how a class of bio-conjugates takes advantage of the antiaggregating, antioxidant and antiglycating properties of trehalose and carnosine. Their ability to sequester acrolein and to inhibit both self- and metal-induced aggregation is here reported. The copper(II) coordination properties of a new trehalose-carnosine conjugate and the relative antioxidant effects have also been investigated. © 2017 Elsevier Masson SAS
Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity
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Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein toxicity
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La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
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Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
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Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
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Impact Factor: 0
View Export to BibTeX Export to EndNote
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (714 views)
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Impact Factor: 4.069
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Vecchio G
* Structural Isomers of Cyclodextrin-Bearing IOX1 Compound as Inhibitors of Aβ Aggregation (478 views)
Chemistryselect (ISSN: 2365-6549), 2017; 2(2): 655-659.
Impact Factor: 1.505
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Grasso GI, Pietropaolo A, Vecchio G
* Trehalose-8-hydroxyquinoline conjugates as antioxidant modulators of Aβ aggregation (1021 views)
Rsc Adv (ISSN: 2046-2069, 2046-2069electronic), 2016; 6(53): 47229-47236.
Impact Factor: 3.108
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (1003 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Tabbì G, Giuffrida A, Bonomo RP
* Determination Of Formal Redox Potentials In Aqueous Solution Of Copper(ii) Complexes With Ligands Having Nitrogen And Oxygen Donor Atoms And Comparisonwith Their Epr And Uv–vis Spectral Features (553 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2013 Nov; 128: 137-145.
Impact Factor: 3.274
View Export to BibTeX Export to EndNote
Di Natale G, Osz K, Kállay C, Pappalardo G, Sanna D, Impellizzeri G, Sóvágó I, Rizzarelli E
* Affinity, speciation, and molecular features of copper(II) complexes with a prion tetraoctarepeat domain in aqueous solution: insights into old and new results (593 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2013 Mar 11; 19(11): 3751-3761.
Impact Factor: 5.696
View Export to BibTeX Export to EndNote
Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C
* Activation of KCNN3/SK3/K(Ca)2. 3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia (635 views)
Glia (ISSN: 1098-1136), 2012 Dec; 60(12): 2050-2064.
Impact Factor: 5.466
View Export to BibTeX Export to EndNote
Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (672 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Kállay C, Dávid A, Timári S, Nagy EM, Sanna D, Garribba E, Micera G, De Bona P, Pappalardo G, Rizzarelli E, Sóvágó I
* Copper(II) complexes of rat amylin fragments (572 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2011 Oct 14; 40(38): 9711-9721.
Impact Factor: 3.838
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (659 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Vagliasindi LI, Arena G, Bonomo RP, Pappalardo G, Tabbì G
* Copper complex species within a fragment of the N-terminal repeat region in opossum PrP protein (562 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2011 Mar 21; 40(11): 2441-2450.
Impact Factor: 3.838
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Vagliasindi LI, Hansson Ö, Bonomo RP, Rizzarelli E
* Copper(II) complex formation with a linear peptide encompassing the putative cell binding site of angiogenin (589 views)
Dalton T (ISSN: 1477-9234, 1477-9226, 1477-9234electronic), 2010 Nov 28; 39(44): 10678-10684.
Impact Factor: 3.647
View Export to BibTeX Export to EndNote
Di Natale G, Pappalardo G, Milardi D, Sciacca MF, Attanasio F, La Mendola D, Rizzarelli E
* Membrane interactions and conformational preferences of human and avian prion N-terminal tandem repeats: The role of copper(II) ions, pH, and membrane mimicking environments (610 views)
J Phys Chem B (ISSN: 1520-6106, 1520-5207, 1520-5207electronic), 2010 Nov 4; 114(43): 13830-13838.
Impact Factor: 3.603
View Export to BibTeX Export to EndNote
La Mendola D, Magrì A, Campagna T, Campitiello MA, Raiola L, Isernia C, Hansson O, Bonomo RP, Rizzarelli E
* A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (1386 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2010 Jun 1; 16(21): 6212-6223.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Bonomo RP, Di Natale G, Rizzarelli E, Tabbì G, Vagliasindi LI
* Copper(II) complexes of prion protein PEG11-tetraoctarepeat fragment: spectroscopic and voltammetric studies (505 views)
Dalton T (ISSN: 1477-9226, 1477-7922, 1477-9234), 2009 Apr 14; (14): 2637-2646.
Impact Factor: 2.908
View Export to BibTeX Export to EndNote
Bonomo RP, Pappalardo G, Rizzarelli E, Santoro AM, Tabbì G, Vagliasindi LI
* Nitrogen oxide interaction with copper complexes formed by small peptides belonging to the prion protein octa-repeat region (737 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2007 Apr 14; (14): 1400-1408.
Impact Factor: 3.212
View Export to BibTeX Export to EndNote
Campagna T, Grasso G, Rizzarelli E, Vecchio G
L- and D-cysteine derivatives of β-cyclodextrin: Different molecular recognition properties of their copper(II) complexes for amino acids (444 views)
Inorg Chim Acta (ISSN: 0020-1693), 1998; 275-276: 395-400.
Impact Factor: 1.454
View Export to BibTeX Export to EndNote
Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A
Effects of graded doses of copper complexes of L-aminoacids on gastric acid secretion in rats (1410 views)
Boll Soc Ital Biol Sper (ISSN: 0037-8771), 1979 Apr 30; 55(8): 769-775.
Impact Factor: 0
View Export to BibTeX Export to EndNote
18 Records (18 excluding Abstracts).
Total impact factor: 66.234 (66.234 excluding Abstracts).
Total 5 year impact factor: 67.491 (67.491 excluding Abstracts).
Total impact factor: 66.234 (66.234 excluding Abstracts).
Total 5 year impact factor: 67.491 (67.491 excluding Abstracts).
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