Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation (544 views)
Chempluschem (ISSN: 2192-6506), 2015; 80(4): 762-770.
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Paper type: Journal Article,
Impact factor: 2.836, 5-year impact factor: 2.91
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969751459&doi=10.1002%2fcplu.201402450&partnerID=40&md5=656f14f5e4393ea293873428745a2d36
Keywords: Amyloid Beta-Peptides, Copper, Glycoconjugates, Metal Chelators, Zinc,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università di Catania, Viale A. Doria 6, Catania, Italy
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via P. Gaifami 18, Catania, Italy
References:
Not available.
Chempluschem (ISSN: 2192-6506), 2015; 80(4): 762-770.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.836, 5-year impact factor: 2.91
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84969751459&doi=10.1002%2fcplu.201402450&partnerID=40&md5=656f14f5e4393ea293873428745a2d36
Keywords: Amyloid Beta-Peptides, Copper, Glycoconjugates, Metal Chelators, Zinc,
Affiliations:
*** IBB - CNR ***
Dipartimento di Chimica, Università di Catania, Viale A. Doria 6, Catania, Italy
Istituto di Biostrutture e Bioimmagini (IBB), CNR, via P. Gaifami 18, Catania, Italy
References:
Not available.
Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation
Cyclodextrins are used increasingly in pharmacotherapy. Experimental and clinical data suggest that cyclodextrins can be used not only as excipients for marketed drugs, but also as active pharmaceutical ingredients to treat neurological diseases including Niemann-Pick typeC disease. Disruption of metal and cholesterol homeostasis, protein misfolding, and aggregation are recognized among the major pathological features in triggering neurodegenerative disorders, and therefore it is becoming more and more evident that the next generation of therapies should have multiple functions to combat the multifactorial nature of diseases. A novel class of compounds obtained by conjugating 8-hydroxyquinoline with cyclodextrin has been proposed to combine antioxidant activity, chelating, antiaggregant, and inclusion ability into one compound designed for metal-associated neurodegenerative diseases. Herein, the synthesis and characterization of the new compound 3A-deoxy-3A-[(8-hydroxyquinolyl)-2-methylamino]-2A(S),3A(R)-β-cyclodextrin is reported. Moreover, the interaction of copper-Aβ and zinc-Aβ amyloid with this class of cyclodextrin conjugates was investigated for the first time. New information about the effects of different modified chelating cyclodextrins may be important for further development of drugs against neurodegenerative disorders. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Cyclodextrins are used increasingly in pharmacotherapy. Experimental and clinical data suggest that cyclodextrins can be used not only as excipients for marketed drugs, but also as active pharmaceutical ingredients to treat neurological diseases including Niemann-Pick typeC disease. Disruption of metal and cholesterol homeostasis, protein misfolding, and aggregation are recognized among the major pathological features in triggering neurodegenerative disorders, and therefore it is becoming more and more evident that the next generation of therapies should have multiple functions to combat the multifactorial nature of diseases. A novel class of compounds obtained by conjugating 8-hydroxyquinoline with cyclodextrin has been proposed to combine antioxidant activity, chelating, antiaggregant, and inclusion ability into one compound designed for metal-associated neurodegenerative diseases. Herein, the synthesis and characterization of the new compound 3A-deoxy-3A-[(8-hydroxyquinolyl)-2-methylamino]-2A(S),3A(R)-β-cyclodextrin is reported. Moreover, the interaction of copper-Aβ and zinc-Aβ amyloid with this class of cyclodextrin conjugates was investigated for the first time. New information about the effects of different modified chelating cyclodextrins may be important for further development of drugs against neurodegenerative disorders. Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation
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Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation
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View Export to BibTeX Export to EndNote
Sciacca MFM, Monaco I, La Rosa C, Milardi D
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
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Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
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Impact Factor: 3.317
View Export to BibTeX Export to EndNote
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Impact Factor: 7.627
View Export to BibTeX Export to EndNote
Grasso GI, Bellia F, Arena G, Satriano C, Vecchio G, Rizzarelli E
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Oliveri V, Bellia F, Vecchio G
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Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
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Impact Factor: 2.847
View Export to BibTeX Export to EndNote
Nicastro MC, Spigolon D, Librizzi F, Moran O, Ortore MG, Bulone D, Biagio PLS, Carrotta R
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Impact Factor: 2.402
View Export to BibTeX Export to EndNote
Palladino P, Aura AM, Spoto G
* Surface plasmon resonance for the label-free detection of Alzheimer's β-amyloid peptide aggregation (729 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2016; 408(3): 849-854.
Impact Factor: 3.431
View Export to BibTeX Export to EndNote
Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (607 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (1003 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
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Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (988 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Rizzarelli E, Vecchio G
* Copper(II)-chelating homocarnosine glycoconjugate as a new multifunctional compound (900 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2014 Feb; 131: 56-63.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Autiero I, Langella E, Saviano M
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View Export to BibTeX Export to EndNote
Autiero I, Saviano M, Langella E
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Impact Factor: 3.18
View Export to BibTeX Export to EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (785 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
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Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (1151 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
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Pannuzzo M, Milardi D, Raudino A, Karttunen M, La Rosa C
* Analytical model and multiscale simulations of Aβ peptide aggregation in lipid membranes: Towards a unifying description of conformational transitions, oligomerization and membrane damage (911 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2013; 15(23): 8940-8951.
Impact Factor: 4.198
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Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (2000 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (552 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
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Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1269 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
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Calafiore M, Copani A, Deng W
* DNA polymerase-β mediates the neurogenic effect of β-amyloid protein in cultured subventricular zone neurospheres (729 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2012 Mar; 90(3): 559-567.
Impact Factor: 2.974
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Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (712 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (806 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
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Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (828 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
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Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (701 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
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Józsa E, Osz K, Kállay C, de Bona P, Damante CA, Pappalardo G, Rizzarelli E, Sóvágó I
* Nickel(ii) and mixed metal complexes of amyloid-β N-terminus (580 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2010 Sep 14; 39(30): 7046-7053.
Impact Factor: 3.647
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Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (814 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
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Damante CA, Osz K, Nagy Z, Pappalardo G, Grasso G, Impellizzeri G, Rizzarelli E, Sóvágó I
* Metal Loading Capacity Of Abeta N-Terminus: A Combined Potentiometric And Spectroscopic Study Of Zinc (ii) Complexes With Abeta (1-16), Its Short Or Mutated Peptide Fragments And Its Polyethylene Glycol-Ylated Analogue (735 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2009 Nov 2; 48(21): 10405-10415.
Impact Factor: 4.657
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Grasso G, Mineo P, Rizzarelli E, Spoto G
* Maldi, Ap/Maldi And Esi Techniques For The Ms Detection Of Amyloid Beta-Peptides (458 views)
Int J Mass Spectrom (ISSN: 1387-3806), 2009 Apr 15; 282(1-2): 50-55.
Impact Factor: 2.117
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Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (613 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (728 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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36 Records (35 excluding Abstracts).
Total impact factor: 146.321 (142.229 excluding Abstracts).
Total 5 year impact factor: 149.089 (144.552 excluding Abstracts).
Total impact factor: 146.321 (142.229 excluding Abstracts).
Total 5 year impact factor: 149.089 (144.552 excluding Abstracts).
544 views. Last view on Sunday 01 December 2024, 0:30:04
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