Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (479 views)
Crit Rev Biochem Mol (ISSN: 1040-9238), 2017 Jun; N/D: 1-29.
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Paper type: Journal Article,
Impact factor: 5.279, 5-year impact factor: 7.589
Url: Not available.
Keywords: Alzheimer, S Disease, Cell Homeostasis, Heat Shock Proteins, Insulin-Degrading Enzyme, Oxidized Proteins Turnover, Type 2 Diabetes, Ubiquitin Proteasome System,
Affiliations:
*** IBB - CNR ***
a Department of Clinical Sciences and Translation Medicine , University of Roma Tor Vergata , Roma , Italy., b CIRCMSB , Bari , Italy., c Center for TeleInfrastructures, University of Roma Tor Vergata , Roma , Italy., d Department of Chemistry , University of Catania , Catania , Italy., e CNR IBB , Catania , Italy., f Department of Chemistry , University of Aarhus , Aarhus , Denmark., g Department of Biology , University of Roma Tre , Roma , Italy., h Universite Paris Descartes, INSERM, U1151, CNRS , Paris , France.,
References:
Not available.
Crit Rev Biochem Mol (ISSN: 1040-9238), 2017 Jun; N/D: 1-29.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.279, 5-year impact factor: 7.589
Url: Not available.
Keywords: Alzheimer, S Disease, Cell Homeostasis, Heat Shock Proteins, Insulin-Degrading Enzyme, Oxidized Proteins Turnover, Type 2 Diabetes, Ubiquitin Proteasome System,
Affiliations:
*** IBB - CNR ***
a Department of Clinical Sciences and Translation Medicine , University of Roma Tor Vergata , Roma , Italy., b CIRCMSB , Bari , Italy., c Center for TeleInfrastructures, University of Roma Tor Vergata , Roma , Italy., d Department of Chemistry , University of Catania , Catania , Italy., e CNR IBB , Catania , Italy., f Department of Chemistry , University of Aarhus , Aarhus , Denmark., g Department of Biology , University of Roma Tre , Roma , Italy., h Universite Paris Descartes, INSERM, U1151, CNRS , Paris , France.,
References:
Not available.
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated. However, further studies on IDE unraveled its ability to degrade several other polypeptides, such as beta-amyloid, amylin, and glucagon, envisaging the possible implication of IDE dys-regulation in the "aggregopathies" and, in particular, in neurodegenerative diseases. Over the last decade, a novel scenario on IDE biology has emerged, pointing out a multi-functional role of this enzyme in several basic cellular processes. In particular, latest advances indicate that IDE behaves as a heat shock protein and modulates the ubiquitin-proteasome system, suggesting a major implication in proteins turnover and cell homeostasis. In addition, recent observations have highlighted that the regulation of glucose metabolism by IDE is not merely based on its largely proposed role in the degradation of insulin in vivo. There is increasing evidence that improper IDE function, regulation, or trafficking might contribute to the etiology of metabolic diseases. In addition, the enzymatic activity of IDE is affected by metals levels, thus suggesting a role also in the metal homeostasis (metallostasis), which is thought to be tightly linked to the malfunction of the "quality control" machinery of the cell. Focusing on the physiological role of IDE, we will address a comprehensive vision of the very complex scenario in which IDE takes part, outlining its crucial role in interconnecting several relevant cellular processes.
Insulin-degrading enzyme (IDE) is a ubiquitous zinc peptidase of the inverzincin family, which has been initially discovered as the enzyme responsible for insulin catabolism; therefore, its involvement in the onset of diabetes has been largely investigated. However, further studies on IDE unraveled its ability to degrade several other polypeptides, such as beta-amyloid, amylin, and glucagon, envisaging the possible implication of IDE dys-regulation in the "aggregopathies" and, in particular, in neurodegenerative diseases. Over the last decade, a novel scenario on IDE biology has emerged, pointing out a multi-functional role of this enzyme in several basic cellular processes. In particular, latest advances indicate that IDE behaves as a heat shock protein and modulates the ubiquitin-proteasome system, suggesting a major implication in proteins turnover and cell homeostasis. In addition, recent observations have highlighted that the regulation of glucose metabolism by IDE is not merely based on its largely proposed role in the degradation of insulin in vivo. There is increasing evidence that improper IDE function, regulation, or trafficking might contribute to the etiology of metabolic diseases. In addition, the enzymatic activity of IDE is affected by metals levels, thus suggesting a role also in the metal homeostasis (metallostasis), which is thought to be tightly linked to the malfunction of the "quality control" machinery of the cell. Focusing on the physiological role of IDE, we will address a comprehensive vision of the very complex scenario in which IDE takes part, outlining its crucial role in interconnecting several relevant cellular processes.
Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
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Multiple functions of insulin-degrading enzyme: a metabolic crosslight?
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Bellia F, GrassoG
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Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
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Grasso G, Rizzarelli E, Spoto G
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View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
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View Export to BibTeX Export to EndNote
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* Dietary influence on adiponectin in patients with type 2 diabetes (299 views)
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View Export to BibTeX Export to EndNote
Aludwan M, Kobyliak N, Abenavoli L, Kyriienko D, Fagoonee S, Pellicano R, Komisarenko I
* Vitamin D3 deficiency is associated with more severe insulin resistance and metformin use in patients with type 2 diabetes (88 views)
Minerva Endocrinol (ISSN: 0391-1977linking, 1827-1634electronic), 2020 Sep; 45(3): 172-180.
Impact Factor: 1.58
View Export to BibTeX Export to EndNote
Della Pepa G, Vetrani C, Brancato V, Vitale M, Monti S, Annuzzi G, Lombardi G, Izzo A, Tommasone M, Cipriano P, Clemente G, Mirabelli P, Mancini M, Salvatore M, Riccardi G, Rivellese AA, Bozzetto L
* Effects of a multifactorial ecosustainable isocaloric diet on liver fat in patients with type 2 diabetes: randomized clinical trial (124 views)
Bmj Open Diabetes Res Care (ISSN: 2052-4897linking), 2020 May; 8(1): N/D-N/D.
Impact Factor: 3.183
View Export to BibTeX Export to EndNote
Clemente G, Giorgini M, Mancini M, Gallo M, Amd-associazione Medici Diabetologi ‘diabetes Cancer’ worki
* Diabetologists and Oncologists attitudes towards treating diabetes in the oncologic patient: Insights from an exploratory survey (305 views)
Diabetes Res Clin Pract (ISSN: 0168-8227linking), 2018 Sep; 143: 420-427.
Impact Factor: 3.639
View Export to BibTeX Export to EndNote
Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-dubouch MP, Marini S, Coletta M
* The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S (407 views) (PDF 119 views)
Cell Mol Life Sci (ISSN: 1420-9071electronic, 1420-682xlinking), 2018 Sep; 75(18): 3441-3456.
Impact Factor: 7.047
View Export to BibTeX Export to EndNote
Tumminia A, Milluzzo A, Cinti F, Parisi M, Tata F, Frasca F, Frittitta L, Vigneri R, Sciacca L
* Abnormal 1-hour post-load glycemia during pregnancy impairs post-partum metabolic status: a single-center experience (199 views)
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2017 Oct 24; N/D: N/D-N/D.
Impact Factor: 3.166
View Export to BibTeX Export to EndNote
Bozzetto L, Costabile G, Luongo D, Naviglio D, Cicala V, Piantadosi C, Patti L, Cipriano P, Annuzzi G, Rivellese AA
* Reduction in liver fat by dietary MUFA in type 2 diabetes is helped by enhanced hepatic fat oxidation (307 views)
Diabetologia (ISSN: 0012-186x), 2016 Dec; 59(12): 2697-2701.
Impact Factor: 6.08
View Export to BibTeX Export to EndNote
Monti SM, Supuran CT, De Simone G
* DPP-4 inhibitors: a patent review (2012 - 2014) (620 views)
Expert Opin Ther Pat (ISSN: 1354-3776, 1744-7674electronic), 2015 Feb; 25(2): 209-236.
Impact Factor: 4.626
View Export to BibTeX Export to EndNote
GrassoG, Satriano C, Milardi D
* A neglected modulator of insulin-degrading enzyme activity and conformation: The pH (564 views)
Biophys Chem (ISSN: 0301-4622, 0301-4622linking), 2015; 203-204: 33-40.
Impact Factor: 2.363
View Export to BibTeX Export to EndNote
Coppo C, Bonfanti D, Bo S, Giordanino C, Gallo M, Cococcia S, Ciccone G, Smedile A, Ciancio A, Bugianesi E, Fagoonee S, Pellicano R, Rizzetto M, Saracco GM
* Risk of microangiopathy in type 2 diabetes mellitus patients with or without chronic hepatitis C: Results of a retrospective long-term controlled cohort study (383 views)
Dig Liver Dis (ISSN: 1590-8658, 1590-8658linking), 2015; 47(5): 405-410.
Impact Factor: 2.719
View Export to BibTeX Export to EndNote
Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1409 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
View Export to BibTeX Export to EndNote
Petretta M, Acampa W, Evangelista L, Daniele S, Zampella E, Assante R, Nappi C, Cantoni V, Fiumara G, Cuocolo A
* Reclassification of cardiovascular risk by myocardial perfusion imaging in diabetic patients with abnormal resting electrocardiogram (597 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2014; 24(6): 588-593.
Impact Factor: 3.323
View Export to BibTeX Export to EndNote
Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (838 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
View Export to BibTeX Export to EndNote
Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (656 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
View Export to BibTeX Export to EndNote
Bellia F, Pietropaolo A, Grasso G
* Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (588 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2013; 48(2): 135-140.
Impact Factor: 2.709
View Export to BibTeX Export to EndNote
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (685 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Marciano C, Galderisi M, Gargiulo P, Acampa W, D'Amore C, Esposito R, Capasso E, Savarese G, Casaretti L, Lo Iudice F, Esposito G, Rengo G, Leosco D, Cuocolo A, Perrone-Filardi P
* Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (1144 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2012 Jul; 39(7): 1199-1206.
Impact Factor: 5.114
View Export to BibTeX Export to EndNote
Striano P, Caranci F, Pappata S, Zara F, Striano S
* Hemidystonia in uncontrolled type 2 diabetes mellitus (432 views)
Arch Neurol (ISSN: 1538-3687electronic, 0003-9942linking), 2011 May; 68(5): 674-675.
Impact Factor: 7.584
View Export to BibTeX Export to EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (648 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Bozzetto L, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA, Annuzzi G
* Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution (554 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2011 Jan; 41(1): 39-44.
Impact Factor: 3.018
View Export to BibTeX Export to EndNote
Masulli M, Mancini M, Liuzzi R, Daniele S, Mainenti PP, Vergara E, Genovese S, Salvatore M, Vaccaro O
* Measurement of the intrarenal arterial resistance index for the identification and prediction of diabetic nephropathy (892 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic, 0939-4753linking), 2009 Jun; 19(5): 358-364.
Impact Factor: 3.517
View Export to BibTeX Export to EndNote
Grasso G, Rizzarelli E, Spoto G
* The proteolytic activity of insulin-degrading enzyme: a mass spectrometry study (664 views)
J Mass Spectrom (ISSN: 1096-9888, 1076-5174), 2009 May; 44(5): 735-741.
Impact Factor: 3.411
View Export to BibTeX Export to EndNote
Ciaccio C, Tundo GR, Grasso G, Spoto G, Marasco D, Ruvo M, Gioia M, Rizzarelli E, Coletta M
* Somatostatin: a novel substrate and a modulator of insulin-degrading enzyme activity (557 views)
J Mol Biol (ISSN: 1089-8638, 0022-2836, 1089-8638electronic), 2009 Feb 6; 385(5): 1556-1567.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Barone E, Calafato S, Bates T, Rizzarelli E, Kostova AT
* Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases (1875 views)
Frontiers In Bioscience (ISSN: 1093-4715, 1093-9946), 2009 Jan 1; 14: 376-397.
Impact Factor: 3.736
View Export to BibTeX Export to EndNote
Viparelli F, Cassese A, Doti N, Paturzo F, Marasco D, Dathan NA, Monti SM, Basile G, Ungaro P, Sabatella M, Miele C, Teperino R, Consiglio E, Pedone C, Beguinot F, Formisano P, Ruvo M
* Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells (534 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Sep 1; 283(31): 21769-21778.
Impact Factor: 5.52
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Bozzetto L, Annuzzi G, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA
* Liver fat and type 2 diabetes: specific roles of diabetes and overweight (329 views)
Diabetologia (ISSN: 0012-186x), 2008 Sep; 51: N/D-N/D.
Impact Factor: 6.418
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Bozzetto L, Annuzzi G, Prinster A, Mancini M, Giacco R, De Natale C, Salvatore M, Riccardi G, Rivellese AA
* Liver Fat Is Increased In Type 2 Diabetes Independently Of Visceral Fat And Insulin-Sensitivity (287 views)
Nutr Metab Cardiovasc Dis, 2008; N/D: N/D-N/D.
Impact Factor: 3.355
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Storto G, Pellegrino T, Sorrentino AR, Luongo L, Petretta M, Cuocolo A
* Estimation of coronary flow reserve by sestamibi imaging in type 2 diabetic patients with normal coronary arteries (602 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2007 Apr; 14(2): 194-199.
Impact Factor: 2.359
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Clemente G, Mancini M, Nazzaro F, Lasorella G, Rivieccio A, Palumbo AM, Rivellese AA, Ferrara L, Giacco R
* Effects of different dairy products on postprandial lipemia (1330 views)
Nutrition (ISSN: 0939-4753, 1590-3729electronic), 2003 Dec; 13(6): 377-383.
Impact Factor: 2.148
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Giacco R, Mancini M, Clemente G, Coppola S, Lasorella G, D’Avanzo G, Rivieccio A M, Ruffa G, Brighenti F, Rivellese AA, Riccardi G
Metabolic effects of resistant starch in patients with Type 2 diabetes (685 views)
Diabetes Nutr Metab Clin Exp (ISSN: 0394-3402), 1998; 11(6): 330-335.
Impact Factor: 0.629
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30 Records (26 excluding Abstracts).
Total impact factor: 112.824 (96.657 excluding Abstracts).
Total 5 year impact factor: 103.83 (91.193 excluding Abstracts).
Total impact factor: 112.824 (96.657 excluding Abstracts).
Total 5 year impact factor: 103.83 (91.193 excluding Abstracts).
479 views. Last view on Friday 06 September 2024, 6:53:57
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