Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties(301 views) Altug C, Gunes H, Nocentini A, Monti SM, Buonanno M, Supuran CT
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 0968-0896linking), 2017 Feb 15; 25(4): 1456-1464.
Keywords: 5-Amidoisoxazole, 5-Amino Isoxazole, Carbonic Anhydrase, Sulfonamide, 2 Cyano N (4 Sulfamoylphenyl)acetamide, 3 (2, 4 Dichlorophenyl) 5 (4 Nitrobenzamido) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 6 Dichlorophenyl) 5 (4 Nitrobenzamido) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 3 (4 Fluorophenyl) 5 (4 Nitrobenzamido) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 (4 Nitrobenzamido) 3 Phenyl N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (2 Chloro 4, 5 Dimethoxyphenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (2 Nitrophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 4 Dichlorophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 6 Dichlorophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (4 Bromophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (4 Chlorophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (4 Fluorophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (4 Nitrophenyl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (5 Chlorofuran 2 Yl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 (5 Chlorothiophen 2 Yl) N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, 5 Amino 3 Aryl N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide Derivative, 5 Amino 3 Phenyl N (4 Sulfamoylphenyl)isoxazole 4 Carboxamide, Analgesic Agent, Antiglaucoma Agent, Benzenesulfonamide Derivative, Carbonate Dehydratase, Carbonate Dehydratase Ii, Carbonate Dehydratase Vii, Isoprotein, Triethylamine, Unclassified Drug, Unindexed Drug, Carbonate Dehydratase Inhibitor, Carbonic Anhydrase Vi, Isoxazole Derivative, Article, Chemical Reaction, Drug Structure, Drug Synthesis, Drug Targeting, Enzyme Inhibition, In Vitro Study, Microwave Radiation, Structure Analysis, Antagonists And Inhibitors, Chemical Structure, Chemistry, Dose Response, Human, Metabolism, Structure Activity Relation, Carbonic Anhydrase Inhibitors, Dose-Response Relationship, Molecular Structure, Structure-Activity Relationship,
Affiliations: *** IBB - CNR ***
Department of Chemistry, Abant Izzet Baysal University, TR-14280 Bolu, Turkey. Electronic address: caltug@gmail.com., Universita degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy., Istituto di Biostrutture e Bioimmagini-CNR, via Mezzocannone 16, 80134 Napoli, Italy., Universita degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, 50019 Sesto Fiorentino, Florence, Italy. Electronic address: claudiu.supuran@unifi.it.,
Università degli Studi di Firenze, NEUROFARBA Dept., Sezione di Scienze Farmaceutiche, Via Ugo Schiff 6, Sesto Fiorentino, Florence 50019, Italy
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Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties