Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy (304 views)
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 0300-0664linking), 2017 Aug; 87(2): 207-215.
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Paper type: Journal Article,
Impact factor: 3.077, 5-year impact factor: 3.277
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Keywords: L-Thyroxine, Athyreotic, Hypothyroidism, Hypothyroidism Treatment, Seasonal Tsh Variations, Adult , Congenital Hypothyroidism Blood Drug Therapy , Cross-Sectional Studies , Female , Hormone Replacement Therapy Methods , Humans , Longitudinal Studies , Middle Aged , Thyroid Dysgenesis Blood Drug Therapy , Thyrotropin Blood , Thyroxine Administration, Dosage Blood , Triiodothyronine Blood,
Affiliations:
*** IBB - CNR ***
Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Catania, Italy., Endocrine Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy., CNR, Institute of Biostructures and Bioimaging, Catania, Italy.,
Endocrine Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy.
CNR, Institute of Biostructures and Bioimaging, Catania, Italy.
References:
Not available.
Clin Endocrinol (ISSN: 0300-0664, 1365-2265, 0300-0664linking), 2017 Aug; 87(2): 207-215.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.077, 5-year impact factor: 3.277
Url: Not available.
Keywords: L-Thyroxine, Athyreotic, Hypothyroidism, Hypothyroidism Treatment, Seasonal Tsh Variations, Adult , Congenital Hypothyroidism Blood Drug Therapy , Cross-Sectional Studies , Female , Hormone Replacement Therapy Methods , Humans , Longitudinal Studies , Middle Aged , Thyroid Dysgenesis Blood Drug Therapy , Thyrotropin Blood , Thyroxine Administration, Dosage Blood , Triiodothyronine Blood,
Affiliations:
*** IBB - CNR ***
Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Catania, Italy., Endocrine Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy., CNR, Institute of Biostructures and Bioimaging, Catania, Italy.,
Endocrine Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy.
CNR, Institute of Biostructures and Bioimaging, Catania, Italy.
References:
Not available.
Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy
BACKGROUND: Whether serum TSH undergoes seasonal fluctuations in euthyroid and hypothyroid residents of temperate climates is controversial. METHODS: Monthly TSH and thyroid hormone levels were cross-sectionally analysed in a large cohort of euthyroid subjects (n=11 806) and L-thyroxine (L-T4)-treated athyreotic patients (n=3 934). Moreover, in a small group (n=119) of athyreotic patients treated with an unchanged dosage of L-T4 monotherapy, hormones were measured both in the coldest and in the hottest seasons of the same year (longitudinal study). RESULTS: No seasonal hormone change was observed in the euthyroid subjects except for a small FT3 increase in winter (+2.9%, P<.001). In contrast, the L-T4-treated athyreotic patients had significantly higher serum TSH values in the cold season when the FT4 values were significantly lower. The differences were more notable in the longitudinal series (TSH, 0.80 vs. 0.20 mU/L and FT4, 16.3 vs. 17.8 pmol/L in December-March vs. June-September, respectively). In these patients also serum FT3 values significantly decreased in winter (in the longitudinal series, 3.80 in winter vs 4.07 pmol/L in summer). Regression analysis showed that in athyreotic subjects, a greater FT4 change is required to obtain a TSH change similar to that of euthyroid controls and that this effect is more pronounced in the summer. CONCLUSION: Athyreotic patients undergoing L-T4 monotherapy have abnormal seasonal variations in TSH. These changes are secondary to the FT4 and FT3 serum decreases in winter, which occur in spite of the constant treatment. The underlying mechanisms are unclear, but in some cases, these changes may be clinically relevant.
BACKGROUND: Whether serum TSH undergoes seasonal fluctuations in euthyroid and hypothyroid residents of temperate climates is controversial. METHODS: Monthly TSH and thyroid hormone levels were cross-sectionally analysed in a large cohort of euthyroid subjects (n=11 806) and L-thyroxine (L-T4)-treated athyreotic patients (n=3 934). Moreover, in a small group (n=119) of athyreotic patients treated with an unchanged dosage of L-T4 monotherapy, hormones were measured both in the coldest and in the hottest seasons of the same year (longitudinal study). RESULTS: No seasonal hormone change was observed in the euthyroid subjects except for a small FT3 increase in winter (+2.9%, P<.001). In contrast, the L-T4-treated athyreotic patients had significantly higher serum TSH values in the cold season when the FT4 values were significantly lower. The differences were more notable in the longitudinal series (TSH, 0.80 vs. 0.20 mU/L and FT4, 16.3 vs. 17.8 pmol/L in December-March vs. June-September, respectively). In these patients also serum FT3 values significantly decreased in winter (in the longitudinal series, 3.80 in winter vs 4.07 pmol/L in summer). Regression analysis showed that in athyreotic subjects, a greater FT4 change is required to obtain a TSH change similar to that of euthyroid controls and that this effect is more pronounced in the summer. CONCLUSION: Athyreotic patients undergoing L-T4 monotherapy have abnormal seasonal variations in TSH. These changes are secondary to the FT4 and FT3 serum decreases in winter, which occur in spite of the constant treatment. The underlying mechanisms are unclear, but in some cases, these changes may be clinically relevant.
Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy
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Seasonal variations in TSH serum levels in athyreotic patients under L-thyroxine replacement monotherapy
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Cella L, Conson M, Liuzzi R, Pacelli R
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* In regard to boomsma et al (482 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2013 Jan 1; 85(1): 11-11.
Impact Factor: 4.176
View Export to BibTeX Export to EndNote
Cella L, Liuzzi R, Conson M, D'Avino V, Salvatore M, Pacelli R
* Development of multivariate NTCP models for radiation-induced hypothyroidism: A comparative analysis (596 views) (PDF 263 views)
Radiat Oncol Radiation Oncology (ISSN: 1748-717x), 2012 Dec 27; 7(1): 224-224.
Impact Factor: 2.107
View Export to BibTeX Export to EndNote
Cella L, Conson M, Caterino M, De Rosa N, Liuzzi R, Picardi M, Grimaldi F, Solla R, Farella A, Salvatore M, Pacelli R
* Thyroid V30 predicts radiation-induced hypothyroidism in patients treated with sequential chemo-radiotherapy for Hodgkin's lymphoma (621 views) (PDF 263 views)
Int J Radiat Oncol (ISSN: 0360-3016, 1879-355x, 1879-355xelectronic), 2012 Apr 1; 82(5): 1802-1808.
Impact Factor: 4.524
View Export to BibTeX Export to EndNote
Salvatore E, Di Maio L, Filla A, Ferrara AM, Rinaldi C, Sacca F, Peluso S, Macchia PE, Pappata S, De Michele G
* Benign hereditary chorea: Clinical and neuroimaging features in an Italian family (455 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2010 Jul 30; 25(10): 1491-1496.
Impact Factor: 4.48
View Export to BibTeX Export to EndNote
Leonardi D, Polizzotti N, Carta A, Gelsomino R, Sava L, Vigneri R, Calaciura F
* Longitudinal study of thyroid function in children with mild hyperthyrotropinemia at neonatal screening for congenital hypothyroidism (598 views)
Journal Of Clinical Endocrinology & Metabolism (ISSN: 0021-972x), 2008 Jul 1; 93(7): 2679-2685.
Impact Factor: 6.325
View Export to BibTeX Export to EndNote
Pezzino V, Sipione C, Vigneri R
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J Endocrinol Invest (ISSN: 0391-4097, 1720-8386electronic, 0391-4097linking), 2008; 31(10): 939-939.
Impact Factor: 1.888
View Export to BibTeX Export to EndNote
6 Records (5 excluding Abstracts).
Total impact factor: 23.5 (21.612 excluding Abstracts).
Total 5 year impact factor: 24.515 (22.384 excluding Abstracts).
Total impact factor: 23.5 (21.612 excluding Abstracts).
Total 5 year impact factor: 24.515 (22.384 excluding Abstracts).
304 views. Last view on Thursday 05 December 2024, 15:27:28
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