Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods (454 views)
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2017 May 20; 40(11): 1235-1241.
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Paper type: Journal Article,
Impact factor: 3.166, 5-year impact factor: 2.346
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Keywords: Aggressive Variant Of Papillary Thyroid Cancer, Classical Papillary Thyroid Carcinoma, Diffuse Sclerosing Variant, Ongoing Risk Stratification, Tall Cell Variant, Adult , Papillary Classification Pathology Surgery , Female , Humans , Middle Aged , Neoplasm Recurrence, Local Pathology Surgery , Prognosis , Retrospective Studies , Risk Factors , Thyroid Neoplasms Classification Pathology Surgery,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. mruss@hotmail.it., Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Via Palermo 636, 95122, Catania, Italy., Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy.,
Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Via Palermo 636, 95122, Catania, Italy.
Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy.
References:
Not available.
J Endocrinol Invest (ISSN: 1720-8386, 0391-4097, 1720-8386electronic), 2017 May 20; 40(11): 1235-1241.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.166, 5-year impact factor: 2.346
Url: Not available.
Keywords: Aggressive Variant Of Papillary Thyroid Cancer, Classical Papillary Thyroid Carcinoma, Diffuse Sclerosing Variant, Ongoing Risk Stratification, Tall Cell Variant, Adult , Papillary Classification Pathology Surgery , Female , Humans , Middle Aged , Neoplasm Recurrence, Local Pathology Surgery , Prognosis , Retrospective Studies , Risk Factors , Thyroid Neoplasms Classification Pathology Surgery,
Affiliations:
*** IBB - CNR ***
Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy. mruss@hotmail.it., Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Via Palermo 636, 95122, Catania, Italy., Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy.,
Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Medical Center, University of Catania, Via Palermo 636, 95122, Catania, Italy.
Institute of Biostructures and Bioimaging, CNR, Via P. Gaifami 18, 95126, Catania, Italy.
References:
Not available.
Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
PURPOSE: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. METHODS: A consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6-24 months after initial treatment, re-classified on the basis of the response to therapy (ongoing risk stratification). RESULTS: Extrathyroidal extension was more frequent in DSV than in TCV and cPTC patients (p < 0.05); moreover, only DSV tumors had a higher rate of recurrent/persistent disease when compared to cPTC treated with the same protocol (total thyroidectomy followed by 131I treatment) (p < 0.01). After initial treatment, 54.2% of TCV and 20.4% of DSV patients were classified at low risk, while at ongoing risk stratification, the excellent response (low risk) was higher for both TCV (77.8%) and DSV (50.0%) patients relative to initial stratification (both p < 0.01). Using ongoing risk classification, positive predictive value (PPV) for persistent/recurrent disease was higher relative to initial risk stratification for both TCV (PPV = 93.8 vs. 39.4%) and DSV (PPV = 63.0 vs. 34.9%), p < 0.05 for both. CONCLUSIONS: In our series DSV, but not TCV patients, had poorer outcome than cPTC treated with the same protocol. Moreover, the ongoing risk stratification predicted outcome better than the initial classification in both TCV and DSV patients.
PURPOSE: Tall cell (TCV) and diffuse sclerosing (DSV) variants are aggressive variants of papillary thyroid cancer (PTC). We compared the risk of recurrent/persistent disease in patients with TCV, DSV and classical PTC (cPTC) and evaluated the prognostic accuracy of initial vs. ongoing risk stratification. METHODS: A consecutive series of DSV (n = 54), TCV (n = 72) and cPTC (n = 184) patients was retrospectively analyzed. TCV and DSV patients were first risk stratified for recurrent/persistent disease without considering the histotype as a risk factor and subsequently, 6-24 months after initial treatment, re-classified on the basis of the response to therapy (ongoing risk stratification). RESULTS: Extrathyroidal extension was more frequent in DSV than in TCV and cPTC patients (p < 0.05); moreover, only DSV tumors had a higher rate of recurrent/persistent disease when compared to cPTC treated with the same protocol (total thyroidectomy followed by 131I treatment) (p < 0.01). After initial treatment, 54.2% of TCV and 20.4% of DSV patients were classified at low risk, while at ongoing risk stratification, the excellent response (low risk) was higher for both TCV (77.8%) and DSV (50.0%) patients relative to initial stratification (both p < 0.01). Using ongoing risk classification, positive predictive value (PPV) for persistent/recurrent disease was higher relative to initial risk stratification for both TCV (PPV = 93.8 vs. 39.4%) and DSV (PPV = 63.0 vs. 34.9%), p < 0.05 for both. CONCLUSIONS: In our series DSV, but not TCV patients, had poorer outcome than cPTC treated with the same protocol. Moreover, the ongoing risk stratification predicted outcome better than the initial classification in both TCV and DSV patients.
Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
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Tall cell and diffuse sclerosing variants of papillary thyroid cancer: outcome and predicting value of risk stratification methods
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Russo M, Malandrino P, Moleti M, Vermiglio F, D'Angelo A, La Rosa G, Sapuppo G, Calaciura F, Regalbuto C, Belfiore A, Vigneri R, Pellegriti G
* Differentiated thyroid cancer in children: Heterogeneity of predictive risk factors (376 views)
Pediatr Blood Cancer (ISSN: 1545-5009linking), 2018 Sep; 65(9): e27226-e27226.
Impact Factor: 2.513
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Malandrino P, Russo M, Regalbuto C, Pellegriti G, Moleti M, Caff A, Squatrito S, Vigneri R
* Outcome of the Diffuse Sclerosing Variant of Papillary Thyroid Cancer: A Meta-Analysis (327 views)
Thyroid (ISSN: 1050-7256, 1050-7256linking), 2016 Sep; 26(9): 1285-1292.
Impact Factor: 5.515
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* Differentiated thyroid cancer in children: Heterogeneity of predictive risk factors (376 views)
Pediatr Blood Cancer (ISSN: 1545-5009linking), 2018 Sep; 65(9): e27226-e27226.
Impact Factor: 2.513
View Export to BibTeX Export to EndNote
Malandrino P, Russo M, Regalbuto C, Pellegriti G, Moleti M, Caff A, Squatrito S, Vigneri R
* Outcome of the Diffuse Sclerosing Variant of Papillary Thyroid Cancer: A Meta-Analysis (327 views)
Thyroid (ISSN: 1050-7256, 1050-7256linking), 2016 Sep; 26(9): 1285-1292.
Impact Factor: 5.515
View Export to BibTeX Export to EndNote
2 Records (2 excluding Abstracts).
Total impact factor: 8.028 (8.028 excluding Abstracts).
Total 5 year impact factor: 5.068 (5.068 excluding Abstracts).
Total impact factor: 8.028 (8.028 excluding Abstracts).
Total 5 year impact factor: 5.068 (5.068 excluding Abstracts).
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