evaluated the prognostic impact of quantitative assessment by maximum
standardized uptake value (SUVmax), metabolic tumour volume (MTV) and
tumour lesion glycolysis (TLG) on [F-18] FDG PET/CT for patients with
peritoneal carcinomatosis from epithelial ovarian cancer (EOC).
patients with EOC underwent PET/CT for an early restaging after
cytoreductive surgery, having been diagnosed with carcinomatosis (before
chemotherapy). The SUVmax, MTV (cm(3); 42% threshold) and TLG (g) were
registered on residual peritoneal lesions. The patients were followed up
20±12months thereafter. The PET/CT results were compared to overall
Kaplan-Meier survival analysis for the SUVmax did not reveal
significant differences in OS (p=0.48). The MTV survival analysis showed
a significant higher OS in patients presenting with a higher tumour
burden than those with less tumour burden (p=0.01; 26 vs. 14 months),
whereas TLG exhibited a similar trend though not significant (p=0.06).
Apart from chemo-resistance, the higher the MTV, the better will be the
response to chemotherapy.
assessment by MTV rather than by SUVmax and TLG on PET/CT may be
helpful for stratifying patients who present with peritoneal
carcinomatosis from EOC, in order to implement the appropriate