Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (476 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
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Paper type: Journal Article,
Impact factor: 3.476, 5-year impact factor: 3.792
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031779417&doi=10.3233%2fJAD-170389&partnerID=40&md5=607c9327d4eee76e9ce54e850679547b
Keywords: Apeh, Alzheimer, S Disease, Blood-Based Indicator System, Oxidized Peptide Hydrolase Activity, Proteasome, Protein Quality Control, Aged , Alzheimer Disease Blood Enzymology , Blotting, Western , Erythrocytes Enzymology , Female , Humans , Peptide Hydrolases Metabolism , Proteasome Endopeptidase Complex Metabolism , Proteostasis , Real-Time Polymerase Chain Reaction , Alzheimer’s Disease,
Affiliations:
*** IBB - CNR ***
Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), Napoli, Italy., Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy., Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.,
Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy.
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
References:
Not available.
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.476, 5-year impact factor: 3.792
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031779417&doi=10.3233%2fJAD-170389&partnerID=40&md5=607c9327d4eee76e9ce54e850679547b
Keywords: Apeh, Alzheimer, S Disease, Blood-Based Indicator System, Oxidized Peptide Hydrolase Activity, Proteasome, Protein Quality Control, Aged , Alzheimer Disease Blood Enzymology , Blotting, Western , Erythrocytes Enzymology , Female , Humans , Peptide Hydrolases Metabolism , Proteasome Endopeptidase Complex Metabolism , Proteostasis , Real-Time Polymerase Chain Reaction , Alzheimer’s Disease,
Affiliations:
*** IBB - CNR ***
Institute of Biosciences and BioResources, National Research Council (CNR-IBBR), Napoli, Italy., Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy., Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.,
Institute of Biostructure and Bioimaging, National Research Council (CNR-IBB), Napoli, Italy.
Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
References:
Not available.
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia. To date, there are no definitive diagnostic tests that can predict or assess onset and progression of the disease. Blood biomarkers for AD are being sought for many years but their identification remains a challenging task. In this study, we investigated the potential relationship between AD and levels of acyl-peptide hydrolase (APEH) and proteasome in erythrocyte samples of 52 participants (26 AD and 26 cognitively healthy controls). A statistically significant decrease in proteasome and exopeptidase/endopeptidase APEH activities was found in AD samples compared to those of healthy controls. Moreover, in contrast to what was observed for proteasome transcripts, APEH activities reduction in AD patients was unrelated to its gene expression levels, suggesting the occurrence of posttranslational modifications or the expression of endogenous inhibitors that might impair enzyme activity. These preliminary data further support a relationship between the APEH-proteasome system and AD molecular players, providing the first evidence of its potential use as a novel blood-based indicator for the routine detection of AD.
Alzheimer's disease (AD) is a progressive, multifactorial neurodegenerative disorder that is the main cause of dementia. To date, there are no definitive diagnostic tests that can predict or assess onset and progression of the disease. Blood biomarkers for AD are being sought for many years but their identification remains a challenging task. In this study, we investigated the potential relationship between AD and levels of acyl-peptide hydrolase (APEH) and proteasome in erythrocyte samples of 52 participants (26 AD and 26 cognitively healthy controls). A statistically significant decrease in proteasome and exopeptidase/endopeptidase APEH activities was found in AD samples compared to those of healthy controls. Moreover, in contrast to what was observed for proteasome transcripts, APEH activities reduction in AD patients was unrelated to its gene expression levels, suggesting the occurrence of posttranslational modifications or the expression of endogenous inhibitors that might impair enzyme activity. These preliminary data further support a relationship between the APEH-proteasome system and AD molecular players, providing the first evidence of its potential use as a novel blood-based indicator for the routine detection of AD.
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
| ▼ Structural characterization of the porphyrins/proteasome interaction |
Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis?
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View Export to BibTeX Export to EndNote
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* Closing or opening proteasome doors by porphyrins (117 views)
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Santoro AM, D’urso A, Cunsolo A, Milardi D, Purrello R, Sbardella D, Tundo GR, Diana D, Fattorusso R, Di Dato A, Paladino A, Persico M, Coletta M, Fattorusso C
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Sbardella D, Tundo GR, Coletta A, Marcoux J, Koufogeorgou EI, Ciaccio C, Santoro AM, Milardi D, Grasso G, Cozza P, Bousquet-dubouch MP, Marini S, Coletta M
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Impact Factor: 7.047
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Dato AD, Cunsolo A, Persico M, Santoro AM, D'Urso A, Milardi D, Purrello R, Stefanelli M, Paolesse R, Tundo GR, Sbardella D, Fattorusso C, Coletta M
* Electrostatic Map Of Proteasome alpha-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding (770 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2017 Dec 6; 7(1): 17098-17098.
Impact Factor: 4.122
View Export to BibTeX Export to EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (659 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
View Export to BibTeX Export to EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (931 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Tundo GR, Sbardella D, Ciaccio C, Grasso G, Gioia M, Coletta A, Polticelli F, Di Pierro D, Milardi D, Van Endert P, Marini S, Coletta M
* Multiple functions of insulin-degrading enzyme: a metabolic crosslight? (486 views)
Crit Rev Biochem Mol (ISSN: 1040-9238), 2017 Jun; N/D: 1-29.
Impact Factor: 5.279
View Export to BibTeX Export to EndNote
Palumbo R, Gogliettino M, Cocca E, Iannitti R, Sandomenico A, Ruvo M, Balestrieri M, Rossi M, Palmieri G
* APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome (396 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067linking), 2016 Sep 23; 17(10): N/D-N/D.
Impact Factor: 3.226
View Export to BibTeX Export to EndNote
Santoro AM, Monaco I, Attanasio F, Lanza V, Pappalardo G, Tomasello MF, Cunsolo A, Rizzarelli E, De Luigi A, Salmona M, Milardi D
* Copper(II) ions affect the gating dynamics of the 20S proteasome: a molecular and in cell study (590 views)
Sci Rep (ISSN: 2045-2322, 2045-2322electronic, 2045-2322linking), 2016 Sep 16; 6: 33444-33444.
Impact Factor: 4.259
View Export to BibTeX Export to EndNote
Santoro AM, Cunsolo A, D'Urso A, Sbardella D, Tundo GR, Ciaccio C, Coletta M, Diana D, Fattorusso R, Persico M, Di Dato A, Fattorusso C, Milardi D, Purrello R
* Cationic porphyrins are tunable gatekeepers of the 20S proteasome (764 views) (PDF 242 views)
Chem Sci (ISSN: 2041-6520, 2041-6520linking, 2041-6520print), 2016; 7(2): 1286-1297.
Impact Factor: 8.668
View Export to BibTeX Export to EndNote
Ciccarelli M, Rusciano MR, Sorriento D, Basilicata MF, Santulli G, Campiglia P, Bertamino A, De Luca N, Trimarco B, Iaccarino G, Illario M
* CaMKII protects MKP-1 from proteasome degradation in endothelial cells (391 views)
Cell Signal (ISSN: 0898-6568), 2014; 26(10): 2167-2174.
Impact Factor: 4.315
View Export to BibTeX Export to EndNote
Bergamo P, Cocca E, Palumbo R, Gogliettino M, Rossi M, Palmieri G
* RedOx status, proteasome and APEH: Insights into anticancer mechanisms of t10, c12-conjugated linoleic acid isomer on A375 melanoma cells (879 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 19; 8(11): N/D-N/D.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (657 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
View Export to BibTeX Export to EndNote
Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (819 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Arena G, Fattorusso R, Grasso G, Grasso GI, Isernia C, Malgieri G, Milardi D, Rizzarelli E
* Zinc(II) complexes of ubiquitin: speciation, affinity and binding features (776 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Oct 4; 17(41): 11596-11603.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (667 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Sciacca MFM, Milardi D, Pappalardo M, La Rosa C, Grasso DM
* Role of electrostatics in the thermal stability of ubiquitin: A combined DSC and MM study (331 views)
Journal Of Thermal Analysis And Calorimetry (ISSN: 1388-6150), 2006 Nov; 86(2): 311-314.
Impact Factor: 1.438
View Export to BibTeX Export to EndNote
18 Records (16 excluding Abstracts).
Total impact factor: 78.134 (70.249 excluding Abstracts).
Total 5 year impact factor: 79.575 (71.177 excluding Abstracts).
Total impact factor: 78.134 (70.249 excluding Abstracts).
Total 5 year impact factor: 79.575 (71.177 excluding Abstracts).
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