A new relational database including clinical data and myocardial perfusion imaging findings in subjects with suspected or known coronary artery disease
A new relational database including clinical data and myocardial perfusion imaging findings in subjects with suspected or known coronary artery disease(395 views) Megna R, Petretta M, Alfano B, Cantoni V, Green R, Daniele S, Acampa W, Nappi C, Gaudieri V, Assante R, Zampella E, Mazziotti E, Mannarini T, Buongiorno P, Cuocolo A
European Heart Journal - Cardiovascular Imaging, 2017 May; 18(Suppl1): i37-i37.
National Research Council, Institute of Biostructure and Bioimaging, Naples, Italy;
Federico II University of Naples, Department of Translational Medical Sciences,Naples, Italy;
References: Not available.
A new relational database including clinical data and myocardial perfusion imaging findings in subjects with suspected or known coronary artery disease
Background: Stress myocardial perfusion imaging (MPI) provides prognostic infor-
mation for clinical decision-making in subjects with suspected or known coronary
artery disease (CAD)
Purpose: The aim of this study was to test a relational database including clinical and
imaging data of subjects with suspected or known CAD undergoing stress MPI
between Jan. 2002 and Dec. 2014 and to assess the impact of age and gender on
MPI findings
Materials and Methods: We developed a relational database (PostgreSQL 9.2)
including the clinical and imaging data of 7563 subjects. Databases included: anam-
nesis informations; other clinical and instrumental (e.g. ECG, echocardiography) fea-
tures; pre-test likelihood of disease by Cadenza; post-processing MPI results; follow-
up information. Data were arranged according to a logic of aggregation and stored in
12 tables. Epidemiological statistics analysis was performed using R statistical
software
Results: Of the overall study population, 68% were male and 32% female. Abnormal
findings were observed in 46% of male subjects showing 35% fixed defect, 32%
reversible defects and 33% mixed perfusion defects. In female subjects, 19% showed
MPI abnormal findings, of these 29% with fixed, 43% with reversible and 28% with
mixed perfusion defects. The number of test performed increased from 198 to 689
(slope6std¼44.467.3, p<0.001), with an almost steady proportion between male and
female gender (67% vs. 33%, in average); only in female gender we found a cyclical
trend (7 years, peak to peak, in 2005 and 2012) relative to positive findings (from
14% to 25%), while no significant trend was detectable in the different perfusion
defect patterns. We divided the study population in six sub-cohort stratified by age
(<55; 55-59; 60-64; 65-69; 70-74; 75 years), founding an incremental number of
abnormal MPI from 32% to 42% (slope6std¼1.9260.23, p¼0.001) in female gender;
also in this case no significant trend was detectable in the different perfusion defect
patterns. Of the 4344 subjects with no history of CAD, 19% showed abnormal findings
with a higher prevalence in male as compared to female subjects (25% and 12%,
respectively, p < 0.001); in both male and female subjects, the prevalence of reversi-
ble perfusion defects was high (66% and 67%, respectively). In 3219 CAD subjects a
high number (61%) of abnormal findings were observed with a higher prevalence in
male as compared to female subjects (64% and 47%, respectively, p < 0.001); in
both male and female subjects a high incidence of fixed (42% and 37%, respectively)
or mixed (38% and 41%, respectively) myocardial perfusion defects was observed
Conclusions: No problem was encountered to connect to the database and for
query/retrieve. Our results indicate a high prevalence of abnormal MPI findings in
male gender for both suspected and known CAD. In female gender, stratifying by
age, a significant trend for abnormal findings during each year was detectable
A new relational database including clinical data and myocardial perfusion imaging findings in subjects with suspected or known coronary artery disease
A new relational database including clinical data and myocardial perfusion imaging findings in subjects with suspected or known coronary artery disease