Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience(407 views) Mazziotti G, Formenti AM, Panarotto MB, Arvat E, Chiti A, Cuocolo A, Dottorini ME, Durante C, Agate L, Filetti S, Felicetti F, Filice A, Pace L, Pellegrino T, Rodari M, Salvatori M, Tranfaglia C, Versari A, Viola D, Frara S, Berruti A, Giustina A, Giubbini R
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2017 Nov 06; 59(1): 90-101.
Keywords: Bone Metastases, Denosumab-Radioiodine, Thyroid Carcinoma, Zoledronate, Radioactive Iodine, Zoledronic Acid, Adolescent, Adult, Aged, Article, Bone Biopsy, Cancer Localization, Cancer Mortality, Cancer Surgery, Cause Of Death, Child, Cohort Analysis, Computer Assisted Tomography, Controlled Study, Differentiated Thyroid Cancer, Disease Association, External Beam Radiotherapy, Female, Hazard Ratio, Human, Hypercalcemia, Informed Consent, Major Clinical Study, Multicenter Study, Nuclear Magnetic Resonance Imaging, Observational Study, Pathologic Fracture, Positron Emission Tomography, Practice Guideline, Priority Journal, Retrospective Study, Spinal Cord Compression, Bone Tumor, Clinical Trial, Middle Aged, Prognosis, Secondary, Thyroid Tumor, Treatment Outcome, Very Elderly, Young Adult, 80 And Over, Bone Neoplasms, Retrospective Studies, Thyroid Neoplasms, Diagnosis, Epidemiology, Bone Neoplasms Diagnosis Epidemiology Secondary Therapy
, Thyroid Neoplasms Diagnosis Epidemiology Pathology Therapy,
Affiliations: *** IBB - CNR ***
Endocrine Unit, ASST Carlo Poma, Mantua, Italy., Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy., Nuclear Medicine, ASST Spedali Civili of Brescia, Brescia, Italy., Nuclear Medicine, University of Brescia, Brescia, Italy., Oncological Endocrinology, University of Turin, Torino, Italy., Nuclear Medicine, Humanitas Research Hospital and Humanitas University, Milan, Italy., Nuclear Medicine, University of Naples Federico II, Napoli, Italy., Nuclear Medicine, "S. Maria della Misericordia" Hospital, Perugia, Italy., Internal Medicine, University Sapienza of Rome, Roma, Italy., Endocrinology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy., Nuclear Medicine, Azienda Ospedaliera Santa Maria Nuova-IRCCS Reggio Emilia, Reggio Emilia, Italy., Department of Medicine and Surgery, University of Salerno, Fisciano, Italy., Institute of Biostructure and Bioimaging of the National Research Council of Italy-CNR, Naples, Italy., Nuclear Medicine, Catholic University of Sacred Heart, Rome, Italy., San Raffaele Vita-Salute University, Milan, Italy., Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., San Raffaele Vita-Salute University, Milan, Italy. giustina.andrea@hsr.it.,
Nuclear Medicine, “S. Maria della Misericordia” Hospital, Perugia, Italy
Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Nuclear Medicine, ASST Spedali Civili of Brescia, Brescia, Italy.
Nuclear Medicine, University of Brescia, Brescia, Italy.
Oncological Endocrinology, University of Turin, Torino, Italy.
Nuclear Medicine, Humanitas Research Hospital and Humanitas University, Milan, Italy.
Nuclear Medicine, "S. Maria della Misericordia" Hospital, Perugia, Italy.
Internal Medicine, University Sapienza of Rome, Roma, Italy.
Endocrinology Unit, Department of Clinical and Experimental Medicine, University of
References: Muresan, M.M., Olivier, P., Leclère, J., Sirveaux, F., Brunaud, L., Klein, M., Zarnegar, R., Weryha, G., Bone metastases from differentiated thyroid carcinoma (2008) Endocr. Relat. Cancer, 15, pp. 37-49. , COI: 1:CAS:528:DC%2BD1cXkslKntbk%3D, PID: 1831027
Durante, C., Haddy, N., Baudin, E., Leboulleux, S., Hartl, D., Travagli, J.P., Caillou, B., Schlumberger, M., Long term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy (2006) J. Clin. Endocrinol. Metab., 91, pp. 2892-2899. , COI: 1:CAS:528:DC%2BD28XosFGhs70%3D, PID: 16684830
Lin, J.D., Huang, M.J., Juang, J.H., Chao, T.C., Huang, B.Y., Chen, K.W., Chen, J.Y., Ho, Y.S., Factors related to the survival of papillary and follicular thyroid carcinoma patients with distant metastases (1999) Thyroid, 9, pp. 1227-1235. , COI: 1:STN:280:DC%2BD3c7htVGrsQ%3D%3D, PID: 10646663
Marcocci, C., Pacini, F., Elisei, R., Schipani, E., Ceccarelli, C., Miccoli, P., Arganini, M., Pinchera, A., Clinical and biologic behavior of bone metastases from differentiated thyroid carcinoma (1989) Surgery, 106, pp. 960-966. , COI: 1:STN:280:DyaK3c%2FmvFymsw%3D%3D, PID: 2588123
Pittas, A.G., Adler, M., Fazzari, M., Tickoo, S., Rosai, J., Larson, S.M., Robbins, R.J., Bone metastases from thyroid carcinoma: clinical characteristics and prognostic variables in one hundred forty-six patients (2000) Thyroid, 10, pp. 261-268. , COI: 1:STN:280:DC%2BD3c3jvFCisA%3D%3D, PID: 10779141
Farooki, A., Leung, V., Tala, H., Tuttle, R.M., Skeletal-related events due to bone metastases from differentiated thyroid cancer (2012) J. Clin. Endocrinol. Metab., 97, pp. 2433-2439. , COI: 1:CAS:528:DC%2BC38XhtFGgs7jO, PID: 22564664
Tucci, M., Mosca, A., Lamanna, G., Porpiglia, F., Terzolo, M., Vana, F., Cracco, C., Berruti, A., Prognostic significance of disordered calcium metabolism in hormone-refractory prostate cancer patients with metastatic bone disease (2009) Prostate Cancer Prostatic Dis., 12, pp. 94-99. , COI: 1:CAS:528:DC%2BD1MXhs1aitLY%3D, PID: 18332901
Cooper, D.S., Doherty, G.M., Haugen, B.R., Kloos, R.T., Lee, S.L., Mandel, S.J., Mazzaferri, E.L., Tuttle, R.M., Revised American Thyroid Association Management Guidelines for patients with thyroid nodules and differentiated thyroid cancer (2009) Thyroid, 19, pp. 1167-1214. , PID: 19860577
Haugen, B.R., Alexander, E.K., Bible, K.C., Doherty, G.M., Mandel, S.J., Nikiforov, Y.E., Pacini, F., Wartofsky, L., American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer (2016) Thyroid, 26, pp. 1-133. , PID: 26462967
Orita, Y., Sugitani, I., Toda, K., Manabe, J., Fujimoto, Y., Zoledronic acid in the treatment of bone metastases from differentiated thyroid carcinoma (2011) Thyroid, 21, pp. 31-35. , COI: 1:CAS:528:DC%2BC3MXktVKjtw%3D%3D, PID: 21058881
Vitale, G., Fonderico, F., Martignetti, A., Caraglia, M., Ciccarelli, A., Nuzzo, V., Abbruzzese, A., Lupoli, G., Pamidronate improves the quality of life and induces clinical remission of bone metastases in patients with thyroid cancer (2001) Br. J. Cancer, 84, pp. 1586-1590. , COI: 1:CAS:528:DC%2BD3MXlt1Oht7o%3D, PID: 11401309
Lipton, A., Fizazi, K., Stopeck, A.T., Henry, D.H., Smith, M.R., Shore, N., Martin, M., Braun, A., Effect of denosumab versus zoledronic acid in preventing skeletal-related events in patients with bone metastases by baseline characteristics (2016) Eur. J. Cancer, 53, pp. 75-83. , COI: 1:CAS:528:DC%2BC2MXhvFems7bO, PID: 26693901
Liu, J., Huang, W., Zhou, R., Jia, S., Tang, W., Luo, Y., Zhang, J., Bisphosphonates in the treatment of patients with metastatic breast, lung, and prostate cancer: a meta-analysis (2015) Medicine, 94. , e2014
Santini, D., Procopio, G., Porta, C., Ibrahim, T., Barni, S., Mazzara, C., Fontana, A., Bracarda, S., Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey (2013) PLoS ONE, 30
Beierwaltes, W.H., Nishiyama, R.H., Thompson, N.W., Copp, J.E., Kubo, A., Survival time and “cure” in papillary and follicular thyroid carcinoma with distant metastases: statistics following University of Michigan therapy (1982) J. Nucl. Med., 23, pp. 561-568. , COI: 1:STN:280:DyaL383hs1ShtQ%3D%3D, PID: 7086528
Schlumberger, M., Challeton, C., De Vathaire, F., Travagli, J.P., Gardet, P., Lumbroso, J.D., Francese, C., Parmentier, C., Radioactive iodine treatment and external radiotherapy for lung and bone metastases from thyroid carcinoma (1996) J. Nucl. Med., 37, pp. 598-605. , COI: 1:CAS:528:DyaK28XislKlurY%3D, PID: 8691248
Mizukami, Y., Mishigishi, T., Nonomura, A., Hashimoto, T., Terahata, S., Noguchi, M., Hisada, K., Matsubara, F., Distant metastases in differentiated thyroid carcinomas: a clinical and pathologic study (1990) Hum. Pathol., 21, pp. 283-290. , COI: 1:STN:280:DyaK3c7osFKmtg%3D%3D, PID: 2312106
Ruegemer, J.J., Hay, I.D., Bergstralh, E.J., Ryan, J.J., Offord, K.P., Gorman, C.A., Distant metastases in differentiated thyroid carcinoma: a multivariate analysis of prognostic variables (1988) J. Clin. Endocrinol. Metab., 67, pp. 501-508. , COI: 1:STN:280:DyaL1czhsFantA%3D%3D, PID: 3410936
Tickoo, S.K., Pittas, A.G., Adler, M., Fazzari, M., Larson, S.M., Robbins, R.J., Rosai, J., Bone metastases from thyroid carcinoma: a histopathologic study with clinical correlates (2000) Arch. Pathol. Lab. Med., 124, pp. 1440-1447. , COI: 1:STN:280:DC%2BD3M%2FhvVWmsw%3D%3D, PID: 11035572
Nikiforov, Y.E., Seethala, R.R., Tallini, G., Baloch, Z.W., Basolo, F., Thompson, L.D., Barletta, J.A., Ghossein, R.A., Nomenclature revision for encapsulated follicular variant of papillary thyroid carcinoma: a paradigm shift to reduce overtreatment of indolent tumors (2016) JAMA Oncol., 2, pp. 1023-1029. , PID: 27078145
Hindié, E., Zanotti-Fregonara, P., Keller, I., Duron, F., Devaux, J.Y., Calzada-Nocaudie, M., Sarfati, E., Toubert, M.E., Bone metastases of differentiated thyroid cancer: impact of early 131I-based detection on outcome (2007) Endocr. Rel. Cancer, 14, pp. 799-807
Verburg, F.A., Aktolun, C., Chiti, A., Frangos, S., Giovanella, L., Hoffmann, M., Iakovou, I., Luster, M., Why the European Association of Nuclear Medicine has declined to endorse the 2015 American Thyroid Association Management Guidelines for adult patients with thyroid nodules and differentiated thyroid cancer (2016) Eur. J. Nucl. Med. Mol. Imaging, 43, pp. 1001-1005. , PID: 26883666
Harel, R., Angelov, L., Spine metastases: current treatments and future directions (2010) Eur. J. Cancer, 46, pp. 2696-2707. , PID: 20627705
Bonadonna, S., Mazziotti, G., Nuzzo, M., Bianchi, A., Fusco, A., De Marinis, L., Giustina, A., Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women (2005) J. Bone Miner. Res., 20, pp. 1837-1844. , PID: 16160741
Mancini, T., Mazziotti, G., Doga, M., Carpinteri, R., Simetovic, N., Vescovi, P.P., Giustina, A., Vertebral fractures in males with type 2 diabetes treated with rosiglitazone (2009) Bone, 45, pp. 784-788. , COI: 1:CAS:528:DC%2BD1MXhtVehurzK, PID: 19527806
Mazziotti, G., Porcelli, T., Mormando, M., De Menis, E., Bianchi, A., Mejia, C., Mancini, T., Giustina, A., Vertebral fractures in males with prolactinoma (2011) Endocrine, 39, pp. 288-293. , COI: 1:CAS:528:DC%2BC3MXksVCrt7k%3D, PID: 21479837
Mazziotti, G., Baracca, M., Doga, M., Porcelli, T., Vescovi, P.P., Giustina, A., Prevalence of thoracic vertebral fractures in hospitalized elderly patients with heart failure (2012) Eur. J. Endocrinol., 167, pp. 865-872. , COI: 1:CAS:528:DC%2BC38Xhsl2iu7nK, PID: 22968484
Torti, C., Mazziotti, G., Soldini, P.A., Focà, E., Maroldi, R., Gotti, D., Carosi, G., Giustina, A., High prevalence of radiological vertebral fractures in HIV-infected males (2012) Endocrine, 41, pp. 512-517. , COI: 1:CAS:528:DC%2BC3MXhs1OjsLzJ, PID: 22198528
Mazziotti, G., Bianchi, A., Porcelli, T., Mormando, M., Maffezzoni, F., Cristiano, A., Giampietro, A., Giustina, A., Vertebral fractures in patients with acromegaly: a 3-year prospective study (2013) J. Clin. Endocrinol. Metab., 98, pp. 3402-3410. , COI: 1:CAS:528:DC%2BC3sXht12gsLnN, PID: 23771918
Mazziotti, G., Dordoni, C., Doga, M., Galderisi, F., Venturini, M., Calzavara-Pinton, P., Maroldi, R., Colombi, M., High prevalence of radiological vertebral fractures in adult patients with Ehlers-Danlos syndrome (2016) Bone, 84, pp. 88-92. , COI: 1:STN:280:DC%2BC28rltFWjsA%3D%3D, PID: 26708925
Pedersini, R., Monteverdi, S., Mazziotti, G., Amoroso, V., Roca, E., Maffezzoni, F., Vassalli, L., Giustina, A., Morphometric vertebral fractures in breast cancer patients treated with adjuvant aromatase inhibitor therapy: a cross-sectional study (2017) Bone, 97, pp. 147-152. , COI: 1:CAS:528:DC%2BC2sXhsFGqt74%3D, PID: 28104509
Mazziotti, G., Sorvillo, F., Piscopo, M., Cioffi, M., Pilla, P., Biondi, B., Iorio, S., Carella, C., Recombinant human TSH modulates in vivo C-telopeptides of type-1 collagen and bone alkaline phosphatase, but not osteoprotegerin production in postmenopausal women monitored for differentiated thyroid carcinoma (2005) J. Bone Miner. Res., 20, pp. 480-486. , COI: 1:CAS:528:DC%2BD2MXis1Knu7Y%3D, PID: 15746993
Mazziotti, G., Mormando, M., Cristiano, A., Bianchi, A., Porcelli, T., Giampietro, A., Maffezzoni, F., Giustina, A., Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism (2014) Eur. J. Endocrinol., 170, pp. 893-899. , COI: 1:CAS:528:DC%2BC2cXhtVamtLjN, PID: 24836549
Bernier, M.O., Leenhardt, L., Hoang, C., Aurengo, A., Mary, J.Y., Menegaux, F., Enkaoua, E., Hejblum, G., Survival and therapeutic modalities in patients with bone metastases of differentiated thyroid carcinomas (2001) J. Clin. Endocrinol. Metab., 86, pp. 1568-1573. , COI: 1:CAS:528:DC%2BD3MXivVClur0%3D, PID: 11297585
Zettinig, G., Fueger, B.J., Passler, C., Kaserer, K., Pirich, C., Dudczak, R., Niederle, B., Long-term follow-up of patients with bone metastases from differentiated thyroid carcinoma—surgery or conventional therapy? (2002) Clin. Endocrinol., 56, pp. 377-382
Ramadan, S., Ugas, M.A., Berwick, R.J., Notay, M., Cho, H., Jerjes, W., Giannoudis, P.V., Spinal metastasis in thyroid cancer (2012) Head Neck Oncol., 4, p. 39. , COI: 1:CAS:528:DC%2BC38Xjt1ansbk%3D, PID: 22730910
Weiss, R.J., Ekström, W., Hansen, B.H., Keller, J., Laitinen, M., Trovik, C., Zaikova, O., Wedin, R., Pathological subtrochanteric fractures in 194 patients: a comparison of outcome after surgical treatment of pathological and non-pathological fractures (2013) J. Surg. Oncol., 107, pp. 498-504. , PID: 23070922
Smith, T., Pelpola, K., Ball, M., Ong, A., Myint, P.K., Pre-operative indicators for mortality following hip fracture surgery: a systematic review and meta-analysis (2014) Age Ageing, 43, pp. 464-471. , PID: 24895018
Kilci, O., Un, C., Sacan, O., Gamli, M., Baskan, S., Baydar, M., Ozkurt, B., Postoperative mortality after hip fracture surgery: a 3 years follow -up (2016) PLoS ONE, 11. , PID: 27788137, 27
Choi, Y.M., Kim, W.G., Kwon, H., Jeon, M.J., Lee, J.J., Ryu, J.S., Hong, E.G., Kim, W.B., Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma (2016) Eur. J. Endocrinol., 175, pp. 165-172. , COI: 1:CAS:528:DC%2BC2sXhtFyms7fI, PID: 27272238
Qiu, Z.L., Song, H.J., Xu, Y.H., Luo, Q.Y., Efficacy and survival analysis of 131I therapy for bone metastases from differentiated thyroid cancer (2011) J. Clin. Endocrinol. Metab., 96, pp. 3078-3086. , COI: 1:CAS:528:DC%2BC3MXhtlyitbnP, PID: 21795449
Roodman, G.D., Mechanisms of bone metastasis (2004) N. Engl. J. Med., 350, pp. 1655-1664. , COI: 1:CAS:528:DC%2BD2cXjt1WksLY%3D, PID: 15084698
Fizazi, K., Lipton, A., Mariette, X., Body, J.J., Rahim, Y., Gralow, J.R., Gao, G., Jun, S., Randomized phase II trial of denosumab in patients with bone metastases from prostate cancer, breast cancer, or other neoplasms after intravenous bisphosphonates (2009) J. Clin. Oncol., 27, pp. 1564-1571. , COI: 1:CAS:528:DC%2BD1MXltVOhtr0%3D, PID: 19237632
Mazziotti, G., Canalis, E., Giustina, A., Drug-induced osteoporosis: mechanisms and clinical implications (2010) Am. J. Med., 123, pp. 877-884. , COI: 1:CAS:528:DC%2BC3cXht1eqtLfJ, PID: 20920685
Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience