Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics (263 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking), 2017 Oct 20; 8: 277-277.
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Paper type: Journal Article,
Impact factor: 3.519, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032856279&doi=10.3389%2ffendo.2017.00277&partnerID=40&md5=a1fef452d2811de0fbd4518cc94910e9
Keywords: Thyroid Cancer Registry, Anaplastic Thyroid Cancer, Thyroid Cancer And Volcanic Environment, Thyroid Cancer Epidemiology,
Affiliations:
*** IBB - CNR ***
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy., Medical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy., Endocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy., Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Motor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy., Osservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy., Institute of Biostructure and Bioimaging, CNR, Catania, Italy.,
Medical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy.
Endocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Motor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy.
Osservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy.
Institute of Biostructure and Bioimaging, CNR, Catania, Italy.
References:
Not available.
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking), 2017 Oct 20; 8: 277-277.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.519, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032856279&doi=10.3389%2ffendo.2017.00277&partnerID=40&md5=a1fef452d2811de0fbd4518cc94910e9
Keywords: Thyroid Cancer Registry, Anaplastic Thyroid Cancer, Thyroid Cancer And Volcanic Environment, Thyroid Cancer Epidemiology,
Affiliations:
*** IBB - CNR ***
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy., Medical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy., Endocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy., Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy., Motor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy., Osservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy., Institute of Biostructure and Bioimaging, CNR, Catania, Italy.,
Medical Oncology, Department of Clinical Experimental Medicine, University of Catania, Policlinic Hospital, Catania, Italy.
Endocrinology, Di.Bi.M.I.S., University of Palermo, Palermo, Italy.
Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
Motor Sciences, School of Human and Social Sciences, "Kore" University, Enna, Italy.
Osservatorio Epidemiologico Regionale, Assessorato Salute Regione Siciliana, Palermo, Italy.
Institute of Biostructure and Bioimaging, CNR, Catania, Italy.
References:
Not available.
Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA. METHODS: Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA. RESULTS: Forty-three ATCs were identified in Sicily in the period 2002-2009. In our series only age <70 years at diagnosis (p = 0.01), coexistence with DTC (p = 0.027) and tumor size ≤6 cm (p = 0.012) were significant factors for increased survival at univariate analysis (only age at multivariate analysis). No difference in ATC incidence was found in urban vs rural areas and in iodine-deficient and industrial vs control areas. By contrast, in the volcanic area of Sicily, where DTC incidence is doubled relative to the rest of the island, also ATC incidence was increased. ATC data in Sicily were similar to those reported in the same period in the USA where overall survival rate at 6 and 12 months, however, was smaller. CONCLUSION: The similar ATC data observed in Sicily and USA (having different genetic background and lifestyle) and the increased ATC incidence in the volcanic area of Sicily paralleling the increased incidence of papillary thyroid cancer are compatible with the possibility that casual additional mutations, more frequent in a background of increased cell replication like DCT, are the major causes of ATC rather than genetic background and/or direct environmental influences.
BACKGROUND: Anaplastic thyroid cancer (ATC) is a rare but extremely aggressive cancer of the thyroid, contributing up to 30-40% of thyroid cancer-specific mortality. We analyzed ATC characteristics and survival rates in Sicily to evaluate the possible influence of environmental factors. With this aim, data regarding ATC incidences in urban/rural and industrial, iodine-deficient, and volcanic vs control areas were compared in Sicily as well as ATC data from Sicily and USA. METHODS: Using the Sicilian Register of Thyroid Cancer (SRTC) database incidence, age, gender, tumor size and histotype, extrathyroidal extension, stage, and coexistence with pre-existing differentiated thyroid cancer (DTC) were evaluated in different areas of Sicily and also compared with Surveillance Epidemiology and End Results data in USA. RESULTS: Forty-three ATCs were identified in Sicily in the period 2002-2009. In our series only age <70 years at diagnosis (p = 0.01), coexistence with DTC (p = 0.027) and tumor size ≤6 cm (p = 0.012) were significant factors for increased survival at univariate analysis (only age at multivariate analysis). No difference in ATC incidence was found in urban vs rural areas and in iodine-deficient and industrial vs control areas. By contrast, in the volcanic area of Sicily, where DTC incidence is doubled relative to the rest of the island, also ATC incidence was increased. ATC data in Sicily were similar to those reported in the same period in the USA where overall survival rate at 6 and 12 months, however, was smaller. CONCLUSION: The similar ATC data observed in Sicily and USA (having different genetic background and lifestyle) and the increased ATC incidence in the volcanic area of Sicily paralleling the increased incidence of papillary thyroid cancer are compatible with the possibility that casual additional mutations, more frequent in a background of increased cell replication like DCT, are the major causes of ATC rather than genetic background and/or direct environmental influences.
Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics
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Anaplastic Thyroid Cancer in Sicily: The Role of Environmental Characteristics
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Russo M, Malandrino P, Moleti M, D'Angelo A, Tavarelli M, Sapuppo G, Giani F, Richiusa P, Squatrito S, Vigneri R, Pellegriti G
* Thyroid Cancer in the Pediatric Age in Sicily: Influence of the Volcanic Environment (353 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 0250-7005linking), 2017 Mar; 37(3): 1515-1522.
Impact Factor: 1.865
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* Thyroid Cancer in the Pediatric Age in Sicily: Influence of the Volcanic Environment (353 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 0250-7005linking), 2017 Mar; 37(3): 1515-1522.
Impact Factor: 1.865
View Export to BibTeX Export to EndNote
1 Records (1 excluding Abstracts).
Total impact factor: 1.865 (1.865 excluding Abstracts).
Total 5 year impact factor: 1.876 (1.876 excluding Abstracts).
Total impact factor: 1.865 (1.865 excluding Abstracts).
Total 5 year impact factor: 1.876 (1.876 excluding Abstracts).
263 views. Last view on Saturday 01 June 2024, 0:48:35
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