Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
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Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (342 views)

Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A

Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.

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Paper type: Journal Article,

Impact factor: 2.507, 5-year impact factor: 2.381

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d

Keywords: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,

Affiliations:
*** IBB - CNR ***

[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy


References:
Not available.
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation

A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation

▼    Chemical protein synthesis and modification for biomedical applications
▼    New synthetic molecules for active targeting of multifunctional theranostic nanosystems
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation

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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
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Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
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14 Records (12 excluding Abstracts).
Total impact factor: 61.366 (51.324 excluding Abstracts).
Total 5 year impact factor: 56.578 (45.964 excluding Abstracts).

Last modified by Marco Comerci on Sunday 12 July 2020, 13:14:46
342 views. Last view on Saturday 18 November 2023, 5:31:25