Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.507, 5-year impact factor: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Keywords: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliations:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
References:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.507, 5-year impact factor: 2.381
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85033800193&doi=10.1002%2fejic.201700768&partnerID=40&md5=20643deddc9ff3220307867adcd9911d
Keywords: Carbohydrates, Carbene Ligands, Bioconjugation, Cytotoxity, Gold, Antitumor Agents, Cancer Cells, In-Vitro, Anticancer Agents, Crystal Structure, Rational Design, Au(i), Metallodrugs, Inhibition,
Affiliations:
*** IBB - CNR ***
[ 1 ] Univ Napoli Federico II, Complesso Univ Monte S Angelo, Dipartimento Sci Chim, Via Cintia 21, I-80126 Naples, Italy
[ 2 ] Consorzio Interuniv Reatt Chim & Catalisi, Via Celso Ulpiani 27, I-70126 Bari, Italy
[ 3 ] CNR, IBB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 4 ] Univ Napoli Federico II, Dipartimento Farm, Via Mezzocannone 16, I-80134 Naples, Italy
[ 5 ] Univ Napoli Federico II, CIRPeB, Via Mezzocannone 16, I-80134 Naples, Italy
[ 6 ] Diagnost & Farmaceut Mol SCRL DFM, Via Mezzocannone 16, I-80134 Naples, Italy
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, Via Cintia 21, Napoli, 80126, Italy
Consorzio Interuniversitario di Reattività Chimica e Catalisi, Via Celso Ulpiani 27, Bari, 70126, Italy
Istituto di Biostrutture e Bioimmagini (IBB) CNR, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia & CIRPeB Università degli Studi di Napoli Federico II, Via Mezzocannone 16, Napoli, 80134, Italy
Diagnostica e Farmaceutica Molecolari S.C.R.L (DFM), Via Mezzocannone 16, Napoli, 80134, Italy
References:
Kelland, L., (2007) Nat. Rev. Cancer, 7, pp. 573-58
Clarke, M.J., Zhu, F., Frasca, D.R., (1999) Chem. Rev., 99, pp. 2511-2533
Komeda, S., Casini, A., (2012) Curr. Top. Med. Chem., 12, pp. 219-235
Nagy, E.M., Ronconi, L., Nardon, C., Fregona, D., (2012) Mini-Rev. Med. Chem., 12, pp. 1216-1229
Messori, L., Casini, A., (2011) Curr. Top. Med. Chem., 11, pp. 2647-2660
Ott, I., (2009) Coord. Chem. Rev., 253, pp. 1670-1681
Roder, C., Thomson, M.J., (2015) Drugs R&D, 15, pp. 13-20
https://clinicaltrials.gov/ct2/show/NCT01747798
Mirabelli, C.K., Johnson, R.K., Hill, D.T., Faucette, L.F., Girard, G.R., Kuo, G.Y., Sung, C.M., Crooket, S.T., (1986) J. Med. Chem., 29, pp. 218-223
Gutiérrez, A., Gracia-Fleta, L., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2014) Dalton Trans., 43, pp. 17054-17066
Goitia, H., Nieto, Y., Villacampa, M.D., Kasper, C., Laguna, A., Gimeno, M.C., (2013) Organometallics, 32, pp. 6069-6078
Gutiérrez, A., Marzo, I., Cativiela, C., Laguna, A., Gimeno, M.C., (2015) Chem. Eur. J., 21, pp. 11088-11095
Baker, M.V., Barnard, P.J., Berners-Price, S.J., Brayshaw, S.K., Hickey, J.L., Skelton, B.W., White, A.H., (2005) J. Organomet. Chem., 690, pp. 5625-5635
Liu, W., Gust, R., (2013) Chem. Soc. Rev., 42, pp. 755-773
Raubenheimer, H.G., Cronje, S., (2008) Chem. Soc. Rev., 37, pp. 1998-2011
Messori, L., Gabbiani, C., (2005) Metal Compounds in Cancer Chemotherapy, pp. 355-375. , “Recent Trends in Antitumor gold(III) Complexes Innovative Cytotoxic Metallodrugs for Cancer Treatment” in, in, (Eds., J. M. Pérez, M. A. Fuertes C. Alonso, Research Signpost, Keral
Tessier, C.A., Cannon, C.L., Youngs, W.J., (2009) Chem. Rev., 109, pp. 3859-3884
Rubbiani, R., Can, S., Kitanovic, I., Alborzinia, H., Stefanopoulou, M., Kokoschka, M., Mönchgesang, S., Ott, I., (2011) J. Med. Chem., 54, pp. 8646-8657
Cisnetti, F., Gautier, A., (2013) Angew. Chem. Int. Ed., 52, pp. 11976-11978
(2013) Angew. Chem., 125, p. 12194
Hu, C., Li, X., Wang, W., Zhang, R., Deng, L., (2014) Curr. Med. Chem., 21, pp. 1220-1230
Gutiérrez, A., Gimeno, M.C., Marzo, I., Metzler-Nolte, N., (2014) Eur. J. Inorg. Chem., pp. 2512-2519
Visbal, R., Fernández-Moreira, V., Marzo, I., Laguna, A., Gimeno, M.C., (2016) Dalton Trans., 45, pp. 15026-15033
Weaver, J., Gaillard, S., Toye, C., Macpherson, S., Nolan, S.P., Riches, A., (2011) Chem. Eur. J., 17, pp. 6620-6624. , For representative examples, see a
Messori, L., Marchetti, L., Massai, L., Scaletti, F., Guerri, A., Landini, I., Nobili, S., Gabbiani, C., (2014) Inorg. Chem., 53, pp. 2396-2403
Cheng, X., Holenya, P., Can, S., Alborzinia, H., Rubbiani, R., Ott, I., Wölfl, S., (2014) Mol. Cancer, 13, p. 221
Tacke, M., (2015) J. Organomet. Chem., 782, pp. 17-21
García-Moreno, E., Gascón, S., García de Jalón, J.A., Romanos, E., Rodriguez-Yoldi, M.J., Laguna, M., (2015) Anti-Cancer Agents Med. Chem., 15, pp. 773-782
Bertrand, B., Casini, A., (2014) Dalton Trans., 43, pp. 4209-4219
Hickey, J.L., Ruhayel, R.A., Barnard, P.J., Baker, M.V., Berners-Price, S.J., Filipovska, A.J., (2008) J. Am. Chem. Soc., 130, pp. 12570-12571
Bindoli, A., Rigobello, M.P., Scutari, G., Gabbiani, C., Casini, A., Messori, L., (2009) Coord. Chem. Rev., 253, pp. 1692-1707
Pratesi, A., Gabbiani, C., Michelucci, E., Ginanneschi, M., Papini, A.M., Rubbiani, R., Ott, I., Messori, L., (2014) J. Inorg. Biochem., 136, pp. 161-169
Bhabak, K.P., Bhuyan, B.J., Mugesh, G., (2011) Dalton Trans., 40, pp. 2099-2111
Krishnamurthy, D., Karver, M.R., Fiorillo, E., Orru, V., Stanford, S.M., Bottini, N., Barrios, A.M., (2008) J. Med. Chem., 51, pp. 4790-4795
Gabbiani, C., Scaletti, F., Massai, L., Michelucci, E., Cinellu, M., Messori, L., (2012) Chem. Commun., 48, pp. 11623-11625
Ferraro, G., Gabbiani, C., Merlino, A., (2016) Bioconjugate Chem., 27, pp. 1584-1587
Bertrand, B., Stefan, L., Pirrotta, M., Monchaud, D., Bodio, E., Richard, P., Le Gendre, P., Casini, A., (2014) Inorg. Chem., 53, pp. 2296-2303
Maftei, C.V., Fodor, E., Jones, P.G., Freytag, M., Franz, M.H., Kelter, G., Fiebig, H.H., Neda, I., (2015) Eur. J. Med. Chem., 101, pp. 431-445
Niu, W., Chen, X., Tan, W., Veige, A.S., (2016) Angew. Chem. Int. Ed., 55, pp. 8889-8893
(2016) Angew. Chem., 128, p. 9035
Vander Heiden, M.G., Cantley, L.C., Thompson, C.B., (2009) Science, 324, pp. 1029-1033
Warburg, O., (1956) Science, 123, pp. 309-314
Wang, Q., Huang, Z., Ma, J., Lu, X., Zhang, L., Wang, X., Wang, P.G., (2016) Dalton Trans., 45, pp. 10366-10374
Storr, T., (2014) Ligand Design in Medicinal Inorganic Chemistry, , in, John Wiley & Sons, Chicheste
Benessere, V., Lega, M., Ruffo, F., (2014) J. Organomet. Chem., 771, pp. 105-116. , and references cited therein
Nishioka, T., Shibata, T., Kinoshita, I., (2007) Organometallics, 26, pp. 1126-1128
Bertrand, B., Bodio, E., Richard, P., Picquet, M., Le Gendre, P., Casini, A., (2015) J. Organomet. Chem., 775, pp. 124-129
de Fremont, P., Scott, N.M., Stevens, E.D., Nolan, S.P., (2005) Organometallics, 24, pp. 2411-2418
Benessere, V., Ruffo, F., (2010) Tetrahedron: Asymmetry, 21, pp. 171-176
Liu, W., Bensdorf, K., Proetto, M., Abram, U., Hagenbach, A., Gust, R., (2011) J. Med. Chem., 54, pp. 8605-8615
Lin, I.J.B., Vasam, C.S., (2005) Can. J. Chem., 83, pp. 812-825
The inertness of [bis(magi)Au][BF,] was confirmed with several cancer cell lines (data not show)
Weinlich, R., Oberst, A., Beere, H.M., Green, D.R., (2017) Nat. Rev. Mol. Cell Biol., 18, pp. 127-136
Uson, R., Laguna, A., Laguna, M., (1989) Inorg. Synth., 26, pp. 85-91
Szarek, W.A., Achmatowicz, O., Plenkiewicz, J., Radatus, B.K., (1978) Tetrahedron, 34, pp. 1427-1433
(2002) SADABS, , Bruker-Nonius, Delf
Altomare, A., Burla, M.C., Camalli, M., Cascarano, G.L., Giacovazzo, C., Guagliardi, A., Moliterni, A.G.G., Spagna, R., (1999) J. Appl. Crystallogr., 32, pp. 115-119
Sheldrick, G.M., (2015) Acta Crystallogr., Sect. C: Cryst. Struct. Commun., 71, pp. 3-8
Farrugia, L.J., (1997) J. Appl. Crystallogr., 30, pp. 565-566
Macrae, C.F., Edgington, P.R., McCabe, P., Pidcock, E., Shields, G.P., Taylor, R., Towler, M., van der Streek, J., (2006) J. Appl. Crystallogr., 39, pp. 453-457
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
A series of neutral and cationic gold(I) complexes bearing a glucopyranoside-incorporated N-heterocyclic carbene (NHC) ligand are synthetized and structurally characterized. Different secondary ligands (chlorido, phosphane, or sugar–NHC) are employed to tune the properties of the complexes. The antiproliferative effects of the compounds are evaluated against PC-3 prostate cancer cells and a panel of human tumor cell lines. The activities of the phosphane complexes are comparable to that observed for cisplatin. The combined results provide further insights into the biological behavior of NHC–gold complexes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
| ▼ Chemical protein synthesis and modification for biomedical applications |
| ▼ New synthetic molecules for active targeting of multifunctional theranostic nanosystems |
Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (540 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (369 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
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Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
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Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (411 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (933 views)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
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* Exploiting Protein N-Terminus for Site-Specific Bioconjugation (2 views)
Molecules, 2021; 26: 3521-3521.
Impact Factor: 4.927
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Siciliano G, Corricelli M, Iacobazzi RM, Canepa F, Comegna D, Fanizza E, Del Gatto A, Saviano M, Laquintana V, Comparelli R, Mascolo G, Murgolo S, Striccoli M, Agostiano A, Denora N, Zaccaro L, Curri ML, Depalo N
* Gold-Speckled SPION@SiO(2) Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications (93 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 Aug 26; 26(48): 11048-11059.
Impact Factor: 4.857
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Doti N, Caporale A, Monti A, Sandomenico A, Selis F, Ruvo M
* A recent update on the use of microbial transglutaminase for the generation of biotherapeutics (89 views)
World J Microbiol Biotechnol (ISSN: 0959-3993linking), 2020 Mar 14; 36(4): 53-53.
Impact Factor: 2.477
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Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (164 views)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
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Oliveri V, Bellia F, Viale M, Maric I, Vecchio G
* Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Impact Factor: 5.158
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Messori L, Merlino A
* Cisplatin binding to proteins: A structural perspective (626 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 315: 67-89.
Impact Factor: 13.324
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Caporale A, Selis F, Pain D, Sandomenico A, Jotti S, Tonon G, Ruvo M
* The LQSP tetrapeptide is a new highly efficient substrate of microbial transglutaminase for the site-specific derivatization of peptides and proteins (682 views)
Biotechnol J (ISSN: 1860-6768), 2015 Jan; 10(1): 154-161.
Impact Factor: 3.781
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (517 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Engelen M, Lombardi A, Vitale R, Lista L, Maglio O, Pavone V, Nastri F
* Branched porphyrins as functional scaffolds for multisite bioconjugation (350 views)
Biotechnol Appl Bioc (ISSN: 0885-4513), 2014 Sep 21; N/D: N/D-N/D.
Impact Factor: 1.362
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Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (540 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Merlino A, Avella G, Di Gaetano S, Arciello A, Piccoli R, Mazzarella L, Sica F
* Structural features for the mechanism of antitumor action of a dimeric human pancreatic ribonuclease variant (369 views)
Protein Sci (ISSN: 0961-8368, 1469-896xelectronic, 0961-8368linking), 2009 Jan; 18(1): 50-57.
Impact Factor: 2.937
View Export to BibTeX Export to EndNote
Sbardella G, Castellano S, Vicidomini C, Rotili D, Nebbioso A, Miceli M, Altucci L, Mai A
* Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases (313 views)
Bioorganic & Medicinal Chemistry Letters (ISSN: 0960-894x), 2008 May 1; 18(9): 2788-2792.
Impact Factor: 2.531
View Export to BibTeX Export to EndNote
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (411 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
View Export to BibTeX Export to EndNote
Leese MP, Leblond B, Smith A, Newman SP, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity (933 views)
J Med Chem (ISSN: 0022-2623print, 0022-2623linking, 1520-4804), 2006 Dec 28; 49(26): 7683-7696.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
14 Records (12 excluding Abstracts).
Total impact factor: 61.366 (51.324 excluding Abstracts).
Total 5 year impact factor: 56.578 (45.964 excluding Abstracts).
Total impact factor: 61.366 (51.324 excluding Abstracts).
Total 5 year impact factor: 56.578 (45.964 excluding Abstracts).
328 views. Last view on Saturday 14 January 2023, 18:20:53
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