Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex (653 views)
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
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Paper type: Journal Article
Impact factor: 2.163, 5-year impact factor: 2.548
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038381085&doi=10.1177%2f1550059417745934&partnerID=40&md5=4c6e4425301fd178391c808c7c65a84e
Keywords: Matrics Consensus Cognitive Battery, Rdoc Positive Valence System, Avolition-Apathy, Motivation Circuits, Working Memory, Adult , Amygdala Physiopathology , Anisotropy , Cerebral Cortex Physiopathology , Diffusion Tensor Imaging Methods , Electroencephalography Methods , Female , Humans , Neural Pathways Physiopathology , Schizophrenia Physiopathology , White Matter Physiopathology, Article, Association, Clinical Article, Controlled Study, Depression, Fractional Anisotropy, Insula, Negative Syndrome, Nerve Cell Network, Nuclear Magnetic Resonance Imaging, Priority Journal, Tractography, Brain Cortex, Nerve Tract, Pathophysiology, Procedures
Affiliations:
*** IBB - CNR ***
1 Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy., 2 Biostructure and Bioimaging Institute, National Research Council, Naples, Italy., 3 Department of Integrated Imaging, IRCCS SDN, Naples, Italy., 4 Department of Motor Sciences & Healthiness, University of Naples Parthenope, Naples, Italy.,
References:
Not available.
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
Export to BibTeX Export to EndNote
Paper type: Journal Article
Impact factor: 2.163, 5-year impact factor: 2.548
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038381085&doi=10.1177%2f1550059417745934&partnerID=40&md5=4c6e4425301fd178391c808c7c65a84e
Keywords: Matrics Consensus Cognitive Battery, Rdoc Positive Valence System, Avolition-Apathy, Motivation Circuits, Working Memory, Adult , Amygdala Physiopathology , Anisotropy , Cerebral Cortex Physiopathology , Diffusion Tensor Imaging Methods , Electroencephalography Methods , Female , Humans , Neural Pathways Physiopathology , Schizophrenia Physiopathology , White Matter Physiopathology, Article, Association, Clinical Article, Controlled Study, Depression, Fractional Anisotropy, Insula, Negative Syndrome, Nerve Cell Network, Nuclear Magnetic Resonance Imaging, Priority Journal, Tractography, Brain Cortex, Nerve Tract, Pathophysiology, Procedures
Affiliations:
*** IBB - CNR ***
1 Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy., 2 Biostructure and Bioimaging Institute, National Research Council, Naples, Italy., 3 Department of Integrated Imaging, IRCCS SDN, Naples, Italy., 4 Department of Motor Sciences & Healthiness, University of Naples Parthenope, Naples, Italy.,
References:
Not available.
Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex
The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural and functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at the level of the nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well as amygdala (Amy) and insular cortex (IC). However, the association of the reported abnormalities with avoliton-apathy is still controversial. In the present study, we investigated white matter connectivity patterns within these regions, using a probabilistic analysis of diffusion tensor imaging (DTI) data, in male subjects with schizophrenia. Thirty-five male subjects with schizophrenia (SCZ) and 17 male healthy controls (HC) matched for age, underwent DTI. SCZ were evaluated using the Schedule for Deficit Syndrome (SDS), the Positive and Negative Syndrome Scale (PANSS), and the MATRICS Consensus Cognitive Battery (MCCB). Probabilistic tractography was applied to investigate pathways connecting the Amy and the NAcc with the OFC and IC. Reduced fractional anisotropy (FA) was observed in left Amy–ventral anterior IC connections, in SCZ compared with controls. This abnormality was negatively correlated with avolition/apathy but not with expressive deficit scores. SCZ showed also a reduced connectivity index between right NAcc and medial OFC, as compared with controls. Finally, the left NAcc-dorsal anterior IC connectivity index was negatively correlated with working memory scores. Our results indicate that only the avolition/apathy domain of negative symptoms is related to abnormal connectivity in the motivation-related circuits. The findings also demonstrate that distinct alterations underlie cognitive impairment and avolition/apathy. © 2017, © EEG and Clinical Neuroscience Society (ECNS) 2017.
The avolition/apathy domain of negative symptoms includes motivation- and pleasure-related impairments. In people with schizophrenia, structural and functional abnormalities were reported in key regions within the motivational reward system, including ventral-tegmental area (VTA), striatum (especially at the level of the nucleus accumbens, NAcc), orbitofrontal cortex (OFC), as well as amygdala (Amy) and insular cortex (IC). However, the association of the reported abnormalities with avoliton-apathy is still controversial. In the present study, we investigated white matter connectivity patterns within these regions, using a probabilistic analysis of diffusion tensor imaging (DTI) data, in male subjects with schizophrenia. Thirty-five male subjects with schizophrenia (SCZ) and 17 male healthy controls (HC) matched for age, underwent DTI. SCZ were evaluated using the Schedule for Deficit Syndrome (SDS), the Positive and Negative Syndrome Scale (PANSS), and the MATRICS Consensus Cognitive Battery (MCCB). Probabilistic tractography was applied to investigate pathways connecting the Amy and the NAcc with the OFC and IC. Reduced fractional anisotropy (FA) was observed in left Amy–ventral anterior IC connections, in SCZ compared with controls. This abnormality was negatively correlated with avolition/apathy but not with expressive deficit scores. SCZ showed also a reduced connectivity index between right NAcc and medial OFC, as compared with controls. Finally, the left NAcc-dorsal anterior IC connectivity index was negatively correlated with working memory scores. Our results indicate that only the avolition/apathy domain of negative symptoms is related to abnormal connectivity in the motivation-related circuits. The findings also demonstrate that distinct alterations underlie cognitive impairment and avolition/apathy. © 2017, © EEG and Clinical Neuroscience Society (ECNS) 2017.
Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex
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Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex
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* Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study (317 views)
J Clin Med (ISSN: 2077-0383electronic, 2077-0383linking), 2021 Dec 23; 11 (1 ): N/D-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
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Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Pellecchia MT, Picillo M, Santangelo G, Longo K, Moccia M, Erro R, Amboni M, Vitale C, Vicidomini C, Salvatore M, Barone P, Pappata S
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6 Records (5 excluding Abstracts).
Total impact factor: 42.878 (40.319 excluding Abstracts).
Total 5 year impact factor: 43.464 (41.099 excluding Abstracts).
Total impact factor: 42.878 (40.319 excluding Abstracts).
Total 5 year impact factor: 43.464 (41.099 excluding Abstracts).
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