Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications(496 views) Calvanese L, Caporale A, Focà G, Iaccarino E, Sandomenico A, Doti N, Apicella I, Incisivo GM, De Falco S, Falcigno L, D’auria G, Ruvo M
Keywords: Cancer Detection, Flow Cytometry, Receptor Binding, Retro-Inverso Peptide Sequence, Cyclopeptide, Vasculotropin Receptor 1, Amino Acid Sequence, Article, Binding Affinity, Circular Dichroism, Controlled Study, Derivatization, Ligand Binding, Molecular Dynamics, Molecular Probe, Molecular Recognition, Nuclear Magnetic Resonance, Priority Journal, Protein Binding, Protein Phosphorylation, Protein Targeting, Structure Analysis,
Affiliations: *** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy., DISTABiF, Universita degli Studi della Campania Luigi Vanvitelli, Via Vivaldi 43, 81100, Caserta, Italy., Angiogenesis Lab, Institute of Genetics and Biophysics-CNR, Via P. Castellino 111, 80131, Naples, Italy., Fresenius Kabi Anti Infectives srl, Via San Leonardo 23, 45010, Villadose, RO, Italy., Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80134, Naples, Italy., Istituto di Biostrutture e Bioimmagini del CNR, CIRPeB, University of Naples Federico II, via Mezzocannone, 16, 80134, Naples, Italy. menotti.ruvo@unina.it., CNR-IBB, via Mezzocannone, 16, 80134, Naples, Italy. menotti.ruvo@unina.it.,
DISTABiF, Università degli Studi della Campania Luigi Vanvitelli, Via Vivaldi 43, Caserta, 81100, Italy
References: Albini, A., The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1/KDR receptor on vascular endothelial cells (1996) Nat Med, 2, pp. 1371-1375. , COI: 1:CAS:528:DyaK28Xntlylsb8%3D, PID: 894683
Binetruy-Tournaire, R., Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis (2000) EMBO J, 19, pp. 1525-1533. , COI: 1:CAS:528:DC%2BD3cXislymt74%3D, PID: 10747021
Byrne, A.M., Bouchier-Hayes, D.J., Harmey, J.H., Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF) (2005) J Cell Mol Med, 9, pp. 777-794. , COI: 1:CAS:528:DC%2BD2sXlvFKhtLg%3D, PID: 16364190
Calvanese, L., Conformational features and binding affinities to cripto, ALK7 and ALK4 of nodal synthetic fragments (2015) J Pept Sci, 21, pp. 283-293. , COI: 1:CAS:528:DC%2BC2MXnvVeguw%3D%3D, PID: 25588905
Caporale, A., Sturlese, M., Schievano, E., Mammi, S., Peggion, E., Synthesis and structural studies of new analogues of PTH(1–11) containing calpha-tetra-substituted amino acids in position 8 (2010) Amino Acids, 39, pp. 1369-1379. , COI: 1:CAS:528:DC%2BC3cXhtlaqtLfK, PID: 20431900
Caporale, A., Gesiot, L., Sturlese, M., Wittelsberger, A., Mammi, S., Peggion, E., Design, conformational studies and analysis of structure–function relationships of PTH (1–11) analogues: the essential role of val in position 2 (2012) Amino Acids, 43, pp. 207-218. , COI: 1:CAS:528:DC%2BC38XotlOhur0%3D, PID: 21918876
Carmeliet, P., Jain, R.K., Angiogenesis in cancer and other diseases (2000) Nature, 407, pp. 249-257. , COI: 1:CAS:528:DC%2BD3cXmvVSls74%3D, PID: 11001068
Chorev, M., The partial retro-inverso modification: a road traveled together (2005) Biopolymers, 80, pp. 67-84. , COI: 1:CAS:528:DC%2BD2MXktFersrg%3D, PID: 15729688
D’Andrea, L.D., Romanelli, A., Di Stasi, R., Pedone, C., Bioinorganic aspects of angiogenesis (2010) Dalton Trans, 39, pp. 7625-7636. , PID: 20535417
De Rosa, L., Miniaturizing VEGF: peptides mimicking the discontinuous VEGF receptor-binding site modulate the angiogenic response (2016) Sci Rep, 6, p. 31295. , PID: 27498819
Detmar, M., Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis (1994) J Exp Med, 180, pp. 1141-1146. , COI: 1:CAS:528:DyaK2cXlsFCksbw%3D, PID: 8064230
Etayash, H., Jiang, K., Azmi, S., Thundat, T., Kaur, K., Real-time detection of breast cancer cells using peptide-functionalized microcantilever arrays (2015) Sci Rep, 5, p. 13967. , COI: 1:CAS:528:DC%2BC2MXhs1Sksr%2FN, PID: 26434765
Ferrara, N., Adamis, A.P., Ten years of anti-vascular endothelial growth factor therapy (2016) Nat Rev Drug Discov, 15, pp. 385-403. , COI: 1:CAS:528:DC%2BC28XoslSrtA%3D%3D, PID: 26775688
Ferrara, N., Kerbel, R.S., Angiogenesis as a therapeutic target (2005) Nature, 438, pp. 967-974. , COI: 1:CAS:528:DC%2BD2MXhtlSksrnI, PID: 16355214
Ferrara, N., Gerber, H.P., LeCouter, J., The biology of VEGF and its receptors (2003) Nat Med, 9, pp. 669-676. , COI: 1:CAS:528:DC%2BD3sXktFOnur4%3D, PID: 12778165
Giordano, R.J., Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors (2005) Chem Biol, 12, pp. 1075-1083. , COI: 1:CAS:528:DC%2BD2MXhtFers7%2FF, PID: 16242650
Giordano, R.J., From combinatorial peptide selection to drug prototype (I): targeting the vascular endothelial growth factor receptor pathway (2010) Proc Natl Acad Sci USA, 107, pp. 5112-5117. , COI: 1:CAS:528:DC%2BC3cXjvFGntb4%3D, PID: 20190181
Gongora-Benitez, M., Tulla-Puche, J., Albericio, F., Multifaceted roles of disulfide bonds. Peptides as therapeutics (2014) Chem Rev, 114, pp. 901-926. , COI: 1:CAS:528:DC%2BC3sXhs1yls7nJ, PID: 24446748
Guntert, P., Automated NMR structure calculation with CYANA (2004) Methods Mol Biol, 278, pp. 353-378. , COI: 1:CAS:528:DC%2BD2cXosVWiu7g%3D, PID: 15318003
Kaminski, G.A., Friesner, R.A., Tirado-Rives, J., Jorgensen, W.L., Evaluation and reparametrization of the OPLS-AA force field for proteins via comparison with accurate quantum chemical calculations on peptides (2001) J Phys Chem B, 105, pp. 6474-6487. , COI: 1:CAS:528:DC%2BD3MXislKhsLk%3D
Kaumaya, P.T., Foy, K.C., Peptide vaccines and targeting HER and VEGF proteins may offer a potentially new paradigm in cancer immunotherapy (2012) Future Oncol, 8, pp. 961-987. , COI: 1:CAS:528:DC%2BC38Xht1WlsL%2FJ, PID: 22894670
Li, Y.L., Zhao, H., Ren, X.B., Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward? (2016) Cancer Biol Med, 13, pp. 206-214. , PID: 27458528
Olsson, A.K., Dimberg, A., Kreuger, J., Claesson-Welsh, L., VEGF receptor signalling—in control of vascular function (2006) Nat Rev Mol Cell Biol, 7, pp. 359-371. , COI: 1:CAS:528:DC%2BD28XjslSktrc%3D, PID: 16633338
Park, S., In vivo monitoring of angiogenesis in a mouse hindlimb ischemia model using fluorescent peptide-based probes (2016) Amino Acids, 48, pp. 1641-1654. , COI: 1:CAS:528:DC%2BC28XmsVeit78%3D, PID: 27098931
Pierce, E.A., Avery, R.L., Foley, E.D., Aiello, L.P., Smith, L.E., Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization (1995) Proc Natl Acad Sci USA, 92, pp. 905-909. , COI: 1:CAS:528:DyaK2MXjsVKhsr0%3D, PID: 7846076
Ponticelli, S., Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1 (2008) J Biol Chem, 283, pp. 34250-34259. , COI: 1:CAS:528:DC%2BD1cXhsVelu7rK, PID: 18922791
Porto, G., Identification of novel immunoregulatory molecules in human thymic regulatory CD4+ CD25+ T cells by phage display (2011) PLoS One, 6. , COI: 1:CAS:528:DC%2BC3MXhtV2ju7rL, PID: 21829599
Rink, R., To protect peptide pharmaceuticals against peptidases (2010) J Pharmacol Toxicol Methods, 61, pp. 210-218. , COI: 1:CAS:528:DC%2BC3cXksVeiur4%3D, PID: 20176117
Robinson, C.J., Stringer, S.E., The splice variants of vascular endothelial growth factor (VEGF) and their receptors (2001) J Cell Sci, 114, pp. 853-865. , COI: 1:CAS:528:DC%2BD3MXit1eit7c%3D, PID: 11181169
Rusnati, M., Presta, M., Angiogenic growth factors interactome and drug discovery: the contribution of surface plasmon resonance (2015) Cytokine Growth Factor Rev, 26, pp. 293-310. , COI: 1:CAS:528:DC%2BC2cXitVSnsr7N, PID: 25465594
Saito, H., Tsujitani, S., Ikeguchi, M., Maeta, M., Kaibara, N., Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue (1998) Br J Cancer, 78, pp. 1573-1577. , COI: 1:CAS:528:DyaK1MXhslKmug%3D%3D, PID: 9862566
Srabovic, N., Mujagic, Z., Mujanovic-Mustedanagic, J., Softic, A., Muminovic, Z., Rifatbegovic, A., Begic, L., Vascular endothelial growth factor receptor-1 expression in breast cancer and its correlation to vascular endothelial growth factor a (2013) Int J Breast Cancer, 2013, p. 746749. , PID: 24416596
Starzec, A., Vassy, R., Martin, A., Lecouvey, M., Di, B.M., Crepin, M., Perret, G.Y., Antiangiogenic and antitumor activities of peptide inhibiting the vascular endothelial growth factor binding to neuropilin-1 (2006) Life Sci, 79, pp. 2370-2381. , COI: 1:CAS:528:DC%2BD28Xht1SgtrrF, PID: 16959272
Starzec, A., Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex (2007) Peptides, 28, pp. 2397-2402. , COI: 1:CAS:528:DC%2BD2sXhtlCqsrnN, PID: 17983687
Tarallo, V., De Falco, S., The vascular endothelial growth factors and receptors family: up to now the only target for anti-angiogenesis therapy (2015) Int J Biochem Cell Biol, 64, pp. 185-189. , COI: 1:CAS:528:DC%2BC2MXnvFSgsLY%3D, PID: 25936669
Tugyi, R., Uray, K., Ivan, D., Fellinger, E., Perkins, A., Hudecz, F., Partial d-amino acid substitution: improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide (2005) Proc Natl Acad Sci USA, 102, pp. 413-418. , COI: 1:CAS:528:DC%2BD2MXptFSkuw%3D%3D, PID: 15630090
Van Der Spoel, D., Lindahl, E., Hess, B., Groenhof, G., Mark, A.E., Berendsen, H.J., GROMACS: fast, flexible, and free (2005) J Comput Chem, 26, pp. 1701-1718
von Wronski, M.A., Tuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor (2006) J Biol Chem, 281, pp. 5702-5710
Wizigmann-Voos, S., Breier, G., Risau, W., Plate, K.H., Up-regulation of vascular endothelial growth factor and its receptors in von Hippel–Lindau disease-associated and sporadic hemangioblastomas (1995) Cancer Res, 55, pp. 1358-1364. , COI: 1:CAS:528:DyaK2MXktlKmtL4%3D, PID: 7533661
Wuthrich, K., (1986) NMR of proteins and nucleic acids, , Wiley, New York
Targeting VEGF receptors with non-neutralizing cyclopeptides for imaging applications
Aloj L, Aurilio M, Rinaldi V, D'Ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R, Von Guggenberg E, Joosten L, Sosabowski JK, Breeman WA, De Blois E, Koelewijn S, Melis M, Waser B, Beetschen K, Reubi JC, De Jong M * The EEE project(449 views) Proc Int Cosm Ray Conf Icrc Universidad Nacional Autonoma De Mexico, 2007; 5(HEPART2): 977-980. Impact Factor:0 ViewExport to BibTeXExport to EndNote