A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity (412 views)
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
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Paper type: Journal Article,
Impact factor: 1.505, 5-year impact factor: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Keywords: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliations:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
References:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
Chemistryselect (ISSN: 2365-6549), 2017 Oct; 2(28): 9122-9129.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 1.505, 5-year impact factor: 1.505
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041835245&doi=10.1002%2fslct.201701148&partnerID=40&md5=fd4e232077e69de46f05aa0a17525e60
Keywords: Amyloid Aggregation, Porphyrin Derivative, Supramolecular Recognition, Toxicity Inhibition,
Affiliations:
*** IBB - CNR ***
CNR-IPCF Istituto per i Processi Chimico-Fisici, V.le F. Stagno d'Alcontres 37, Messina, 98158, Italy
CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
Program in Translational Biomedicine, Università di Catania, Viale A. Doria 6, Catania, 95125, Italy
Marie Curie action Incipit-Cofund project, PhD Program in Chemical Sciences, CNR-IBB Istituto di Biostrutture e Bioimmagini, Via Paolo Gaifami 18, Catania, 95126, Italy
References:
Haass, C., Selkoe, D.J., (2007) Nat. Rev. Mol. Cell Biol., 8, pp. 101-11
Hardy, J., Selkoe, D.J., (2002) Science, 297, pp. 353-356
Bona, P.D., Giuffrida, M.L., Caraci, F., Copani, A., Pignataro, B., Attanasio, F., Cataldo, S., Rizzarelli, E., (2009) J. Pept. Sci., 15, pp. 220-228
Sinopoli, A., Giuffrida, A., Tomasello, M.F., Giuffrida, M.L., Leone, M., Attanasio, F., Caraci, F., Saviano, M., (2016) ChemBioChem, 17, pp. 1541-1549
Tay, W.M., Huang, D., Rosenberry, T.L., Paravastu, A.K., (2013) J. Mol. Biol., 425, pp. 2494-2508
Hubin, E., van Nuland, N.A.J., Broersen, K., Pauwels, K., (2014) Cell. Mol. Life Sci., 71, pp. 3507-3521
Cleary, J.P., Walsh, D.M., Hofmeister, J.J., Shankar, G.M., Kuskowski, M.A., Selkoe, D.J., Ashe, K.H., (2005) Nat. Neurosci., 8, pp. 79-84
Li, S., Hong, S., Shepardson, N.E., Walsh, D.M., Shankar, G.M., Selkoe, D., (2009) Neuron, 62, pp. 788-801
Wilcox, K.C., Lacor, P.N., Pitt, J., Klein, W.L., (2011) Cell. Mol. Neurobiol., 31, pp. 939-948
Jana, M.K., Cappai, R., Pham, C.L.L., Ciccotosto, G.D., (2016) J. Neurochem., 136, pp. 594-608
Lowe, T.L., Strzelec, A., Kiessling, L.L., Murphy, R.M., (2001) Biochemistry, 40, pp. 7882-7889
Bieschke, J., Herbst, M., Wiglenda, T., Friedrich, R.P., Boeddrich, A., Schiele, F., Kleckers, D., Wang, Q., (2012) Nat. Chem. Biol., 8, pp. 93-101
Francioso, A., Punzi, P., Boffi, A., Lori, C., Martire, S., Giordano, C., D'Erme, M., Mosca, L., (2015) Bioorg. Med. Chem., 23, pp. 1671-1683
Goyal, D., Shuaib, S., Mann, S., Goyal, B., (2017) ACS Comb. Sci., 19, pp. 55-80
Tjernberg, L.O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A.R., Thyberg, J., Terenius, L., Nordstedt, C., (1996) J. Biol. Chem., 271, pp. 8545-8548
Soto, C., Sigurdsson, E.M., Morelli, L., Kumar, R.A., Castaño, E.M., Frangione, B., (1998) Nat. Med., 4, pp. 822-826
Ouberai, M., Dumy, P., Chierici, S., Garcia, J., (2009) Bioconjug. Chem., 20, pp. 2123-2132
Zhang, Q., Hu, X., Wang, W., Yuan, Z., (2016) Biomacromolecules, 17, pp. 661-668
Bao, Q., Luo, Y., Li, W., Sun, X., Zhu, C., Li, P., Huang, Z.-X., Tan, X., (2011) J. Biol. Inorg. Chem., 16, pp. 809-816
Yuan, C., Gao, Z., (2013) Chem. Res. Toxicol., 26, pp. 262-269
Liu, Y., Carver, J.A., Ho, L.H., Elias, A.K., Musgrave, I.F., Pukala, T.L., (2014) Biochem. Biophys. Res. Commun., 454, pp. 295-300
Zhang, X.-A., Lovejoy, K.S., Jasanoff, A., Lippard, D.P., (2007) Proc. Natl. Acad. Sci., U. S. A., 104, pp. 10780-10785
Hachimine, K., Shibaguchi, H., Kuroki, M., Yamada, H., Kinugasa, T., Nakae, Y., Asano, R., Kuroki, M., (2007) Cancer Sci., 98, pp. 916-920
Wu, C.W., Liao, P.C., Yu, L., Wang, S.T., Chen, S.T., Wu, C.M., Kuo, Y.M., (2004) Neurobiol. Dis., 17, pp. 367-377
Ghosh, C., Mukherjee, S., Seal, M., Ghosh, S., (2016) Dey, Inorg. Chem., 55, pp. 1748-1757
Lee, B.I., Lee, S., Suh, Y.S., Lee, J.S., Kim, A.K., Kwon, O.Y., Yu, K., Park, C.B., (2015) Angew. Chem. - Int. Ed., 54, pp. 11472-11476
Hirabayashi, A., Shindo, Y., Oka, K., Takahashi, D., Toshima, K., (2014) Chem. Commun., 50, pp. 9543-9546
Zhou, Y., Wang, J., Liu, L., Wang, R., Lai, X., Xu, M., (2013) ACS Chem. Neurosci., 4, pp. 535-539
Villari, V., Mazzaglia, A., Darcy, R., O'Driscoll, C.M., Micali, N., (2013) Biomacromolecules, 14, pp. 811-817
Shen, C.L., Scott, G.L., Merchant, F., Murphy, R.M., (1993) Biophys. J., 65, pp. 2383-2395
Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., (2003) Proc. Natl. Acad. Sci. USA, 100, pp. 330-335
Mazzaglia, A., Micali, N., Scolaro, L.M., Attanasio, F., Magrí, A., Pappalardo, G., Villari, V., (2010) J. Phys. Chem. B, 114, pp. 705-713
Villari, V., Mineo, P., Scamporrino, E., Micali, N., (2012) RSC Adv., 2, pp. 12989-12998
Arosio, P., Knowles, T.P.J., Linse, S., (2015) Phys. Chem. Chem. Phys., 17, pp. 7606-7618
Angelini, N., Micali, N., Mineo, P., Scamporrino, E., Villari, V., Vitalini, D., (2005) J. Phys. Chem. B, 109, pp. 18645-18651
Mineo, P., Micali, N., Villari, V., Donato, M.G., Scamporrino, E., (2012) Chem. Eur. J., 18, pp. 12452-12457
Sweeney, P.J., Walker, J.M., (1993) Enzym. Mol. Biol., pp. 277-281. , in, (Ed., M. M. Burrell, Humana Press, Totowa New Jersey
Copani, A., Condorelli, F., Caruso, A., Vancheri, C., Sala, A., Stella, A.M.G., Canonico, P.L., Sortino, M.A., (1999) FASEB J., 13, pp. 2225-2234
Giuffrida, M.L., Tomasello, M.F., Pandini, G., Caraci, F., Battaglia, G., Busceti, C., Pietro, P.D., Copani, A., (2015) Front. Cell. Neurosci., 9, p. 297
A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity
Molecules that inhibit Aβ misfolding have received considerable attention in view of their potential use in the prevention or treatment of Alzheimer's disease. We designed a peptide-porphyrin conjugate incorporating two recognition sites enabling it to interact strongly with the Aβ42 peptide. The inhibitory effect on Aβ42 fibril formation was determined in aqueous solution by a variety of spectroscopic techniques including UV-vis, fluorescence, Circular Dichroism, Dynamic Light Scattering, Maldi-Time of Flight-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. A working mechanism of the antifibrillogenic action of the conjugate was proposed based on the experimental observations. The neuroprotective activity of the conjugate was also inferred by using primary neuronal or neuron-like differentiated SH-SY5Y cell cultures. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Molecules that inhibit Aβ misfolding have received considerable attention in view of their potential use in the prevention or treatment of Alzheimer's disease. We designed a peptide-porphyrin conjugate incorporating two recognition sites enabling it to interact strongly with the Aβ42 peptide. The inhibitory effect on Aβ42 fibril formation was determined in aqueous solution by a variety of spectroscopic techniques including UV-vis, fluorescence, Circular Dichroism, Dynamic Light Scattering, Maldi-Time of Flight-Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy. A working mechanism of the antifibrillogenic action of the conjugate was proposed based on the experimental observations. The neuroprotective activity of the conjugate was also inferred by using primary neuronal or neuron-like differentiated SH-SY5Y cell cultures. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity
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A Metalloporphyrin-Peptide Conjugate as an Effective Inhibitor of Amyloid-β Peptide Fibrillation and Cytotoxicity
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
* Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer's Disease (460 views)
Acs Med Chem Lett (ISSN: 1948-5875, 1948-5875linking), 2016 Sep 26; 7(12): 1145-1150.
Impact Factor: 3.746
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (516 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin 3-functionalized with 8-hydroxyquinoline as an antioxidant inhibitor of metal-induced amyloid aggregation (426 views)
Chempluschem (ISSN: 2192-6506), 2015; 80(4): 762-770.
Impact Factor: 2.836
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Oliveri V, Grasso GI, Bellia F, Attanasio F, Viale M, Vecchio G
* Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation (678 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2015; 54(6): 2591-2602.
Impact Factor: 4.82
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Santoro AM, Lo Giudice MC, D'Urso A, Lauceri R, Purrello R, Milardi D
* Cationic porphyrins are reversible proteasome inhibitors (446 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2012 Jun 27; 134(25): 10451-10457.
Impact Factor: 10.677
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Improta R, Ferrante C, Bozio R, Barone V
* The polarizability in solution of tetra-phenyl-porphyrin derivatives in their excited electronic states: A PCM/TD-DFT study (342 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2009; 11(22): 4664-4673.
Impact Factor: 4.116
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Castiglioni E, Abbate S, Longhi G, Gangemi R, Lauceri R, Purrello R
* Absorption flattening as one cause of distortion of circular dichroism spectra of Δ-RuPhen3·H2TPPS complex (303 views)
Chirality (ISSN: 0899-0042), 2007 Sep; 19(8): 642-646.
Impact Factor: 2.436
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Mammana A, D'Urso A, Lauceri R, Purrello R
* Switching off and on the supramolecular chiral memory in porphyrin assemblies (328 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2007 Jul 4; 129(26): 8062-8063.
Impact Factor: 7.885
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Puglisi A, Purrello R, Rizzarelli E, Sortino S, Vecchio G
* Spectroscopic and self-association behavior of a porphyrin-β- cyclodextrin conjugate (375 views)
New J Chem (ISSN: 1144-0546), 2007; 31(8): 1499-1506.
Impact Factor: 2.651
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Angela M, Massimo De N, Rosaria L, Roberto P
* Induction and memory of chirality in porphyrin hetero-aggregates: The role of the central metal ion (416 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2005 Sep 1; 13(17): 5159-5163.
Impact Factor: 2.286
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Lauceria R, Purrellob R
* Transfer, memory and amplification of chirality in porphyrin aggregates (302 views)
Supramol Chem (ISSN: 1061-0278), 2005; 17(1-2): 61-66.
Impact Factor: 1.715
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Lombardi A, Nastri F, Marasco D, Maglio O, De Sanctis G, Sinibaldi F, Santucci R, Coletta M, Pavone V
* Design of a new mimochrome with unique topology (525 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2003 Nov 21; 9(22): 5643-5654.
Impact Factor: 4.353
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Moschetto A, Lauceri R, Gulino FG, Sciotto D, Purrello R
* Non-covalent synthesis in aqueous solution of discrete multi-porphyrin aggregates with programmable stoichiometry and sequence (419 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2002 Dec 11; 124(49): 14536-14537.
Impact Factor: 6.201
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Lauceri R, Raudino A, Scolaro LM, Micali N, Purrello R
* From achiral porphyrins to template-imprinted chiral aggregates and further. Self-replication of chiral memory from scratch (564 views)
J Am Chem Soc (ISSN: 0002-7863print, 0002-7863linking, 1520-5126electronic), 2002 Feb 13; 120(47): 894-895.
Impact Factor: 9.023
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Lauceri R, Purrello R, Shetty SJ, Vicente MGH
* Interactions of anionic carboranylated porphyrins with DNA [3] (318 views)
J Am Chem Soc (ISSN: 0002-7863, 0002-2786, 1520-5126), 2001 Jun 20; 123(24): 5835-5836.
Impact Factor: 6.079
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De Luca S, Bruno G, Fattorusso R, Isernia C, Pedone C, Morelli G
New synthetic tools for peptide-tetraphenylporphyrin derivatives (321 views)
Int J Pept Res Ther (ISSN: 0929-5666, 1573-3149), 1998 Jul; 5(4): 269-276.
Impact Factor: 0.557
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Bustamante C, Gurrieri S, Pasternack RF, Purrello R, Rizzarelli E
Interaction of water-soluble porphyrins with single- and double-stranded polyribonucleotides (395 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 1994 Sep; 34(8): 1099-1104.
Impact Factor: 2.425
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20 Records (20 excluding Abstracts).
Total impact factor: 89.585 (89.585 excluding Abstracts).
Total 5 year impact factor: 99.709 (99.709 excluding Abstracts).
Total impact factor: 89.585 (89.585 excluding Abstracts).
Total 5 year impact factor: 99.709 (99.709 excluding Abstracts).
412 views. Last view on Saturday 14 January 2023, 18:22:15
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