Liver fibrosis: the 2017 state of art (328 views)
Panminerva Med (ISSN: 0031-0808, 1827-1898electronic, 0031-0808linking), 2017 Dec; 59(4): 320-331.
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Impact factor: 2.102, 5-year impact factor: 1.525
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*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - caviglia.giampi@libero.it., Department of Medical Sciences, University of Turin, Turin, Italy., Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center, University of Turin, Turin, Italy., Unit of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy.,
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Panminerva Med (ISSN: 0031-0808, 1827-1898electronic, 0031-0808linking), 2017 Dec; 59(4): 320-331.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.102, 5-year impact factor: 1.525
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - caviglia.giampi@libero.it., Department of Medical Sciences, University of Turin, Turin, Italy., Institute for Biostructures and Bioimages-CNR c/o Molecular Biotechnology Center, University of Turin, Turin, Italy., Unit of Gastroenterology and Hepatology, Molinette Hospital, Turin, Italy.,
References:
Not available.
Liver fibrosis: the 2017 state of art
Liver fibrosis is a wound-healing response to a wide spectrum of chronic liver injuries. It is characterized by loss of hepatocytes and alteration in hepatic architecture following an imbalance between extracellular matrix synthesis and degradation. Irrespectively of underlying etiology, fibrosis may progress to cirrhosis and specific pathogenetic mechanisms as well as different disease patterns may be identified according to etiology. Liver biopsy is still considered the gold standard for fibrosis assessment, despite the fact that it is invasive, has poor patient compliance and is not exempt of complications. Several reliable and non-invasive tools are currently used in clinical practice, including imaging methods and surrogate serum biomarkers, commonly combined into composite scores. The main limitation of non-invasive methods is the low performance in the discrimination of intermediate stages of fibrosis. However, with the recent availability of novel treatment options, particularly for chronic hepatitis C, a precise staging of liver fibrosis is becoming clinically less relevant. Conversely, since patients with cirrhosis need to be monitored for the risk of hepatocellular carcinoma development, the accurate detection of this condition is a primary endpoint. Finally, several promising antifibrotic agents are under investigation in phase I and II trials. Nevertheless, further efforts are needed for the identification of novel potential targets for the development of antifibrotic drugs able to arrest, and possibly revert liver fibrogenesis.
Liver fibrosis is a wound-healing response to a wide spectrum of chronic liver injuries. It is characterized by loss of hepatocytes and alteration in hepatic architecture following an imbalance between extracellular matrix synthesis and degradation. Irrespectively of underlying etiology, fibrosis may progress to cirrhosis and specific pathogenetic mechanisms as well as different disease patterns may be identified according to etiology. Liver biopsy is still considered the gold standard for fibrosis assessment, despite the fact that it is invasive, has poor patient compliance and is not exempt of complications. Several reliable and non-invasive tools are currently used in clinical practice, including imaging methods and surrogate serum biomarkers, commonly combined into composite scores. The main limitation of non-invasive methods is the low performance in the discrimination of intermediate stages of fibrosis. However, with the recent availability of novel treatment options, particularly for chronic hepatitis C, a precise staging of liver fibrosis is becoming clinically less relevant. Conversely, since patients with cirrhosis need to be monitored for the risk of hepatocellular carcinoma development, the accurate detection of this condition is a primary endpoint. Finally, several promising antifibrotic agents are under investigation in phase I and II trials. Nevertheless, further efforts are needed for the identification of novel potential targets for the development of antifibrotic drugs able to arrest, and possibly revert liver fibrogenesis.
Liver fibrosis: the 2017 state of art
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Liver fibrosis: the 2017 state of art
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Impact Factor: 4.817
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Di Lorenzo F, Silipo A, Bianconi I, Lore' NI, Scamporrino A, Sturiale L, Garozzo D, Lanzetta R, Parrilli M, Bragonzi A, Molinaro A
* Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity (790 views)
Mol Immunol (ISSN: 0161-5890), 2015; 63(2): 166-175.
Impact Factor: 3.375
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Monti S, Palma G, Ragucci M, Mannelli L, Mancini M, Prinster A
* Optimization of tagged MRI for quantification of liver stiffness using computer simulated data (2606 views) (PDF 271 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Oct 31; 9(10): e111852-e111852.
Impact Factor: 3.234
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Camera L, Severino R, Faggiano A, Masone S, Mansueto G, Maurea S, Fonti R, Salvatore M
* Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma (877 views)
World J Radiol (ISSN: 1949-8470, 1949-8470electronic, 1949-8470linking), 2014 Oct 28; 6(10): 840-845.
Impact Factor: 0.567
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Monti S, Palma G, Ragucci M, Salomone Megna A, Ascione A, Mancini M, Prinster A
* Optimization Of Tagged Mri For The Assessment Of Liver Fibrosis (603 views) (PDF 279 views)
Gnb 2014, 2014 Jun 24; N/D: N/D-N/D.
Impact Factor: 0
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De Chiara L, Fagoonee S, Ranghino A, Bruno S, Camussi G, Tolosano E, Silengo L, Altruda F
* Renal cells from spermatogonial germline stem cells protect against kidney injury (621 views)
J Am Soc Nephrol (ISSN: 1046-6673), 2014 Feb; 25(2): 316-328.
Impact Factor: 9.343
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (869 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Gentile I, Coppola N, Pasquale G, Liuzzi R, D'Armiento M, Di Lorenzo ME, Capoluongo N, Buonomo AR, Sagnelli E, Morisco F, Caporaso N, Borgia G
* A Simple Noninvasive Score Based on Routine Parameters can Predict Liver Cirrhosis in Patients With Chronic Hepatitis (591 views)
Hepat Mon (ISSN: 1735-143xprint, 1735-143xlinking), 2013 May 8; 13(5): e8352-e8352.
Impact Factor: 1.796
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Camera L, Campanile F, Imbriaco M, Ippolito R, Sirignano C, Santoro C, Galderisi M, Salvatore M
* Idiopathic pulmonary fibrosis complicated by acute thromboembolic disease: Chest X-ray, HRCT and multi-detector row CT angiographic findings (663 views) (PDF 59 views)
J Thorac Dis (ISSN: 2072-1439), 2013 Feb; 5(1): 82-86.
Impact Factor: 0.895
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Montella S, Maglione M, Bruzzese D, Mollica C, Pignata C, Aloj G, Manna A, Esposito A, Mirra V, Santamaria F
* Magnetic resonance imaging is an accurate and reliable method to evaluate non-cystic fibrosis paediatric lung disease (922 views)
Respirology (ISSN: 1323-7799, 1440-1843electronic), 2012 Jan; 17(1): 87-91.
Impact Factor: 2.781
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Palmieri G, Bergamo P, Luini A, Ruvo M, Gogliettino M, Langella E, Saviano M, Hegde RN, Sandomenico A, Rossi M
* Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation (1008 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Oct 10; 6(10): e25888-e25888.
Impact Factor: 4.092
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Piazza O, De Robertis E, Caranci F, Quarantelli M, Tufano R
* Riedel's thyroiditis and cerebral venous sinuses thrombosis: A case report (605 views)
Panminerva Med (ISSN: 0031-0808, 1827-1898electronic, 0031-0808linking), 2010 Dec; 52(4): 362-364.
Impact Factor: 1.957
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Sorriento D, Iaccarino G, Trimarco B
The role of the transcription factor nuclear factor kappa B in the regulation of cardiac hypertrophy (1037 views)
High Blood Press Cardiovasc Prev High Blood Pressure And Cardiovascular Prevention (ISSN: 1120-9879), 2010; 17(4): 209-217.
Impact Factor: 0
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Montella S, Santamaria F, Salvatore M, Pignata C, Maglione M, Iacotucci P, Mollica C
* Assessment of chest high-field magnetic resonance imaging in children and young adults with noncystic fibrosis chronic lung disease: comparison to high-resolution computed tomography and correlation with pulmonary function (419 views)
Invest Radiol (ISSN: 1536-0210, 0020-9996, 1536-0210electronic), 2009 Sep; 44(9): 532-538.
Impact Factor: 4.85
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Migliore T, Parrella LS, Caputi A, Silvestri N, Romano R, Pace L, Imbriaco M, Losi MA, Betocchi S
* Pathogenesis of hypertrophic cardiomyopathy. Impact of growth factors on left ventricular anatomy (675 views)
Minerva Cardioangiol (ISSN: 0026-4725), 2008 Feb; 56(1): 13-20.
Impact Factor: 0.481
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Cuzzocrea S, Genovese T, Failla M, Vecchio G, Fruciano M, Mazzon E, Di Paola R, Muià C, La Rosa C, Crimi N, Rizzarelli E, Vancheri C
* Protective effect of orally administered carnosine on bleomycin-induced lung injury (1274 views)
Am J Physiol Lung Cell Mol Physiol (ISSN: 1040-0605), 2007 May; 292(5): L1095-L1095.
Impact Factor: 4.214
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Grasso G, D'Agata R, Rizzarelli E, Spoto G, D'Andrea LD, Pedone C, Picardi A, Romanelli A, Fragai M, Yeo KJ
* Activity of anchored human matrix metalloproteinase-1 catalytic domain on Au(111) surfaces monitored by ESI-MS (885 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2005 Dec; 40(12): 1565-1571.
Impact Factor: 3.574
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Picardi M, Martinelli V, Ciancia R, Soscia E, Morante R, Sodano A, Fortunato G, Rotoli B
* Measurement of spleen volume by ultrasound scanning in patients with thrombocytosis: a prospective study (612 views)
Haematologica (ISSN: 0006-4971, 0006-6497, 0390-6078), 2002 Jun 1; 99(11): 4228-4230.
Impact Factor: 9.631
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Klain M, Imbriaco M, Cuocolo A, Celentano L, Maurea S, Carrillo F, Salvatore M
Morphofunctional evaluation of the kidney in retroperitoneal fibrosis. Correlations of computerized tomography, magnetic resonance and radionuclide renography (571 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1994 Jul; 88(1-2): 146-149.
Impact Factor: 0.967
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Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (1011 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
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37 Records (33 excluding Abstracts).
Total impact factor: 123.994 (108.661 excluding Abstracts).
Total 5 year impact factor: 105.453 (89.611 excluding Abstracts).
Total impact factor: 123.994 (108.661 excluding Abstracts).
Total 5 year impact factor: 105.453 (89.611 excluding Abstracts).
328 views. Last view on Friday 11 April 2025, 14:12:48
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