NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging
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NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging (717 views) (PDF public 249 views)

Depalo N, Corricelli M, De Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML

Acs Appl Mater Inter (ISSN: 1944-8244), 2017 Dec 13; 9(49): 43113-43126.

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Paper type: Journal Article,

Impact factor: 8.097, 5-year impact factor: 8.284

Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038208885&doi=10.1021%2facsami.7b14155&partnerID=40&md5=d75bf560fca161cb4640e6a8bc3ff9bd

Keywords: Nir Emitting Quantum Dots, Cyclic Rgd Peptide, Silica-Coated Nanoprobes, Targeted Imaging, Alphavbeta3 Integrin Receptor, αvβ3 Integrin Receptor, Amino Acids, Infrared Devices, Lead Compounds, Microemulsions, Nanocrystals, Nanostructures, Semiconducting Lead Compounds, Solutions, Tumors, Arginine-Glycine-Aspartic Acids, Luminescent Nanostructures, Photoluminescence Emission, Silica Coated, Water-In-Oil Microemulsions, Semiconductor Quantum Dots,

Affiliations:
*** IBB - CNR ***

Istituto per i Processi Chimico-Fisici-CNR SS Bari , Via Orabona 4, 70125 Bari, Italy., Istituto di Biostrutture e Bioimmagini-CNR , Via Mezzocannone 16, 80134 Napoli, Italy., Istituto Tumori IRCCS Giovanni Paolo II , Viale Orazio Flacco 65, 70124 Bari, Italy., Istituto di Cristallografia-CNR Bari , Via Amendola 122/O, 70126 Bari, Italy.,
Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, 70125, Italy
Dipartimento di Farmacia-Scienze Del Farmaco, Università degli Studi di Bari Aldo Moro, Via Orabona 4, Bari, 70125, Italy
Electron Microscopy Facility, Istituto Italiano di Tecnologia (IIT), via Morego 30, Genova, Italy


References:
Not available.
NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging

Here, silica-coated PbS quantum dots (QDs) with photoluminescence emission properties in the near-infrared (NIR) region are proposed as potential effective single particle optical nanoprobes for future in vivo imaging of tumors. The dispersibility in aqueous medium of hydrophobic PbS QDs was accomplished by growing a silica shell on their surface by exploiting a base assisted water-in-oil microemulsion method. The silica-coated PbS QDs were then conjugated with a specifically designed cyclic arginine-glycine-aspartic acid (cRGD) peptide that is able to specifically recognize αvβ3 integrins, which are overexpressed in angiogenic tumor-induced vasculatures and on some solid tumors, to achieve tumor-specific targeting. The cRGD peptide PbS silica-coated QDs were systematically characterized, at each step of their preparation, by means of complementary optical and structural techniques, demonstrating appropriate colloidal stability and the maintenance of their optical futures in aqueous solutions. The cellular uptake of cRGD peptide functionalized luminescent nanostructures in human melanoma cells, where overexpression of αvβ3 was observed, was assessed by means of confocal microscopy analysis and cytometric study. The selectivity of the cRGD peptide PbS silica-coated QDs for the αvβ3 integrin was established, consequently highlighting the significant potential of the developed NIR emitting nanostructures as optically traceable nanoprobes for future αvβ3 integrin receptor in vivo targeting in the NIR region. © 2017 American Chemical Society.
NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging

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NIR Emitting Nanoprobes Based on Cyclic RGD Motif Conjugated PbS Quantum Dots for Integrin-Targeted Optical Bioimaging

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Camorani S, Fedele M, Zannetti A, Cerchia L
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Di Pietro P, Zaccaro L, Comegna D, Del Gatto A, Saviano M, Snyders R, Cossement D, Satriano C, Rizzarelli E
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Valente G, Depalo N, De Paola I, Iacobazzi RM, Denora N, Laquintana V, Comparelli R, Altamura E, Latronico T, Altomare M, Fanizza E, Striccoli M, Agostiano A, Saviano M, Del Gatto A, Zaccaro L, Curri ML
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4 Records (4 excluding Abstracts).
Total impact factor: 23.741 (23.741 excluding Abstracts).
Total 5 year impact factor: 16.901 (16.901 excluding Abstracts).

Last modified by Gennaro Angrisano on Sunday 12 July 2020, 13:14:42
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