Keywords: Cest, Contrast Media, Iodinated Contrast Media, Pulsed-Cest, Radiographic Agents, Train Pulses, Magnetic Resonance Imaging, Ph Sensors, Chemical Exchange, Chemical Exchange Saturation Transfer, Clinical Scanners, Physiological Range,
Affiliations: *** IBB - CNR ***
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Universita degli Studi di Torino, Torino, Italy., CRB Bracco Imaging S.p.A., Via Ribes 5, Colleretto Giacosa (TO), Italy., Department of High-field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tubingen, Germany., Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Universita degli Studi di Torino, Torino, Italy; Consiglio Nazionale delle Ricerche (CNR), Istituto di Biostrutture e Bioimmagini, Torino, Italy. Electronic address: dario.longo@unito.it.,
References: Not available.
Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging
Several molecules have been exploited for developing MRI pH sensors based on the chemical exchange saturation transfer (CEST) technique. A ratiometric approach, based on the saturation of two exchanging pools at the same saturation power, or by varying the saturation power levels on the same pool, is usually needed to rule out the concentration term from the pH measurement. However, all these methods have been demonstrated by using a continuous wave saturation scheme that limits its translation to clinical scanners. This study shows a new ratiometric CEST-MRI pH-mapping approach based on a pulsed CEST saturation scheme for a radiographic contrast agent (iodixanol) possessing a single chemical exchange site. This approach is based on the ratio of the CEST contrast effects at two different flip angles combinations (180 degrees /360 degrees and 180 degrees /720 degrees ), keeping constant the mean irradiation RF power (Bavg power). The proposed ratiometric approach index is concentration independent and it showed good pH sensitivity and accuracy in the physiological range between 6.0 and 7.4.
Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging
No results.
Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging