Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging (430 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Oct 16; 56(20): 12206-12213.
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Paper type: Journal Article,
Impact factor: 4.7, 5-year impact factor: 4.513
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States., Molecular Imaging Center, Department of Molecular Biotechnologies & Health Sciences, University of Torino , 10126 Torino, Italy.,
References:
Not available.
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2017 Oct 16; 56(20): 12206-12213.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.7, 5-year impact factor: 4.513
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Department of Chemistry, University of Minnesota , Minneapolis, Minnesota 55455, United States., Molecular Imaging Center, Department of Molecular Biotechnologies & Health Sciences, University of Torino , 10126 Torino, Italy.,
References:
Not available.
Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging
Accurate mapping of small changes in pH is essential to the diagnosis of diseases such as cancer. The difficulty in mapping pH accurately in vivo resides in the need for the probe to have a ratiometric response so as to be able to independently determine the concentration of the probe in the body independently from its response to pH. The complex Fe(II)-DOTAm-F12 behaves as an MRI contrast agent with dual (19)F and CEST modality. The magnitude of its CEST response is dependent both on the concentration of the complex and on the pH, with a significant increase in saturation transfer between pH 6.9 and 7.4, a pH range that is relevant to cancer diagnosis. The signal-to-noise ratio of the (19)F signal of the probe, on the other hand, depends only on the concentration of the contrast agent and is independent of pH. As a result, the complex can ratiometrically map pH and accurately distinguish between pH 6.9 and 7.4. Moreover, the iron(II) complex is stable in air at room temperature and adopts a rare 8-coordinate geometry.
Accurate mapping of small changes in pH is essential to the diagnosis of diseases such as cancer. The difficulty in mapping pH accurately in vivo resides in the need for the probe to have a ratiometric response so as to be able to independently determine the concentration of the probe in the body independently from its response to pH. The complex Fe(II)-DOTAm-F12 behaves as an MRI contrast agent with dual (19)F and CEST modality. The magnitude of its CEST response is dependent both on the concentration of the complex and on the pH, with a significant increase in saturation transfer between pH 6.9 and 7.4, a pH range that is relevant to cancer diagnosis. The signal-to-noise ratio of the (19)F signal of the probe, on the other hand, depends only on the concentration of the contrast agent and is independent of pH. As a result, the complex can ratiometrically map pH and accurately distinguish between pH 6.9 and 7.4. Moreover, the iron(II) complex is stable in air at room temperature and adopts a rare 8-coordinate geometry.
Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging
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Eight-Coordinate, Stable Fe(II) Complex as a Dual (19)F and CEST Contrast Agent for Ratiometric pH Imaging
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18 Records (17 excluding Abstracts).
Total impact factor: 92.224 (89.075 excluding Abstracts).
Total 5 year impact factor: 90.411 (87.29 excluding Abstracts).
Total impact factor: 92.224 (89.075 excluding Abstracts).
Total 5 year impact factor: 90.411 (87.29 excluding Abstracts).
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