Data demonstrating the anti-oxidant role of hemopexin in the heart(341 views) Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E
Data Brief (ISSN: 2352-3409print, 2352-3409linking), 2017 May 13; 13: 69-76.
Dept. Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy., Dept. Internal Medicine II, University Hospital Regensburg, Regensburg, Germany., Dept. Medicine, Universita degli Studi di Verona-Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy., Heidelberg University Hospital / EMBL Heidelberg, Heidelberg, Germany.,
References: Not available.
Data demonstrating the anti-oxidant role of hemopexin in the heart
The data presented in this article are related to the research article entitled Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress (G. Ingoglia, C. M. Sag, N. Rex, L. De Franceschi, F. Vinchi, J. Cimino, S. Petrillo, S. Wagner, K. Kreitmeier, L. Silengo, F. Altruda, L. S. Maier, E. Hirsch, A. Ghigo and E. Tolosano, 2017) [1]. Data show that heme induces reactive oxygen species (ROS) production in primary cardiomyocytes. H9c2 myoblastic cells treated with heme bound to human Hemopexin (Hx) are protected from heme accumulation and oxidative stress. Similarly, the heme-driven oxidative response is reduced in primary cardiomyocytes treated with Hx-heme compared to heme alone. Our in vivo data show that mouse models of hemolytic disorders, beta-thalassemic mice and phenylhydrazine-treated mice, have low serum Hx associated to enhanced expression of heme- and oxidative stress responsive genes in the heart. Hx(-/-) mice do not show signs of heart fibrosis or overt inflammation. For interpretation and discussion of these data, refer to the research article referenced above.
Data demonstrating the anti-oxidant role of hemopexin in the heart
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Data demonstrating the anti-oxidant role of hemopexin in the heart
Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G * Adrenergic Receptors(410 views) Endocrinol Of The Heart In Health And Dis (ISSN: 9780-1280311249780128031117), 2016; N/D: 285-315. Impact Factor:0 ViewExport to BibTeXExport to EndNote