Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (462 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.069, 5-year impact factor: 4.079
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031780307&doi=10.1039%2fc7mt00156h&partnerID=40&md5=9b811013f7c93bbb19a53d9e87903930
Keywords: Bioactivity, Cell Death, Copper, Cytology, Diseases, 8-Hydroxyquinoline Derivatives, Anti-Cancer Agents, Antiproliferative Agents, Concentration-Dependent Manners, Pathological Conditions, Programmed Cell Deaths, Proteasome Inhibitors, Ubiquitin-Proteasome System, 2 Amino 8 Hydroxyquinoline, 5 Amino 8 Hydroxyquinoline, 5 Aminomethyl 8 Hydroxyquinoline, 5 Chloromethyl 8 Hydroxyquinoline, 8 Quinolinol Derivative, Amino 8 Hydroxyquinoline Derivative, Antineoplastic Agent, Chloro 8 Hydroxyquinoline Derivative, Chymotrypsin, Clioquinol, Cloxiquine, Copper Complex, Copper Ion, Unclassified Drug, 5-Amino-8-Hydroxyquinoline, A-549 Cell Line, A2780 Cell Line, Antiproliferative Activity, Apoptosis, Article, Cancer Inhibition, Cancer Resistance, Chemical Analysis, Clinical Evaluation, Concentration Response, Controlled Study, Cytotoxicity, Drug Structure, Human, Human Cell, Physical Chemistry, Priority Journal, Cell Proliferation, Drug Effects, Female, Tumor Cell Culture, Ubiquitination, Proteasome Endopeptidase Complex,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. gr.vecchio@unict.it.,
Consorzio Interuniversitario di Ricerca in Chimica Dei Metalli Nei Sistemi Biologici, C.I.R.C.M.S.B., Unità di Ricerca di Catania, Viale A. Doria 6, Catania, 95125, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via P. Gaifami 18, Catania, 95126, Italy
Ospedale Policlinico San Martino, U.O.C. Bioterapie, Lgo R. Benzi 10, Genova, 16132, Italy
References:
Brooks, P., Fuertes, G., Murray, R.Z., Bose, S., Knecht, E., Rechsteiner, M.C., Hendil, K.B., Rivett, J., Subcellular localization of proteasomes and their regulatory complexes in mammalian cells (2000) Biochem. J., 346, pp. 155-16
Arendt, C.S., Hochstrasser, M., Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 7156-7161
Heinemeyer, W., Fischer, M., Krimmer, T., Stachon, U., Wolf, D.H., The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing (1997) J. Biol. Chem., 272, pp. 25200-25209
Kisselev, A.F., Callard, A., Goldberg, A.L., Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate (2006) J. Biol. Chem., 281, pp. 8582-8590
Kisselev, A.F., Goldberg, A.L., Proteasome inhibitors: From research tools to drug candidates (2001) Chem. Biol., 8, pp. 739-758
Santoro, A.M., Cunsolo, A., D'Urso, A., Sbardella, D., Tundo, G.R., Ciaccio, C., Coletta, M., Purrello, R., Cationic porphyrins are tunable gatekeepers of the 20S proteasome (2016) Chem. Sci., 7, pp. 1286-1297
Santoro, A.M., Lo Giudice, M.C., D'Urso, A., Lauceri, R., Purrello, R., Milardi, D., Cationic Porphyrins Are Reversible Proteasome Inhibitors (2012) J. Am. Chem. Soc., 134, pp. 10451-10457
Almond, J.B., Cohen, G.M., The proteasome: A novel target for cancer chemotherapy (2002) Leukemia, 16, pp. 433-443
Gandin, V., Pellei, M., Tisato, F., Porchia, M., Santini, C., Marzano, C., A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signaling (2012) J. Cell. Mol. Med., 16, pp. 142-151
Gandin, V., Tisato, F., Dolmella, A., Pellei, M., Santini, C., Giorgetti, M., Marzano, C., Porchia, M., In Vitro and in Vivo Anticancer Activity of Copper(i) Complexes with Homoscorpionate Tridentate Tris (pyrazolyl) borate and Auxiliary Monodentate Phosphine Ligands (2014) J. Med. Chem., 57, pp. 4745-4760
Kisselev, A.F., Van Der Linden, W.A., Overkleeft, H.S., Proteasome inhibitors: An expanding army attacking a unique target (2012) Chem. Biol., 19, pp. 99-115
Chen, D., Frezza, M., Schmitt, S., Kanwar, J., Dou, Q.P., Bortezomib as the first proteasome inhibitor anticancer drug: Current status and future perspectives (2011) Curr. Cancer Drug Targets, 11, pp. 239-253
Orlowski, R.Z., Kuhn, D.J., Proteasome inhibitors in cancer therapy: Lessons from the first decade (2008) Clin. Cancer Res., 14, pp. 1649-1657
Oliveri, V., Giuffrida, M.L., Vecchio, G., Aiello, C., Viale, M., Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs (2012) Dalton Trans., 41, pp. 4530-4535
Oliveri, V., Vecchio, G., 8-Hydroxyquinolines in medicinal chemistry: A structural perspective (2016) Eur. J. Med. Chem., 120, pp. 252-274
Ruschak, A.M., Slassi, M., Kay, L.E., Schimmer, A.D., Novel proteasome inhibitors to overcome bortezomib resistance (2011) J. Natl. Cancer Inst., 103, pp. 1007-1017
Santoro, A.M., Monaco, I., Attanasio, F., Lanza, V., Pappalardo, G., Tomasello, M.F., Cunsolo, A., Milardi, D., Copper(II) ions affect the gating dynamics of the 20S proteasome: A molecular and in cell study (2016) Sci. Rep., 6, p. 33444
Daniel, K.G., Gupta, P., Harbach, R.H., Guida, W.C., Dou, Q.P., Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells (2004) Biochem. Pharmacol., 67, pp. 1139-1151
Wang, T., Guo, Z.J., Copper in medicine: Homeostasis, chelation therapy and antitumor drug design (2006) Curr. Med. Chem., 13, pp. 525-537
Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q.P., Padhye, S., Sarkar, F.H., Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells (2006) J. Med. Chem., 49, pp. 7242-7246
Heidary, D.K., Howerton, B.S., Glazer, E.C., Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethylphenanthroline, Scaffold Radically Improves Potency for Potential as Antineoplastic Agents (2014) J. Med. Chem., 57, pp. 8936-8946
Milardi, D., Arnesano, F., Grasso, G., Magrì, A., Tabbì, G., Scintilla, S., Natile, G., Rizzarelli, E., Ubiquitin Stability and the Lys 63-Linked Polyubiquitination Site Are Compromised on Copper Binding (2007) Angew. Chem., Int. Ed., 46, pp. 7993-7995
Arena, G., Bellia, F., Frasca, G., Grasso, G., Lanza, V., Rizzarelli, E., Tabbì, G., Milardi, D., Inorganic stressors of ubiquitin (2013) Inorg. Chem., 52, pp. 9567-9573
Kaiser, S.M., Escher, B.I., The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes (2006) Environ. Sci. Technol., 40, pp. 1784-1791
Budimir, A., Humbert, N., Elhabiri, M., Osinska, I., Biruš, M., Albrecht-Gary, A.M., Hydroxyquinoline based binders: Promising ligands for chelatotherapy? (2011) J. Inorg. Biochem., 105, pp. 490-496
Oliveri, V., Grasso, G.I., Bellia, F., Attanasio, F., Viale, M., Vecchio, G., Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation (2015) Inorg. Chem., 54, pp. 2591-2602
Oliveri, V., Bellia, F., Pietropaolo, A., Vecchio, G., Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (2015) Chem.-Eur. J., 21, pp. 14047-14059
Nancollas, G.H., Tomson, M.B., Guidelines for the determination of stability constants (1982) Pure Appl. Chem., 54, pp. 2675-2692
Sgarlata, C., Oliveri, V., Spencer, J., A 8-Hydroxyquinoline-Cyclodextrin Conjugate as an Efficient Chelating Agent for Cobalt(II) and Nickel(II) in Neutral Aqueous Solution (2015) Eur. J. Inorg. Chem., pp. 5886-5891
Oliveri, V., Sgarlata, C., Vecchio, G., Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation (2016) Chem.-Asian J., 11, pp. 2436-2442
Oliveri, V., Pietropaolo, A., Sgarlata, C., Vecchio, G., Zinc Complexes of Cyclodextrin-bearing 8-Hydroxyquinoline Ligands: A Comparative Study (2017) Chem.-Asian J., 12, pp. 110-115
Johnston, W.D., Freiser, H., Structure and Behavior of Organic Analytical Reagents. III. Stability of Chelates of 8-Hydroxyquinoline and Analogous Reagents1 (1952) J. Am. Chem. Soc., 74, pp. 5239-5242
Di Vaira, M., Bazzicalupi, C., Orioli, P., Messori, L., Bruni, B., Zatta, P., Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes (2004) Inorg. Chem., 43, pp. 3795-3797
Alfano, C., Faggiano, S., Pastore, A., The Ball and Chain of Polyubiquitin Structures (2016) Trends Biochem. Sci., 41, pp. 371-385
Katano, H., Tanaka, R., Maruyama, C., Hamano, Y., Assay of enzymes forming AMP + PPi by the pyrophosphate determination based on the formation of 18-molybdopyrophosphate (2012) Anal. Biochem., 421, pp. 308-312
Berndsen, C.E., Wolberger, C., A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins (2011) Anal. Biochem., 418, pp. 102-110
Oliveri, V., Viale, M., Caron, G., Aiello, C., Gangemi, R., Vecchio, G., Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy (2013) Dalton Trans., 42, pp. 2023-2034
Oliveri, V., New glycoconjugates for the treatment of diseases related to metal dyshomeostasis (2015) ChemistryOpen, 4, pp. 792-795
Fuster, J.J., Sanz-González, S.M., Moll, U.M., Andrés, V., Classic and novel roles ofp53: Prospects for anticancer therapy (2007) Trends Mol. Med., 13, pp. 192-199
Gadducci, A., Cosio, S., Muraca, S., Genazzani, A.R., Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: Biological data and clinical implications (2002) Eur. J. Gynaecol. Oncol., 23, pp. 390-396
Clark, D.E., Pickett, S.D., Computational methods for the prediction of 'druglikeness' (2000) Drug Discovery Today, 5, pp. 49-58
Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and developments settings (1997) Adv. Drug Delivery Rev., 23, p. 3e25
Gans, P., Sabatini, A., Vacca, A., Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs (1996) Talanta, 43, pp. 1739-1753
Smith, R.M., Martell, A.E., (1976) Critical Stability Constants, , Plenum Press, New York, 4
Crumbliss, A.L., Poulos, A.T., Kinetics of Oxidation of a Cuprous 2,2′,2′′-Terpyridine Complex by Molecular Oxygen (1975) Inorg. Chem., 14, pp. 1529-1534
Dell'Erba, C., Chiavarina, B., Fenoglio, C., Petrillo, G., Cordazzo, C., Boncompagni, E., Spinelli, D., Viale, M., Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo (2005) Pharmacol. Res., 52, pp. 271-282
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.069, 5-year impact factor: 4.079
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031780307&doi=10.1039%2fc7mt00156h&partnerID=40&md5=9b811013f7c93bbb19a53d9e87903930
Keywords: Bioactivity, Cell Death, Copper, Cytology, Diseases, 8-Hydroxyquinoline Derivatives, Anti-Cancer Agents, Antiproliferative Agents, Concentration-Dependent Manners, Pathological Conditions, Programmed Cell Deaths, Proteasome Inhibitors, Ubiquitin-Proteasome System, 2 Amino 8 Hydroxyquinoline, 5 Amino 8 Hydroxyquinoline, 5 Aminomethyl 8 Hydroxyquinoline, 5 Chloromethyl 8 Hydroxyquinoline, 8 Quinolinol Derivative, Amino 8 Hydroxyquinoline Derivative, Antineoplastic Agent, Chloro 8 Hydroxyquinoline Derivative, Chymotrypsin, Clioquinol, Cloxiquine, Copper Complex, Copper Ion, Unclassified Drug, 5-Amino-8-Hydroxyquinoline, A-549 Cell Line, A2780 Cell Line, Antiproliferative Activity, Apoptosis, Article, Cancer Inhibition, Cancer Resistance, Chemical Analysis, Clinical Evaluation, Concentration Response, Controlled Study, Cytotoxicity, Drug Structure, Human, Human Cell, Physical Chemistry, Priority Journal, Cell Proliferation, Drug Effects, Female, Tumor Cell Culture, Ubiquitination, Proteasome Endopeptidase Complex,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. gr.vecchio@unict.it.,
Consorzio Interuniversitario di Ricerca in Chimica Dei Metalli Nei Sistemi Biologici, C.I.R.C.M.S.B., Unità di Ricerca di Catania, Viale A. Doria 6, Catania, 95125, Italy
Istituto di Biostrutture e Bioimmagini, CNR, Via P. Gaifami 18, Catania, 95126, Italy
Ospedale Policlinico San Martino, U.O.C. Bioterapie, Lgo R. Benzi 10, Genova, 16132, Italy
References:
Brooks, P., Fuertes, G., Murray, R.Z., Bose, S., Knecht, E., Rechsteiner, M.C., Hendil, K.B., Rivett, J., Subcellular localization of proteasomes and their regulatory complexes in mammalian cells (2000) Biochem. J., 346, pp. 155-16
Arendt, C.S., Hochstrasser, M., Identification of the yeast 20S proteasome catalytic centers and subunit interactions required for active-site formation (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 7156-7161
Heinemeyer, W., Fischer, M., Krimmer, T., Stachon, U., Wolf, D.H., The active sites of the eukaryotic 20 S proteasome and their involvement in subunit precursor processing (1997) J. Biol. Chem., 272, pp. 25200-25209
Kisselev, A.F., Callard, A., Goldberg, A.L., Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate (2006) J. Biol. Chem., 281, pp. 8582-8590
Kisselev, A.F., Goldberg, A.L., Proteasome inhibitors: From research tools to drug candidates (2001) Chem. Biol., 8, pp. 739-758
Santoro, A.M., Cunsolo, A., D'Urso, A., Sbardella, D., Tundo, G.R., Ciaccio, C., Coletta, M., Purrello, R., Cationic porphyrins are tunable gatekeepers of the 20S proteasome (2016) Chem. Sci., 7, pp. 1286-1297
Santoro, A.M., Lo Giudice, M.C., D'Urso, A., Lauceri, R., Purrello, R., Milardi, D., Cationic Porphyrins Are Reversible Proteasome Inhibitors (2012) J. Am. Chem. Soc., 134, pp. 10451-10457
Almond, J.B., Cohen, G.M., The proteasome: A novel target for cancer chemotherapy (2002) Leukemia, 16, pp. 433-443
Gandin, V., Pellei, M., Tisato, F., Porchia, M., Santini, C., Marzano, C., A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signaling (2012) J. Cell. Mol. Med., 16, pp. 142-151
Gandin, V., Tisato, F., Dolmella, A., Pellei, M., Santini, C., Giorgetti, M., Marzano, C., Porchia, M., In Vitro and in Vivo Anticancer Activity of Copper(i) Complexes with Homoscorpionate Tridentate Tris (pyrazolyl) borate and Auxiliary Monodentate Phosphine Ligands (2014) J. Med. Chem., 57, pp. 4745-4760
Kisselev, A.F., Van Der Linden, W.A., Overkleeft, H.S., Proteasome inhibitors: An expanding army attacking a unique target (2012) Chem. Biol., 19, pp. 99-115
Chen, D., Frezza, M., Schmitt, S., Kanwar, J., Dou, Q.P., Bortezomib as the first proteasome inhibitor anticancer drug: Current status and future perspectives (2011) Curr. Cancer Drug Targets, 11, pp. 239-253
Orlowski, R.Z., Kuhn, D.J., Proteasome inhibitors in cancer therapy: Lessons from the first decade (2008) Clin. Cancer Res., 14, pp. 1649-1657
Oliveri, V., Giuffrida, M.L., Vecchio, G., Aiello, C., Viale, M., Gluconjugates of 8-hydroxyquinolines as potential anti-cancer prodrugs (2012) Dalton Trans., 41, pp. 4530-4535
Oliveri, V., Vecchio, G., 8-Hydroxyquinolines in medicinal chemistry: A structural perspective (2016) Eur. J. Med. Chem., 120, pp. 252-274
Ruschak, A.M., Slassi, M., Kay, L.E., Schimmer, A.D., Novel proteasome inhibitors to overcome bortezomib resistance (2011) J. Natl. Cancer Inst., 103, pp. 1007-1017
Santoro, A.M., Monaco, I., Attanasio, F., Lanza, V., Pappalardo, G., Tomasello, M.F., Cunsolo, A., Milardi, D., Copper(II) ions affect the gating dynamics of the 20S proteasome: A molecular and in cell study (2016) Sci. Rep., 6, p. 33444
Daniel, K.G., Gupta, P., Harbach, R.H., Guida, W.C., Dou, Q.P., Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells (2004) Biochem. Pharmacol., 67, pp. 1139-1151
Wang, T., Guo, Z.J., Copper in medicine: Homeostasis, chelation therapy and antitumor drug design (2006) Curr. Med. Chem., 13, pp. 525-537
Adsule, S., Barve, V., Chen, D., Ahmed, F., Dou, Q.P., Padhye, S., Sarkar, F.H., Novel Schiff base copper complexes of quinoline-2 carboxaldehyde as proteasome inhibitors in human prostate cancer cells (2006) J. Med. Chem., 49, pp. 7242-7246
Heidary, D.K., Howerton, B.S., Glazer, E.C., Coordination of Hydroxyquinolines to a Ruthenium Bis-dimethylphenanthroline, Scaffold Radically Improves Potency for Potential as Antineoplastic Agents (2014) J. Med. Chem., 57, pp. 8936-8946
Milardi, D., Arnesano, F., Grasso, G., Magrì, A., Tabbì, G., Scintilla, S., Natile, G., Rizzarelli, E., Ubiquitin Stability and the Lys 63-Linked Polyubiquitination Site Are Compromised on Copper Binding (2007) Angew. Chem., Int. Ed., 46, pp. 7993-7995
Arena, G., Bellia, F., Frasca, G., Grasso, G., Lanza, V., Rizzarelli, E., Tabbì, G., Milardi, D., Inorganic stressors of ubiquitin (2013) Inorg. Chem., 52, pp. 9567-9573
Kaiser, S.M., Escher, B.I., The evaluation of liposome-water partitioning of 8-hydroxyquinolines and their copper complexes (2006) Environ. Sci. Technol., 40, pp. 1784-1791
Budimir, A., Humbert, N., Elhabiri, M., Osinska, I., Biruš, M., Albrecht-Gary, A.M., Hydroxyquinoline based binders: Promising ligands for chelatotherapy? (2011) J. Inorg. Biochem., 105, pp. 490-496
Oliveri, V., Grasso, G.I., Bellia, F., Attanasio, F., Viale, M., Vecchio, G., Soluble sugar-based quinoline derivatives as new antioxidant modulators of metal-induced amyloid aggregation (2015) Inorg. Chem., 54, pp. 2591-2602
Oliveri, V., Bellia, F., Pietropaolo, A., Vecchio, G., Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (2015) Chem.-Eur. J., 21, pp. 14047-14059
Nancollas, G.H., Tomson, M.B., Guidelines for the determination of stability constants (1982) Pure Appl. Chem., 54, pp. 2675-2692
Sgarlata, C., Oliveri, V., Spencer, J., A 8-Hydroxyquinoline-Cyclodextrin Conjugate as an Efficient Chelating Agent for Cobalt(II) and Nickel(II) in Neutral Aqueous Solution (2015) Eur. J. Inorg. Chem., pp. 5886-5891
Oliveri, V., Sgarlata, C., Vecchio, G., Cyclodextrins 3-Functionalized with 8-Hydroxyquinolines: Copper-Binding Ability and Inhibition of Synuclein Aggregation (2016) Chem.-Asian J., 11, pp. 2436-2442
Oliveri, V., Pietropaolo, A., Sgarlata, C., Vecchio, G., Zinc Complexes of Cyclodextrin-bearing 8-Hydroxyquinoline Ligands: A Comparative Study (2017) Chem.-Asian J., 12, pp. 110-115
Johnston, W.D., Freiser, H., Structure and Behavior of Organic Analytical Reagents. III. Stability of Chelates of 8-Hydroxyquinoline and Analogous Reagents1 (1952) J. Am. Chem. Soc., 74, pp. 5239-5242
Di Vaira, M., Bazzicalupi, C., Orioli, P., Messori, L., Bruni, B., Zatta, P., Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: Structural characterization of its zinc(II) and copper(II) complexes (2004) Inorg. Chem., 43, pp. 3795-3797
Alfano, C., Faggiano, S., Pastore, A., The Ball and Chain of Polyubiquitin Structures (2016) Trends Biochem. Sci., 41, pp. 371-385
Katano, H., Tanaka, R., Maruyama, C., Hamano, Y., Assay of enzymes forming AMP + PPi by the pyrophosphate determination based on the formation of 18-molybdopyrophosphate (2012) Anal. Biochem., 421, pp. 308-312
Berndsen, C.E., Wolberger, C., A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins (2011) Anal. Biochem., 418, pp. 102-110
Oliveri, V., Viale, M., Caron, G., Aiello, C., Gangemi, R., Vecchio, G., Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy (2013) Dalton Trans., 42, pp. 2023-2034
Oliveri, V., New glycoconjugates for the treatment of diseases related to metal dyshomeostasis (2015) ChemistryOpen, 4, pp. 792-795
Fuster, J.J., Sanz-González, S.M., Moll, U.M., Andrés, V., Classic and novel roles ofp53: Prospects for anticancer therapy (2007) Trends Mol. Med., 13, pp. 192-199
Gadducci, A., Cosio, S., Muraca, S., Genazzani, A.R., Molecular mechanisms of apoptosis and chemosensitivity to platinum and paclitaxel in ovarian cancer: Biological data and clinical implications (2002) Eur. J. Gynaecol. Oncol., 23, pp. 390-396
Clark, D.E., Pickett, S.D., Computational methods for the prediction of 'druglikeness' (2000) Drug Discovery Today, 5, pp. 49-58
Lipinski, C.A., Lombardo, F., Dominy, B.W., Feeney, P.J., Experimental and computational approaches to estimate solubility and permeability in drug discovery and developments settings (1997) Adv. Drug Delivery Rev., 23, p. 3e25
Gans, P., Sabatini, A., Vacca, A., Investigation of equilibria in solution. Determination of equilibrium constants with the HYPERQUAD suite of programs (1996) Talanta, 43, pp. 1739-1753
Smith, R.M., Martell, A.E., (1976) Critical Stability Constants, , Plenum Press, New York, 4
Crumbliss, A.L., Poulos, A.T., Kinetics of Oxidation of a Cuprous 2,2′,2′′-Terpyridine Complex by Molecular Oxygen (1975) Inorg. Chem., 14, pp. 1529-1534
Dell'Erba, C., Chiavarina, B., Fenoglio, C., Petrillo, G., Cordazzo, C., Boncompagni, E., Spinelli, D., Viale, M., Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo (2005) Pharmacol. Res., 52, pp. 271-282
Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents
Proliferation and programmed cell death are tightly correlated with the ubiquitin-proteasome system (UPS). Alterations in the UPS may be implicated in pathological conditions such as the proteasome over-activity in cancer cells. Mounting evidence indicates that many types of actively proliferating malignant cells are more sensitive to proteasome inhibition than normal cells, and therefore UPS inhibitors are actively pursued as anticancer agents. The approval of the proteasome inhibitor drug bortezomib for the treatment of myeloma and lymphoma further highlights the need for UPS inhibitors. Recent studies have suggested that clioquinol and 5-amino-8-hydroxyquinoline can inhibit proteasome activity and induce apoptosis in human cancer cells. As for clioquinol, a copper-dependent and -independent mechanism has been proposed to explain the inhibition of the proteasome whereas the activity of 5-amino-8-hydroxyquinoline has not been explored in the presence of copper(ii) ions. Herein, we investigated the biological activity of some 8-hydroxyquinolines by using human ovarian (A2780) and lung (A549) cancer cells. The effect of copper(ii) on the activity of these compounds was also evaluated. The investigated systems inhibit the chymotrypsin-like activity of the proteasome and induce growth inhibition and apoptosis in a concentration-dependent manner. Copper(ii) ions increase the activity of 8-hydroxyquinoline derivatives except in the case of 5-amino-8-hydroxyquinoline. This study suggests the great potential of amino- and chloro-8-hydroxyquinolines as anticancer agents. Furthermore, it clarifies some aspects concerning the activity of 5-amino-8-hydroxyquinoline, which has been previously proposed as a proteasome inhibitor capable of overcoming resistance to bortezomib. © 2017 The Royal Society of Chemistry.
Proliferation and programmed cell death are tightly correlated with the ubiquitin-proteasome system (UPS). Alterations in the UPS may be implicated in pathological conditions such as the proteasome over-activity in cancer cells. Mounting evidence indicates that many types of actively proliferating malignant cells are more sensitive to proteasome inhibition than normal cells, and therefore UPS inhibitors are actively pursued as anticancer agents. The approval of the proteasome inhibitor drug bortezomib for the treatment of myeloma and lymphoma further highlights the need for UPS inhibitors. Recent studies have suggested that clioquinol and 5-amino-8-hydroxyquinoline can inhibit proteasome activity and induce apoptosis in human cancer cells. As for clioquinol, a copper-dependent and -independent mechanism has been proposed to explain the inhibition of the proteasome whereas the activity of 5-amino-8-hydroxyquinoline has not been explored in the presence of copper(ii) ions. Herein, we investigated the biological activity of some 8-hydroxyquinolines by using human ovarian (A2780) and lung (A549) cancer cells. The effect of copper(ii) on the activity of these compounds was also evaluated. The investigated systems inhibit the chymotrypsin-like activity of the proteasome and induce growth inhibition and apoptosis in a concentration-dependent manner. Copper(ii) ions increase the activity of 8-hydroxyquinoline derivatives except in the case of 5-amino-8-hydroxyquinoline. This study suggests the great potential of amino- and chloro-8-hydroxyquinolines as anticancer agents. Furthermore, it clarifies some aspects concerning the activity of 5-amino-8-hydroxyquinoline, which has been previously proposed as a proteasome inhibitor capable of overcoming resistance to bortezomib. © 2017 The Royal Society of Chemistry.
Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents
Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents
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Russo L, Mascanzoni F, Farina B, Dolga AM, Monti A, Caporale A, Culmsee C, Fattorusso R, Ruvo M, Doti N
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Scognamiglio PL, Platella C, Napolitano E, Musumeci D, Roviello GN
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
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Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla R
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
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Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
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Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
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Impact Factor: 5.16
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
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Doti N, Ruvo M
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
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Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
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Musumeci D, Roviello GN, Rigione G, Capasso D, Di Gaetano S, Riccardi C, Roviello V, Montesarchio D
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
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Bellia F, GrassoG
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
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Bellia F, Pietropaolo A, Grasso G
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Musumeci D, Roviello GN, Montesarchio D, Sapio R, Valente M, Anr V, Bucci EM
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
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Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, Amodeo P, Tancredi T, Laccetti P, Corbier C, Benedetti E
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
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* Design, Optimization, and Structural Characterization of an Apoptosis-Inducing Factor Peptide Targeting Human Cyclophilin A to Inhibit Apoptosis Inducing Factor-Mediated Cell Death (11 views)
J Med Chem (ISSN: 0022-2623linking), 2021 Aug 12; 64 (15 ): 11445-11459.
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Scognamiglio PL, Platella C, Napolitano E, Musumeci D, Roviello GN
* From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides (28 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2021 Jun 10; 26(12): 3558-3558.
Impact Factor: 4.411
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
* Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy (165 views)
Sci Transl Med (ISSN: 1946-6234linking), 2021 Feb 17; 13(581): N/D-N/D.
Impact Factor: 17.956
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Longo F, Perri F, Caponigro F, Della Vittoria Scarpati G, Guida A, Pavone E, Aversa C, Muto P, Giuliano M, Ionna F, Solla R
* Boosting the Immune Response with the Combination of Electrochemotherapy and Immunotherapy: A New Weapon for Squamous Cell Carcinoma of the Head and Neck? (55 views)
Cancers (ISSN: 2072-6694linking), 2020 Sep 28; 12(10): N/D-N/D.
Impact Factor: 6.126
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Miceli M, Cutignano A, Conte M, Ummarino R, Romanelli A, Ruvo M, Leone M, Mercurio FA, Doti N, Manzo E, Romano G, Altucci L, Ianora A
* Monoacylglycerides from the Diatom Skeletonema marinoi Induce Selective Cell Death in Cancer Cells (158 views)
Mar Drugs (ISSN: 1660-3397linking), 2019 Nov 1; 17 (11 ): N/D-N/D.
Impact Factor: 3.345
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Conte C, Moret F, Esposito D, Dal Poggetto G, Avitabile C, Ungaro F, Romanelli A, Laurienzo P, Reddi E, Quaglia F
* Biodegradable nanoparticles exposing a short anti-FLT1 peptide as antiangiogenic platform to complement docetaxel anticancer activity (214 views)
Mater Sci Eng C Mater Biol Appl (ISSN: 0928-4931linking), 2019 Sep; 102: 876-886.
Impact Factor: 5.08
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Carafa V, Nebbioso A, Cuomo F, Rotili D, Cobellis G, Bontempo P, Baldi A, Spugnini EP, Citro G, Chambery A, Russo R, Ruvo M, Ciana P, Maravigna L, Shaik J, Radaelli E, De Antonellis P, Tarantino D, Pirolli A, Ragno R, Zollo M, Stunnenberg HG, Mai A, Altucci L
* RIP1-HAT1-SIRT Complex Identification and Targeting in Treatment and Prevention of Cancer (244 views)
Clin Cancer Res (ISSN: 1078-0432print, 1078-0432linking), 2018 Jun 15; 24(12): 2886-2900.
Impact Factor: 6.488
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Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (284 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
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Riccardi C, Musumeci D, Capuozzo A, Irace C, King S, Russo Krauss I, Paduano L, Montesarchio D
* "dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (197 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Impact Factor: 0
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Farina B, Sturlese M, Mascanzoni F, Caporale A, Monti A, Sorbo GD, Fattorusso R, Ruvo M, Doti N
* Binding mode of AIF(370–394) peptide to CypA: insights from NMR, label-free and molecular docking studies (1064 views)
Biochem J (ISSN: 0264-6021, 1470-8728electronic, 0264-6021linking), 2018; 475(14): 2377-2393.
Impact Factor: 4.897
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Cutrin JC, Alberti D, Bernacchioni C, Ciambellotti S, Turano P, Luchinat C, Crich SG, Aime S
* Cancer cell death induced by ferritins and the peculiar role of their labile iron pool (210 views)
Oncotarget, 2018; N/D: N/D-N/D.
Impact Factor: 5.168
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Di Stasi R, Diana D, Capasso D, Di Gaetano S, De Rosa L, Celentano V, Isernia C, Fattorusso R, D'Andrea LD
* VEGFR Recognition Interface of a Proangiogenic VEGF-Mimetic Peptide Determined In Vitro and in the Presence of Endothelial Cells by NMR Spectroscopy (337 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(44): 11461-11466.
Impact Factor: 5.16
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Sgarlata C, Arena G, Bonomo RP, Giuffrida A, Tabbì G
* Simple and mixed complexes of copper(II) with 8-hydroxyquinoline derivatives and amino acids: Characterization in solution and potential biological implications (406 views) (PDF 160 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2017 Dec 8; 180: 89-100.
Impact Factor: 3.063
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Doti N, Ruvo M
* Relevance and therapeutic potential of CypA targeting to block apoptosis inducing factor-mediated neuronal cell death (365 views)
Neural Regen Res (ISSN: 1673-5374), 2017 Sep; 12(9): 1428-1429.
Impact Factor: 2.234
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Magrì A, Tabbì G, Breglia R, De Gioia L, Fantucci P, Bruschi M, Bonomo RP, La Mendola D
* Copper ion interaction with the RNase catalytic site fragment of the angiogenin protein: an experimental and theoretical investigation (359 views) (PDF 179 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2017 Jul 04; 46(26): 8524-8538.
Impact Factor: 4.099
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Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E, Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P
* Insights into the anticancer properties of the first antimicrobial peptide from Archaea (409 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0304-4165linking), 2017 Jun 15; 1861(9): 2155-2164.
Impact Factor: 4.28
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Musumeci D, Roviello GN, Rigione G, Capasso D, Di Gaetano S, Riccardi C, Roviello V, Montesarchio D
* Benzodifuran derivatives as potential antiproliferative agents: possible correlation between the bioactivity and their aggregation properties (476 views)
Chempluschem, 2017; 82: 251-260.
Impact Factor: 2.8
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Martínez-fernández L, Granucci G, Pollum M, Crespo-hernández CE, Persico M, Corral I
* Decoding the Molecular Basis for the Population Mechanism of the Triplet Phototoxic Precursors in UVA Light-Activated Pyrimidine Anticancer Drugs (363 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(11): 2619-2627.
Impact Factor: 5.16
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
Biochemistry (ISSN: 0006-2960, 1520-4995), 2015 Sep 15; 54(36): 5646-5656.
Impact Factor: 2.876
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Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (323 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
* Interaction between AIF and CHCHD4 Regulates Respiratory Chain Biogenesis (521 views)
Mol Cell (ISSN: 1097-2765, 1097-4164), 2015; 58(6): 1001-1014.
Impact Factor: 13.958
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
J Pharmacol Exp Ther (ISSN: 0022-3565, 1521-0103), 2014 Sep; 350(2): 273-289.
Impact Factor: 3.972
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Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (727 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
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Messori L, Scaletti F, Massai L, Cinellu MA, Russo Krauss I, Di Martino G, Vergara A, Paduano L, Merlino A
* Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound (339 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2014; 6(2): 233-236.
Impact Factor: 3.585
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Milardi D, Sciacca MF, Randazzo L, Raudino A, La Rosa C
* The role of calcium, lipid membranes and islet amyloid polypeptide in the onset of type 2 diabetes: Innocent bystanders or partners in a crime? (526 views)
Front Endocrinol (ISSN: 1664-2392, 1664-2392linking, 1664-2392print), 2014; 5(DEC): 216-216.
Impact Factor: 3.675
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Bellia F, GrassoG
* The role of copper(II) and zinc(II) in the degradation of human and murine IAPP by insulin-degrading enzyme (505 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2014; 49(4): 274-279.
Impact Factor: 2.379
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Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D, Portella G
* Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells (444 views)
Endocr Relat Cancerendocrine Related Cancer (ISSN: 1351-0088), 2013 Sep 19; 20(5): 633-647.
Impact Factor: 4.907
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Nande R, Greco A, Gossman MS, Lopez JP, Claudio L, Salvatore M, Brunetti A, Denvir J, Howard CM, Claudio PP
* Microbubble-assisted p53, RB, and p130 gene transfer in combination with radiation therapy in prostate cancer (457 views)
Current Gene Therapy (ISSN: 1875-5631, 1566-5232), 2013 Jun 1; 13(3): 163-174.
Impact Factor: 4.906
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Lombardo B, Rocco T, Esposito MT, Cantilena B, Gargiulo S, Greco A, Montanaro D, Brunetti A, Pastore L
* Thymidine Kinase-Mediated Shut Down of Bone Morphogenetic Protein-4 Expression Allows Regulated Bone Production (350 views)
Current Gene Therapy (ISSN: 1566-5232, 1875-5631), 2013 Jun 1; 13(3): 202-210.
Impact Factor: 4.906
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
* Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure (428 views)
J Am Heart Assoc Journal Of The American Heart Association (ISSN: 2047-9980), 2013 May 20; 2(3): e000086-e000086.
Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
* Mitochondrial Small Conductance SK2 Channels Prevent Glutamate-induced Oxytosis and Mitochondrial Dysfunction (520 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2013 Apr 12; 288(15): 10792-10804.
Impact Factor: 4.6
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Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (493 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
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Bellia F, Pietropaolo A, Grasso G
* Formation of insulin fragments by insulin-degrading enzyme: The role of zinc(II) and cystine bridges (450 views)
J Mass Spectrom (ISSN: 1076-5174, 1096-9888), 2013; 48(2): 135-140.
Impact Factor: 2.709
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Musumeci D, Roviello GN, Montesarchio D, Sapio R, Valente M, Anr V, Bucci EM
* Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity (434 views)
Rsc Adv (ISSN: 2046-2069), 2013; 3(30): 12176-12184.
Impact Factor: 3.708
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Travaglia A, La Mendola D, Magrì A, Nicoletti VG, Pietropaolo A, Rizzarelli E
* Copper, BDNF and Its N-terminal domain: inorganic features and biological perspectives (506 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2012 Dec 3; 18(49): 15618-15631.
Impact Factor: 5.831
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
* Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity (3484 views)
Bba-Gen Subjects (ISSN: 0006-3002, 0925-4439, 1570-9639), 2012 May; 1822(5): 753-783.
Impact Factor: 3.733
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Folgiero V, Di Carlo SE, Bossi G, Spugnini E, Di Benedetto A, Bon G, Milella M, Fabi A, Accardo A, Morelli G, Mottolese M, Falcioni R
* Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells (517 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2012; 3(12): N/D-N/D.
Impact Factor: 6.044
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Diana D, Basile A, De Rosa L, Di Stasi R, Auriemma S, Arra C, Pedone C, Turco MC, Fattorusso R, D'Andrea LD
* Beta-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (vegf) Receptors: Design, Nmr Characterization, And Biological Activity (620 views)
Jbc Papers (ISSN: 1083-351x, 0021-9258, 0021-9258linking), 2011 Dec 2; 286(48): 41680-41691.
Impact Factor: 4.773
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Dettin M, Ghezzo F, Conconi MT, Urbani L, D'Auria G, Falcigno L, Guidolin D, Nico B, Ribatti D, Di Bello C, Parnigotto PP
* In vitro and in vivo pro-angiogenic effects of thymosin-β4-derived peptides (480 views)
Cell Immunol (ISSN: 0008-8749), 2011; 271(2): 299-307.
Impact Factor: 1.974
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Alberobello AT, D'Esposito V, Marasco D, Doti N, Ruvo M, Bianco R, Tortora G, Esposito I, Fiory F, Miele C, Beguinot F, Formisano P
* Selective Disruption of Insulin-like Growth Factor-1 (IGF-1) Signaling via Phosphoinositide-dependent Kinase-1 Prevents the Protective Effect of IGF-1 on Human Cancer Cell Death (578 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2010 Feb 26; 285(9): 6563-6572.
Impact Factor: 5.328
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Giuffrida ML, Caraci F, Pignataro B, Cataldo S, De Bona P, Bruno V, Molinaro G, Pappalardo G, Messina A, Palmigiano A, Garozzo D, Nicoletti F, Rizzarelli E, Copani A
* Beta-Amyloid Monomers Are Neuroprotective (659 views)
J Neurosci (ISSN: 1529-2401, 0270-6474), 2009 Sep 26; 29(34): 10582-10587.
Impact Factor: 3.669
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Ponticelli S, Marasco D, Tarallo V, Albuquerque RJC, Mitola S, Takeda A, Stassen J, Presta M, Ambati J, Ruvo M, De Falco S
* Modulation of Angiogenesis by a Tetrameric Tripeptide That Antagonizes Vascular Endothelial Growth Factor Receptor (536 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Dec 5; 283(49): 34250-34259.
Impact Factor: 5.52
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Sinibaldi F, Fiorucci L, Patriarca A, Lauceri R, Ferri T, Coletta M, Santucci R
* Insights into cytochrome c-cardiolipin interaction. Role played by ionic strength (394 views)
Biochemistry (ISSN: 0006-2960, 1520-4995, 1520-4995electronic), 2008 Jul 1; 47(26): 6928-6935.
Impact Factor: 3.379
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Zeni O, Palumbo R, Bernini R, Zeni L, Sarti M, Scarfi MR
* Cytotoxicity investigation on cultured human blood cells treated with single-wall carbon nanotubes (321 views)
Sensors (ISSN: 1424-3210, 1424-8220, 1424-8220electronic), 2008 Jan; 8(1): 488-499.
Impact Factor: 1.87
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Diana D, Ziaco B, Colombo G, Scarabelli G, Romanelli A, Fedone C, Fattorusso R, D'Andrea LD
* Structural determinants of the unusual helix stability of a de novo engineered vascular endothelial growth factor (VEGF) mimicking peptide (470 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2008; 14(14): 4164-4166.
Impact Factor: 5.454
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Zannetti A, Fonti R, Iommelli F, Papaccioli A, Sommella J, Tortora G, Bianco R, Salvatore M, Del Vecchio S
* SPECT imaging of endoplasmic reticulum-mediated tumor response to gefitinib and erlotinib in lung cancer (424 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Oct; 34: 277-309.
Impact Factor: 4.101
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Nicoletti VG, Santoro AM, Grasso G, Vagliasindi LI, Giuffrida ML, Cuppari C, Purrello VS, Stella AMG, Rizzarelli E
* Carnosine interaction with nitric oxide and astroglial cell protection (647 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Sep 1; 85(10): 2239-2245.
Impact Factor: 3.268
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Ntziachristos V, Cuénod CA, Fournier L, Balvay D, Pradel C, Siauve N, Clement O, Jouannot E, Lucidarme O, Vecchio SD, Salvatore M, Law B, Tung C-H, Jain RK, Fukumura D, Munn LL, Brown EB, Schellenberger E, Montet X, Weissleder R, Clerck ND, Postnov A
* Tumor Imaging (350 views)
Textbook Of In Vivo Imaging In Vertebrates (ISSN: 9780-4700), 2007 Jul 16; 1: 277-309.
Impact Factor: 1.148
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Papa S, Monti SM, Vitale RM, Bubici C, Jayawardena S, Alvarez K, De Smaele E, Dathan N, Pedone C, Ruvo M, Franzoso G
* Insights Into The Structural Basis Of The Gadd45beta-Mediated Inactivation Of The Jnk Kinase, Mkk7/Jnkk2 (489 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2007 Jun 29; 282(26): 19029-19041.
Impact Factor: 5.581
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Grasso G, Fragai M, Rizzarelli E, Spoto G, Yeo KJ
* A new methodology for monitoring the activity of cdMMP-12 anchored and freeze-dried on Au (111) (351 views)
Journal Of The American Society For Mass Spectrometry (ISSN: 1044-0305), 2007 May; 18(5): 961-969.
Impact Factor: 3.664
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Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (481 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
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Dalla Bona A, Formaggio F, Peggion C, Kaptein B, Broxterman Quirinus B, Galdiero S, Galdiero M, Vitiello M, Benedetti E, Toniolo C
* Synthesis, conformation, and bioactivity of novel analogues of the antiviral lipopeptide halovir (474 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2006 Dec; 12(12): 748-757.
Impact Factor: 1.801
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Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (584 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
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Rossi F, Zanotti G, Saviano M, Iacovino R, Palladino P, Saviano G, Amodeo P, Tancredi T, Laccetti P, Corbier C, Benedetti E
* New antitumour cyclic astin analogues: Synthesis, conformation and bioactivity (445 views)
J Pept Sci (ISSN: 1075-2617, 1099-1387, 1075-2617print), 2004 Feb; 10(2): 92-102.
Impact Factor: 1.652
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Portella G, Pacelli R, Libertini S, Cella L, Vecchio G, Salvatore M, Fusco A
* ONYX-015 Enhances Radiation-Induced Death of Human Anaplastic Thyroid Carcinoma Cells (467 views)
J Clin Endocrinol Metab Journal Of Clinical Endocrinology And Metabolism (ISSN: 0021-972x), 2003 Oct 1; 88(10): 5027-5032.
Impact Factor: 5.873
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Russo M, Palumbo R, Mupo A, Tosto M, Iacomino G, Scognamiglio A, Tedesco I, Galano G, Russo GL
* Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Cα (436 views)
Oncogene (ISSN: 0950-9232, 1476-5594), 2003; 22(21): 3330-3342.
Impact Factor: 6.495
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Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB
The effect of various nitric oxide-donor agents on hydrogen peroxide-mediated toxicity: A direct correlation between nitric oxide formation and protection (685 views)
Arch Bioch Bioph (ISSN: 0003-9861, 0003-9861linking), 1996 Jul 15; 331(2): 241-248.
Impact Factor: 2.649
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Arena G, Bindoni M, Cardile V, Maccarrone G, Riello MC, Rizzarelli E, Sciuto S
Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results (477 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Apr 1; 50(1): 31-45.
Impact Factor: 1.342
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59 Records (56 excluding Abstracts).
Total impact factor: 250.22 (237.619 excluding Abstracts).
Total 5 year impact factor: 216.251 (207.325 excluding Abstracts).
Total impact factor: 250.22 (237.619 excluding Abstracts).
Total 5 year impact factor: 216.251 (207.325 excluding Abstracts).
462 views. Last view on Sunday 29 January 2023, 10:45:52
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