Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin (464 views)
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.158, 5-year impact factor: 5.326
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028943848&doi=10.1016%2fj.carbpol.2017.08.103&partnerID=40&md5=4f04878724b43a8a10113ddbf4a2e312
Keywords: 4-(4, 6-Dimethoxy-1, 5-Triazin-2-Yl)-4-Methylmorpholinium Chloride (pubchem Cid:2734059), Cancer, Carbohydrates, Cyclodextrins, Doxorubicin (pubchem Cid: 31703), Nanoparticles, Polymers, Tumors, Anti-Proliferative Activities, Cyclodextrin Cavities, Gamma-Cyclodextrin, Inclusion Complex, Polyglutamic Acids, Polymeric Nanoparticles, Beta Cyclodextrin Derivative, Drug Carrier, Gamma Cyclodextrin Derivative, Chemistry, Human, Tumor Cell Line, Beta-Cyclodextrins,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Via P. Gaifami 18, 95126 Catania, Italy., Ospedale Policlinico San Martino, U.O.C. Bioterapie, L.go R. Benzi 10, 16132 Genova, Italy., Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: Gr.vecchio@unict.it.,
References:
Adeoye, O., Cabral-Marques, H., Cyclodextrin nanosystems in oral drug delivery: A mini review (2017) International Journal of Pharmaceutic
Anand, R., Malanga, M., Manet, I., Manoli, F., Tuza, K., Aykaç, A., Citric acid-γ-cyclodextrin crosslinked oligomers as carriers for doxorubicin delivery (2013) Photochemical & Photobiological Sciences, 12, pp. 1841-1854
Anand, R., Manoli, F., Manet, I., Daoud-Mahammed, S., Agostoni, V., Gref, R., β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: A spectroscopic and photophysical study (2012) Photochemical & Photobiological Sciences, 11, pp. 1285-1292
Ao, X., Stenken, J.A., Water-soluble cyclodextrin polymers for enhanced relative recovery of hydrophobic analytes during microdialysis sampling (2003) Analyst, 128, pp. 1143-1149
Avnesh, S., Thakor, M.D., Sanjiv, S., Gambhir, M.D., Nanooncology: The future of cancer diagnosis and therapy (2013) CA: A Cancer Journal for Clinicians, 63, pp. 395-418
Bakkour, Y., Vermeersch, G., Morcellet, M., Boschin, F., Martel, B., Azaroual, N., Formation of cyclodextrin inclusion complexes with doxycycline-hyclate: NMR investigation of their characterisation and stability (2006) Journal of Inclusion Phenomena and Macrocyclic Chemistry, 54, pp. 109-114
Bartlett, D.W., Davis, M.E., Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles (2007) Bioconjugate Chemistry, 18, pp. 456-468
Bellia, F., Oliveri, V., Rizzarelli, E., Vecchio, G., New derivative of carnosine for nanoparticle assemblies (2013) European Journal of Medical Chemistry, 70, pp. 225-232
Bonnet, V., Gervaise, C., Djedaïni-Pilard, F., Furlan, A., Sarazin, C., Cyclodextrin nanoassemblies: A promising tool for drug delivery (2015) Drug Discovery Today, 20, pp. 1120-1126
Bonomi, P., Paclitaxel poliglumex (PPX, CT-2103): Macromolecular medicine for advanced non-small-cell lung cancer (2007) Expert Review of Anticancer Therapy, 7, pp. 415-422
Bozzuto, G., Molinari, A., Liposomes as nanomedical devices (2015) International Journal of Nanomedicine, 10, pp. 975-999
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., 3-Amino derivative of β-cyclodextrin: Thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis (2004) Journal of Chromatography B, 800, pp. 127-133
D'Estea, M., Eglina, D., Alini, M., A systematic analysis of DMTMM vs EDC/NHS for ligation of amines to hyaluronan in water (2014) Carbohydrate Polymers, 108, pp. 239-246
Dal Ben, D., Palumbo, M., Zagotto, G., Capranico, G., Moro, S., DNA topoisomerase II structures and anthracycline activity: Insights into ternary complex formation (2007) Current Pharmaceutical Design, 13, pp. 2766-2780
Davis, M.E., Zuckerman, J.E., Choi, C.H., Seligson, D., Tolcher, A., Alabi, C.A., Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles (2010) Nature, 464, pp. 1067-1070
Folch-Cano, C., Yazdani-Pedram, M., Olea-Azar, C., Inclusion and functionalization of polymers with cyclodextrins: Current applications and future prospects (2014) Molecules, 19, pp. 14066-14079
Fülöp, Z., Kurkov, S.V., Nielsen, T.T., Larsen, K.L., Loftsson, T., Self-assembly of cyclodextrins: Formation of cyclodextrin polymer-based nanoparticles (2012) Journal of Drug Delivery Science and Technology, 22, pp. 215-222
Gidwani, B., Vyas, A., Synthesis, characterization and application of epichlorohydrin-β-cyclodextrin polymer (2014) Colloids and Surfaces B, 114, pp. 130-137
Giglio, V., Sgarlata, C., Vecchio, G., Novel amino-cyclodextrin cross-linked oligomer as efficient carrier for anionic drugs: A spectroscopic and nanocalorimetric investigation (2015) RSC Advances, 5, pp. 16664-16671
Giglio, V., Bellia, F., Oliveri, V., Vecchio, G., Amino-cyclodextrin oligomers as protective agents of protein aggregation (2016) ChemPlusChem, 81, pp. 660-665
Giglio, V., Viale, M., Monticone, M., Aura, A.M., Spoto, G., Natile, G., Cyclodextrin polymers as carriers for the platinum-based anticancer agent LA-12 (2016) RSC Advances, 6, pp. 12461-12466
Gil, E.S., Li, J., Xiao, H., Lowe, T.L., Quaternary ammonium-cyclodextrin nanoparticles for enhancing doxorubicin permeability across the in vitro blood–brain barrier (2009) Biomacromolecules, 10, pp. 505-516
Gonil, P., Sajomsang, W., Uracha, R.R., Pimpha, N., Sramala, I., Nuchuchua, O., Novel quaternized chitosan containing β-cyclodextrin moiety: Synthesis, characterization and antimicrobial activity (2011) Carbohydrate Polymers, 83, pp. 905-913
Guan, H., McGuire, M.J., Li, S., Brown, K.C., Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of αvβ6-positive cancers (2008) Bioconjugate Chemistry, 19, pp. 1813-1821
Hu, C.-M.J., Fang, R.H., Luk, B.T., Zhang, L., Polymeric nanotherapeutics: Clinical development and advances in stealth functionalization strategies (2014) Nanoscale, 6, pp. 65-75
Kono, H., Teshirogi, T., Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery (2015) International Journal of Biological Macromolecules, 72, pp. 299-308
Lakkakula, J.R., Krause, R.W.M., A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications (2014) Nanomedicine, 9, pp. 877-894
Longworth, L.G., The mutual diffusion of light and heavy water (1960) Journal of Physical Chemistry, 64, pp. 1914-1917
Maeda, H., Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity (2015) Advanced Drug Delivery Reviews, 91, pp. 3-6
Manocha, B., Margaritis, A., Controlled release of doxorubicin from doxorubicin/γ-polyglutamic acid ionic complex (2010) Journal of Nanomaterials, , ID 780171
Matsumoto, K., Kawamura, A., Miyata, T., Conformationally regulated molecular binding and release of molecularly imprinted polypeptide hydrogels that undergo helix-coil transition (2017) Macromolecules, 50, pp. 2136-2144
Monteiro, A.P.F., Caminhas, L.D., Ardisson, J.D., Paniago, R., Cortés, M.E., Sinisterra, R.D., Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery (2017) Carbohydrate Polymers, 163, pp. 1-9
Nair, L.S., Laurencin, C.T., Biodegradable polymers as biomaterials (2007) Progress in Polymer Science, 32, pp. 762-798
Oliveri, V., Bellia, F., Vecchio, G., Cyclodextrin nanoparticles bearing 8-hydroxyquinoline ligands as multifunctional biomaterials (2017) Chemistry – A European Journal, 23, pp. 4442-4449
Oliveri, V., D'Agata, R., Giglio, V., Spoto, G., Vecchio, G., Cyclodextrin-functionalised gold nanoparticles via streptavidin: A supramolecular approach (2013) Supramolecular Chemistry, 25, pp. 465-473
Oliveri, V., Viale, M., Caron, G., Aiello, C., Gangemi, R., Vecchio, G., Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy (2013) Dalton Transactions, 42, pp. 2023-2034
Perdih, P., Čebašek, S., Možir, A., Žagar, E., Post-polymerization modification of poly(L-glutamic acid) with D-(+)-glucosamine (2014) Molecules, 19, pp. 19751-19768
Perez-Herrero, E., Fernández-Medarde, A., Perez-Herrero, E., Fernández-Medarde, A., Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy (2015) European Journal of Pharmaceutics and Biopharmaceutics, 93, pp. 52-79
Pessine, F.B.T.P., Calderini, A., Alexandrino, G.L., Magnetic resonance spectroscopy (2012), InTech
Przybylski, C., Blin, F., Jarroux, N., Toward a more accurate structural determination of high molecular weight polyrotaxanes based on cyclodextrins by MALDI-TOF MS (2011) Macromolecules, 44, pp. 1821-1830
Ruiz-Esparza, G.U., Wu, S., Segura-Ibarra, V., Cara, F.E., Evans, K.W., Milosevic, M., Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release (2014) Advanced Functional Materials, 24, pp. 4753-4771
Swaminathan, S., Cavalli, R., Trotta, F., Cyclodextrin-based nanosponges: A versatile platform for cancer nanotherapeutics development (2016) WIREs Nanomedicine and Nanobiotechnology, 8, pp. 579-601
Tang, G.P., Guo, H.Y., Alexis, F., Wang, X., Zeng, S., Lim, T.M., Low molecular weight polyethylenimines linked by β-cyclodextrin for gene transfer into the nervous system (2006) Journal of Gene Medicine, 8, pp. 736-744
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, Y., Efficient regioselective synthesis of mono-2-O-sulfonyl-cyclodextrins by the combination of sulfonyl imidazole and molecular sieves (1998) Journal of Carbohydrate Chemistry, 17, pp. 489-494
Viale, M., Giglio, V., Monticone, M., Maric, I., Lentini, G., Rocco, M., New doxorubicin nanocarriers based on cyclodextrins (2017) Investigational New Drugs
Yang, S., Feiyan Zhu, F., Qian Wang, Q., Fuxin Liang, F., Xiaozhong Qu, X., Zhihua Gan, Z., Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment (2016) Journal of Materials Chemistry B, 4, pp. 7283-7292
Xiong, Q., Cui, M., Bai, Y., Liu, Y., Liu, D., Song, T., A supramolecular nanoparticle system based on β-cyclodextrin-conjugated poly-L-lysine and hyaluronic acid for co-delivery of gene and chemotherapy agent targeting hepatocellular carcinoma (2017) Colloids Surfaces B: Biointerfaces, 155, pp. 93-103
Carbohyd Polym (ISSN: 0144-8617), 2017 Dec 1; 177: 355-360.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 5.158, 5-year impact factor: 5.326
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85028943848&doi=10.1016%2fj.carbpol.2017.08.103&partnerID=40&md5=4f04878724b43a8a10113ddbf4a2e312
Keywords: 4-(4, 6-Dimethoxy-1, 5-Triazin-2-Yl)-4-Methylmorpholinium Chloride (pubchem Cid:2734059), Cancer, Carbohydrates, Cyclodextrins, Doxorubicin (pubchem Cid: 31703), Nanoparticles, Polymers, Tumors, Anti-Proliferative Activities, Cyclodextrin Cavities, Gamma-Cyclodextrin, Inclusion Complex, Polyglutamic Acids, Polymeric Nanoparticles, Beta Cyclodextrin Derivative, Drug Carrier, Gamma Cyclodextrin Derivative, Chemistry, Human, Tumor Cell Line, Beta-Cyclodextrins,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy., Istituto di Biostrutture e Bioimmagini, CNR, Via P. Gaifami 18, 95126 Catania, Italy., Ospedale Policlinico San Martino, U.O.C. Bioterapie, L.go R. Benzi 10, 16132 Genova, Italy., Dipartimento di Scienze Chimiche, Universita degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy. Electronic address: Gr.vecchio@unict.it.,
References:
Adeoye, O., Cabral-Marques, H., Cyclodextrin nanosystems in oral drug delivery: A mini review (2017) International Journal of Pharmaceutic
Anand, R., Malanga, M., Manet, I., Manoli, F., Tuza, K., Aykaç, A., Citric acid-γ-cyclodextrin crosslinked oligomers as carriers for doxorubicin delivery (2013) Photochemical & Photobiological Sciences, 12, pp. 1841-1854
Anand, R., Manoli, F., Manet, I., Daoud-Mahammed, S., Agostoni, V., Gref, R., β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: A spectroscopic and photophysical study (2012) Photochemical & Photobiological Sciences, 11, pp. 1285-1292
Ao, X., Stenken, J.A., Water-soluble cyclodextrin polymers for enhanced relative recovery of hydrophobic analytes during microdialysis sampling (2003) Analyst, 128, pp. 1143-1149
Avnesh, S., Thakor, M.D., Sanjiv, S., Gambhir, M.D., Nanooncology: The future of cancer diagnosis and therapy (2013) CA: A Cancer Journal for Clinicians, 63, pp. 395-418
Bakkour, Y., Vermeersch, G., Morcellet, M., Boschin, F., Martel, B., Azaroual, N., Formation of cyclodextrin inclusion complexes with doxycycline-hyclate: NMR investigation of their characterisation and stability (2006) Journal of Inclusion Phenomena and Macrocyclic Chemistry, 54, pp. 109-114
Bartlett, D.W., Davis, M.E., Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles (2007) Bioconjugate Chemistry, 18, pp. 456-468
Bellia, F., Oliveri, V., Rizzarelli, E., Vecchio, G., New derivative of carnosine for nanoparticle assemblies (2013) European Journal of Medical Chemistry, 70, pp. 225-232
Bonnet, V., Gervaise, C., Djedaïni-Pilard, F., Furlan, A., Sarazin, C., Cyclodextrin nanoassemblies: A promising tool for drug delivery (2015) Drug Discovery Today, 20, pp. 1120-1126
Bonomi, P., Paclitaxel poliglumex (PPX, CT-2103): Macromolecular medicine for advanced non-small-cell lung cancer (2007) Expert Review of Anticancer Therapy, 7, pp. 415-422
Bozzuto, G., Molinari, A., Liposomes as nanomedical devices (2015) International Journal of Nanomedicine, 10, pp. 975-999
Cucinotta, V., Giuffrida, A., La Mendola, D., Maccarrone, G., Puglisi, A., Rizzarelli, E., 3-Amino derivative of β-cyclodextrin: Thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis (2004) Journal of Chromatography B, 800, pp. 127-133
D'Estea, M., Eglina, D., Alini, M., A systematic analysis of DMTMM vs EDC/NHS for ligation of amines to hyaluronan in water (2014) Carbohydrate Polymers, 108, pp. 239-246
Dal Ben, D., Palumbo, M., Zagotto, G., Capranico, G., Moro, S., DNA topoisomerase II structures and anthracycline activity: Insights into ternary complex formation (2007) Current Pharmaceutical Design, 13, pp. 2766-2780
Davis, M.E., Zuckerman, J.E., Choi, C.H., Seligson, D., Tolcher, A., Alabi, C.A., Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles (2010) Nature, 464, pp. 1067-1070
Folch-Cano, C., Yazdani-Pedram, M., Olea-Azar, C., Inclusion and functionalization of polymers with cyclodextrins: Current applications and future prospects (2014) Molecules, 19, pp. 14066-14079
Fülöp, Z., Kurkov, S.V., Nielsen, T.T., Larsen, K.L., Loftsson, T., Self-assembly of cyclodextrins: Formation of cyclodextrin polymer-based nanoparticles (2012) Journal of Drug Delivery Science and Technology, 22, pp. 215-222
Gidwani, B., Vyas, A., Synthesis, characterization and application of epichlorohydrin-β-cyclodextrin polymer (2014) Colloids and Surfaces B, 114, pp. 130-137
Giglio, V., Sgarlata, C., Vecchio, G., Novel amino-cyclodextrin cross-linked oligomer as efficient carrier for anionic drugs: A spectroscopic and nanocalorimetric investigation (2015) RSC Advances, 5, pp. 16664-16671
Giglio, V., Bellia, F., Oliveri, V., Vecchio, G., Amino-cyclodextrin oligomers as protective agents of protein aggregation (2016) ChemPlusChem, 81, pp. 660-665
Giglio, V., Viale, M., Monticone, M., Aura, A.M., Spoto, G., Natile, G., Cyclodextrin polymers as carriers for the platinum-based anticancer agent LA-12 (2016) RSC Advances, 6, pp. 12461-12466
Gil, E.S., Li, J., Xiao, H., Lowe, T.L., Quaternary ammonium-cyclodextrin nanoparticles for enhancing doxorubicin permeability across the in vitro blood–brain barrier (2009) Biomacromolecules, 10, pp. 505-516
Gonil, P., Sajomsang, W., Uracha, R.R., Pimpha, N., Sramala, I., Nuchuchua, O., Novel quaternized chitosan containing β-cyclodextrin moiety: Synthesis, characterization and antimicrobial activity (2011) Carbohydrate Polymers, 83, pp. 905-913
Guan, H., McGuire, M.J., Li, S., Brown, K.C., Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of αvβ6-positive cancers (2008) Bioconjugate Chemistry, 19, pp. 1813-1821
Hu, C.-M.J., Fang, R.H., Luk, B.T., Zhang, L., Polymeric nanotherapeutics: Clinical development and advances in stealth functionalization strategies (2014) Nanoscale, 6, pp. 65-75
Kono, H., Teshirogi, T., Cyclodextrin-grafted chitosan hydrogels for controlled drug delivery (2015) International Journal of Biological Macromolecules, 72, pp. 299-308
Lakkakula, J.R., Krause, R.W.M., A vision for cyclodextrin nanoparticles in drug delivery systems and pharmaceutical applications (2014) Nanomedicine, 9, pp. 877-894
Longworth, L.G., The mutual diffusion of light and heavy water (1960) Journal of Physical Chemistry, 64, pp. 1914-1917
Maeda, H., Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity (2015) Advanced Drug Delivery Reviews, 91, pp. 3-6
Manocha, B., Margaritis, A., Controlled release of doxorubicin from doxorubicin/γ-polyglutamic acid ionic complex (2010) Journal of Nanomaterials, , ID 780171
Matsumoto, K., Kawamura, A., Miyata, T., Conformationally regulated molecular binding and release of molecularly imprinted polypeptide hydrogels that undergo helix-coil transition (2017) Macromolecules, 50, pp. 2136-2144
Monteiro, A.P.F., Caminhas, L.D., Ardisson, J.D., Paniago, R., Cortés, M.E., Sinisterra, R.D., Magnetic nanoparticles coated with cyclodextrins and citrate for irinotecan delivery (2017) Carbohydrate Polymers, 163, pp. 1-9
Nair, L.S., Laurencin, C.T., Biodegradable polymers as biomaterials (2007) Progress in Polymer Science, 32, pp. 762-798
Oliveri, V., Bellia, F., Vecchio, G., Cyclodextrin nanoparticles bearing 8-hydroxyquinoline ligands as multifunctional biomaterials (2017) Chemistry – A European Journal, 23, pp. 4442-4449
Oliveri, V., D'Agata, R., Giglio, V., Spoto, G., Vecchio, G., Cyclodextrin-functionalised gold nanoparticles via streptavidin: A supramolecular approach (2013) Supramolecular Chemistry, 25, pp. 465-473
Oliveri, V., Viale, M., Caron, G., Aiello, C., Gangemi, R., Vecchio, G., Glycosylated copper(II) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapy (2013) Dalton Transactions, 42, pp. 2023-2034
Perdih, P., Čebašek, S., Možir, A., Žagar, E., Post-polymerization modification of poly(L-glutamic acid) with D-(+)-glucosamine (2014) Molecules, 19, pp. 19751-19768
Perez-Herrero, E., Fernández-Medarde, A., Perez-Herrero, E., Fernández-Medarde, A., Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy (2015) European Journal of Pharmaceutics and Biopharmaceutics, 93, pp. 52-79
Pessine, F.B.T.P., Calderini, A., Alexandrino, G.L., Magnetic resonance spectroscopy (2012), InTech
Przybylski, C., Blin, F., Jarroux, N., Toward a more accurate structural determination of high molecular weight polyrotaxanes based on cyclodextrins by MALDI-TOF MS (2011) Macromolecules, 44, pp. 1821-1830
Ruiz-Esparza, G.U., Wu, S., Segura-Ibarra, V., Cara, F.E., Evans, K.W., Milosevic, M., Polymer nanoparticles encased in a cyclodextrin complex shell for potential site- and sequence-specific drug release (2014) Advanced Functional Materials, 24, pp. 4753-4771
Swaminathan, S., Cavalli, R., Trotta, F., Cyclodextrin-based nanosponges: A versatile platform for cancer nanotherapeutics development (2016) WIREs Nanomedicine and Nanobiotechnology, 8, pp. 579-601
Tang, G.P., Guo, H.Y., Alexis, F., Wang, X., Zeng, S., Lim, T.M., Low molecular weight polyethylenimines linked by β-cyclodextrin for gene transfer into the nervous system (2006) Journal of Gene Medicine, 8, pp. 736-744
Teranishi, K., Watanabe, K., Hisamatsu, M., Yamada, Y., Efficient regioselective synthesis of mono-2-O-sulfonyl-cyclodextrins by the combination of sulfonyl imidazole and molecular sieves (1998) Journal of Carbohydrate Chemistry, 17, pp. 489-494
Viale, M., Giglio, V., Monticone, M., Maric, I., Lentini, G., Rocco, M., New doxorubicin nanocarriers based on cyclodextrins (2017) Investigational New Drugs
Yang, S., Feiyan Zhu, F., Qian Wang, Q., Fuxin Liang, F., Xiaozhong Qu, X., Zhihua Gan, Z., Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment (2016) Journal of Materials Chemistry B, 4, pp. 7283-7292
Xiong, Q., Cui, M., Bai, Y., Liu, Y., Liu, D., Song, T., A supramolecular nanoparticle system based on β-cyclodextrin-conjugated poly-L-lysine and hyaluronic acid for co-delivery of gene and chemotherapy agent targeting hepatocellular carcinoma (2017) Colloids Surfaces B: Biointerfaces, 155, pp. 93-103
Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin
Cyclodextrins have been used to encapsulate drugs improving their stability and efficiently regulating their release. Polymeric nanoparticles containing cyclodextrins are currently undergoing clinical trials as nanotherapeutics. In this context, we have synthesized new linear polymers based on polyglutamic acid with pendant β- or γ-cyclodextrins, using a high yield reaction route. The new polymers with an average number of about 17 cyclodextrin cavities were characterized (NMR, MALDI-MS, DLS) and tested as carriers of doxorubicin in human tumor cells. They can include doxorubicin, and the inclusion complexes show antiproliferative activity in human tumor cells. © 2017 Elsevier Ltd
Cyclodextrins have been used to encapsulate drugs improving their stability and efficiently regulating their release. Polymeric nanoparticles containing cyclodextrins are currently undergoing clinical trials as nanotherapeutics. In this context, we have synthesized new linear polymers based on polyglutamic acid with pendant β- or γ-cyclodextrins, using a high yield reaction route. The new polymers with an average number of about 17 cyclodextrin cavities were characterized (NMR, MALDI-MS, DLS) and tested as carriers of doxorubicin in human tumor cells. They can include doxorubicin, and the inclusion complexes show antiproliferative activity in human tumor cells. © 2017 Elsevier Ltd
Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin
| ▼ New synthetic molecules for active targeting of multifunctional theranostic nanosystems |
Linear polymers of beta and gamma cyclodextrins with a polyglutamic acid backbone as carriers for doxorubicin
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Caso JV, Russo L, Palmieri M, Malgieri G, Galdiero S, Falanga A, Isernia C, Iacovino R
* Investigating the inclusion properties of aromatic amino acids complexing beta-cyclodextrins in model peptides (418 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; N/D: N/D-N/D.
Impact Factor: 3.196
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Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (546 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
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Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (649 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (469 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
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Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
View Export to BibTeX Export to EndNote
Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
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Bellia F, La Mendola D, Pedone C, Rizzarelli E, Saviano M, Vecchio G
* Selectively functionalized cyclodextrins and their metal complexes (415 views)
Chem Soc Rev (ISSN: 1460-4744, 0306-0012, 1460-4744electronic), 2009 Sep; 38(9): 2756-2781.
Impact Factor: 20.086
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Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (370 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
View Export to BibTeX Export to EndNote
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (410 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
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Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
View Export to BibTeX Export to EndNote
Impellizzeri G, D'Alessandro F, Pappalardo G, Tringali C
* Synthesis And Structural Characterisation Of Two Novel Diastereoisomeric Naproxen-Appended Beta-Cyclodextrin Derivatives (346 views)
J Incl Phenom (ISSN: 0923-0750), 2005; 51(3-4): 173-180.
Impact Factor: 1.02
View Export to BibTeX Export to EndNote
Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (412 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (459 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M
* The Simultaneous Separation Of Different Enantiomeric Pairs In Capillary Electrophoresis By Mixing Different Hemispherodextrins, A Very Versatile Class Of Receptors (258 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2002 Dec 6; 979(1-2): 137-145.
Impact Factor: 3.098
View Export to BibTeX Export to EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (290 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Erratum: Solid state and solution conformation of 6-{4-[N-tert- butoxycarbonyl-N-(N'-ethyl)propanamide]imidazolyl}-6- deoxycyclomaltoheptaose: Evidence of self-inclusion of the boc group within the β-cyclodextrin cavity (European Journal of Organic Chemistry (2000) (1065-1076)) (447 views)
Eur J Org Chem (ISSN: 1434-193x), 2000; (12): 2345-2345.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Solid state and solution conformation of 6-{4-[N-tert-butoxycarbonyl-N- (N'-ethyl)propanamide]imidazolyl}-6-deoxycyclomaltoheptaose: Evidence of self-inclusion of the Boc group within the β-cyclodextrin cavity (360 views)
European J Org Chem (ISSN: 1434-193x), 2000; (6): 1065-1076.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
View Export to BibTeX Export to EndNote
Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (426 views)
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Di Blasio B, Galdiero S, Saviano M, De Simone G, Benedetti E, Pedone C, Gibbons WA, Deschenaux R, Rizzarelli E, Vecchio G
Functionalized cyclodextrins: Synthesis and structural characterization of 6-deoxy-6-{4-[N-tert-butoxycarbonyl-2-aminoethyl]-imidazolyl}-cyclomaltoheptaose (326 views)
Supramol Chem (ISSN: 1061-0278), 1996; 7(1): 47-54.
Impact Factor: 3.19
View Export to BibTeX Export to EndNote
Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Rossi F, Zaccaro L, Di Blasio B, Pavone V, Maglio O, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
beta-Cyclodextrins as potent bioactive delivery system (435 views)
Peptides, 1992; N/D: 577-578.
Impact Factor: 0
View Export to BibTeX Export to EndNote
* Gold-Speckled SPION@SiO(2) Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications (93 views)
Chemistry (ISSN: 0947-6539linking, 1521-3765electronic), 2020 Aug 26; 26(48): 11048-11059.
Impact Factor: 4.857
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Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (362 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
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Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (616 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
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Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
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Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (328 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
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Giglio V, Bellia F, Oliveri V, Vecchio G
* Aminocyclodextrin Oligomers as Protective Agents of Protein Aggregation (450 views)
Chempluschem, 2016; 81(7): 660-665.
Impact Factor: 0
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Lanza V, D'Agata R, Iacono G, Bellia F, Spoto G, Vecchio G
* Cyclam glycoconjugates as lectin ligands and protective agents of metal-induced amyloid aggregation (517 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2015; 153: 377-382.
Impact Factor: 3.205
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Caso JV, Russo L, Palmieri M, Malgieri G, Galdiero S, Falanga A, Isernia C, Iacovino R
* Investigating the inclusion properties of aromatic amino acids complexing beta-cyclodextrins in model peptides (418 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2015; N/D: N/D-N/D.
Impact Factor: 3.196
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Pietropaolo A, Vecchio G
* Unusual Cyclodextrin Derivatives as a New Avenue to Modulate Self- and Metal-Induced Aβ Aggregation (546 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2015; 21(40): 14047-14059.
Impact Factor: 5.771
View Export to BibTeX Export to EndNote
Oliveri V, Attanasio F, Puglisi A, Spencer J, Sgarlata C, Vecchio G
* Multifunctional 8-hydroxyquinoline-appended cyclodextrins as new inhibitors of metal-induced protein aggregation (649 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2014 Jul 14; 20(29): 8954-8964.
Impact Factor: 5.731
View Export to BibTeX Export to EndNote
Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Riccio A, Cubellis MV
* Gain of function in CDKN1C (503 views)
Nature Genetics (ISSN: 1061-4036), 2012 Jul; 44(7): 737-738.
Impact Factor: 35.209
View Export to BibTeX Export to EndNote
Grasso GI, Arena G, Bellia F, Maccarrone G, Parrinello M, Pietropaolo A, Vecchio G, Rizzarelli E
* Intramolecular weak interactions in the thermodynamic stereoselectivity of copper(II) complexes with carnosine-trehalose conjugates (469 views)
Chemistry (ISSN: 1521-3765, 0947-6539, 1521-3765electronic), 2011 Sep 16; 17(34): 9448-9455.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, MacCarrone G, Mazzaglia A, Messina M, Vecchio G
* Diaminotrehalose-capped β-cyclodextrin, a new member of hemispherodextrins: Synthesis, thermodynamic and spectroscopic characterization and its exploitation in chiral electrokinetic chromatography (400 views)
J Sep Sci (ISSN: 1615-9306), 2011 Jan; 34(1): 70-76.
Impact Factor: 2.733
View Export to BibTeX Export to EndNote
Puglisi A, Rizzarelli E, Vecchio G, Iacovino R, Benedetti E, Pedone C, Saviano M
* Crystal And Molecular Structure Of Beta-Cyclodextrins Functionalized With The Anti-Inflammatory Drug Etodolac (416 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2009 Dec; 91(12): 1227-1235.
Impact Factor: 2.605
View Export to BibTeX Export to EndNote
Bellia F, La Mendola D, Pedone C, Rizzarelli E, Saviano M, Vecchio G
* Selectively functionalized cyclodextrins and their metal complexes (415 views)
Chem Soc Rev (ISSN: 1460-4744, 0306-0012, 1460-4744electronic), 2009 Sep; 38(9): 2756-2781.
Impact Factor: 20.086
View Export to BibTeX Export to EndNote
Amorini AM, Bellia F, Di Pietro V, Giardina B, La Mendola D, Lazzarino G, Sortino S, Tavazzi B, Rizzarelli E, Vecchio G
* Synthesis And Antioxidant Activity Of New Homocarnosine Beta-Cyclodextrin Conjugates (370 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 1768-3254electronic), 2007 Jul; 42(7): 910-920.
Impact Factor: 2.301
View Export to BibTeX Export to EndNote
Di Fiore A, Scozzafava A, Winum JY, Montero JL, Pedone C, Supuran CT, De Simone G
* Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties (410 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2007 Mar 15; 17(6): 1726-1731.
Impact Factor: 2.604
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M, Vecchio G
* High selectivity in new chiral separations of dansyl amino acids by cyclodextrin derivatives in electrokinetic chromatography (290 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2007; 1155(2): 172-179.
Impact Factor: 3.641
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Maccarrone G, Messina M, Puglisi A, Rizzarelli E, Vecchio G
* Coordination properties of 3-functionalized β-cyclodextrins. Thermodynamic stereoselectivity of copper(II) complexes of the A, B-diamino derivative and its exploitation in LECE (356 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9234electronic), 2005 Sep 21; (16): 2731-2736.
Impact Factor: 3.003
View Export to BibTeX Export to EndNote
Impellizzeri G, D'Alessandro F, Pappalardo G, Tringali C
* Synthesis And Structural Characterisation Of Two Novel Diastereoisomeric Naproxen-Appended Beta-Cyclodextrin Derivatives (346 views)
J Incl Phenom (ISSN: 0923-0750), 2005; 51(3-4): 173-180.
Impact Factor: 1.02
View Export to BibTeX Export to EndNote
Puglisi A, Tabbì G, Vecchio G
* Bioconjugates of cyclodextrins of manganese salen-type ligand with superoxide dismutase activity (412 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2004 Jun; 98(6): 969-976.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, La Mendola D, Maccarrone G, Puglisi A, Rizzarelli E, Vecchio G
* 3-Amino Derivative Of Beta-Cyclodextrin: Thermodynamics Of Copper (ii) Complexes And Exploitation Of Its Enantioselectivity In The Separation Of Amino Acid Racemates By Ligand Exchange Capillary Electrophoresis (350 views)
And Life Sciencesjournal Of Chromatography B Analytical Technologies In The Biomedical, 2004 Feb 5; 800(1-2): 127-133.
Impact Factor: 1.403
View Export to BibTeX Export to EndNote
Mineo P, Vitalini D, La Mendola D, Rizzarelli E, Scamporrino E, Vecchio G
* Coordination Features Of Difunctionalized Beta-Cyclodextrins With Carnosine: Esi-Ms And Spectroscopic Investigations On 6a, 6d-Di-(beta-Alanyl-L-Histidine)-6a, 6d-Dideoxy-Beta-Cyclodextrin And 6a, 6c-Di-(beta-Alanyl-L-Histidine)-6a, 6c-Dideoxy-Beta-Cyclodextrin And Their Copper (ii) Complexes (459 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2004 Feb; 98(2): 254-265.
Impact Factor: 2.225
View Export to BibTeX Export to EndNote
Cucinotta V, Giuffrida A, Grasso G, Maccarrone G, Messina M
* The Simultaneous Separation Of Different Enantiomeric Pairs In Capillary Electrophoresis By Mixing Different Hemispherodextrins, A Very Versatile Class Of Receptors (258 views)
J Chromatogr A (ISSN: 0021-9673, 0021-9673linking), 2002 Dec 6; 979(1-2): 137-145.
Impact Factor: 3.098
View Export to BibTeX Export to EndNote
Vecchio G, La Mendola D, Rizzarelli E, Sortino S
* SOD-like activity of copper(II) complexes of beta-cyclodextrins functionalized with carnosine (290 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Sep; 86(1): N/D-N/D.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Erratum: Solid state and solution conformation of 6-{4-[N-tert- butoxycarbonyl-N-(N'-ethyl)propanamide]imidazolyl}-6- deoxycyclomaltoheptaose: Evidence of self-inclusion of the boc group within the β-cyclodextrin cavity (European Journal of Organic Chemistry (2000) (1065-1076)) (447 views)
Eur J Org Chem (ISSN: 1434-193x), 2000; (12): 2345-2345.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
Impellizzeri G, Pappalardo G, D'Alessandro F, Rizzarelli E, Saviano M, Iacovino R, Benedetti E, Pedone C
Solid state and solution conformation of 6-{4-[N-tert-butoxycarbonyl-N- (N'-ethyl)propanamide]imidazolyl}-6-deoxycyclomaltoheptaose: Evidence of self-inclusion of the Boc group within the β-cyclodextrin cavity (360 views)
European J Org Chem (ISSN: 1434-193x), 2000; (6): 1065-1076.
Impact Factor: 2.15
View Export to BibTeX Export to EndNote
Bonomo RP, Cucinotta V, D'Alessandro F, Impellizzeri G, Maccarrone G, Rizzarelli E, Vecchio G, Carima L, Corradini R, Sartor G, Marchelli R
Chiral recognition by the copper(ii) complex of 6-deoxy-6-n-(2 - methylaminopyridine)-β-cyclodextrin (378 views)
Chirality (ISSN: 0899-0042), 1997; 9(4): 341-349.
Impact Factor: 1.915
View Export to BibTeX Export to EndNote
Di Blasio B, Galdiero S, Saviano M, Pedone C, Benedetti E, Rizzarelli E, Pedotti S, Vecchio G, Gibbons WA
Synthesis And Structural Characterization Of 6i, 6ii-Diamino-6i, 6ii-Dideoxy-Cyclomaltoheptaose, A Difunctionalized Beta-Cyclodextrin (426 views)
Carbohydr Res, 1996 Feb 28; 282(1): 41-52.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Di Blasio B, Galdiero S, Saviano M, De Simone G, Benedetti E, Pedone C, Gibbons WA, Deschenaux R, Rizzarelli E, Vecchio G
Functionalized cyclodextrins: Synthesis and structural characterization of 6-deoxy-6-{4-[N-tert-butoxycarbonyl-2-aminoethyl]-imidazolyl}-cyclomaltoheptaose (326 views)
Supramol Chem (ISSN: 1061-0278), 1996; 7(1): 47-54.
Impact Factor: 3.19
View Export to BibTeX Export to EndNote
Cucinotta V, Mangano A, Nobile G, Santoro AM, Vecchio G
New platinum(II) complexes of β-cyclodextrin diamine derivatives and their antitumor activity (468 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1993 Nov 15; 52(3): 183-190.
Impact Factor: 1.342
View Export to BibTeX Export to EndNote
Rossi F, Zaccaro L, Di Blasio B, Pavone V, Maglio O, Saviano M, Pedone C, Cucinotta V, Impellizzeri G, Rizzarelli E, Vecchio G
beta-Cyclodextrins as potent bioactive delivery system (435 views)
Peptides, 1992; N/D: 577-578.
Impact Factor: 0
View Export to BibTeX Export to EndNote
33 Records (31 excluding Abstracts).
Total impact factor: 144.717 (140.838 excluding Abstracts).
Total 5 year impact factor: 152.499 (146.046 excluding Abstracts).
Total impact factor: 144.717 (140.838 excluding Abstracts).
Total 5 year impact factor: 152.499 (146.046 excluding Abstracts).
464 views. Last view on Monday 13 February 2023, 8:47:19
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