Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers (608 views)
Cancer Biomark (ISSN: 1574-0153, 1574-0153linking), 2017 Dec 15; 21(3): 603-612.
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Paper type: Journal Article, Multicenter Study,
Impact factor: 2.392, 5-year impact factor: 2.141
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043601501&doi=10.3233%2fCBM-170551&partnerID=40&md5=cfea6db176257fb5a5431d8e42b687e4
Keywords: Alpha-Fetoprotein, Chronic Liver Disease, Protein Induced By Vitamin K Absence, Antagonist-Ii, Adult, 80 And Over, Biomarkers Blood, Tumor, Carcinoma, Hepatocellular Blood Diagnosis Epidemiology Etiology, Chronic Disease, Female, Humans, Immunoenzyme Techniques, Italy Epidemiology, Liver Diseases Complications Epidemiology Etiology, Liver Neoplasms Blood Diagnosis Epidemiology Etiology, Middle Aged, Population Surveillance, Protein Precursors Blood, Prothrombin, Roc Curve, Protein Induced By Vitamin K Absence Antagonist-Ii, Alanine Aminotransferase, Alpha Fetoprotein, Decarboxyprothrombin, Biological Marker, Tumor Marker, Article, Chemoluminescence, Diagnostic Accuracy, Enzyme Immunoassay, Liver Cell Carcinoma, Liver Cirrhosis, Major Clinical Study, Predictive Value, Priority Journal, Protein Blood Level, Retrospective Study, Sensitivity And Specificity, Tumor Volume, Clinical Trial, Health Survey, Liver Tumor, Multicenter Study, Receiver Operating Characteristic, Very Elderly,
Affiliations:
*** IBB - CNR ***
Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Centre of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, 56124 Pisa, Italy., Department of Medicine, University of Padua, 35121 Padua, Italy., Department of Medical Sciences, Citta della Salute e della Scienza Hospital, University of Turin, 10126 Turin, Italy., Institute of Biostructure and Bioimaging, National Research Council, 80145 Naples, Italy., Institute for Health, Medical Center, University of Pittsburgh, 53042 Chianciano Terme, Siena, Italy., Fondazione Italiana Fegato, Science Park Campus Basovizza, 34149 Trieste, Italy., Internal Medicine, Department of Clinical and Experimental Medicine, University of Pisa, 56127 Pisa, Italy.,
Hepatology Unit, Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Centre of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, Via Paradisa 2, Pisa, 56124, Italy
References:
Bosch, F.X., Ribes, J., Dìaz, M., Cléries, R., Primary liver cancer worldwide incidence and trends (2004) Gastroenterology, 127, pp. S5-S1
El-Serag, H.B., Epidemiology of viral hepatitis and hepatocellular carcinoma (2012) Gastroenterology, 142 (6), pp. 1264-1273
Stroffolini, T., Trevisani, F., Pinzello, G., Brunello, F., Tommasini, M.A., Iavarone, M., Di Marco, V., Gaeta, G.B., Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance (2011) Dig Liver Dis, 43 (11), pp. 875-880
Bruix, J., Sherman, M., American association for the study of liver diseases (2011) Management of Hepatocellular Carcinoma: An Update, Hepatology, 53 (3), pp. 1020-1022
Singal, A., Volk, M.L., Waljee, A., Salgia, R., Higgins, P., Rogers, M.A., Marrero, J.A., Meta-analysis: Surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis (2009) Aliment Pharmacol Ther, 30, pp. 30-47
European association for the study of the liver
European organisation for research and treatment of cancer. Easleortc clinical practice guidelines: Management of hepatocellular carcinoma (2012) J Hepatol, 56, pp. 908-943
Song, P., Tobe, R.G., Inagaki, Y., Kokudo, N., Hasegawa, K., Sugawara, Y., Tang, W., The management of hepatocellular carcinoma around the world: A comparison of guidelines from 2001 to 2011 (2012) Liver Int, 32, pp. 1053-1063
Lok, A.S., Sterling, R.K., Everhart, J.E., Wright, E.C., Hoefs, J.C., Di Bisceglie, A.M., Morgan, T.R., Dienstag, J.L., HALT-C Trial Group Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma (2010) Gastroenterology, 138, pp. 493-502
Huo, T.I., Hsia, C.Y., Chu, C.J., Huang, Y.H., Lui, W.Y., Wu, J.C., Lee, P.C., Lee, S.D., The predictive ability of serum alpha-fetoprotein for hepatocellular carcinoma is linked with the characteristics of the target population at surveillance (2007) Journal of Surgical Oncology, 95, pp. 645-651
Gopal, P., Yopp, A.C., Waljee, A.K., Chiang, J., Nehra, M., Kandunoori, P., Singal, A.G., Factors that affect accuracy of a-Fetoprotein Test in Detection of Hepatocellular Carcinoma in Patients with Cirrhosis (2014) Clin Gastroenterol Hepatol, 12 (5), pp. 870-877
Liebman, H.A., Furie, B.C., Tong, M.J., Blanchard, R.A., Lo, K.J., Lee, S.D., Coleman, M.S., Furie, B., Des-gammacarboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma (1984) N Engl J Med, 310, pp. 1427-1431
Tamano, M., Sugaya, H., Oguma, M., Iijima, M., Yoneda, M., Murohisa, T., Kojima, K., Terano, A., Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma (2002) Hepatol. Res, 22, pp. 261-269
Fujikawa, T., Shirara, H., Ueda, N., Takaoka, N., Nakanishi, Y., Matsuo, N., Tanaka, S., Shiratori, Y., Des-gamma-carboxyl prothromobin-promoted Vascular Endothelial Cell Proliferation and Migration (2007) J Biol Chem, 282, pp. 8741-8748
Marrero, J.A., Feng, Z., Wang, Y., Nguyen, M.H., Befeler, A.S., Roberts, L.R., Reddy, K.R., Schwartz, M., Alpha-fetoprotein des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma (2009) Gastroenterology, 137 (1), pp. 110-118
Kudo, M., Matsui, O., Izumi, N., Iijima, H., Kadoya, M., Imai, Y., Okusaka, T., Yamakado, K., Liver cancer study group of Japan jsh consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 update by the liver cancer study group of Japan (2014) Liver Cancer, 3 (3-4), pp. 458-468
Zhu, R.X., Seto, W.K., Lai, C.L., Yuen, M.F., Epidemiology of hepatocellular carcinoma in the Asia-pacific region (2016) Gut Liver, 10 (3), pp. 332-339
Chen, L.P., Zhao, J., Du, Y., Han, Y.F., Su, T., Zhang, H.W., Cao, G.W., Antiviral treatment to prevent chronic hepatitis B or C-related hepatocellular carcinoma (2012) World J Virol, 1 (6), pp. 174-183
El-Serag, H.B., Kanwal, F., Richardson, P., Kramer, J., Risk of hepatocellular carcinoma after sustained virologic response in Veterans with hepatitis C virus infection (2016) Hepatology, 64 (1), pp. 130-137
Wirth, T.C., Manns, M.P., The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma (2016) Ann Oncol, 27 (8), pp. 1467-1474
Llovet, J.M., Brú, C., Bruix, J., Prognosis of hepatocellular carcinoma: The BCLC staging classification (1999) Semin Liver Dis, 19 (3), pp. 329-338
Volk, M.L., Hernandez, J.C., Su, G.L., Lok, A.S., Marrero, J.A., Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: A comparison of AFP (2007) DCP, and AFP-L3, Cancer Biomarkers, 3, pp. 79-87
Lim, T.S., Kim, D.Y., Han, K.H., Kim, H.S., Shin, S.H., Jung, K.S., Kim, B.K., Ahn, S.H., Combined use of AFP PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients (2016) Scand J Gastroenterol, 51 (3), pp. 344-353
Seo, S.I., Kim, H.S., Kim, W.J., Shin, W.G., Kim, D.J., Kim, K.H., Jang, M.K., Park, C.K., Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma (2015) World J Gastroenterol, 21 (13), pp. 3928-3935
Viggiani, V., Palombi, S., Gennarini, G., D'Ettorre, G., De Vito, C., Angeloni, A., Frati, L., Anastasi, E., Protein Induced by Vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients (2016) Scand J Gastroenterol, 51 (10), pp. 1257-1262
Kuhlmann, W.D., Peschke, P., Hepatic progenitor cells stem cells, and AFP expression in models of liver injury (2006) Int J Exp Pathol, 87 (5), pp. 343-359
Uehara, S., Gotoh, K., Handa, H., Honjo, K., Hirayama, A., Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin (1999) Clin Chim Acta, 289, pp. 33-44
Matsubara, M., Shiraha, H., Kataoka, J., Iwamuro, M., Horiguchi, S., Nishina, S., Takaoka, N., Yamamoto, K., Desgamma-carboxyl prothrombin is associated with tumor angiogensis in hepatocellular carcinoma (2012) J Gastroenterol Hepatol, 27 (10), pp. 1602-1608
Jang, E.S., Jeong, S.H., Kim, J.W., Choi, Y.S., Leissner, P., Brechot, C., Diagnostic performance of alpha-fetoprotein protein induced by Vitamin K absence, osteopontin, dickkopf-1 and its combinations for hepatocellular carcinoma (2016) PloS ONE, 11 (3), p. e0151069
Li, C., Zhang, Z., Zhang, P., Liu, J., Diagnostic accuracy of des-gamma-carboxy prothrombin versus alpha-fetoprotein for hepatocellular carcinoma: A systematic review (2014) Hepatol Res, 44 (10), pp. E11-25
Caviglia, G.P., Abate, M.L., Petrini, E., Gaia, S., Rizzetto, M., Smedile, A., Highly sensitive alpha-fetoprotein Lens culinaris agglutinin-reactive fraction fo alpha-fetoprotein and desgamma-carboxyprothrombin for hepatocellular carcinoma detection (2016) Hepatol Res, 46 (3), pp. E130-E135
Kim, G.A., Seock, C.H., Park, J.W., An, J., Lee, K.S., Yang, J.E., Lim, Y.S., Lee, H.C., Reappraisal of serum alpha-fetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment (2015) Liver Int, 35 (1), pp. 232-239
Cancer Biomark (ISSN: 1574-0153, 1574-0153linking), 2017 Dec 15; 21(3): 603-612.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Multicenter Study,
Impact factor: 2.392, 5-year impact factor: 2.141
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043601501&doi=10.3233%2fCBM-170551&partnerID=40&md5=cfea6db176257fb5a5431d8e42b687e4
Keywords: Alpha-Fetoprotein, Chronic Liver Disease, Protein Induced By Vitamin K Absence, Antagonist-Ii, Adult, 80 And Over, Biomarkers Blood, Tumor, Carcinoma, Hepatocellular Blood Diagnosis Epidemiology Etiology, Chronic Disease, Female, Humans, Immunoenzyme Techniques, Italy Epidemiology, Liver Diseases Complications Epidemiology Etiology, Liver Neoplasms Blood Diagnosis Epidemiology Etiology, Middle Aged, Population Surveillance, Protein Precursors Blood, Prothrombin, Roc Curve, Protein Induced By Vitamin K Absence Antagonist-Ii, Alanine Aminotransferase, Alpha Fetoprotein, Decarboxyprothrombin, Biological Marker, Tumor Marker, Article, Chemoluminescence, Diagnostic Accuracy, Enzyme Immunoassay, Liver Cell Carcinoma, Liver Cirrhosis, Major Clinical Study, Predictive Value, Priority Journal, Protein Blood Level, Retrospective Study, Sensitivity And Specificity, Tumor Volume, Clinical Trial, Health Survey, Liver Tumor, Multicenter Study, Receiver Operating Characteristic, Very Elderly,
Affiliations:
*** IBB - CNR ***
Hepatology Unit and Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Centre of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, 56124 Pisa, Italy., Department of Medicine, University of Padua, 35121 Padua, Italy., Department of Medical Sciences, Citta della Salute e della Scienza Hospital, University of Turin, 10126 Turin, Italy., Institute of Biostructure and Bioimaging, National Research Council, 80145 Naples, Italy., Institute for Health, Medical Center, University of Pittsburgh, 53042 Chianciano Terme, Siena, Italy., Fondazione Italiana Fegato, Science Park Campus Basovizza, 34149 Trieste, Italy., Internal Medicine, Department of Clinical and Experimental Medicine, University of Pisa, 56127 Pisa, Italy.,
Hepatology Unit, Laboratory of Molecular Genetics and Pathology of Hepatitis Viruses, Reference Centre of the Tuscany Region for Chronic Liver Disease and Cancer, University Hospital of Pisa, Via Paradisa 2, Pisa, 56124, Italy
References:
Bosch, F.X., Ribes, J., Dìaz, M., Cléries, R., Primary liver cancer worldwide incidence and trends (2004) Gastroenterology, 127, pp. S5-S1
El-Serag, H.B., Epidemiology of viral hepatitis and hepatocellular carcinoma (2012) Gastroenterology, 142 (6), pp. 1264-1273
Stroffolini, T., Trevisani, F., Pinzello, G., Brunello, F., Tommasini, M.A., Iavarone, M., Di Marco, V., Gaeta, G.B., Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance (2011) Dig Liver Dis, 43 (11), pp. 875-880
Bruix, J., Sherman, M., American association for the study of liver diseases (2011) Management of Hepatocellular Carcinoma: An Update, Hepatology, 53 (3), pp. 1020-1022
Singal, A., Volk, M.L., Waljee, A., Salgia, R., Higgins, P., Rogers, M.A., Marrero, J.A., Meta-analysis: Surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis (2009) Aliment Pharmacol Ther, 30, pp. 30-47
European association for the study of the liver
European organisation for research and treatment of cancer. Easleortc clinical practice guidelines: Management of hepatocellular carcinoma (2012) J Hepatol, 56, pp. 908-943
Song, P., Tobe, R.G., Inagaki, Y., Kokudo, N., Hasegawa, K., Sugawara, Y., Tang, W., The management of hepatocellular carcinoma around the world: A comparison of guidelines from 2001 to 2011 (2012) Liver Int, 32, pp. 1053-1063
Lok, A.S., Sterling, R.K., Everhart, J.E., Wright, E.C., Hoefs, J.C., Di Bisceglie, A.M., Morgan, T.R., Dienstag, J.L., HALT-C Trial Group Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma (2010) Gastroenterology, 138, pp. 493-502
Huo, T.I., Hsia, C.Y., Chu, C.J., Huang, Y.H., Lui, W.Y., Wu, J.C., Lee, P.C., Lee, S.D., The predictive ability of serum alpha-fetoprotein for hepatocellular carcinoma is linked with the characteristics of the target population at surveillance (2007) Journal of Surgical Oncology, 95, pp. 645-651
Gopal, P., Yopp, A.C., Waljee, A.K., Chiang, J., Nehra, M., Kandunoori, P., Singal, A.G., Factors that affect accuracy of a-Fetoprotein Test in Detection of Hepatocellular Carcinoma in Patients with Cirrhosis (2014) Clin Gastroenterol Hepatol, 12 (5), pp. 870-877
Liebman, H.A., Furie, B.C., Tong, M.J., Blanchard, R.A., Lo, K.J., Lee, S.D., Coleman, M.S., Furie, B., Des-gammacarboxy (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma (1984) N Engl J Med, 310, pp. 1427-1431
Tamano, M., Sugaya, H., Oguma, M., Iijima, M., Yoneda, M., Murohisa, T., Kojima, K., Terano, A., Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma (2002) Hepatol. Res, 22, pp. 261-269
Fujikawa, T., Shirara, H., Ueda, N., Takaoka, N., Nakanishi, Y., Matsuo, N., Tanaka, S., Shiratori, Y., Des-gamma-carboxyl prothromobin-promoted Vascular Endothelial Cell Proliferation and Migration (2007) J Biol Chem, 282, pp. 8741-8748
Marrero, J.A., Feng, Z., Wang, Y., Nguyen, M.H., Befeler, A.S., Roberts, L.R., Reddy, K.R., Schwartz, M., Alpha-fetoprotein des-gamma carboxyprothrombin, and lectin-bound alpha-fetoprotein in early hepatocellular carcinoma (2009) Gastroenterology, 137 (1), pp. 110-118
Kudo, M., Matsui, O., Izumi, N., Iijima, H., Kadoya, M., Imai, Y., Okusaka, T., Yamakado, K., Liver cancer study group of Japan jsh consensus-based clinical practice guidelines for the management of hepatocellular carcinoma: 2014 update by the liver cancer study group of Japan (2014) Liver Cancer, 3 (3-4), pp. 458-468
Zhu, R.X., Seto, W.K., Lai, C.L., Yuen, M.F., Epidemiology of hepatocellular carcinoma in the Asia-pacific region (2016) Gut Liver, 10 (3), pp. 332-339
Chen, L.P., Zhao, J., Du, Y., Han, Y.F., Su, T., Zhang, H.W., Cao, G.W., Antiviral treatment to prevent chronic hepatitis B or C-related hepatocellular carcinoma (2012) World J Virol, 1 (6), pp. 174-183
El-Serag, H.B., Kanwal, F., Richardson, P., Kramer, J., Risk of hepatocellular carcinoma after sustained virologic response in Veterans with hepatitis C virus infection (2016) Hepatology, 64 (1), pp. 130-137
Wirth, T.C., Manns, M.P., The impact of the revolution in hepatitis C treatment on hepatocellular carcinoma (2016) Ann Oncol, 27 (8), pp. 1467-1474
Llovet, J.M., Brú, C., Bruix, J., Prognosis of hepatocellular carcinoma: The BCLC staging classification (1999) Semin Liver Dis, 19 (3), pp. 329-338
Volk, M.L., Hernandez, J.C., Su, G.L., Lok, A.S., Marrero, J.A., Risk factors for hepatocellular carcinoma may impair the performance of biomarkers: A comparison of AFP (2007) DCP, and AFP-L3, Cancer Biomarkers, 3, pp. 79-87
Lim, T.S., Kim, D.Y., Han, K.H., Kim, H.S., Shin, S.H., Jung, K.S., Kim, B.K., Ahn, S.H., Combined use of AFP PIVKA-II, and AFP-L3 as tumor markers enhances diagnostic accuracy for hepatocellular carcinoma in cirrhotic patients (2016) Scand J Gastroenterol, 51 (3), pp. 344-353
Seo, S.I., Kim, H.S., Kim, W.J., Shin, W.G., Kim, D.J., Kim, K.H., Jang, M.K., Park, C.K., Diagnostic value of PIVKA-II and alpha-fetoprotein in hepatitis B virus-associated hepatocellular carcinoma (2015) World J Gastroenterol, 21 (13), pp. 3928-3935
Viggiani, V., Palombi, S., Gennarini, G., D'Ettorre, G., De Vito, C., Angeloni, A., Frati, L., Anastasi, E., Protein Induced by Vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients (2016) Scand J Gastroenterol, 51 (10), pp. 1257-1262
Kuhlmann, W.D., Peschke, P., Hepatic progenitor cells stem cells, and AFP expression in models of liver injury (2006) Int J Exp Pathol, 87 (5), pp. 343-359
Uehara, S., Gotoh, K., Handa, H., Honjo, K., Hirayama, A., Process of carboxylation of glutamic acid residues in the gla domain of human des-gamma-carboxyprothrombin (1999) Clin Chim Acta, 289, pp. 33-44
Matsubara, M., Shiraha, H., Kataoka, J., Iwamuro, M., Horiguchi, S., Nishina, S., Takaoka, N., Yamamoto, K., Desgamma-carboxyl prothrombin is associated with tumor angiogensis in hepatocellular carcinoma (2012) J Gastroenterol Hepatol, 27 (10), pp. 1602-1608
Jang, E.S., Jeong, S.H., Kim, J.W., Choi, Y.S., Leissner, P., Brechot, C., Diagnostic performance of alpha-fetoprotein protein induced by Vitamin K absence, osteopontin, dickkopf-1 and its combinations for hepatocellular carcinoma (2016) PloS ONE, 11 (3), p. e0151069
Li, C., Zhang, Z., Zhang, P., Liu, J., Diagnostic accuracy of des-gamma-carboxy prothrombin versus alpha-fetoprotein for hepatocellular carcinoma: A systematic review (2014) Hepatol Res, 44 (10), pp. E11-25
Caviglia, G.P., Abate, M.L., Petrini, E., Gaia, S., Rizzetto, M., Smedile, A., Highly sensitive alpha-fetoprotein Lens culinaris agglutinin-reactive fraction fo alpha-fetoprotein and desgamma-carboxyprothrombin for hepatocellular carcinoma detection (2016) Hepatol Res, 46 (3), pp. E130-E135
Kim, G.A., Seock, C.H., Park, J.W., An, J., Lee, K.S., Yang, J.E., Lim, Y.S., Lee, H.C., Reappraisal of serum alpha-fetoprotein as a surveillance test for hepatocellular carcinoma during entecavir treatment (2015) Liver Int, 35 (1), pp. 232-239
Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers
BACKGROUND: The role of serum biomarkers in the surveillance of hepatocellular carcinoma (HCC) is controversial. OBJECTIVE: We assessed the diagnostic performances of alpha-fetoprotein (AFP) and protein-induced by vitamin-K-absence/antagonist-II (PIVKA-II) in 388 cirrhotic patients with chronic liver disease (CLD). METHODS: Biomarkers were quantified by automated chemiluminescent-enzyme-immunoassays (Fujirebio, Tokyo, Japan) at HCC diagnosis in 258 patients (204 males; median age 66.9 years) and in 130 cirrhotics without HCC (104 males; median-age 60.6 years). CLD etiology in HCC/non-HCC was CHB in 48/35, CHC in 126/56 and Non-Viral in 84/39. RESULTS: Overall AUROC values for AFP and PIVKA-II were 0.698 (95%CI = 0.642-0.753, P< 0.001) and 0.780 (95%CI = 0.730-0.831, P< 0.001). AFP/PIVKA-II AUROC (95%CI) were: 0.822 (0.728-0.915)/0.833 (0.739-0.926) in CHB, 0.648 (0.560-0.736)/0.732 (0.650-0.814) in CHC; 0.640 (0.540-0.740)/0.806 (0.722-0.889) in Non-Viral-CLD. AFP/PIVKA-II diagnostic accuracy was 40.5-59.8%/62.7-73.5% and combining both markers 78.2% for CHB, 77% for Non-Viral-CLD and 75% for CHC. AFP correlated with ALT in HCC patients with CHC (= 0.463/P< 0.001) and Non-Viral CLD (= 0.359/P= 0.047), but not in CHB (treated with antivirals). PIVKA-II correlated with tumour size independently of CLD-etiology (P< 0.001) and AFP in CHB patients only (P= 0.007). CONCLUSION: The diagnostic performance of AFP and PIVKA-II is significantly influenced by the etiology and activity of CLD; their combination provides a better diagnostic accuracy. © 2018 - IOS Press and the authors. All rights reserved.
BACKGROUND: The role of serum biomarkers in the surveillance of hepatocellular carcinoma (HCC) is controversial. OBJECTIVE: We assessed the diagnostic performances of alpha-fetoprotein (AFP) and protein-induced by vitamin-K-absence/antagonist-II (PIVKA-II) in 388 cirrhotic patients with chronic liver disease (CLD). METHODS: Biomarkers were quantified by automated chemiluminescent-enzyme-immunoassays (Fujirebio, Tokyo, Japan) at HCC diagnosis in 258 patients (204 males; median age 66.9 years) and in 130 cirrhotics without HCC (104 males; median-age 60.6 years). CLD etiology in HCC/non-HCC was CHB in 48/35, CHC in 126/56 and Non-Viral in 84/39. RESULTS: Overall AUROC values for AFP and PIVKA-II were 0.698 (95%CI = 0.642-0.753, P< 0.001) and 0.780 (95%CI = 0.730-0.831, P< 0.001). AFP/PIVKA-II AUROC (95%CI) were: 0.822 (0.728-0.915)/0.833 (0.739-0.926) in CHB, 0.648 (0.560-0.736)/0.732 (0.650-0.814) in CHC; 0.640 (0.540-0.740)/0.806 (0.722-0.889) in Non-Viral-CLD. AFP/PIVKA-II diagnostic accuracy was 40.5-59.8%/62.7-73.5% and combining both markers 78.2% for CHB, 77% for Non-Viral-CLD and 75% for CHC. AFP correlated with ALT in HCC patients with CHC (= 0.463/P< 0.001) and Non-Viral CLD (= 0.359/P= 0.047), but not in CHB (treated with antivirals). PIVKA-II correlated with tumour size independently of CLD-etiology (P< 0.001) and AFP in CHB patients only (P= 0.007). CONCLUSION: The diagnostic performance of AFP and PIVKA-II is significantly influenced by the etiology and activity of CLD; their combination provides a better diagnostic accuracy. © 2018 - IOS Press and the authors. All rights reserved.
Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers
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Impact of etiology of chronic liver disease on hepatocellular carcinoma biomarkers
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Impact Factor: 3.016
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De Luca S, Fonti R, Camera L, Salvatore B, Faggiano A, Ciarmiello A, Segreto S, Colao A, Salvatore M, Del Vecchio S
* Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma (334 views)
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Impact Factor: 1.396
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Camera L, Romano F, Liccardo I, Liuzzi R, Imbriaco M, Mainenti PP, Pizzuti LM, Segreto S, Maurea S, Brunetti A
* Balancing Radiation and Contrast Media Dose in Single-Pass Abdominal Multidetector CT: Prospective Evaluation of Image Quality (380 views)
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Impact Factor: 1.966
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
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N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Loewe C, Arnaiz J, Krause D, Marti-bonmati L, Haneder S, Kramer U, Dalia Study Group , Lell M, Lonjedo E, Tartaro A, Aschauer M, Burrel M, Lombardi M, Izzillo R, Mainenti PP, Heautot JF, Leicher-düber A, Krug B, Arteaga C
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Impact Factor: 2.66
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Fonti R, Pace L, Cerchione C, Catalano L, Salvatore B, Pane F, Salvatore M, Del Vecchio S
* 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the prediction of outcome of patients with multiple myeloma: a comparative study (433 views) (PDF 256 views)
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Impact Factor: 4.278
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Cervo A, Cocozza S, Saccà F, Giorgio SM, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M
* The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis (424 views)
Eur J Radiol (ISSN: 0720-048x), 2015 Jan; 84(1): 151-157.
Impact Factor: 2.593
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
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Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
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Impact Factor: 2.526
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Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (397 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (546 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Pedicini P, Strigari L, Benassi M, Caivano R, Fiorentino A, Nappi A, Salvatore M, Storto G
* Critical dose and toxicity index of organs at risk in radiotherapy: analyzing the calculated effects of modified dose fractionation in non-small cell lung cancer (659 views)
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Impact Factor: 0.76
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Federico A, Zappavigna S, Romano M, Grieco P, Luce A, Marra M, Gravina AG, Stiuso P, D'Armiento FP, Vitale G, Tuccillo C, Novellino E, Loguercio C, Caraglia M
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Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2014 Mar; 44(3): 285-294.
Impact Factor: 2.734
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
* Prevalence of extramammary findings on breast MRI: a large retrospective single-centre study (380 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Oct; 118(7): 1109-1118.
Impact Factor: 1.368
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Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (393 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (301 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Gentile I, Coppola N, Pasquale G, Liuzzi R, D'Armiento M, Di Lorenzo ME, Capoluongo N, Buonomo AR, Sagnelli E, Morisco F, Caporaso N, Borgia G
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Hepat Mon (ISSN: 1735-143xprint, 1735-143xlinking), 2013 May 8; 13(5): e8352-e8352.
Impact Factor: 1.796
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Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (344 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
* Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking (441 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (588 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (405 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
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Franchin A, Corradin ML, Giantin V, Rossi F, Zanatta F, Attanasio F, Toffanello ED, Manzato E
* Diabetes in a geriatric ward: Efficacy and safety of new insulin analogs in very old inpatients (292 views)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2012 Jun; 24(SUPPL.3): 17-19.
Impact Factor: 1.006
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (793 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G
* The relationship between cerebral vascular disease and parkinsonism: The VADO study (498 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Impact Factor: 3.274
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Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
* Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations (462 views)
Molecular Imaging And Biology (ISSN: 1860-2002, 1536-1632), 2011 Oct; 13(5): 1029-1035.
Impact Factor: 3.844
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Iavarone A, Lorè E, De Falco C, Milan G, Mosca R, Pappata S, Galeone F, Sorrentino P, Scognamiglio M, Postiglione A
* Dysexecutive performance of healthy oldest old subjects on the Frontal Assessment Battery (353 views)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2011 Oct; 23(5-6): 351-356.
Impact Factor: 1.552
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Durazzo M, Campion D, Fagoonee S, Pellicano R, Sonne JU, Erckenbrecht JF, Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
* Changes, functional disorders, and diseases in the gastrointestinal tract of elderly (165 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking, 1432-1289electronic), 2011 Jul; 2655108(6): 659-668.
Impact Factor: 0.913
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Berti V, Sciagrà R, Acampa W, Ricci F, Cerisano G, Gallicchio R, Vigorito C, Pupi A, Cuocolo A
* Relationship between infarct size and severity measured by gated SPECT and long-term left ventricular remodelling after acute myocardial infarction (548 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Jun; 38(6): 1124-1131.
Impact Factor: 4.991
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Pedone C, Napoli N, Pozzilli P, Rossi FF, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R
* Dietary pattern and bone density changes in elderly women: a longitudinal study (366 views)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2011 Apr; 30(2): 149-154.
Impact Factor: 2.29
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (335 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (370 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Clemente F, Arpaia P, Cimmino P
* A piezo-film-based measurement system for global haemodynamic assessment (378 views)
Physiological Measurement (ISSN: 0967-3334), 2010 May; 31(5): 697-714.
Impact Factor: 1.567
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Perrone-Filardi P, Costanzo P, Dellegrottaglie S, Gargiulo P, Ruggiero D, Savarese G, Parente A, D'Amore C, Cuocolo A, Chiariello M
* Prognostic role of myocardial single photon emission computed tomography in the elderly (544 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2010 Apr; 17(2): 310-315.
Impact Factor: 2.811
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (431 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Messalli G, Palumbo A, Maffei E, Martini C, Seitun S, Aldrovandi A, Imbriaco M, Salvatore M, Weustink A, Mollet N, Cademartiri F
* Assessment of left ventricular volumes with cardiac MRI: Comparison between two semiautomated quantitative software packages (470 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Sep; 114(5): 718-727.
Impact Factor: 1.454
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Fabbricini R, Catalano L, Pace L, Del Vecchio S, Fonti R, Salvatore M, Rotoli B
* Bone scintigraphy and SPECT/CT in bisphosphonate-induced osteonecrosis of the jaw (288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2009 Aug; 50(8): 1385-1385.
Impact Factor: 6.424
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Iaccarino C, Tedeschi E, Rapanà A, Massarelli I, Belfiore G, Quarantelli M, Bellotti A
* Is the distance between mammillary bodies predictive of a thickened third ventricle floor? (328 views)
J Neurosurg (ISSN: 0022-3085), 2009 May; 110(5): 852-857.
Impact Factor: 2.594
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (366 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Gentile I, Viola C, Graf M, Liuzzi R, Quarto M, Cerini R, Piazza M, Borgia G
* A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis (418 views)
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
Impact Factor: 2.207
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Iaccarino C, Tedeschi E, Rapanà A, Massarelli I, Belfiore G, Quarantelli M, Bellotti A
* Is the distance between mammillary bodies predictive of a thickened third ventricle floor? Clinical article (393 views)
J Neurosurg (ISSN: 0022-3085), 2009; 110(5): 852-857.
Impact Factor: 2.594
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Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
* Cardiac performance during exercise in patients with Fabry's disease (371 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2008 Dec; 38(12): 910-917.
Impact Factor: 2.784
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Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (644 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Storto G, Klain M, Paone G, Liuzzi R, Molino L, Marinelli A, Soricelli A, Pace L, Salvatore M
* Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases (394 views)
Bone (ISSN: 8756-3282), 2006 Jul; 39(1): 35-41.
Impact Factor: 3.829
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Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (396 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Tamburrini S, Brunetti A, Brown MA, Sirlin CB, Casola G
* CT appearance of the normal appendix in adults (387 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2005 Oct; 15(10): 2096-2103.
Impact Factor: 2.437
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Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (335 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: 179-183.
Impact Factor: 3.883
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Imbriaco M, Megibow AJ, Ragozzino A, Liuzzi R, Mainenti PP, Bortone S, Camera L, Salvatore M
* Value of the single-phase technique in MDCT assessment of pancreatic tumors (362 views)
Am J Roentgenol (ISSN: 0361-803x), 2005 Apr; 184(4): 1111-1117.
Impact Factor: 2.209
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (431 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Clemente F, D'Avino E, Guaragno M, Menichetti A
* An on line technique to detect cardiac output variations and cardiovascular performances during abdominal aortic surgery (495 views)
Journal Of Clinical Monitoring And Computing (ISSN: 1387-1307), 2004 Apr; 18(2): 81-87.
Impact Factor: 0.888
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Romano M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Multidetector row computed tomographic angiography of the abdominal aorta and lower limbs arteries: A new diagnostic tool in patients with peripheral arterial occlusive disease (332 views)
Minerva Cardioangiol, 2004 Feb; 52(1): 9-17.
Impact Factor: 0.481
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (306 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
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Imbriaco M, Megibow AJ, Camera L, Pace L, Mainenti PP, Romano M, Selva G, Salvatore M
* Dual-phase versus single-phase helical CT to detect and assess resectability of pancreatic carcinoma (373 views)
Am J Roentgenol (ISSN: 0361-803x), 2002 Jun; 178(6): 1473-1479.
Impact Factor: 2.424
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Caprio MG, Carbone G, Bracigliano A, Acampa W, Mainolfi C, Molea G, Salvatore M
* Sentinel lymph node detection by lymphoscintigraphy in malignant melanoma (309 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S43-S43.
Impact Factor: 0.267
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (471 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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Cirillo LC, Camera L, Della Noce M, Castiglione F, Mazzacca G, Salvatore M
Accuracy of enteroclysis in Crohn's disease of the small bowel: A retrospective study (472 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2000; 10(12): 1894-1898.
Impact Factor: 1.119
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Formisano C, Limite G, Lamberti M, Fonti R, Forestieri P
Lymph node mapping and sentinel lymph node biopsy for evaluation of axillary lymph node status in early invasive breast cancer. Our experience (353 views)
Przegl Lek (ISSN: 0033-2240print, 0033-2240linking), 2000; 57Suppl5: 113-115.
Impact Factor: 0
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Marano I, Mainenti PP, Selva G, Cannavale M, Sodano A
[Computerized tomography-guided drainage of postoperative abdominal fluid collections] (242 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1999 Mar; 97(3): 160-165.
Impact Factor: 0.967
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Catalano L, Pace L, Califano C, Pinto AM, De Renzo A, Di Gennaro F, Del Vecchio S, Fonti R, Salvatore M, Rotoli B
Detection of focal myeloma lesions by technetium-99m-sestaMIBI scintigraphy (358 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1998 Nov 15; 92(10): 119-124.
Impact Factor: 1.876
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Alfano B, Brunetti A, Arpaia M, Ciarmiello A, Covelli EM, Salvatore M
Multiparametric display of spin-echo data from MR studies of brain (316 views) (PDF 620 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 1995 Mar; 5(2): 217-225.
Impact Factor: 1.277
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Mancini M, De Chiara S, Ferrara LA, Gallotta G, Postiglione A
TRANSCRANIAL DOPPLER EVALUATION OF CEREBROVASCULAR REACTIVITY TO ACETAZOLAMIDE IN NORMAL SUBJECTS (665 views)
15th World Congress Angiology Rome, 1989; 20(4): 284-284.
Impact Factor: 0
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* Evaluation of a multiparametric MRI radiomic-based approach for stratification of equivocal PI-RADS 3 and upgraded PI-RADS 4 prostatic lesions (77 views)
Sci Rep (ISSN: 2045-2322linking, 2045-2322electronic), 2021 Jan 12; 11(1): 643-643.
Impact Factor: 4.379
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Mercurio V, Cuomo A, Della Pepa R, Ciervo D, Cella L, Pirozzi F, Parrella P, Campi G, Franco R, Varricchi G, Abete P, Marone G, Petretta M, Bonaduce D, Pacelli R, Picardi M, Tocchetti CG
* What Is the Cardiac Impact of Chemotherapy and Subsequent Radiotherapy in Lymphoma Patients? (182 views)
Antioxid Redox Signal (ISSN: 1523-0864linking, 1557-7716), 2019 Nov 20; 31 (15 ): 1166-1174.
Impact Factor: 7.581
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Camera L, Pezzullo F, Acampora A, Liuzzi R, Rispo A, Nardone OM, Luglio G, Bucci L, Castiglione F, Brunetti A
* Multi-detector CT enterography in active inflammatory bowel disease: Image quality and diagnostic efficacy of a low-radiation high contrast protocol (117 views)
Clin Imaging (ISSN: 0899-7071linking, 1873-4499), 2019 Nov; 58: 27-33.
Impact Factor: 0.658
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Durazzo M, Campion D, Fagoonee S, Pellicano R
* Gastrointestinal tract disorders in the elderly (291 views)
Hepatology (ISSN: 0026-4806, 1827-1669electronic, 0026-4806linking), 2017 Dec; 108(6): 575-591.
Impact Factor: 2.863
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Mazziotti G, Formenti AM, Panarotto MB, Arvat E, Chiti A, Cuocolo A, Dottorini ME, Durante C, Agate L, Filetti S, Felicetti F, Filice A, Pace L, Pellegrino T, Rodari M, Salvatori M, Tranfaglia C, Versari A, Viola D, Frara S, Berruti A, Giustina A, Giubbini R
* Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience (409 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2017 Nov 06; 59(1): 90-101.
Impact Factor: 3.179
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Mancini M, Salomone Megna A, Ragucci M, De Luca M, Marino Marsilia G, Nardone G, Coccoli P, Prinster A, Mannelli L, Vergara E, Monti S, Liuzzi R, Incoronato M
* Reproducibility of shear wave elastography (SWE) in patients with chronic liver disease (234 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2017 Oct 12; 12(10): e0185391-e0185391.
Impact Factor: 2.766
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Segreto S, Fonti R, Ottaviano M, Pellegrino S, Pace L, Damiano V, Palmieri G, Del Vecchio S
* Evaluation of metabolic response with (18)F-FDG PET-CT in patients with advanced or recurrent thymic epithelial tumors (256 views)
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Impact Factor: 3.016
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De Luca S, Fonti R, Camera L, Salvatore B, Faggiano A, Ciarmiello A, Segreto S, Colao A, Salvatore M, Del Vecchio S
* Multimodal imaging with (18)F-FDG-PET/CT and (111)In-Octreotide SPECT in patients with metastatic medullary thyroid carcinoma (334 views)
Ann Nucl Med (ISSN: 0914-7187, 1864-6433, 0914-7187linking), 2016 Jan 11; 30(3): 1-8.
Impact Factor: 1.396
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Camera L, Romano F, Liccardo I, Liuzzi R, Imbriaco M, Mainenti PP, Pizzuti LM, Segreto S, Maurea S, Brunetti A
* Balancing Radiation and Contrast Media Dose in Single-Pass Abdominal Multidetector CT: Prospective Evaluation of Image Quality (380 views)
Acad Radiol (ISSN: 1076-6332, 1878-4046electronic, 1076-6332linking), 2015 Nov; 22(11): 1419-1426.
Impact Factor: 1.966
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Kim YH, Shin SW, Pellicano R, Fagoonee S, Choi IJ, Kim YI, Park B, Choi JM, Kim SG, Choi J, Park JY, Oh S, Yang HJ, Lim JH, Im JP, Kim JS, Jung HC, Ponzetto A, Figura N, Malfertheiner P, Choi IJ, Kook MC, Kim YI, Cho SJ, Lee JY, Kim CG, Park B, Nam BH, Bae SE, Choi KD, Choe J, Kim SO, Na HK, Choi JY, Ahn JY, Jung KW, Lee J, Kim DH, Chang HS, Song HJ, Lee GH, Jung HY, Seta T, Takahashi Y, Noguchi Y, Shikata S, Sakai T, Sakai K, Yamashita Y, Nakayama T, Leja M, Park JY, Murillo R, Liepniece-karele I, Isajevs S, Kikuste I, Rudzite D, Krike P, Parshutin S, Polaka I, Kirsners A, Santare D, Folkmanis V, Daugule I, Plummer M, Herrero R, Tsukamoto T, Nakagawa M, Kiriyama Y, Toyoda T, Cao X, Corral JE, Mera R, Dye CW, Morgan DR, Lee YC, Lin JT, Garcia Martin R, Matia Cubillo A, Lee SH, Park JM, Han YM, Ko WJ, Hahm KB, Leontiadis GI, Ford AC, Ichinose M, Sugano K, Jeong M, Park JM, Han YM, Park KY, Lee DH, Yoo JH, Cho JY, Hahm KB, Bang CS, Baik GH, Shin IS, Kim JB, Suk KT, Yoon JH, Kim YS, Kim DJ
* Helicobacter pylori Eradication for Prevention of Metachronous Recurrence after Endoscopic Resection of Early Gastric Cancer (341 views)
N Engl J Med (ISSN: 0028-4793, 0028-4793linking, 1533-4406electronic), 2015 Jun; 30642104201566393291: 749-756.
Impact Factor: 59.558
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Loewe C, Arnaiz J, Krause D, Marti-bonmati L, Haneder S, Kramer U, Dalia Study Group , Lell M, Lonjedo E, Tartaro A, Aschauer M, Burrel M, Lombardi M, Izzillo R, Mainenti PP, Heautot JF, Leicher-düber A, Krug B, Arteaga C
* MR Angiography at 3 T of Peripheral Arterial Disease: A Randomized Prospective Comparison of Gadoterate Meglumine and Gadobutrol (284 views)
Am J Roentgenol (ISSN: 0361-803x), 2015 Jun; 204(6): 1311-1321.
Impact Factor: 2.66
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Fonti R, Pace L, Cerchione C, Catalano L, Salvatore B, Pane F, Salvatore M, Del Vecchio S
* 18F-FDG PET/CT, 99mTc-MIBI, and MRI in the prediction of outcome of patients with multiple myeloma: a comparative study (433 views) (PDF 256 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 2015 Apr; 40(4): 303-308.
Impact Factor: 4.278
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Cervo A, Cocozza S, Saccà F, Giorgio SM, Morra VB, Tedeschi E, Marsili A, Vacca G, Palma V, Brunetti A, Quarantelli M
* The combined use of conventional MRI and MR spectroscopic imaging increases the diagnostic accuracy in amyotrophic lateral sclerosis (424 views)
Eur J Radiol (ISSN: 0720-048x), 2015 Jan; 84(1): 151-157.
Impact Factor: 2.593
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Neve Polimeno M, Ierano C, D'Alterio C, Simona Losito N, Napolitano M, Portella L, Scognamiglio G, Tatangelo F, Maria Trotta A, Curley S, Costantini S, Liuzzi R, Izzo F, Scala S
* CXCR4 expression affects overall survival of HCC patients whereas CXCR7 expression does not (671 views)
Cell Mol Immunol (ISSN: 1672-7681), 2014 Nov 3; 12(4): 474-482.
Impact Factor: 4.112
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Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (518 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
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Gallicchio R, Giacomobono S, Nardelli A, Pellegrino T, Simeon V, Gattozzi D, Maddalena F, Mainenti PP, Storto G
* Palliative Treatment Of Bone Metastases With Samarium-153 Edtmp At Onset Of Pain (397 views)
J Bone Miner Metab (ISSN: 0914-8779), 2014 Jul; 32(4): 434-440.
Impact Factor: 2.46
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Gallicchio R, Mansueto G, Simeon V, Nardelli A, Guariglia R, Capacchione D, Soscia E, Pedicini P, Gattozzi D, Musto P, Storto G
* F-18 FDG PET/CT quantization parameters as predictors of outcome in patients with diffuse large B-cell lymphoma (546 views)
Eur J Haematol (ISSN: 0902-4441), 2014 May; 92(5): 382-389.
Impact Factor: 2.066
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Pedicini P, Strigari L, Benassi M, Caivano R, Fiorentino A, Nappi A, Salvatore M, Storto G
* Critical dose and toxicity index of organs at risk in radiotherapy: analyzing the calculated effects of modified dose fractionation in non-small cell lung cancer (659 views)
Med Dosim (ISSN: 0958-3947, 1873-4022), 2014 Mar; 39(1): 23-30.
Impact Factor: 0.76
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Federico A, Zappavigna S, Romano M, Grieco P, Luce A, Marra M, Gravina AG, Stiuso P, D'Armiento FP, Vitale G, Tuccillo C, Novellino E, Loguercio C, Caraglia M
* Urotensin-II receptor is over-expressed in colon cancer cell lines and in colon carcinoma in humans (444 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2014 Mar; 44(3): 285-294.
Impact Factor: 2.734
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Iodice D, Di Donato O, Liccardo I, Lamanna L, Segreto S, Salvatore M, Imbriaco M
* Prevalence of extramammary findings on breast MRI: a large retrospective single-centre study (380 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Oct; 118(7): 1109-1118.
Impact Factor: 1.368
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Cella L, D'Avino V, Liuzzi R, Conson M, Doria F, Faiella A, Loffredo F, Salvatore M, Pacelli R
* Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer (393 views)
Radiation Oncology (ISSN: 1748-717x), 2013 Sep 23; 8(1): 221-221.
Impact Factor: 2.36
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Giacomobono S, Gallicchio R, Capacchione D, Nardelli A, Gattozzi D, Lettini G, Molinari L, Mainenti P, Cammarota A, Storto G
* F-18 FDG PET/CT in the assessment of patients with unexplained CEA rise after surgical curative resection for colorectal cancer (301 views)
International Journal Of Colorectal Disease (ISSN: 0179-1958, 0179-1958linking), 2013 Jul 12; 28(12): 1699-1705.
Impact Factor: 2.415
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Gentile I, Coppola N, Pasquale G, Liuzzi R, D'Armiento M, Di Lorenzo ME, Capoluongo N, Buonomo AR, Sagnelli E, Morisco F, Caporaso N, Borgia G
* A Simple Noninvasive Score Based on Routine Parameters can Predict Liver Cirrhosis in Patients With Chronic Hepatitis (351 views)
Hepat Mon (ISSN: 1735-143xprint, 1735-143xlinking), 2013 May 8; 13(5): e8352-e8352.
Impact Factor: 1.796
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Pacelli R, Conson M, Cella L, Liuzzi R, Troncone G, Iorio V, Solla R, Farella A, Scala S, Pagliarulo C, Salvatore M
* Radiation therapy following surgery for localized breast cancer: Outcome prediction by classical prognostic factors and approximated genetic subtypes (344 views)
J Rad Res Journal Of Radiation Research (ISSN: 1349-9157, 0449-3060, 1349-9157electronic), 2013 Mar 1; 54(2): 292-298.
Impact Factor: 1.691
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Mancini M, Di Donato O, Saldalamacchia G, Liuzzi R, Rivellese A, Salvatore M
* Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking (441 views)
Radiol Med (ISSN: 1826-6983, 0033-8362, 1826-6983electronic), 2013 Mar; 118(2): 206-214.
Impact Factor: 1.368
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Fonti R, Larobina M, Del Vecchio S, Fabbricini R, Catalano L, Pane F, Salvatore M, Pace L
* Metabolic tumor volume assessed by 18F-FDG PET/CT for the prediction of outcome in patients with multiple myeloma (588 views)
J Nucl Med (ISSN: 1535-5667, 0161-5505, 1535-5667electronic), 2012 Dec; 53(12): 1829-1835.
Impact Factor: 5.774
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Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (405 views) (PDF 259 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
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Franchin A, Corradin ML, Giantin V, Rossi F, Zanatta F, Attanasio F, Toffanello ED, Manzato E
* Diabetes in a geriatric ward: Efficacy and safety of new insulin analogs in very old inpatients (292 views)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2012 Jun; 24(SUPPL.3): 17-19.
Impact Factor: 1.006
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Saccà F, Quarantelli M, Rinaldi C, Tucci T, Piro R, Perrotta G, Carotenuto B, Marsili A, Palma V, De Michele G, Brunetti A, Brescia Morra V, Filla A, Salvatore M
* A randomized controlled clinical trial of growth hormone in amyotrophic lateral sclerosis: clinical, neuroimaging, and hormonal results (793 views)
J Neurol (ISSN: 1432-1459, 0340-5354, 1432-1459electronic), 2012 Jan; 259(1): 132-138.
Impact Factor: 3.578
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Antonini A, Vitale C, Barone P, Cilia R, Righini A, Bonuccelli U, Abbruzzese G, Ramat S, Petrone A, Quatrale R, Marconi R, Ceravolo R, Stefani A, Lopiano L, Zappia M, Capus L, Morgante L, Tamma F, Tinazzi M, Colosimo C, Guerra UP, Valzania F, Fagioli G, Distefano A, Bagnato A, Feggi L, Anna S, Maria Teresa Rosaria De Cr, Nobili F, Mazzuca N, Baldari S, Eleopra R, Bestetti A, Benti R, Varrone A, Volterrani D, Massa R, Stocchi F, Schillaci O, Dore F, Zibetti M, Castellano G, Battista SG, Giorgetti G
* The relationship between cerebral vascular disease and parkinsonism: The VADO study (498 views)
Parkinsonism Relat D (ISSN: 1353-8020, 1873-5126, 1873-5126electronic), 2012; 18(6): 775-780.
Impact Factor: 3.274
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Pace L, Nicolai E, D'Amico D, Ibello F, Della Morte AM, Salvatore B, Pizzuti LM, Salvatore M, Soricelli A
* Determinants of physiologic 18F-FDG uptake in brown adipose tissue in sequential PET/CT examinations (462 views)
Molecular Imaging And Biology (ISSN: 1860-2002, 1536-1632), 2011 Oct; 13(5): 1029-1035.
Impact Factor: 3.844
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Iavarone A, Lorè E, De Falco C, Milan G, Mosca R, Pappata S, Galeone F, Sorrentino P, Scognamiglio M, Postiglione A
* Dysexecutive performance of healthy oldest old subjects on the Frontal Assessment Battery (353 views)
Aging Clin Exp Res (ISSN: 1594-0667, 1720-8319), 2011 Oct; 23(5-6): 351-356.
Impact Factor: 1.552
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Durazzo M, Campion D, Fagoonee S, Pellicano R, Sonne JU, Erckenbrecht JF, Grassi M, Petraccia L, Mennuni G, Fontana M, Scarno A, Sabetta S, Fraioli A
* Changes, functional disorders, and diseases in the gastrointestinal tract of elderly (165 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking, 1432-1289electronic), 2011 Jul; 2655108(6): 659-668.
Impact Factor: 0.913
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Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (596 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
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Berti V, Sciagrà R, Acampa W, Ricci F, Cerisano G, Gallicchio R, Vigorito C, Pupi A, Cuocolo A
* Relationship between infarct size and severity measured by gated SPECT and long-term left ventricular remodelling after acute myocardial infarction (548 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2011 Jun; 38(6): 1124-1131.
Impact Factor: 4.991
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Pedone C, Napoli N, Pozzilli P, Rossi FF, Lauretani F, Bandinelli S, Ferrucci L, Antonelli-Incalzi R
* Dietary pattern and bone density changes in elderly women: a longitudinal study (366 views)
J Am Coll Nutr (ISSN: 1541-1087, 0731-5724), 2011 Apr; 30(2): 149-154.
Impact Factor: 2.29
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Mainenti PP, Iodice D, Segreto S, Storto G, Magliulo M, De Palma GD, Salvatore M, Pace L
* Colorectal cancer and 18FDG-PET/CT: what about adding the T to the N parameter in loco-regional staging? (335 views)
World J Gastroentero (ISSN: 2219-2840, 1007-9327, 1007-9327linking), 2011 Mar 21; 17(11): 1427-1433.
Impact Factor: 2.471
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Mainenti PP, Mancini M, Mainolfi C, Camera L, Maurea S, Manchia A, Tanga M, Persico F, Addeo P, D'Antonio D, Speranza A, Bucci L, Persico G, Pace L, Salvatore M
* Detection of colo-rectal liver metastases: Prospective comparison of contrast enhanced US, multidetector CT, PET/CT, and 1. 5 Tesla MR with extracellular and reticulo-endothelial cell specific contrast agents (445 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2010 Oct; 35(5): 511-521.
Impact Factor: 1.95
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Strianese D, Tranfa F, Finelli M, De Renzo A, Staibano S, Schiemer R, Cardone D, Pacelli R, Perna F, Mascolo M, De Rosa G, Bonavolonta G
* Hepatitis C virus infection in ocular adnexal lymphomas (370 views)
Arch Ophthalmol (ISSN: 1538-3601, 0003-9950), 2010 Oct; 128(10): 1295-1299.
Impact Factor: 3.516
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Clemente F, Arpaia P, Cimmino P
* A piezo-film-based measurement system for global haemodynamic assessment (378 views)
Physiological Measurement (ISSN: 0967-3334), 2010 May; 31(5): 697-714.
Impact Factor: 1.567
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Napolitano M, Ottaiano A, Mauro F, Ieranò C, Satriano R, Pacelli R, Franco R, De Angelis V, Castello G, Scala S
* CD4(+)CD45RA(+)CXCR4(+) lymphocytes are inversely associated with progression in stages I-III melanoma patients (403 views)
Cancer Immunol Immunother (ISSN: 0340-7004, 0340-7004linking), 2010 Apr; 59(4): 511-517.
Impact Factor: 4.293
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Perrone-Filardi P, Costanzo P, Dellegrottaglie S, Gargiulo P, Ruggiero D, Savarese G, Parente A, D'Amore C, Cuocolo A, Chiariello M
* Prognostic role of myocardial single photon emission computed tomography in the elderly (544 views)
J Nucl Cardiol (ISSN: 1532-6551, 1071-3581, 1532-6551electronic), 2010 Apr; 17(2): 310-315.
Impact Factor: 2.811
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Capaccio D, Ciccodicola A, Sabatino L, Casamassimi A, Pancione M, Fucci A, Febbraro, Merlino A, Graziano G, Colantuoni V
* A novel germline mutation in Peroxisome Proliferator-Activated Receptor γ gene associated with large intestine polyp formation and dyslipidemia (431 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2010; 1802(6): 572-581.
Impact Factor: 2.773
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Messalli G, Palumbo A, Maffei E, Martini C, Seitun S, Aldrovandi A, Imbriaco M, Salvatore M, Weustink A, Mollet N, Cademartiri F
* Assessment of left ventricular volumes with cardiac MRI: Comparison between two semiautomated quantitative software packages (470 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Sep; 114(5): 718-727.
Impact Factor: 1.454
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Fabbricini R, Catalano L, Pace L, Del Vecchio S, Fonti R, Salvatore M, Rotoli B
* Bone scintigraphy and SPECT/CT in bisphosphonate-induced osteonecrosis of the jaw (288 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2009 Aug; 50(8): 1385-1385.
Impact Factor: 6.424
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Iaccarino C, Tedeschi E, Rapanà A, Massarelli I, Belfiore G, Quarantelli M, Bellotti A
* Is the distance between mammillary bodies predictive of a thickened third ventricle floor? (328 views)
J Neurosurg (ISSN: 0022-3085), 2009 May; 110(5): 852-857.
Impact Factor: 2.594
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Maurea S, Caleo O, Mollica C, Imbriaco M, Mainenti PP, Palumbo C, Mancini M, Camera L, Salvatore M
* Comparative diagnostic evaluation with MR cholangiopancreatography, ultrasonography and CT in patients with pancreatobiliary disease (366 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 2009 Apr; 114(3): 390-402.
Impact Factor: 1.454
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Gentile I, Viola C, Graf M, Liuzzi R, Quarto M, Cerini R, Piazza M, Borgia G
* A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis (418 views)
J Clin Gastroenterol (ISSN: 0192-0790), 2009 Jan; 43(1): 81-87.
Impact Factor: 2.207
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Iaccarino C, Tedeschi E, Rapanà A, Massarelli I, Belfiore G, Quarantelli M, Bellotti A
* Is the distance between mammillary bodies predictive of a thickened third ventricle floor? Clinical article (393 views)
J Neurosurg (ISSN: 0022-3085), 2009; 110(5): 852-857.
Impact Factor: 2.594
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Spinelli L, Nicolai E, Acampa W, Imbriaco M, Pisani A, Rao MA, Scopacasa F, Cianciaruso B, De Luca N, Cuocolo A
* Cardiac performance during exercise in patients with Fabry's disease (371 views)
Eur J Clin Invest (ISSN: 0014-2972, 1365-2362, 0014-2972linking), 2008 Dec; 38(12): 910-917.
Impact Factor: 2.784
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Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (644 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
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Tamburrini S, Brunetti A, Brown M, Sirlin C, Casola G
* Acute appendicitis: Diagnostic value of nonenhanced CT with selective use of contrast in routine clinical settings (366 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2007 Sep; 17(8): 2055-2061.
Impact Factor: 3.405
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Mainenti PP, Cirillo LC, Camera L, Persico F, Cantalupo T, Pace L, De Palma GD, Persico G, Salvatore M
* Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer (321 views)
Eur J Radiol (ISSN: 0720-048x), 2006 Dec; 60(3): 453-459.
Impact Factor: 1.332
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Storto G, Klain M, Paone G, Liuzzi R, Molino L, Marinelli A, Soricelli A, Pace L, Salvatore M
* Combined therapy of Sr-89 and zoledronic acid in patients with painful bone metastases (394 views)
Bone (ISSN: 8756-3282), 2006 Jul; 39(1): 35-41.
Impact Factor: 3.829
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Pace L, Klain M, Albanese C, Salvatore B, Storto G, Soricelli A, Salvatore M
* Short-term outcome of differentiated thyroid cancer patients receiving a second iodine-131 therapy on the basis of a detectable serum thyroglobulin level after initial treatment (396 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Feb; 33(2): 179-183.
Impact Factor: 4.041
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Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (504 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
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Tamburrini S, Brunetti A, Brown MA, Sirlin CB, Casola G
* CT appearance of the normal appendix in adults (387 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2005 Oct; 15(10): 2096-2103.
Impact Factor: 2.437
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Pace L, Klain M, Soricelli A, Albanese C, Salvatore B, Storto G, Salvatore M
* Short Term Outcome of Differentiated Thyroid Cancer Patients with Detectable Serum Thyroglobulin after Initial Treatment Receiving a Second 131-IODINE Therapy (335 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2005 Sep; 32: 179-183.
Impact Factor: 3.883
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Imbriaco M, Megibow AJ, Ragozzino A, Liuzzi R, Mainenti PP, Bortone S, Camera L, Salvatore M
* Value of the single-phase technique in MDCT assessment of pancreatic tumors (362 views)
Am J Roentgenol (ISSN: 0361-803x), 2005 Apr; 184(4): 1111-1117.
Impact Factor: 2.209
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Mainenti PP, Romano M, Imbriaco M, Camera L, Pace L, D'Antonio D, Bucci L, Galloro G, Salvatore M
* Added value of CT colonography after a positive conventional colonoscopy: Impact on treatment strategy (431 views)
Abdom Imaging (ISSN: 0942-8925, 1432-0509), 2005 Jan; 30(1): 42-47.
Impact Factor: 1.034
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Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (553 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
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Clemente F, D'Avino E, Guaragno M, Menichetti A
* An on line technique to detect cardiac output variations and cardiovascular performances during abdominal aortic surgery (495 views)
Journal Of Clinical Monitoring And Computing (ISSN: 1387-1307), 2004 Apr; 18(2): 81-87.
Impact Factor: 0.888
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Romano M, Amato B, Markabaoui K, Tamburrini O, Salvatore M
* Multidetector row computed tomographic angiography of the abdominal aorta and lower limbs arteries: A new diagnostic tool in patients with peripheral arterial occlusive disease (332 views)
Minerva Cardioangiol, 2004 Feb; 52(1): 9-17.
Impact Factor: 0.481
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Andretta C, Catalano L, Pace L, Fonti R, Annunziata G, Rotoli B
* 99mTc-sestaMIBI scintigraphy in thalidomide-treated refractory or relapsed multiple myeloma patients [2] (306 views)
Leuk Lymphoma (ISSN: 1042-8194, 1026-8022linking), 2003 Jun; 44(6): 1081-1082.
Impact Factor: 1.163
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Imbriaco M, Megibow AJ, Camera L, Pace L, Mainenti PP, Romano M, Selva G, Salvatore M
* Dual-phase versus single-phase helical CT to detect and assess resectability of pancreatic carcinoma (373 views)
Am J Roentgenol (ISSN: 0361-803x), 2002 Jun; 178(6): 1473-1479.
Impact Factor: 2.424
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Del Vecchio S, Zannetti A, Ciarmiello A, Aloj L, Caracò C, Fonti R, Botti G, D'Aiuto G, Salvatore M
* Dynamic coupling of Tc-99m-MIBI efflux and apoptotic pathway activation in untreated breast cancer patients (483 views)
Eur J Nucl Med (ISSN: 1619-7070, 0340-6997, 1619-7089), 2002 Jun; 29(6): 809-814.
Impact Factor: 3.568
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Caprio MG, Carbone G, Bracigliano A, Acampa W, Mainolfi C, Molea G, Salvatore M
* Sentinel lymph node detection by lymphoscintigraphy in malignant melanoma (309 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2002 May; 88(3): S43-S43.
Impact Factor: 0.267
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Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma (471 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 2000 Mar 15; 60(6): 1546-1551.
Impact Factor: 8.46
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Cirillo LC, Camera L, Della Noce M, Castiglione F, Mazzacca G, Salvatore M
Accuracy of enteroclysis in Crohn's disease of the small bowel: A retrospective study (472 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2000; 10(12): 1894-1898.
Impact Factor: 1.119
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Formisano C, Limite G, Lamberti M, Fonti R, Forestieri P
Lymph node mapping and sentinel lymph node biopsy for evaluation of axillary lymph node status in early invasive breast cancer. Our experience (353 views)
Przegl Lek (ISSN: 0033-2240print, 0033-2240linking), 2000; 57Suppl5: 113-115.
Impact Factor: 0
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Marano I, Mainenti PP, Selva G, Cannavale M, Sodano A
[Computerized tomography-guided drainage of postoperative abdominal fluid collections] (242 views)
Radiol Med (ISSN: 0033-8362, 1826-6983, 1826-6983electronic), 1999 Mar; 97(3): 160-165.
Impact Factor: 0.967
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Catalano L, Pace L, Califano C, Pinto AM, De Renzo A, Di Gennaro F, Del Vecchio S, Fonti R, Salvatore M, Rotoli B
Detection of focal myeloma lesions by technetium-99m-sestaMIBI scintigraphy (358 views)
Haematologica (ISSN: 0390-6078, 0006-4971, 0006-6497), 1998 Nov 15; 92(10): 119-124.
Impact Factor: 1.876
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Alfano B, Brunetti A, Arpaia M, Ciarmiello A, Covelli EM, Salvatore M
Multiparametric display of spin-echo data from MR studies of brain (316 views) (PDF 620 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 1995 Mar; 5(2): 217-225.
Impact Factor: 1.277
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Carriero MV, Franco P, Del Vecchio S, Massa O, Botti G, D'Aiuto G, Stoppelli MP, Salvatore M
Tissue distribution of soluble and receptor-bound urokinase in human breast cancer using a panel of monoclonal antibodies (500 views)
Cancer Res (ISSN: 0008-5472, 1538-7445, 1538-7445electronic), 1994 Oct 15; 54(20): 5445-5454.
Impact Factor: 8.426
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Mancini M, De Chiara S, Ferrara LA, Gallotta G, Postiglione A
TRANSCRANIAL DOPPLER EVALUATION OF CEREBROVASCULAR REACTIVITY TO ACETAZOLAMIDE IN NORMAL SUBJECTS (665 views)
15th World Congress Angiology Rome, 1989; 20(4): 284-284.
Impact Factor: 0
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75 Records (71 excluding Abstracts).
Total impact factor: 264.377 (256.46 excluding Abstracts).
Total 5 year impact factor: 281.918 (269.689 excluding Abstracts).
Total impact factor: 264.377 (256.46 excluding Abstracts).
Total 5 year impact factor: 281.918 (269.689 excluding Abstracts).
608 views. Last view on Sunday 04 June 2023, 17:33:02
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