Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?(433 views) Gaglione R, Smaldone G, Di Girolamo R, Piccoli R, Pedone E, Arciello A
Keywords: Amyloidosis, Apolipoprotein A-I, Conformational Diseases, Fibrillogenesis, Recombinant Protein, Amino Acid Substitution, Animal Cell, Animal Experiment, Article, Atomic Force Microscopy, Cell Function, Cell Ultrastructure, Circular Dichroism, Controlled Study, Cutaneous Amyloidosis, Embryo, Fluorometry, Heart Amyloidosis, Hepatic Amyloidosis, Human, Human Cell, Kidney Amyloidosis, Laryngeal Amyloidosis, Mutation, Nonhuman, Organ Distribution, Photon Correlation Spectroscopy, Priority Journal, Protein Conformation, Protein Destabilization, Protein Structure, Function And Variability, Tissue Specificity, Cell Line, Comparative Study, Familial Amyloidosis, Genetics, Hep-G2 Cell Line, Metabolism, Protein Degradation, Spectrofluorometry, Dynamic Light Scattering, Hep G2 Cells, Proteolysis, Spectrometry, Fluorescence,
Affiliations: *** IBB - CNR ***
Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.
IRCCS SDN, Via E. Gianturco 113, 80143 Naples, Italy.
Istituto Nazionale di Biostrutture e Biosistemi (INBB), Italy.
Istituto di Biostrutture e Bioimmagini, CNR, Naples, Italy
Research Centre on Bioactive Peptides (CIRPeB), University of Naples Federico II, Via Mezzocannone 16, 80134 Naples, Italy. Electronic address: empedone@unina.it.
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Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?