Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study (643 views)
European Neuropsychopharmacology (ISSN: 0924-977x), 2018 Apr; 28(5): 589-602.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.239, 5-year impact factor: 4.577
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045110663&doi=10.1016%2fj.euroneuro.2018.03.013&partnerID=40&md5=7fbb060dd65291a61bba17ef2817fcee
Keywords: Functional Brain Imaging, Insular Cortex, Motivation, Prefrontal Cortex, Schizophrenia, Ventral Tegmental Area, Dopamine, Neuroleptic Agent, Adult, Apathy, Article, Avolition, Bold Signal, Clinical Article, Controlled Study, Dorsolateral Prefrontal Cortex, Female, Functional Connectivity, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Human, Negative Syndrome, Occipital Cortex, Positive Syndrome, Post Hoc Analysis, Priority Journal, Ventrolateral Prefrontal Cortex,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, Naples, 80138, Italy
Laboratory of Neuronal Networks, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, Naples, 80138, Italy
Biostructure and Bioimaging Institute, National Research Council, Via De Amicis 95, Naples, 80145, Italy
Department of Motor Sciences & Healthiness, University of Naples “Parthenope”, Via Medina 40, Naples, 80133, Italy
I.R.C.C.S. Research Institute SDN, Via Gianturco 113, Naples, 80143, Italy
References:
Abram, S.V., Fronto-temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia (2017) Hum. Brain Mapp., 38 (3), pp. 1111-112
Ballard, I.C., Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior (2011) J. Neurosci., 31 (28), pp. 10340-10346
Barch, D.M., Dowd, E.C., Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions (2010) Schizophr. Bull., 36 (5), pp. 919-934
Barch, D.M., Mechanisms underlying motivational deficits in psychopathology: similarities and differences in depression and schizophrenia (2016) Curr. Top. Behav. Neurosci., 27, pp. 411-449
Bissonette, G.B., Roesch, M.R., Neurophysiology of reward-guided behavior: correlates related to predictions, value, motivation, errors, attention, and action (2016) Curr. Top. Behav. Neurosci., 27, pp. 199-230
Bromberg-Martin, E.S., Dopamine in motivational control: rewarding, aversive, and alerting (2010) Neuron, 68 (5), pp. 815-834
Bruni, S., Processing and integration of contextual information in monkey ventrolateral prefrontal neurons during selection and execution of goal-directed manipulative actions (2015) J. Neurosci., 35 (34), pp. 11877-11890
Chai, X.J., Anticorrelations in resting state networks without global signal regression (2012) Neuroimage, 59 (2), pp. 1420-1428
Cordes, D., Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data (2001) Am. J. Neuroradiol., 22 (7), pp. 1326-1333
D'Ardenne, K., BOLD responses reflecting dopaminergic signals in the human ventral tegmental area (2008) Science, 319 (5867), pp. 1264-1267
Deserno, L., Striatal dopamine, reward, and decision making in schizophrenia (2016) Dialog-. Clin. Neurosci., 18 (1), pp. 77-89
Erez, Y., Duncan, J., Discrimination of visual categories based on behavioral relevance in widespread regions of frontoparietal cortex (2015) J. Neurosci., 35 (36), pp. 12383-12393
Esposito, F., Independent component model of the default-mode brain function: combining individual-level and population-level analyses in resting-state fMRI (2008) Magn. Reson Imaging, 26 (7), pp. 905-913
Esslinger, C., Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients (2012) Schizophr. Res, 140 (1-3), pp. 114-121
Fervaha, G., Measuring motivation in people with schizophrenia (2015) Schizophr. Res., 169 (1-3), pp. 423-426
Fervaha, G., Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome (2015) Schizophr. Res., 166 (1-3), pp. 9-16
Fervaha, G., Extrapyramidal symptoms and cognitive test performance in patients with schizophrenia (2015) Schizophr. Res., 161 (2-3), pp. 351-356
Forman, S.D., Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold (1995) Magn. Reson. Med., 33 (5), pp. 636-647
Foussias, G., Motivational deficits as the central link to functioning in schizophrenia: a pilot study (2009) Schizophr. Res, 115 (2-3), pp. 333-337
Foussias, G., Remington, G., Negative symptoms in schizophrenia: avolition and Occam's razor (2010) Schizophr. Bull., 36 (2), pp. 359-369
Friston, K.J., Statistical parametric maps in functional imaging: a general linear approach (1995) Hum. Brain Mapp., 2, pp. 189-210
Galderisi, S., Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome (2013) Schizophr. Res., 147 (1), pp. 157-162
Galderisi, S., The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia (2014) World Psychiatry, 13 (3), pp. 275-287
Galderisi, S., Neurobiological background of negative symptoms (2015) Eur. Arch. Psychiatry Clin. Neurosci., 265 (7), pp. 543-558
Galderisi, S., Dissecting negative symptoms of schizophrenia: history, assessment, pathophysiological mechanisms and treatment (2016) Schizophr. Res.
Galderisi, S., Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives (2016) Schizophr. Res, 175 (1-3), pp. 154-160
Gardner, D.M., International consensus study of antipsychotic dosing (2010) Am. J Psychiatry, 167 (6), pp. 686-693
Gradin, V.B., Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia (2013) Psychiatry Res., 211 (2), pp. 104-111
Green, M.F., From perception to functional outcome in schizophrenia: modeling the role of ability and motivation (2012) Arch. Gen. Psychiatry, 69 (12), pp. 1216-1224
Gu, H., Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity (2010) Neuroimage, 53 (2), pp. 593-601
Hadley, J.A., Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia (2014) Neuropsychopharmacology, 39 (4), pp. 1020-1030
Heinrichs, D.W., The quality of life scale: an instrument for rating the schizophrenic deficit syndrome (1984) Schizophr. Bull., 10 (3), pp. 388-398
Juckel, G., Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics (2006) Psychopharmacology, 187 (2), pp. 222-228
Kaiser, S., Individual negative symptoms and domains - relevance for assessment, pathomechanisms and treatment (2016) Schizophr. Res.
Kay, S.R., The positive and negative syndrome scale (PANSS) for schizophrenia (1987) Schizophr. Bull., 13 (2), pp. 261-276
Kimhy, D., The factorial structure of the schedule for the deficit syndrome in schizophrenia (2006) Schizophr. Bull., 32 (2), pp. 274-278
Kirkpatrick, B., The schedule for the deficit syndrome: an instrument for research in schizophrenia (1989) Psychiatry Res, 30 (2), pp. 119-123
Kirschner, M., Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia (2016) J. Psychiatry Neurosci., 41 (3), pp. 152-161
Koch, K., Functional connectivity and grey matter volume of the striatum in schizophrenia (2014) Br. J Psychiatry, 205 (3), pp. 204-213
Labouesse, M.A., Abnormal context-reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia (2015) Transl. Psychiatry, 5, p. e637
Lui, S., Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by “resting state” functional magnetic resonance imaging (2010) Arch. Gen. Psychiatry, 67 (8), pp. 783-792
Meyer, U., Feldon, J., Epidemiology-driven neurodevelopmental animal models of schizophrenia (2010) Prog. Neurobiol., 90 (3), pp. 285-326
Miller, E.K., Cohen, J.D., An integrative theory of prefrontal cortex function (2001) Annu Rev. Neurosci., 24, pp. 167-202
Miller, E.M., Dissociating motivation from reward in human striatal activity (2014) J Cogn. Neurosci., 26 (5), pp. 1075-1084
Morales, M., Margolis, E.B., Ventral tegmental area: cellular heterogeneity, connectivity and behaviour (2017) Nat. Rev. Neurosci., 18 (2), pp. 73-85
Morris, R.W., Corticostriatal control of goal-directed action is impaired in schizophrenia (2015) Biol. Psychiatry, 77 (2), pp. 187-195
Mucci, A., Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (2015) Psychol. Med., 45 (8), pp. 1765-1778
Murphy, K., The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? (2009) Neuroimage, 44 (3), pp. 893-905
Murty, V.P., Resting state networks distinguish human ventral tegmental area from substantia nigra (2014) Neuroimage, 100, pp. 580-589
Nakagami, E., The prospective relationships among intrinsic motivation, neurocognition, and psychosocial functioning in schizophrenia (2010) Schizophr. Bull., 36 (5), pp. 935-948
Nielsen, M.O., Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia (2012) Arch. Gen. Psychiatry, 69 (12), pp. 1195-1204
Nielsen, M.O., Alterations of the brain reward system in antipsychotic naive schizophrenia patients (2012) Biol. Psychiatry, 71 (10), pp. 898-905
O'Doherty, J.P., Multiple systems for the motivational control of behavior and associated neural substrates in humans (2016) Curr. Top. Behav. Neurosci., 27, pp. 291-312
Ochsner, K.N., Functional imaging studies of emotion regulation: a synthetic review and evolving model of the cognitive control of emotion (2012) Ann. N Y Acad. Sci., 1251, pp. E1-E24
Palaniyappan, L., Liddle, P.F., Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction (2012) J Psychiatry Neurosci., 37 (1), pp. 17-27
Parkes, S.L., Balleine, B.W., Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions (2013) J. Neurosci., 33 (20), pp. 8753-8763
Parkes, S.L., Interaction of insular cortex and ventral striatum mediates the effect of incentive memory on choice between goal-directed actions (2015) J. Neurosci., 35 (16), pp. 6464-6471
Power, J.D., Methods to detect, characterize, and remove motion artifact in resting state fMRI (2014) Neuroimage, 84, pp. 320-341
Pu, W., Altered functional connectivity links in neuroleptic-naive and neuroleptic-treated patients with schizophrenia, and their relation to symptoms including volition (2014) Neuroimage Clin., 6, pp. 463-474
Schlagenhauf, F., Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine (2008) Psychopharmacology, 196 (4), pp. 673-684
Schmidt, A., Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis (2016) J. Psychiatry Neurosci., 41 (6), pp. 367-376
Schmidt, L., Disconnecting force from money: effects of basal ganglia damage on incentive motivation (2008) Brain, 131, pp. 1303-1310
Sheehan, D.V., The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 (1998) J. Clin. Psychiatry, 59, pp. 22-33. , (quiz 34-57)
Simon, J.J., Neural correlates of reward processing in schizophrenia–relationship to apathy and depression (2010) Schizophr. Res., 118 (1-3), pp. 154-161
Simpson, E.H., Schizophrenia in translation: dissecting motivation in schizophrenia and rodents (2012) Schizophr. Bull., 38 (6), pp. 1111-1117
Soddu, A., Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness (2012) Hum. Brain Mapp., 33 (4), pp. 778-796
Strauss, G.P., The emotion paradox of anhedonia in schizophrenia: or is it? (2013) Schizophr. Bull., 39 (2), pp. 247-250
Strauss, G.P., Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a progressive ratio task (2016) Schizophr. Res, 170 (1), pp. 198-204
Tedeschi, G., Interaction between aging and neurodegeneration in amyotrophic lateral sclerosis (2012) Neurobiol. Aging, 33 (5), pp. 886-898
Tian, L., Neuroimaging analysis of the dopamine basis for apathetic behaviors in an MPTP-lesioned primate model (2015) PLoS One, 10 (7), p. e0132064
Tomasi, D., Volkow, N.D., Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD (2014) Cereb. Cortex, 24 (4), pp. 935-944
Vijayaraghavan, L., A selective role for right insula–basal ganglia circuits in appetitive stimulus processing (2013) Soc. Cogn. Affect. Neurosci., 8 (7), pp. 813-819
Vuillermot, S., A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia (2010) J. Neurosci., 30 (4), pp. 1270-1287
Vytlacil, J., An approach for identifying brainstem dopaminergic pathways using resting state functional MRI (2014) PLoS One, 9 (1), p. e87109
Waltz, J.A., Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers (2009) Neuropsychopharmacology, 34 (6), pp. 1567-1577
Watanabe, M., Sakagami, M., Integration of cognitive and motivational context information in the primate prefrontal cortex (2007) Cereb. Cortex, 17. , (i101-109)
Whitfield-Gabrieli, S., Nieto-Castanon, A., Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks (2012) Brain Connect, 2 (3), pp. 125-141
Zhang, J.T., Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence from resting state functional magnetic resonance imaging (2015) Behav. Brain Funct., 11 (1), p. 37
European Neuropsychopharmacology (ISSN: 0924-977x), 2018 Apr; 28(5): 589-602.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 4.239, 5-year impact factor: 4.577
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85045110663&doi=10.1016%2fj.euroneuro.2018.03.013&partnerID=40&md5=7fbb060dd65291a61bba17ef2817fcee
Keywords: Functional Brain Imaging, Insular Cortex, Motivation, Prefrontal Cortex, Schizophrenia, Ventral Tegmental Area, Dopamine, Neuroleptic Agent, Adult, Apathy, Article, Avolition, Bold Signal, Clinical Article, Controlled Study, Dorsolateral Prefrontal Cortex, Female, Functional Connectivity, Functional Magnetic Resonance Imaging, Functional Neuroimaging, Human, Negative Syndrome, Occipital Cortex, Positive Syndrome, Post Hoc Analysis, Priority Journal, Ventrolateral Prefrontal Cortex,
Affiliations:
*** IBB - CNR ***
Department of Psychiatry, University of Campania “Luigi Vanvitelli”, Largo Madonna delle Grazie 1, Naples, 80138, Italy
Laboratory of Neuronal Networks, Department of Mental and Physical Health and Preventive Medicine, University of Campania “Luigi Vanvitelli”, Via Luciano Armanni 5, Naples, 80138, Italy
Biostructure and Bioimaging Institute, National Research Council, Via De Amicis 95, Naples, 80145, Italy
Department of Motor Sciences & Healthiness, University of Naples “Parthenope”, Via Medina 40, Naples, 80133, Italy
I.R.C.C.S. Research Institute SDN, Via Gianturco 113, Naples, 80143, Italy
References:
Abram, S.V., Fronto-temporal connectivity predicts cognitive empathy deficits and experiential negative symptoms in schizophrenia (2017) Hum. Brain Mapp., 38 (3), pp. 1111-112
Ballard, I.C., Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior (2011) J. Neurosci., 31 (28), pp. 10340-10346
Barch, D.M., Dowd, E.C., Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions (2010) Schizophr. Bull., 36 (5), pp. 919-934
Barch, D.M., Mechanisms underlying motivational deficits in psychopathology: similarities and differences in depression and schizophrenia (2016) Curr. Top. Behav. Neurosci., 27, pp. 411-449
Bissonette, G.B., Roesch, M.R., Neurophysiology of reward-guided behavior: correlates related to predictions, value, motivation, errors, attention, and action (2016) Curr. Top. Behav. Neurosci., 27, pp. 199-230
Bromberg-Martin, E.S., Dopamine in motivational control: rewarding, aversive, and alerting (2010) Neuron, 68 (5), pp. 815-834
Bruni, S., Processing and integration of contextual information in monkey ventrolateral prefrontal neurons during selection and execution of goal-directed manipulative actions (2015) J. Neurosci., 35 (34), pp. 11877-11890
Chai, X.J., Anticorrelations in resting state networks without global signal regression (2012) Neuroimage, 59 (2), pp. 1420-1428
Cordes, D., Frequencies contributing to functional connectivity in the cerebral cortex in “resting-state” data (2001) Am. J. Neuroradiol., 22 (7), pp. 1326-1333
D'Ardenne, K., BOLD responses reflecting dopaminergic signals in the human ventral tegmental area (2008) Science, 319 (5867), pp. 1264-1267
Deserno, L., Striatal dopamine, reward, and decision making in schizophrenia (2016) Dialog-. Clin. Neurosci., 18 (1), pp. 77-89
Erez, Y., Duncan, J., Discrimination of visual categories based on behavioral relevance in widespread regions of frontoparietal cortex (2015) J. Neurosci., 35 (36), pp. 12383-12393
Esposito, F., Independent component model of the default-mode brain function: combining individual-level and population-level analyses in resting-state fMRI (2008) Magn. Reson Imaging, 26 (7), pp. 905-913
Esslinger, C., Ventral striatal activation during attribution of stimulus saliency and reward anticipation is correlated in unmedicated first episode schizophrenia patients (2012) Schizophr. Res, 140 (1-3), pp. 114-121
Fervaha, G., Measuring motivation in people with schizophrenia (2015) Schizophr. Res., 169 (1-3), pp. 423-426
Fervaha, G., Motivational deficits in early schizophrenia: prevalent, persistent, and key determinants of functional outcome (2015) Schizophr. Res., 166 (1-3), pp. 9-16
Fervaha, G., Extrapyramidal symptoms and cognitive test performance in patients with schizophrenia (2015) Schizophr. Res., 161 (2-3), pp. 351-356
Forman, S.D., Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold (1995) Magn. Reson. Med., 33 (5), pp. 636-647
Foussias, G., Motivational deficits as the central link to functioning in schizophrenia: a pilot study (2009) Schizophr. Res, 115 (2-3), pp. 333-337
Foussias, G., Remington, G., Negative symptoms in schizophrenia: avolition and Occam's razor (2010) Schizophr. Bull., 36 (2), pp. 359-369
Friston, K.J., Statistical parametric maps in functional imaging: a general linear approach (1995) Hum. Brain Mapp., 2, pp. 189-210
Galderisi, S., Categorical and dimensional approaches to negative symptoms of schizophrenia: focus on long-term stability and functional outcome (2013) Schizophr. Res., 147 (1), pp. 157-162
Galderisi, S., The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia (2014) World Psychiatry, 13 (3), pp. 275-287
Galderisi, S., Neurobiological background of negative symptoms (2015) Eur. Arch. Psychiatry Clin. Neurosci., 265 (7), pp. 543-558
Galderisi, S., Dissecting negative symptoms of schizophrenia: history, assessment, pathophysiological mechanisms and treatment (2016) Schizophr. Res.
Galderisi, S., Pathways to functional outcome in subjects with schizophrenia living in the community and their unaffected first-degree relatives (2016) Schizophr. Res, 175 (1-3), pp. 154-160
Gardner, D.M., International consensus study of antipsychotic dosing (2010) Am. J Psychiatry, 167 (6), pp. 686-693
Gradin, V.B., Salience network-midbrain dysconnectivity and blunted reward signals in schizophrenia (2013) Psychiatry Res., 211 (2), pp. 104-111
Green, M.F., From perception to functional outcome in schizophrenia: modeling the role of ability and motivation (2012) Arch. Gen. Psychiatry, 69 (12), pp. 1216-1224
Gu, H., Mesocorticolimbic circuits are impaired in chronic cocaine users as demonstrated by resting-state functional connectivity (2010) Neuroimage, 53 (2), pp. 593-601
Hadley, J.A., Ventral tegmental area/midbrain functional connectivity and response to antipsychotic medication in schizophrenia (2014) Neuropsychopharmacology, 39 (4), pp. 1020-1030
Heinrichs, D.W., The quality of life scale: an instrument for rating the schizophrenic deficit syndrome (1984) Schizophr. Bull., 10 (3), pp. 388-398
Juckel, G., Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics (2006) Psychopharmacology, 187 (2), pp. 222-228
Kaiser, S., Individual negative symptoms and domains - relevance for assessment, pathomechanisms and treatment (2016) Schizophr. Res.
Kay, S.R., The positive and negative syndrome scale (PANSS) for schizophrenia (1987) Schizophr. Bull., 13 (2), pp. 261-276
Kimhy, D., The factorial structure of the schedule for the deficit syndrome in schizophrenia (2006) Schizophr. Bull., 32 (2), pp. 274-278
Kirkpatrick, B., The schedule for the deficit syndrome: an instrument for research in schizophrenia (1989) Psychiatry Res, 30 (2), pp. 119-123
Kirschner, M., Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia (2016) J. Psychiatry Neurosci., 41 (3), pp. 152-161
Koch, K., Functional connectivity and grey matter volume of the striatum in schizophrenia (2014) Br. J Psychiatry, 205 (3), pp. 204-213
Labouesse, M.A., Abnormal context-reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia (2015) Transl. Psychiatry, 5, p. e637
Lui, S., Short-term effects of antipsychotic treatment on cerebral function in drug-naive first-episode schizophrenia revealed by “resting state” functional magnetic resonance imaging (2010) Arch. Gen. Psychiatry, 67 (8), pp. 783-792
Meyer, U., Feldon, J., Epidemiology-driven neurodevelopmental animal models of schizophrenia (2010) Prog. Neurobiol., 90 (3), pp. 285-326
Miller, E.K., Cohen, J.D., An integrative theory of prefrontal cortex function (2001) Annu Rev. Neurosci., 24, pp. 167-202
Miller, E.M., Dissociating motivation from reward in human striatal activity (2014) J Cogn. Neurosci., 26 (5), pp. 1075-1084
Morales, M., Margolis, E.B., Ventral tegmental area: cellular heterogeneity, connectivity and behaviour (2017) Nat. Rev. Neurosci., 18 (2), pp. 73-85
Morris, R.W., Corticostriatal control of goal-directed action is impaired in schizophrenia (2015) Biol. Psychiatry, 77 (2), pp. 187-195
Mucci, A., Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (2015) Psychol. Med., 45 (8), pp. 1765-1778
Murphy, K., The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? (2009) Neuroimage, 44 (3), pp. 893-905
Murty, V.P., Resting state networks distinguish human ventral tegmental area from substantia nigra (2014) Neuroimage, 100, pp. 580-589
Nakagami, E., The prospective relationships among intrinsic motivation, neurocognition, and psychosocial functioning in schizophrenia (2010) Schizophr. Bull., 36 (5), pp. 935-948
Nielsen, M.O., Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia (2012) Arch. Gen. Psychiatry, 69 (12), pp. 1195-1204
Nielsen, M.O., Alterations of the brain reward system in antipsychotic naive schizophrenia patients (2012) Biol. Psychiatry, 71 (10), pp. 898-905
O'Doherty, J.P., Multiple systems for the motivational control of behavior and associated neural substrates in humans (2016) Curr. Top. Behav. Neurosci., 27, pp. 291-312
Ochsner, K.N., Functional imaging studies of emotion regulation: a synthetic review and evolving model of the cognitive control of emotion (2012) Ann. N Y Acad. Sci., 1251, pp. E1-E24
Palaniyappan, L., Liddle, P.F., Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction (2012) J Psychiatry Neurosci., 37 (1), pp. 17-27
Parkes, S.L., Balleine, B.W., Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions (2013) J. Neurosci., 33 (20), pp. 8753-8763
Parkes, S.L., Interaction of insular cortex and ventral striatum mediates the effect of incentive memory on choice between goal-directed actions (2015) J. Neurosci., 35 (16), pp. 6464-6471
Power, J.D., Methods to detect, characterize, and remove motion artifact in resting state fMRI (2014) Neuroimage, 84, pp. 320-341
Pu, W., Altered functional connectivity links in neuroleptic-naive and neuroleptic-treated patients with schizophrenia, and their relation to symptoms including volition (2014) Neuroimage Clin., 6, pp. 463-474
Schlagenhauf, F., Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine (2008) Psychopharmacology, 196 (4), pp. 673-684
Schmidt, A., Dysfunctional insular connectivity during reward prediction in patients with first-episode psychosis (2016) J. Psychiatry Neurosci., 41 (6), pp. 367-376
Schmidt, L., Disconnecting force from money: effects of basal ganglia damage on incentive motivation (2008) Brain, 131, pp. 1303-1310
Sheehan, D.V., The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 (1998) J. Clin. Psychiatry, 59, pp. 22-33. , (quiz 34-57)
Simon, J.J., Neural correlates of reward processing in schizophrenia–relationship to apathy and depression (2010) Schizophr. Res., 118 (1-3), pp. 154-161
Simpson, E.H., Schizophrenia in translation: dissecting motivation in schizophrenia and rodents (2012) Schizophr. Bull., 38 (6), pp. 1111-1117
Soddu, A., Identifying the default-mode component in spatial IC analyses of patients with disorders of consciousness (2012) Hum. Brain Mapp., 33 (4), pp. 778-796
Strauss, G.P., The emotion paradox of anhedonia in schizophrenia: or is it? (2013) Schizophr. Bull., 39 (2), pp. 247-250
Strauss, G.P., Avolition in schizophrenia is associated with reduced willingness to expend effort for reward on a progressive ratio task (2016) Schizophr. Res, 170 (1), pp. 198-204
Tedeschi, G., Interaction between aging and neurodegeneration in amyotrophic lateral sclerosis (2012) Neurobiol. Aging, 33 (5), pp. 886-898
Tian, L., Neuroimaging analysis of the dopamine basis for apathetic behaviors in an MPTP-lesioned primate model (2015) PLoS One, 10 (7), p. e0132064
Tomasi, D., Volkow, N.D., Functional connectivity of substantia nigra and ventral tegmental area: maturation during adolescence and effects of ADHD (2014) Cereb. Cortex, 24 (4), pp. 935-944
Vijayaraghavan, L., A selective role for right insula–basal ganglia circuits in appetitive stimulus processing (2013) Soc. Cogn. Affect. Neurosci., 8 (7), pp. 813-819
Vuillermot, S., A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia (2010) J. Neurosci., 30 (4), pp. 1270-1287
Vytlacil, J., An approach for identifying brainstem dopaminergic pathways using resting state functional MRI (2014) PLoS One, 9 (1), p. e87109
Waltz, J.A., Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers (2009) Neuropsychopharmacology, 34 (6), pp. 1567-1577
Watanabe, M., Sakagami, M., Integration of cognitive and motivational context information in the primate prefrontal cortex (2007) Cereb. Cortex, 17. , (i101-109)
Whitfield-Gabrieli, S., Nieto-Castanon, A., Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks (2012) Brain Connect, 2 (3), pp. 125-141
Zhang, J.T., Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence from resting state functional magnetic resonance imaging (2015) Behav. Brain Funct., 11 (1), p. 37
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
Avolition, a deficit in goal-directed behavior, is a key aspect of negative symptoms. It is highly prevalent in schizophrenia and is associated to poor functional outcome and to measures of real life motivation, indicating that central to the concept is the lack of interest and motivation. In this study we tested the hypothesis that avolition is related to altered connectivity within dopaminergic cortico-striatal circuits involved in motivation processes. Since dopamine input to these circuits derives mostly from the ventro-tegmental area (VTA), we investigated the relationships between the resting-state functional connectivity (RS-FC) of the VTA and avolition in twenty-six subjects with schizophrenia (SCZ), treated with second-generation antipsychotics only, compared to twenty-two healthy controls (HC). SCZ, in comparison to HC, showed significantly reduced RS-FC of the VTA with bilateral ventro-lateral prefrontal cortex (VLPFC), bilateral insular cortex (IC) and right (R) lateral occipital complex (LOC) and increased RS-FC of the VTA with bilateral dorso-lateral prefrontal cortex (DLPFC). Significant negative correlations were found between avolition and RS-FC of the VTA with the bilateral IC, R VLPFC and R LOC. According to our findings, avolition is linked to a disconnectivity of the VTA from several key cortical regions involved in the integration of value information with action selection. These findings are in line with translational animal models of “auto-activation apathy”. © 2018 Elsevier B.V. and ECNP
Avolition, a deficit in goal-directed behavior, is a key aspect of negative symptoms. It is highly prevalent in schizophrenia and is associated to poor functional outcome and to measures of real life motivation, indicating that central to the concept is the lack of interest and motivation. In this study we tested the hypothesis that avolition is related to altered connectivity within dopaminergic cortico-striatal circuits involved in motivation processes. Since dopamine input to these circuits derives mostly from the ventro-tegmental area (VTA), we investigated the relationships between the resting-state functional connectivity (RS-FC) of the VTA and avolition in twenty-six subjects with schizophrenia (SCZ), treated with second-generation antipsychotics only, compared to twenty-two healthy controls (HC). SCZ, in comparison to HC, showed significantly reduced RS-FC of the VTA with bilateral ventro-lateral prefrontal cortex (VLPFC), bilateral insular cortex (IC) and right (R) lateral occipital complex (LOC) and increased RS-FC of the VTA with bilateral dorso-lateral prefrontal cortex (DLPFC). Significant negative correlations were found between avolition and RS-FC of the VTA with the bilateral IC, R VLPFC and R LOC. According to our findings, avolition is linked to a disconnectivity of the VTA from several key cortical regions involved in the integration of value information with action selection. These findings are in line with translational animal models of “auto-activation apathy”. © 2018 Elsevier B.V. and ECNP
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
| ▼ Relaxometry based MRI brain segmentation |
Functional connectivity of the ventral tegmental area and avolition in subjects with schizophrenia: a resting state functional MRI study
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Iasevoli F, D , #xambrosio L, Ciccarelli M, Barone A, Gaudieri V, Cocozza S, Pontillo G, Brunetti A, Cuocolo A, De Bartolomeis A, Pappata S
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Impact Factor: 9.306
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Giordano GM, Pezzella P, Quarantelli M, Bucci P, Prinster A, Soricelli A, Perrottelli A, Giuliani L, Fabrazzo M, Galderisi S
* Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study (8 views)
J Clin Med (ISSN: 2077-0383electronic), 2021 Dec 23; 11 (1 ): N/D-N/D.
Impact Factor:
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Canna A, Prinster A, Cantone E, Ponticorvo S, Russo AG, Di Salle F, Esposito F
* Intensity-related distribution of sweet and bitter taste fMRI responses in the insular cortex (163 views)
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Impact Factor: 4.927
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Nicoletti F, Orlando R, Di Menna L, Cannella M, Notartomaso S, Mascio G, Iacovelli L, Matrisciano F, Fazio F, Caraci F, Copani A, Battaglia G, Bruno V
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Impact Factor: 2.857
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Amodio A, Quarantelli M, Mucci A, Prinster A, Soricelli A, Vignapiano A, Giordano GM, Merlotti E, Nicita A, Galderisi S
* Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex (334 views)
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
Impact Factor: 2.163
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Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
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Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
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Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
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Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
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Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (261 views) (PDF 207 views)
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
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Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M
* Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (389 views)
Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.
Impact Factor: 5.491
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Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (331 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
Impact Factor: 1.579
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Volpe U, Mucci A, Plescia GM, Montefusco V, Romano P, Dima D, Gallo O, Soricelli A, Bucci P, Frangou S, Prinster A, Salvatore M, Maj M, Galderisi S
* REWARD ANTICIPATION IN SCHIZOPHRENIA: A FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY (324 views)
Eur Psychiat (ISSN: 0924-9338), 2014; 29: N/D-N/D.
Impact Factor: 3.439
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Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
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Impact Factor: 19.358
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Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (606 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
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Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (404 views) (PDF 208 views)
Prog Neuro Psychopharmacol Biol Psychiatry (ISSN: 0278-5846), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
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Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
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Impact Factor: 3.677
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Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (414 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
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Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
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Impact Factor: 8.017
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Mcnab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T
* Changes in cortical dopamine D1 receptor binding associated with cognitive training (360 views)
Science (ISSN: 0036-8075, 0036-8075linking), 2009 Feb 6; 323(5915): 800-802.
Impact Factor: 29.747
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Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G, Rossi A, Vita A, Pini S, Cassano P, Daneluzzo E, De Peri L, Stratta P, Brunetti A, Maj M
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Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic), 2008 Mar; 34(2): 393-401.
Impact Factor: 6.592
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Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (397 views)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
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Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (476 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
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Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D
* Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task (579 views)
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Impact Factor: 6.519
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De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (474 views)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
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Galderisi S, Mucci A, Quarantelli M, Volpe U, Amati G, Alfano B, Maj M
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Impact Factor: 4.128
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Galderisi S, Del Zompo M, Invernizzi G, Pini S, Quarantelli M, Rossi A, Cassano P, Severino G, Stratta P, Vita A, Volpe U, Salvatore M, Maj M
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Le Provost JB, Bartres-faz D, Paillere-martinot ML, Artiges E, Pappata S, Recasens C, Perez-gomez M, Bernardo M, Baeza I, Bayle F, Martinot JL
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
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Impact Factor: 5.624
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Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
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Impact Factor: 14.857
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Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H
* Diffusion tensor imaging: Concepts and applications (3930 views)
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Impact Factor: 2.41
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* Altered Patterns of Brain Glucose Metabolism Involve More Extensive and Discrete Cortical Areas in Treatment-resistant Schizophrenia Patients Compared to Responder Patients and Controls: Results From a Head-to-Head 2-[18F]-FDG-PET Study (20 views)
Schizophr Bull (ISSN: 0586-7614linking), 2022 Oct 21; N/D: N/D-N/D.
Impact Factor: 9.306
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Giordano GM, Pezzella P, Quarantelli M, Bucci P, Prinster A, Soricelli A, Perrottelli A, Giuliani L, Fabrazzo M, Galderisi S
* Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study (8 views)
J Clin Med (ISSN: 2077-0383electronic), 2021 Dec 23; 11 (1 ): N/D-N/D.
Impact Factor:
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Canna A, Prinster A, Cantone E, Ponticorvo S, Russo AG, Di Salle F, Esposito F
* Intensity-related distribution of sweet and bitter taste fMRI responses in the insular cortex (163 views)
Hum Brain Mapp (ISSN: 1065-9471linking, 1097-0193electronic), 2019 Aug 15; 40(12): 3631-3646.
Impact Factor: 4.927
View Export to BibTeX Export to EndNote
Nicoletti F, Orlando R, Di Menna L, Cannella M, Notartomaso S, Mascio G, Iacovelli L, Matrisciano F, Fazio F, Caraci F, Copani A, Battaglia G, Bruno V
* Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia (149 views)
Front Psychiatry (ISSN: 1664-0640linking, 1664-0640electronic), 2019 Feb 14; 10: 49-49.
Impact Factor: 2.857
View Export to BibTeX Export to EndNote
Amodio A, Quarantelli M, Mucci A, Prinster A, Soricelli A, Vignapiano A, Giordano GM, Merlotti E, Nicita A, Galderisi S
* Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy Between Amygdala and Insular Cortex (334 views)
Clin Eeg Neurosci (ISSN: 2169-5202electronic, 1550-0594linking), 2018 Jan; 49(1): 55-65.
Impact Factor: 2.163
View Export to BibTeX Export to EndNote
Di Menna L, Joffe ME, Iacovelli L, Orlando R, Lindsley CW, Mairesse J, Gressèns P, Cannella M, Caraci F, Copani A, Bruno V, Battaglia G, Conn PJ, Nicoletti F
* Functional partnership between mGlu3 and mGlu5 metabotropic glutamate receptors in the central nervous system (396 views)
Neuropharm (ISSN: 0028-3908linking, 1873-7064electronic), 2018 Jan; 128: 301-313.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (291 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Sacchi S, Cappelletti P, Pirone L, Smaldone G, Pedone E, Pollegioni L
* Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility (358 views)
Febs Lett (ISSN: 1873-3468, 0014-5793, 0014-5793print), 2017 Feb; 591(4): 646-655.
Impact Factor: 2.999
View Export to BibTeX Export to EndNote
Birolo L, Sacchi S, Smaldone G, Molla G, Leo G, Caldinelli L, Pirone L, Eliometri P, Di Gaetano S, Orefice I, Pedone E, Pucci P, Pollegioni L
* Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction (261 views) (PDF 207 views)
Febs J (ISSN: 1742-464x), 2016 Sep; 283(18): 3353-3370.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Mucci A, Dima D, Soricelli A, Volpe U, Bucci P, Frangou S, Prinster A, Salvatore M, Galderisi S, Maj M
* Is avolition in schizophrenia associated with a deficit of dorsal caudate activity? A functional magnetic resonance imaging study during reward anticipation and feedback (389 views)
Psychol Med (ISSN: 0033-2917), 2015 Jan 12; 45(8): 1765-1778.
Impact Factor: 5.491
View Export to BibTeX Export to EndNote
Quarantelli M, Palladino O, Prinster A, Schiavone V, Carotenuto B, Brunetti A, Marsili A, Casiello M, Muscettola G, Salvatore M, De Bartolomeis A
* Patients with poor response to antipsychotics have a more severe pattern of frontal atrophy: a voxel-based morphometry study of treatment resistance in schizophrenia (331 views)
Biomed Res Int (ISSN: 2314-6133, 2314-6141, 2314-6141electronic), 2014; 2014: 325052-325052.
Impact Factor: 1.579
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Plescia GM, Montefusco V, Romano P, Dima D, Gallo O, Soricelli A, Bucci P, Frangou S, Prinster A, Salvatore M, Maj M, Galderisi S
* REWARD ANTICIPATION IN SCHIZOPHRENIA: A FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY (324 views)
Eur Psychiat (ISSN: 0924-9338), 2014; 29: N/D-N/D.
Impact Factor: 3.439
View Export to BibTeX Export to EndNote
Dynkevich Y, Rother KI, Whitford I, Qureshi S, Galiveeti S, Szulc AL, Danoff A, Breen TL, Kaviani N, Shanik MH, LeRoith D, Vigneri R, Koch CA, Roth J
* Tumors, IGF-2, and Hypoglycemia: Insights From the Clinic, the Laboratory, and the Historical Archive (1669 views)
Endocrine Reviews (ISSN: 0163-769x), 2013 Dec; 34(6): 798-826.
Impact Factor: 19.358
View Export to BibTeX Export to EndNote
Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (606 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Volpe U, Mucci A, Quarantelli M, Galderisi S, Maj M
* Dorsolateral prefrontal cortex volume in patients with deficit or nondeficit schizophrenia (404 views) (PDF 208 views)
Prog Neuro Psychopharmacol Biol Psychiatry (ISSN: 0278-5846), 2012 Jun 1; 37(2): 264-269.
Impact Factor: 3.552
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (987 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Varnäs K, Nyberg S, Halldin C, Varrone A, Takano A, Karlsson P, Andersson J, McCarthy D, Smith M, Pierson ME, Söderström J, Farde L
* Quantitative analysis of [11C]AZ10419369 binding to 5-HT 1B receptors in human brain (414 views)
J Cereb Blood Flow Metab (ISSN: 0271-678x), 2011 Jan; 31(1): 113-123.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (879 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
View Export to BibTeX Export to EndNote
Mcnab F, Varrone A, Farde L, Jucaite A, Bystritsky P, Forssberg H, Klingberg T
* Changes in cortical dopamine D1 receptor binding associated with cognitive training (360 views)
Science (ISSN: 0036-8075, 0036-8075linking), 2009 Feb 6; 323(5915): 800-802.
Impact Factor: 29.747
View Export to BibTeX Export to EndNote
Galderisi S, Quarantelli M, Volpe U, Mucci A, Cassano GB, Invernizzi G, Rossi A, Vita A, Pini S, Cassano P, Daneluzzo E, De Peri L, Stratta P, Brunetti A, Maj M
* Patterns of structural MRI abnormalities in deficit and nondeficit schizophrenia (490 views) (PDF 187 views)
Schizophr Bull (ISSN: 0586-7614, 1745-1701electronic), 2008 Mar; 34(2): 393-401.
Impact Factor: 6.592
View Export to BibTeX Export to EndNote
Barbarulo AM, Pappata S, Puoti G, Prinster A, Grossi D, Cotrufo R, Salvatore M, Trojano L
* Rehabilitation of gesture imitation: a case study with fMRI (397 views)
Neurocase (ISSN: 1465-3656, 1355-4794), 2008; 14(4): 293-306.
Impact Factor: 0.918
View Export to BibTeX Export to EndNote
Varrone A, Pagani M, Salvatore E, Salmaso D, Sansone V, Amboni M, Nobili F, De Michele G, Filla A, Barone P, Pappata S, Salvatore M
* Identification by [Tc-99]ECD SPECT of anterior cingulate hypoperfusion in progressive supranuclear palsy, in comparison with Parkinson's disease (476 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Jul; 34(7): 1071-1081.
Impact Factor: 4.101
View Export to BibTeX Export to EndNote
Landmann C, Dehaene S, Pappata S, Jobert A, Bottlaender M, Roumenov D, Le Bihan D
* Dynamics of prefrontal and cingulate activity during a reward-based logical deduction task (579 views)
Cereb Cortex (ISSN: 1047-3211), 2007 Apr; 17(4): 749-759.
Impact Factor: 6.519
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Antiobesity carbonic anhydrase inhibitors (474 views)
Curr Top Med Chem (ISSN: 1568-0266, 1568-0266linking, 1873-4294electronic), 2007; 7(9): 879-884.
Impact Factor: 4.325
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Galderisi S, Mucci A, Quarantelli M, Volpe U, Amati G, Alfano B, Maj M
* Structural and functional brain imaging findings in deficit and nondeficit schizophrenia (299 views)
International Journal Of Neuropsychopharmacology (ISSN: 1461-1457), 2004 Jun; 7: N/D-N/D.
Impact Factor: 4.128
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Galderisi S, Del Zompo M, Invernizzi G, Pini S, Quarantelli M, Rossi A, Cassano P, Severino G, Stratta P, Vita A, Volpe U, Salvatore M, Maj M
* MRI, neuropsychological and genetic findings in deficit and non-deficit schizophrenia: A multicentre study (275 views)
Eur Psychiat (ISSN: 0924-9338), 2004 Apr; 19: N/D-N/D.
Impact Factor: 1.191
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Le Provost JB, Bartres-faz D, Paillere-martinot ML, Artiges E, Pappata S, Recasens C, Perez-gomez M, Bernardo M, Baeza I, Bayle F, Martinot JL
* Paracingulate sulcus morphology in men with early-onset schizophrenia (243 views)
Br J Psychiatry (ISSN: 0007-1250), 2003 Mar; 182(MAR.): 228-232.
Impact Factor: 4.421
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Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (443 views) (PDF 309 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
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Quarantelli M, Larobina M, Volpe U, Amati G, Tedeschi E, Ciarmiello A, Brunetti A, Galderisi S, Alfano B
* Stereotaxy-based regional brain volumetry applied to segmented MRI: Validation and results in deficit and nondeficit schizophrenia (377 views) (PDF 208 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2002 Sep; 17(1): 373-384.
Impact Factor: 5.624
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Meyer Lindenberg A, Miletich RS, Kohn PD, Esposito G, Carson RE, Quarantelli M, Weinberger DR, Berman KF
* Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia (769 views)
Nat Neurosci (ISSN: 1097-6256), 2002 Mar; 5(3): 267-271.
Impact Factor: 14.857
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Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, Chabriat H
* Diffusion tensor imaging: Concepts and applications (3930 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2001 Apr; 13(4): 534-546.
Impact Factor: 2.41
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31 Records (27 excluding Abstracts).
Total impact factor: 176.605 (164.313 excluding Abstracts).
Total 5 year impact factor: 190.8 (174.898 excluding Abstracts).
Total impact factor: 176.605 (164.313 excluding Abstracts).
Total 5 year impact factor: 190.8 (174.898 excluding Abstracts).
643 views. Last view on Friday 24 March 2023, 11:44:48
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