Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity (1774 views)
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T
Impact factor: 5.835, 5-year impact factor: 7.168
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046799629&doi=10.1016%2fj.neuroimage.2018.04.048&partnerID=40&md5=e1981f264f389307eed9683af6331d38
Keywords: Alzheimer Disease, Brain Functional Mri, Default Mode Network, Fludeoxyglucose Pet, Intrinsic Functional Connectivity, Mild Cognitive Impairment, Fluorodeoxyglucose F 18, Adult, Article, Bioenergy, Bold Signal, Brain Cortex Atrophy, Caudate Nucleus, Cingulate Gyrus, Clinical Article, Controlled Study, Diffusion Weighted Imaging, Echo Planar Imaging, Effect Size, Executive Function, Female, Frontal Gyrus, Functional Magnetic Resonance Imaging, Glucose Metabolism, Glucose Utilization, Gray Matter, Head Movement, Human, Inferior Parietal Lobule, Intrinsic Activity, Middle Frontal Gyrus, Middle Temporal Gyrus, Mini Mental State Examination, Neuropsychological Test, Neurotransmission, Positron Emission Tomography-Computed Tomography, Posterior Cingulate, Precuneus, Primary Progressive Aphasia, Priority Journal, Superior Temporal Gyrus, Thalamus, Aged , Aging Metabolism Physiology , Alzheimer Disease Diagnostic Imaging Metabolism Physiopathology , Amnesia Diagnostic Imaging Metabolism Physiopathology , Cognitive Dysfunction Diagnostic Imaging Metabolism Physiopathology , Connectome Methods , Fluorodeoxyglucose F18 , Magnetic Resonance Imaging Methods , Middle Aged , Multimodal Imaging , Positron-Emission Tomography Methods
Affiliations:
*** IBB - CNR ***
IRCCS SDN, Institute of Nuclear and Diagnostic Research, Via E. Gianturco 113, 80143, Naples, Italy.
INSERM U894, Universite Paris Descartes, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cite, Paris, France
CNRS U8240, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France
Institut Universitaire de France, Paris, France.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Department of Clinical Medicine & Surgery, University of Naples "Federico II", Naples, Italy.
Dept of Medical, Surgical Neurological Metabolic and Aging Sciences. University of Campania "L. Vanvitelli", Italy.
Centro Geriatrico Frullone, ASL Napoli 1 Centro, Naples, Italy.
Department of Neuroscience Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy.
Dept of Neurology, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, INSERM U894, Paris, France.
References:
Not available.
Neuroimage (ISSN: 1053-8119linking), 2018 Aug 1; 176: 246-258.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Research Support, Non-U. S. Gov'T
Impact factor: 5.835, 5-year impact factor: 7.168
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85046799629&doi=10.1016%2fj.neuroimage.2018.04.048&partnerID=40&md5=e1981f264f389307eed9683af6331d38
Keywords: Alzheimer Disease, Brain Functional Mri, Default Mode Network, Fludeoxyglucose Pet, Intrinsic Functional Connectivity, Mild Cognitive Impairment, Fluorodeoxyglucose F 18, Adult, Article, Bioenergy, Bold Signal, Brain Cortex Atrophy, Caudate Nucleus, Cingulate Gyrus, Clinical Article, Controlled Study, Diffusion Weighted Imaging, Echo Planar Imaging, Effect Size, Executive Function, Female, Frontal Gyrus, Functional Magnetic Resonance Imaging, Glucose Metabolism, Glucose Utilization, Gray Matter, Head Movement, Human, Inferior Parietal Lobule, Intrinsic Activity, Middle Frontal Gyrus, Middle Temporal Gyrus, Mini Mental State Examination, Neuropsychological Test, Neurotransmission, Positron Emission Tomography-Computed Tomography, Posterior Cingulate, Precuneus, Primary Progressive Aphasia, Priority Journal, Superior Temporal Gyrus, Thalamus, Aged , Aging Metabolism Physiology , Alzheimer Disease Diagnostic Imaging Metabolism Physiopathology , Amnesia Diagnostic Imaging Metabolism Physiopathology , Cognitive Dysfunction Diagnostic Imaging Metabolism Physiopathology , Connectome Methods , Fluorodeoxyglucose F18 , Magnetic Resonance Imaging Methods , Middle Aged , Multimodal Imaging , Positron-Emission Tomography Methods
Affiliations:
*** IBB - CNR ***
IRCCS SDN, Institute of Nuclear and Diagnostic Research, Via E. Gianturco 113, 80143, Naples, Italy.
INSERM U894, Universite Paris Descartes, Centre Hospitalier Sainte-Anne, Sorbonne Paris Cite, Paris, France
CNRS U8240, Universite Paris Descartes, Sorbonne Paris Cite, Paris, France
Institut Universitaire de France, Paris, France.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
Department of Clinical Medicine & Surgery, University of Naples "Federico II", Naples, Italy.
Dept of Medical, Surgical Neurological Metabolic and Aging Sciences. University of Campania "L. Vanvitelli", Italy.
Centro Geriatrico Frullone, ASL Napoli 1 Centro, Naples, Italy.
Department of Neuroscience Reproductive Sciences and Odontostomatology, Federico II University, Naples, Italy.
Dept of Neurology, Centre Hospitalier Sainte-Anne, Universite Paris Descartes, INSERM U894, Paris, France.
References:
Not available.
Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity
Simultaneously evaluating resting-state brain glucose metabolism and
intrinsic functional activity has potential to impact the clinical
neurosciences of Alzheimer Disease (AD). Indeed, integrating such
combined information obtained in the same physiological setting may
clarify how impairments in neuroenergetic and neuronal function interact
and contribute to the mechanisms underlying AD. The present study used
this multimodality approach to investigate, by means of a hybrid PET/MR
scanner, the coupling between glucose consumption and intrinsic
functional activity in 23 patients with AD-related cognitive impairment
ranging from amnestic mild cognitive impairment (MCI) to mild-moderate
AD (aMCI/AD), in comparison with a group of 23 healthy elderly controls.
Between-group (Controls > Patients) comparisons were conducted on
data from both imaging modalities using voxelwise 2-sample t-tests,
corrected for partial-volume effects, head motion, age, gender and
multiple tests. FDG-PET/fMRI relationships were assessed within and
across subjects using Spearman partial correlations for three different
resting-state fMRI (rs-fMRI) metrics sensitive to AD: fractional
amplitude of low frequency fluctuations (fALFF), regional homogeneity
(ReHo) and group independent component analysis with dual regression
(gICA-DR). FDG and rs-fMRI metrics distinguished aMCI/AD from controls
according to spatial patterns analogous to those found in stand-alone
studies. Within-subject correlations were comparable across the three
rs-fMRI metrics. Correlations were overall high in healthy controls
(ρ = 0.80 ± 0.04), but showed a significant 17% reduction (p < 0.05)
in aMCI/AD patients (ρ = 0.67 ± 0.05). Positive across-subject
correlations were overall moderate (ρ = 0.33 ± 0.07) and consistent
across rs-fMRI metrics. These were confined around AD-target posterior
regions for metrics of functional connectivity (ReHo and gICA-DR). In
contrast, FDG/fALFF correlations were distributed in the frontal gyrus,
thalami and caudate nuclei. Taken together, these results support the
presence of bioenergetic coupling between glucose utilization and rapid
transmission of neural information in healthy ageing, which is
substantially reduced in aMCI/AD, suggesting that abnormal glucose
utilization is in some way linked to communication breakdown among brain
regions impacted by the underlying pathological process.
Simultaneously evaluating resting-state brain glucose metabolism and
intrinsic functional activity has potential to impact the clinical
neurosciences of Alzheimer Disease (AD). Indeed, integrating such
combined information obtained in the same physiological setting may
clarify how impairments in neuroenergetic and neuronal function interact
and contribute to the mechanisms underlying AD. The present study used
this multimodality approach to investigate, by means of a hybrid PET/MR
scanner, the coupling between glucose consumption and intrinsic
functional activity in 23 patients with AD-related cognitive impairment
ranging from amnestic mild cognitive impairment (MCI) to mild-moderate
AD (aMCI/AD), in comparison with a group of 23 healthy elderly controls.
Between-group (Controls > Patients) comparisons were conducted on
data from both imaging modalities using voxelwise 2-sample t-tests,
corrected for partial-volume effects, head motion, age, gender and
multiple tests. FDG-PET/fMRI relationships were assessed within and
across subjects using Spearman partial correlations for three different
resting-state fMRI (rs-fMRI) metrics sensitive to AD: fractional
amplitude of low frequency fluctuations (fALFF), regional homogeneity
(ReHo) and group independent component analysis with dual regression
(gICA-DR). FDG and rs-fMRI metrics distinguished aMCI/AD from controls
according to spatial patterns analogous to those found in stand-alone
studies. Within-subject correlations were comparable across the three
rs-fMRI metrics. Correlations were overall high in healthy controls
(ρ = 0.80 ± 0.04), but showed a significant 17% reduction (p < 0.05)
in aMCI/AD patients (ρ = 0.67 ± 0.05). Positive across-subject
correlations were overall moderate (ρ = 0.33 ± 0.07) and consistent
across rs-fMRI metrics. These were confined around AD-target posterior
regions for metrics of functional connectivity (ReHo and gICA-DR). In
contrast, FDG/fALFF correlations were distributed in the frontal gyrus,
thalami and caudate nuclei. Taken together, these results support the
presence of bioenergetic coupling between glucose utilization and rapid
transmission of neural information in healthy ageing, which is
substantially reduced in aMCI/AD, suggesting that abnormal glucose
utilization is in some way linked to communication breakdown among brain
regions impacted by the underlying pathological process.
Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity
| ▼ Relaxometry based MRI brain segmentation |
Simultaneous resting-state FDG-PET/fMRI in Alzheimer Disease: Relationship between glucose metabolism and intrinsic activity
Other filter: ([btitle,keywords] "Alzheimer Disease" O ...
Vicidomini C, Borbone N, Roviello V, Roviello GN, Oliviero G
* Summary of the Current Status of DNA Vaccination for Alzheimer Disease (308 views)
Vaccines, 2023 Dec 14; 11: 1706-1706.
Impact Factor: 7.8
View Export to BibTeX Export to EndNote
Allocca M, Linguanti F, Calcagni ML, Cistaro A, Gaudieri V, Guerra UP, Morbelli S, Nobili F, Pappata S, Sestini S, Volterrani D, Berti V, For The Neurology Study Group Of The Italian Association Of Nuclear M
* Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study (233 views)
J Clin Med (ISSN: 2077-0383linking), 2021 Oct 25; 10(21): N/D-N/D.
Impact Factor: 4.963
View Export to BibTeX Export to EndNote
Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (278 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
View Export to BibTeX Export to EndNote
Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (1173 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
View Export to BibTeX Export to EndNote
Cocozza S, Pontillo G, Quarantelli M, Sacca F, Riccio E, Costabile T, Olivo G, Brescia Morra V, Pisani A, Brunetti A, Tedeschi E
* Default mode network modifications in Fabry disease: A resting-state fMRI study with structural correlations (866 views)
Hum Brain Mapp (ISSN: 1097-0193electronic, 1065-9471linking), 2018 Jan 09; 39(4): 1755-1764.
Impact Factor: 5.88
View Export to BibTeX Export to EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (827 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (1060 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (1427 views) (PDF 243 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (500 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (615 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (1086 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Cocozza S, Sacca F, Cervo A, Marsili A, Russo CV, Giorgio SM, De Michele G, Filla A, Brunetti A, Quarantelli M
* Modifications of resting state networks in spinocerebellar ataxia type two (700 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2015 Sep; 30(10): 1382-1390.
Impact Factor: 6.01
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (884 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (1599 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (730 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (584 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Milardi D, Pappalardo M
* Molecular dynamics: New advances in drug discovery (695 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 1-3.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (1060 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
View Export to BibTeX Export to EndNote
Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (584 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2014; 41(3): 709-714.
Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (1452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (889 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (1552 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (2218 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (839 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (700 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (598 views) (PDF 332 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1145 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1366 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (953 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (3006 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (1274 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (932 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (866 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
View Export to BibTeX Export to EndNote
Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (790 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (1081 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (947 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (834 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Varrone A, Halldin C
Molecular imaging of the dopamine transporter (783 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
View Export to BibTeX Export to EndNote
Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (768 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (2046 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (1049 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (1042 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (1562 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (2065 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (867 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (657 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1817 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (1365 views) (PDF 332 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
View Export to BibTeX Export to EndNote
Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (2014 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (866 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1504 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (1010 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (998 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (987 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (725 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (1533 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (1014 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (995 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (1035 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (802 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (1073 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (849 views) (PDF 365 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
View Export to BibTeX Export to EndNote
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (993 views) (PDF 325 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.
Impact Factor: 1.302
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (728 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
View Export to BibTeX Export to EndNote
Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (1000 views) (PDF 647 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (805 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (681 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
View Export to BibTeX Export to EndNote
Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (513 views)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.
Impact Factor: 4.989
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (708 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
* Summary of the Current Status of DNA Vaccination for Alzheimer Disease (308 views)
Vaccines, 2023 Dec 14; 11: 1706-1706.
Impact Factor: 7.8
View Export to BibTeX Export to EndNote
Allocca M, Linguanti F, Calcagni ML, Cistaro A, Gaudieri V, Guerra UP, Morbelli S, Nobili F, Pappata S, Sestini S, Volterrani D, Berti V, For The Neurology Study Group Of The Italian Association Of Nuclear M
* Evaluation of Age and Sex-Related Metabolic Changes in Healthy Subjects: An Italian Brain 18F-FDG PET Study (233 views)
J Clin Med (ISSN: 2077-0383linking), 2021 Oct 25; 10(21): N/D-N/D.
Impact Factor: 4.963
View Export to BibTeX Export to EndNote
Coppola C, Saracino D, Oliva M, Cipriano L, Puoti G, Pappata S, Di Fede G, Catania M, Ricci M, Cimini S, Giaccone G, Bonavita S, Rossi G
* Singular cases of Alzheimer's disease disclose new and old genetic "acquaintances" (278 views)
Neurol Sci (ISSN: 1590-1874linking, 1590-3478), 2021 May; 42(5): 2021-2029.
Impact Factor: 1.447
View Export to BibTeX Export to EndNote
Lanza V, Milardi D, Di Natale G, Pappalardo G
* Repurposing of Copper(II)-chelating Drugs for the Treatment of Neurodegenerative Diseases (1173 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Feb 12; 25(4): 525-539.
Impact Factor: 3.249
View Export to BibTeX Export to EndNote
Cocozza S, Pontillo G, Quarantelli M, Sacca F, Riccio E, Costabile T, Olivo G, Brescia Morra V, Pisani A, Brunetti A, Tedeschi E
* Default mode network modifications in Fabry disease: A resting-state fMRI study with structural correlations (866 views)
Hum Brain Mapp (ISSN: 1097-0193electronic, 1065-9471linking), 2018 Jan 09; 39(4): 1755-1764.
Impact Factor: 5.88
View Export to BibTeX Export to EndNote
Oliveri V, Zimbone S, Giuffrida ML, Bellia F, Tomasello MF, Vecchio G
* Porphyrin Cyclodextrin Conjugates Modulate Amyloid Beta Peptide Aggregation and Cytotoxicity (827 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2018; 24(24): 6349-6353.
Impact Factor: 5.476
View Export to BibTeX Export to EndNote
Caraci F, Nicoletti F, Copani A
* Metabotropic glutamate receptors: the potential for therapeutic applications in Alzheimer's disease (1060 views)
Curr Opin Pharmacol (ISSN: 1471-4892), 2017 Dec 23; 38: 1-7.
Impact Factor: 6.313
View Export to BibTeX Export to EndNote
Zimbone S, Monaco I, Giani F, Pandini G, Copani AG, Giuffrida ML, Rizzarelli E
* Amyloid Beta monomers regulate cyclic adenosine monophosphate response element binding protein functions by activating type-1 insulin-like growth factor receptors in neuronal cells (1427 views) (PDF 243 views)
Aging Cell (ISSN: 1474-9726, 1474-9718linking), 2017 Nov 01; 17(1): N/D-N/D.
Impact Factor: 7.627
View Export to BibTeX Export to EndNote
Caraci F, Bruno V, Copani A, Matrisciano F, Nicoletti F, Battaglia G
* The impact of metabotropic glutamate receptors into active neurodegenerative processes: A "dark side" in the development of new symptomatic treatments for neurologic and psychiatric disorders (500 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2017 Mar 15; 115: 180-192.
Impact Factor: 5.012
View Export to BibTeX Export to EndNote
Palmieri G, Cocca E, Gogliettino M, Valentino R, Ruvo M, Cristofano G, Angiolillo A, Balestrieri M, Rossi M, Di Costanzo A
* Low Erythrocyte Levels of Proteasome and Acyl-Peptide Hydrolase (APEH) Activities in Alzheimer's Disease: A Sign of Defective Proteostasis? (615 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2017; 60(3): 1097-1106.
Impact Factor: 3.476
View Export to BibTeX Export to EndNote
D'Andrea LD, Rosa LD, Vigliotti C, Cataldi M
* VEGF mimic peptides: Potential applications in central nervous system therapeutics (1086 views)
New Horizons Transl Med (ISSN: 2307-5023), 2017; 3(5): 233-251.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Cocozza S, Sacca F, Cervo A, Marsili A, Russo CV, Giorgio SM, De Michele G, Filla A, Brunetti A, Quarantelli M
* Modifications of resting state networks in spinocerebellar ataxia type two (700 views)
Mov Disord (ISSN: 0885-3185, 1531-8257, 0885-3185linking), 2015 Sep; 30(10): 1382-1390.
Impact Factor: 6.01
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello MF, Pandini G, Caraci F, Battaglia G, Busceti C, Di Pietro P, Pappalardo G, Attanasio F, Chiechio S, Bagnoli S, Nacmias B, Sorbi S, Vigneri R, Rizzarelli E, Nicoletti F, Copani A
* Monomeric ss-amyloid interacts with type-1 insulin-like growth factor receptors to provide energy supply to neurons (884 views)
Front Cell Neurosci (ISSN: 1662-5102), 2015 Aug 7; 9(AUGUST): 297-297.
Impact Factor: 4.609
View Export to BibTeX Export to EndNote
Caraci F, Pappalardo G, Basile L, Giuffrida A, Copani A, Tosto R, Sinopoli A, Giuffrida ML, Pirrone E, Drago F, Pignatello R, Guccione S
* Neuroprotective effects of the monoamine oxidase inhibitor Tranylcypromine and its amide derivatives against Abeta(1-42)-induced toxicity (1599 views)
Eur J Pharmacol (ISSN: 0014-2999), 2015 Jul 7; 764: 256-263.
Impact Factor: 2.73
View Export to BibTeX Export to EndNote
Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (730 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
View Export to BibTeX Export to EndNote
Merlo S, Basile L, Giuffrida ML, Sortino MA, Guccione S, Copani A
* Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity (584 views)
J Nat Prod (ISSN: 0163-3864), 2015; 78(11): 2704-2711.
Impact Factor: 3.662
View Export to BibTeX Export to EndNote
Milardi D, Pappalardo M
* Molecular dynamics: New advances in drug discovery (695 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2015; 91: 1-3.
Impact Factor: 3.902
View Export to BibTeX Export to EndNote
Perani D, Della Rosa PA, Cerami C, Gallivanone F, Fallanca F, Vanoli EG, Panzacchi A, Nobili F, Pappata S, Marcone A, Garibotto V, Castiglioni I, Magnani G, Cappa SF, Gianolli L; EADC-PET Consortium
* Validation of an optimized SPM procedure for FDG-PET in dementia diagnosis in a clinical setting (1060 views)
Neuroimage Clin (ISSN: 2213-1582, 2213-1582electronic, 2213-1582linking), 2014 Oct 24; 6: 445-454.
Impact Factor: 2.526
View Export to BibTeX Export to EndNote
Testi S, Peluso S, Fabrizi GM, Antenora A, Russo CV, Pappata S, Padovani A, Ferrarini M, Filla A
* A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia (584 views)
J Alzheimers Dis (ISSN: 1387-2877, 1387-2877linking), 2014; 41(3): 709-714.
Impact Factor: 4.151
View Export to BibTeX Export to EndNote
Quarantelli M, Salvatore E, Giorgio SM, Filla A, Cervo A, Russo CV, Cocozza S, Massarelli M, Brunetti A, De Michele G
* Default-mode network changes in Huntington's disease: an integrated MRI study of functional connectivity and morphometry (1452 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Aug 19; 8(8): e72159-e72159.
Impact Factor: 3.534
View Export to BibTeX Export to EndNote
Booij J, Arbizu J, Darcourt J, Hesse S, Nobili F, Payoux P, Pappata S, Tatsch K, Walker Z, Pagani M
* Appropriate use criteria for amyloid PET imaging cannot replace guidelines: on behalf of the European Association of Nuclear Medicine (889 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Jul; 40(7): 1122-1125.
Impact Factor: 5.217
View Export to BibTeX Export to EndNote
Attanasio F, Convertino M, Magno A, Caflisch A, Corazza A, Haridas H, Esposito G, Cataldo S, Pignataro B, Milardi D, Rizzarelli E
* Carnosine Inhibits Abeta(42) Aggregation By Perturbing The H-Bond Network In And Around The Central Hydrophobic Cluster (1552 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2013 Mar 18; 14(5): 583-592.
Impact Factor: 3.06
View Export to BibTeX Export to EndNote
Giuffrida ML, Tomasello F, Caraci F, Chiechio S, Nicoletti F, Copani A
* Beta-Amyloid monomer and insulin/IGF-1 signaling in Alzheimer's disease (2218 views)
Mol Neurobiol (ISSN: 0893-7648), 2012 Dec; 46(3): 605-613.
Impact Factor: 5.471
View Export to BibTeX Export to EndNote
Grasso G, Salomone F, Tundo GR, Pappalardo G, Ciaccio C, Spoto G, Pietropaolo A, Coletta M, Rizzarelli E
* Metal ions affect insulin-degrading enzyme activity (839 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Dec; 117: 351-358.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (700 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2012 Nov 13; 13(11): 14766-14787.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Pascual B, Prieto E, Arbizu J, Marti-climent JM, Penuelas I, Quincoces G, Zarauza R, Pappata S, Masdeu JC
* Decreased carbon-11-flumazenil binding in early Alzheimer's disease (598 views) (PDF 332 views)
Brain (ISSN: 0006-8950, 1460-2156electronic, 0006-8950linking), 2012 Sep; 135(Pt9): 2817-2825.
Impact Factor: 9.915
View Export to BibTeX Export to EndNote
Caraci F, Battaglia G, Sortino MA, Spampinato S, Molinaro G, Copani A, Nicoletti F, Bruno V
* Metabotropic glutamate receptors in neurodegeneration/neuroprotection: Still a hot topic? (1145 views)
Neurochem Int (ISSN: 0197-0186), 2012 Sep; 61(4): 559-565.
Impact Factor: 2.659
View Export to BibTeX Export to EndNote
Grasso G, Giuffrida ML, Rizzarelli E
* Metallostasis And Amyloid Beta-Degrading Enzymes (1366 views)
Metallomics (ISSN: 1756-5901, 1756-591x, 1756-591xelectronic), 2012 Sep; 4(9): 937-949.
Impact Factor: 4.099
View Export to BibTeX Export to EndNote
Travaglia A, Pietropaolo A, La Mendola D, Nicoletti VG, Rizzarelli E
* The inorganic perspectives of neurotrophins and Alzheimer's disease (953 views)
J Chem Res (ISSN: 1873-3344, 0162-0134, 0162-0134print), 2012 Jun; 111: 130-137.
Impact Factor: 3.197
View Export to BibTeX Export to EndNote
Caraci F, Spampinato S, Sortino MA, Bosco P, Battaglia G, Bruno V, Drago F, Nicoletti F, Copani A
* Dysfunction of TGF-β1 signaling in Alzheimer's disease: Perspectives for neuroprotection (3006 views)
Cell Tissue Res (ISSN: 0302-766x), 2012 Jan; 347(1): 291-301.
Impact Factor: 3.677
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Cuzzocrea S, Iavicoli I, Rizzarelli E, Calabrese EJ
* Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity (1274 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 279-304.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Bellia F, Vecchio G, Cuzzocrea S, Calabrese V, Rizzarelli E
* Neuroprotective features of carnosine in oxidative driven diseases (932 views)
Molecular Aspects Of Medicine (ISSN: 1872-9452, 0098-2997), 2011 Sep; 32(4-6): 258-266.
Impact Factor: 9.97
View Export to BibTeX Export to EndNote
Damante CA, Ösz K, Nagy Z, Grasso G, Pappalardo G, Rizzarelli E, Sóvágó I
* Zn2+'s ability to alter the distribution of Cu2+ among the available binding sites of A beta(1-16)-polyethylenglycol-ylated peptide: Implications in Alzheimer's disease (866 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 1520-510xelectronic), 2011 Jun 20; 50(12): 5342-5350.
Impact Factor: 4.601
View Export to BibTeX Export to EndNote
Gulyas B, Vas A, Toth M, Takano A, Varrone A, Cselenyi Z, Schain M, Mattsson P, Halldin C
* Age and disease related changes in the translocator protein (TSPO) system in the human brain: Positron emission tomography measurements with [11C]vinpocetine (790 views)
Neuroimage (ISSN: 1053-8119, 1053-8119linking), 2011 Jun 1; 56(3): 1111-1121.
Impact Factor: 5.895
View Export to BibTeX Export to EndNote
Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (1081 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2011 Mar 15; 6(3): e17971-e17971.
Impact Factor: 4.092
View Export to BibTeX Export to EndNote
Caraci F, Molinaro G, Battaglia G, Giuffrida ML, Riozzi B, Traficante A, Bruno V, Cannella M, Merlo S, Wang X, Heinz BA, Nisenbaum ES, Britton TC, Drago F, Sortino MA, Copani A, Nicoletti F
* Targeting group II Metabotropic Glutamate (mGlu) receptors for the treatment of psychosis associated with alzheimer's disease: Selective activation of mGlu2 receptors amplifies β-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective (947 views)
Mol Pharmacol (ISSN: 0026-895x), 2011 Mar; 79(3): 618-626.
Impact Factor: 4.883
View Export to BibTeX Export to EndNote
Grasso G, Pietropaolo A, Spoto G, Pappalardo G, Tundo GR, Ciaccio C, Coletta M, Rizzarelli E
* Copper(I) and Copper(II) Inhibit A beta Peptides Proteolysis by Insulin-Degrading Enzyme Differently: Implications for Metallostasis Alteration in Alzheimer's Disease (834 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Feb 25; 17(9): 2752-2762.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Varrone A, Halldin C
Molecular imaging of the dopamine transporter (783 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
View Export to BibTeX Export to EndNote
Pappata S, Varrone A, Vicidomini C, Milan G, De Falco C, Sansone V, Iavarone A, Comerci M, Loré E, Panico M, Quarantelli M, Postiglione A, Salvatore M
* SPECT imaging of GABAA/benzodiazepine receptors and cerebral perfusion in mild cognitive impairment (768 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2010 Jun; 37(6): 1156-1163.
Impact Factor: 5.036
View Export to BibTeX Export to EndNote
Bruni AC, Bernardi L, Colao R, Rubino E, Smirne N, Frangipane F, Terni B, Curcio SA, Mirabelli M, Clodomiro A, Di Lorenzo R, Maletta R, Anfossi M, Gallo M, Geracitano S, Tomaino C, Muraca MG, Leotta A, Lio SG, Pinessi L, Rainero I, Sorbi S, Nee L, Milan G, Pappata S, Postiglione A, Abbamondi N, Forloni G, St George Hyslop P, Rogaeva E, Bugiani O, Giaccone G, Foncin JF, Spillantini MG, Puccio G
* Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation (2046 views)
Neurology (ISSN: 0028-3878, 1526-632x, 1526-632xelectronic), 2010 Mar 9; 74(10): 798-806.
Impact Factor: 8.017
View Export to BibTeX Export to EndNote
Giuffrida ML, Caraci F, De Bona P, Pappalardo G, Nicoletti F, Rizzarelli E, Copani A
* The monomer state of beta-amyloid: where the Alzheimer's disease protein meets physiology (1049 views)
Rev Neurosci (ISSN: 0334-1763), 2010; 21(2): 83-93.
Impact Factor: 2.047
View Export to BibTeX Export to EndNote
Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (1042 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (1562 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Rizzarelli E, Owen JB, Dinkova-Kostova AT, Butterfield DA
* Nitric oxide in cell survival: a janus molecule (2065 views)
Antioxid Redox Signal (ISSN: 1557-7716, 1523-0864, 1523-0864linking), 2009 Nov; 11(11): 2717-2739.
Impact Factor: 7.581
View Export to BibTeX Export to EndNote
Arnesano F, Scintilla S, Calò V, Bonfrate E, Ingrosso C, Losacco M, Pellegrino T, Rizzarelli E, Natile G
* Copper-triggered aggregation of ubiquitin (867 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2009 Sep 16; 4(9): e7052-e7052.
Impact Factor: 4.351
View Export to BibTeX Export to EndNote
Vergote J, Chalon S, Emond P, Vercouillie J, Pappata S, Guilloteau D
* New SPECT and PET dementia tracers (657 views)
Med Nucl (ISSN: 0928-1258), 2009 Mar; 33(3): 137-141.
Impact Factor: 0.155
View Export to BibTeX Export to EndNote
Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1817 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
View Export to BibTeX Export to EndNote
Pappata S, Salvatore E, Postiglione A
* In vivo imaging of neurotransmission and brain receptors in dementia (1365 views) (PDF 332 views)
J Neuroimaging (ISSN: 1051-2284, 1051-2284linking), 2008 Apr; 18(2): 111-124.
Impact Factor: 1.811
View Export to BibTeX Export to EndNote
Milan G, Lamenza F, Iavarone A, Galeone F, Lore E, De Falco C, Sorrentino P, Postiglione A
* Frontal Behavioural Inventory in the differential diagnosis of dementia (2014 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2008; 117(4): 260-265.
Impact Factor: 2.317
View Export to BibTeX Export to EndNote
Copani A, Guccione S, Giurato L, Caraci F, Calafiore M, Sortino MA
* The cell cycle molecules behind neurodegeneration in Alzheimer's disease: Perspectives for drug development (866 views)
Curr Med Chem (ISSN: 0929-8673, 1875-533x, 1875-533xelectronic), 2008; 15(24): 2420-2432.
Impact Factor: 4.823
View Export to BibTeX Export to EndNote
Calabrese V, Mancuso C, Calvani M, Rizzarelli E, Butterfield DA, Stella AM
* Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity (1504 views)
Nature Reviews Neuroscience (ISSN: 1471-0048), 2007 Oct; 8(10): 766-775.
Impact Factor: 24.52
View Export to BibTeX Export to EndNote
Copani A, Caraci F, Hoozemans J, Calafiore M, Sortino M, Nicoletti F
* The nature of the cell cycle in neurons: Focus on a "non-canonical" pathway of DNA replication causally related to death (1010 views)
Bba-Gen Subjects (ISSN: 0925-4439, 0006-3002, 1570-9639), 2007 Apr; 1772(4): 409-412.
Impact Factor: 3.078
View Export to BibTeX Export to EndNote
Giuffrida ML, Grasso G, Ruvo M, Pedone C, Saporito A, Marasco D, Pignataro B, Cascio C, Copani A, Rizzarelli E
* Abeta(25-35) And Its C- And/Or N-Blocked Derivatives: Copper Driven Structural Features And Neurotoxicity (998 views)
Journal Of Neuroscience Research (ISSN: 0360-4012), 2007 Feb 15; 85(3): 623-633.
Impact Factor: 3.268
View Export to BibTeX Export to EndNote
Serrano CM, Allegri RF, Caramelli P, Taragano FE, Camera L
* Mild cognitive impairment. Survey of attitudes of specialists and general physicians (987 views)
Medicina (ISSN: 0025-7680), 2007; 67(1): 19-25.
Impact Factor: 0.193
View Export to BibTeX Export to EndNote
Bosco P, Caraci F, Copani A, Spada R, Sortino M, Salluzzo R, Salemi M, Nicoletti F, Ferri R
* The CDC2 I-G-T haplotype associated with the APOE ε4 allele increases the risk of sporadic Alzheimer's disease in Sicily (725 views)
Neurosci Lett (ISSN: 0304-3940), 2007; 419(3): 195-198.
Impact Factor: 2.085
View Export to BibTeX Export to EndNote
Esposito L, Pedone C, Vitagliano L
* Molecular dynamics analyses of cross-beta-spine steric zipper models: beta-sheet twisting and aggregation (1533 views)
P Natl Acad Sci Usa (ISSN: 0027-8424, 1091-6490, 0027-8424print), 2006 Sep 1; 103(31): 11533-11538.
Impact Factor: 9.643
View Export to BibTeX Export to EndNote
Copani A, Hoozemans JJM, Caraci F, Calafiore M, Van Haastert ES, Veerhuis R, Rozemuller AJM, Aronica E, Sortino MA, Nicoletti F
* Dna Polymerase-Beta Is Expressed Early In Neurons Of Alzheimer'S Disease Brain And Is Loaded Into Dna Replication Forks In Neurons Challenged With Beta-Amyloid (1014 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2006; 26(43): 10949-10957.
Impact Factor: 2.117
View Export to BibTeX Export to EndNote
Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G
* Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity (995 views)
Neuroreport (ISSN: 0959-4965), 2005 Sep 1; 16(11): 1223-1226.
Impact Factor: 1.995
View Export to BibTeX Export to EndNote
Filippo C, Mariangela C, Giuseppina F, Pier Luigi C, Angelo B, Marco C, Giuseppe B, Paolo B, Ferdinando N, Agata C, Maria Angela S
* Nicergoline, a drug used for age-dependent cognitive impairment, protects cultured neurons against β-amyloid toxicity (1035 views)
Brain Res (ISSN: 0006-8993), 2005; 1047(1): 30-37.
Impact Factor: 2.296
View Export to BibTeX Export to EndNote
Caricasole A, Copani A, Caraci F, Aronica E, Rozemuller AJ, Caruso A, Storto M, Gaviraghi G, Terstappen GC, Nicoletti F
* Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain (802 views)
J Neurosci (ISSN: 0270-6474, 0361-803x, 1529-2401), 2004 Jun 30; 24(26): 6021-6027.
Impact Factor: 2.384
View Export to BibTeX Export to EndNote
Wiesehan K, Buder K, Linke RP, Patt S, Stoldt M, Unger E, Schmitt B, Bucci E, Willbold D
* Selection of D-amino-acid peptides that bind to Alzheimer's disease amyloid peptide Aβ1-42 by mirror image phage display (1073 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-7633electronic), 2003; 4(8): 748-753.
Impact Factor: 3.992
View Export to BibTeX Export to EndNote
Varrone A, Pappata S, Caracò C, Soricelli A, Milan G, Quarantelli M, Alfano B, Postiglione A, Salvatore M
* Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks (849 views) (PDF 365 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 2002 Nov; 29(11): 1447-1454.
Impact Factor: 3.568
View Export to BibTeX Export to EndNote
Brunetti A, Postiglione A, Tedeschi E, Ciarmiello A, Quarantelli M, Covelli EM, Milan G, Larobina M, Soricelli A, Sodano A, Alfano B
Measurement of global brain atrophy in Alzheimer's disease with unsupervised segmentation of spin-echo MRI studies (993 views) (PDF 325 views)
J Magn Reson Imaging (ISSN: 1053-1807, 1522-2586electronic), 2000 Mar; 11(3): 260-266.
Impact Factor: 1.302
View Export to BibTeX Export to EndNote
Varrone A, Soricelli A, Postiglione A, Salvatore M
Comparison between cortical distribution of I-123 lomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT (728 views)
Clin Nucl Med (ISSN: 0363-9762, 1536-0229, 1536-0229electronic), 1999 Sep; 24(9): 660-665.
Impact Factor: 0.253
View Export to BibTeX Export to EndNote
Alfano B, Quarantelli M, Brunetti A, Larobina M, Covelli EM, Tedeschi E, Salvatore M
Reproducibility of intracranial volume measurement by unsupervised multispectral brain segmentation (1000 views) (PDF 647 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 1998 Mar; 39(3): 497-499.
Impact Factor: 2.962
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli A, Grossi D, Romano M, Mainenti PP, Ruocco A, Fragrassi N, Chiacchio L, Milan G, De Chiara S, Brunetti A
Changes in cerebral blood flow during cognitive activation evaluated by single photon emission computed tomography in patients with Alzheimer's disease (805 views)
Alzheimer S Res (ISSN: 1356-918x), 1997 Jun; 3(3): 93-99.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Postiglione A, Soricelli, Salvatore M, Lassen NA
123I-iomazenil as a clinical tool for studying neuronal loss [4] (681 views)
J Am Geriatr Soc (ISSN: 0002-8614), 1997 Apr; 45(4): 534-536.
Impact Factor: 2.806
View Export to BibTeX Export to EndNote
Soricelli A, Varrone A, Acampa W, Postiglione A, Salvatore M, Lassen N
Brain perfusion with Tc-99m HMPAO and neuronal loss with 123-iomazenil in Alzheimer disease (513 views)
Radiology (ISSN: 0033-8419, 1527-1315, 1527-1315electronic), 1996 Nov; 201: N/D-N/D.
Impact Factor: 4.989
View Export to BibTeX Export to EndNote
Soricelli A, Postiglione A, GrivetFojaja M, Mainenti PP, Discepolo A, Varrone A, Salvatore M, Lassen N
Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses (708 views)
Eur J Nucl Med (ISSN: 0340-6997, 1619-7070, 1619-7089), 1996 Oct; 23(10): 1323-1328.
Impact Factor: 2.692
View Export to BibTeX Export to EndNote
69 Records (65 excluding Abstracts).
Total impact factor: 303.189 (286.223 excluding Abstracts).
Total 5 year impact factor: 313.834 (294.624 excluding Abstracts).
Total impact factor: 303.189 (286.223 excluding Abstracts).
Total 5 year impact factor: 313.834 (294.624 excluding Abstracts).
1774 views. Last view on Friday 21 March 2025, 21:58:36
ibb.cnr.it
