Warranty period of normal stress myocardial perfusion imaging in hypertensive patients: A parametric survival analysis(566 views) Acampa W, Rozza F, Zampella E, Assante R, Mannarino T, Nappi C, Mainolfi C, Petretta M, Trimarco B, Cuocolo A
Keywords: Mpi, Spect, Diagnostic And Prognostic Applicatio,
Affiliations: *** IBB - CNR ***
Department of Advanced Biomedical Sciences, University Federico II, Via Pansini 5, Naples, 80131, Italy
Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy
Department of Translational Medical Sciences, University Federico II, Naples, Italy
References: Not available.
Warranty period of normal stress myocardial perfusion imaging in hypertensive patients: A parametric survival analysis
BACKGROUND:
We evaluated the warranty period
of a normal stress myocardial perfusion single-photon emission computed
tomography (MPS) in hypertensive patients.
METHODS AND RESULTS:
A
total of 471 consecutive hypertensive patients with suspected coronary
artery disease and normal perfusion at stress MPS were followed for a
mean of 76 ± 21 months. Endpoint events were cardiac death or nonfatal
myocardial infarction. With Cox analysis, age (hazard ratio 1.1,
P < .005) and stress test type (hazard ratio 2.7, P < .005) were
independent predictors of events. With parametric Weibull analysis,
patients ≤60 years old undergoing exercise stress test remained at low
risk for the entire length of follow-up, while the highest probability
of events and the major risk acceleration were observed in
those >
60 years old who underwent pharmacologic stress test. In
patients undergoing exercise test, peak systolic blood pressure (BP;
hazard ratio 1.1, P < .005) emerged as predictor of events, and only
subjects with peak systolic BP < 160 mmHg remained at low risk for
the entire length of follow-up. In contrast, for patients with peak
systolic BP ≥180 mmHg, the time to achieve a cumulative cardiac risk
level of 3% was 18 months.
CONCLUSIONS:
In hypertensive
patients, the warranty period of a normal stress MPS varies according to
stress type and peak systolic BP. A normal stress MPS can be considered
reassuring in subjects ≤60 years old who performed exercise stress test
and a peak systolic BP < 160 mmHg.
Warranty period of normal stress myocardial perfusion imaging in hypertensive patients: A parametric survival analysis
No results.
Warranty period of normal stress myocardial perfusion imaging in hypertensive patients: A parametric survival analysis