Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2-related Parkinson's disease(386 views) De Rosa A, Peluso S, De Lucia N, Russo P, Annarumma I, Esposito M, Manganelli F, Brunetti A, De Michele G, Pappata S
Keywords: Cognitive, Fdg-Pet, Lrrk2, Parkinson, S Disease, Fluorodeoxyglucose F 18, Adult, Apathy, Article, Brain Metabolism, Clinical Article, Clinical Feature, Controlled Study, Dementia, Demography, Disease Duration, Disease Severity, Dyskinesia, Female, Gene, Gene Mutation, Genetic Screening, Hallucination, Human, Inferior Parietal Cortex, Italian (citizen), Long Term Memory, Lrrk2 Gene, Mental Disease, Mini Mental State Examination, Neuropsychology, North American, Parietal Lobe, Parkinson Disease, Pathogenicity, Phenotype, Positron Emission Tomography, Priority Journal, Temporal Lobe,
Affiliations: *** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy
Department of Psychology, University of Campania, Luigi Vanvitelli, Naples, Italy
Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
Institute of Biostructure and Bioimaging, National Council of Research, Naples, Italy
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Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2-related Parkinson's disease
INTRODUCTION:
LRRK2 gene mutations underlie
the most common mendelian form of Parkinson's Disease (PD), designated
PARK8, that shows clinical features similar to those in idiopathic PD
(IPD). We assessed the cognitive functions and the cerebral metabolism
measured with 18F-fluorodeoxyglucose (FDG)-PET in PARK8 patients
compared with IPD.
PATIENTS AND METHODS:
We enrolled
eight PARK8 patients and eight IPD patients, comparable for onset age,
stage, severity and duration of disease. Mean age ± SD was 61.8 ± 10.9
years and disease duration 8.4 ± 5.8 in PARK8, and 61.4 ± 14.7 and
7.0 ± 4.8 in IPD. All subjects underwent a wide neuropsychological
assessment and a FDG-PET. Cerebral regional relative metabolic maps were
evaluated using voxel-based analysis with statistical parametric
mapping.
RESULTS:
Motor and non-motor phenotype and
neuropsychological evaluation did not differ between PARK8 and IPD. We
detected one case of dementia and four of Mild Cognitive Impairment in
each group. At FDG-PET, compared to controls, IPD patients revealed a
significant relative posterior cortical hypometabolism in the left
temporal and inferior parietal and in the right inferior and superior
parietal regions, whereas patients with LRRK2 mutation, at a less
conservative threshold, showed only a relative left inferior parietal
hypometabolism. No differences were found between patients with PARK8
and IPD.
CONCLUSIONS:
The results confirm a comparable
cognitive profile between LRRK2 and IPD patients. FDG-PET study showed a
pattern of posterior cortical hypometabolism in both groups, although
less severe in LRRK2-related PD. The milder decrease of cortical
metabolism in PARK8 might be due to a less marked pathological
involvement compared to IPD.
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