(13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro(642 views) Cavallari E, Carrera C, Aime S, Reineri F
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017 Jan 23; 23(5): 1200-1204.
Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino, Italy., Istituto Bioimmagini e Biostrutture del CNR, Sezione di Torino c/o Center of Molecular Imaging, Via Nizza 52, Torino, Italy.,
References: Not available.
(13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro
Hyperpolarization of the (13) C magnetic resonance signal of l-[1-(13) C]lactate has been obtained using the chemically based, cost-effective method called parahydrogen-induced polarization by means of side-arm hydrogenation (PHIP-SAH). Two ester derivatives of lactate were tested and the factors that determine the polarization level on the product have been investigated in detail. The metabolic conversion of hyperpolarized l-[1-(13) C]lactate into pyruvate has been observed in vitro using lactate dehydrogenase (LDH) and in a cells lysate. From the acquisition of a series of (13) C NMR spectra, the metabolic build-up of the [1-(13) C]pyruvate signal has been observed. These studies demonstrate that, even if the experimental set-up used for these PHIP-SAH hyperpolarization studies is still far from optimal, the attained polarization level is already sufficient to carry out in vitro metabolic studies.
(13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro
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