EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (902 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
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Paper type: Journal Article,
Impact factor: 3.862, 5-year impact factor: 4.229
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018360809&doi=10.1016%2fj.ijpharm.2017.04.040&partnerID=40&md5=4da5e65d7c67d41ef103cc0be4be6173
Keywords: Cest, Chemical Exchange Saturation Transfer, Excipients, Imaging, Tumor, 2 Pyrrolidinone, Ascorbic Acid, Meglumine, N Acetylglucosamine, Sucrose, Contrast Medium, Proton, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Cancer Model, Continuous Infusion, Controlled Study, Female, In Vitro Study, In Vivo Study, Melanoma, Molecular Imaging, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Proton Nuclear Magnetic Resonance, Single Drug Dose, Tumor Volume, Tumor Xenograft, Algorithm, Bagg Albino Mouse, Chemistry, Diagnostic Imaging, Drug Screening, Neoplasm, Inbred Balb C, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via Nizza 52, Torino, 10126, Italy
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy
MSD Belgium, Lynx Binnenhof 5, Brussels, 1200, Belgium
References:
Not available.
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.862, 5-year impact factor: 4.229
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018360809&doi=10.1016%2fj.ijpharm.2017.04.040&partnerID=40&md5=4da5e65d7c67d41ef103cc0be4be6173
Keywords: Cest, Chemical Exchange Saturation Transfer, Excipients, Imaging, Tumor, 2 Pyrrolidinone, Ascorbic Acid, Meglumine, N Acetylglucosamine, Sucrose, Contrast Medium, Proton, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Cancer Model, Continuous Infusion, Controlled Study, Female, In Vitro Study, In Vivo Study, Melanoma, Molecular Imaging, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Proton Nuclear Magnetic Resonance, Single Drug Dose, Tumor Volume, Tumor Xenograft, Algorithm, Bagg Albino Mouse, Chemistry, Diagnostic Imaging, Drug Screening, Neoplasm, Inbred Balb C, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via Nizza 52, Torino, 10126, Italy
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy
MSD Belgium, Lynx Binnenhof 5, Brussels, 1200, Belgium
References:
Not available.
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-D-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers). All the investigated molecules showed remarkable CEST contrast upon i.v. administration in the range 1–3 ppm according to the type of mobile proton groups. A marked increase of CEST contrast was observed in tumor regions up to 30 min post injection. The combination of marked tumor contrast enhancement and lack of toxicity make these molecules potential candidates for the diagnosis of tumors within the MRI-CEST approach. © 2017 Elsevier B.V.
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-D-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers). All the investigated molecules showed remarkable CEST contrast upon i.v. administration in the range 1–3 ppm according to the type of mobile proton groups. A marked increase of CEST contrast was observed in tumor regions up to 30 min post injection. The combination of marked tumor contrast enhancement and lack of toxicity make these molecules potential candidates for the diagnosis of tumors within the MRI-CEST approach. © 2017 Elsevier B.V.
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
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EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
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* In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model (123 views)
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View Export to BibTeX Export to EndNote
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Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
View Export to BibTeX Export to EndNote
Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (499 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Longo DL, Irrera P, Consolino L, Sun PZ, Mcmahon MT
* Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept (236 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 241-256.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (254 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K
* Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla (299 views)
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
Impact Factor: 2.983
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Arena F, Capozza M, Longo DL
* Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH (477 views)
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
View Export to BibTeX Export to EndNote
Kujawa A, Kim M, Demetriou E, Anemone A, Livio Longo D, Zaiss M, Golay X
* Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging (119 views)
J Magn Reson (ISSN: 1090-7807linking), 2019 Mar; 300: 120-134.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (516 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
* Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging (418 views)
J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Longo DL, Aime S
* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (624 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 2017 Jul 07; 79(3): 1553-1558.
Impact Factor: 4.082
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (320 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S
* Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (473 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2017; 30(7): N/D-N/D.
Impact Factor: 3.031
View Export to BibTeX Export to EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (488 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
View Export to BibTeX Export to EndNote
Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (756 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (597 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
View Export to BibTeX Export to EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (543 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
View Export to BibTeX Export to EndNote
Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (434 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (372 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
Impact Factor: 1.56
View Export to BibTeX Export to EndNote
Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (565 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
View Export to BibTeX Export to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (731 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
View Export to BibTeX Export to EndNote
21 Records (21 excluding Abstracts).
Total impact factor: 63.072 (63.072 excluding Abstracts).
Total 5 year impact factor: 71.388 (71.388 excluding Abstracts).
Total impact factor: 63.072 (63.072 excluding Abstracts).
Total 5 year impact factor: 71.388 (71.388 excluding Abstracts).
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