EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging (372 views)
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.862, 5-year impact factor: 4.229
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018360809&doi=10.1016%2fj.ijpharm.2017.04.040&partnerID=40&md5=4da5e65d7c67d41ef103cc0be4be6173
Keywords: Cest, Chemical Exchange Saturation Transfer, Excipients, Imaging, Tumor, 2 Pyrrolidinone, Ascorbic Acid, Meglumine, N Acetylglucosamine, Sucrose, Contrast Medium, Proton, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Cancer Model, Continuous Infusion, Controlled Study, Female, In Vitro Study, In Vivo Study, Melanoma, Molecular Imaging, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Proton Nuclear Magnetic Resonance, Single Drug Dose, Tumor Volume, Tumor Xenograft, Algorithm, Bagg Albino Mouse, Chemistry, Diagnostic Imaging, Drug Screening, Neoplasm, Inbred Balb C, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via Nizza 52, Torino, 10126, Italy
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy
MSD Belgium, Lynx Binnenhof 5, Brussels, 1200, Belgium
References:
Abrantes, C.G., Duarte, D., Reis, C.P., An overview of pharmaceutical excipients: safe or not safe? (2016) J. Pharm. Sci., 105, pp. 2019-202
Aime, S., Botta, M., Terreno, E., Gd(III)-based contrast agents for MRI (2005) Adv. Inorg. Chem., 57, pp. 173-237
Aime, S., Calabi, L., Biondi, L., De Miranda, M., Ghelli, S., Paleari, L., Rebaudengo, C., Terreno, E., Iopamidol: exploring the potential use of a well-established x-ray contrast agent for MRI (2005) Magn. Reson. Med., 53, pp. 830-834
Anemone, A., Consolino, L., Longo, D.L., MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (2017) Eur. Radiol., 27, pp. 2170-2179
Bar-Shir, A., Liu, G., Chan, K.W., Oskolkov, N., Song, X., Yadav, N.N., Walczak, P., Gilad, A.A., Human protamine-1 as an MRI reporter gene based on chemical exchange (2014) ACS Chem. Biol., 9, pp. 134-138
Bar-Shir, A., Liang, Y., Chan, K.W., Gilad, A.A., Bulte, J.W., Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging (2015) Chem. Commun. (Camb), 51, pp. 4869-4871
Cai, K., Singh, A., Poptani, H., Li, W., Yang, S., Lu, Y., Hariharan, H., Reddy, R., CEST signal at 2 ppm (CEST@2 ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor (2015) NMR Biomed., 28, pp. 1-8
Casas, M., Aguilar-de-Leyva, A., Caraballo, I., Towards a rational basis for selection of excipients: excipient efficiency for controlled release (2015) Int. J. Pharm., 494, pp. 288-295
Chan, K.W., McMahon, M.T., Kato, Y., Liu, G., Bulte, J.W., Bhujwalla, Z.M., Artemov, D., van Zijl, P.C., Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer (2012) Magn. Reson. Med., 68, pp. 1764-1773
Chen, L.Q., Randtke, E.A., Jones, K.M., Moon, B.F., Howison, C.M., Pagel, M.D., Evaluations of tumor acidosis within in vivo tumor models using parametric maps generated with AcidoCEST MRI (2015) Mol. Imaging Biol.
Geraldes, C.F., Laurent, S., Classification and basic properties of contrast agents for magnetic resonance imaging (2009) Contrast Media Mol. Imaging, 4, pp. 1-23
Haris, M., Nanga, R.P., Singh, A., Cai, K., Kogan, F., Hariharan, H., Reddy, R., Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI (2012) NMR Biomed., 25, pp. 1305-1309
Heeg, J.F., Born, G.S., Kessler, W.V., Shaw, S.M., Lange, W.E., Absorption, distribution, and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate (1977) J. Pharm. Sci., 66, pp. 96-99
Jin, T., Nicholls, F.J., Crum, W.R., Ghuman, H., Badylak, S.F., Modo, M., Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke (2017) Biomaterials, 113, pp. 176-190
Jones, K.M., Randtke, E.A., Howison, C.M., Cardenas-Rodriguez, J., Sime, P.J., Kottmann, M.R., Pagel, M.D., Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI (2015) Mol. Imaging Biol., 17, pp. 177-184
Lesniak, W.G., Oskolkov, N., Song, X., Lal, B., Yang, X., Pomper, M., Laterra, J., McMahon, M.T., Salicylic acid conjugated dendrimers are a tunable, high performance CEST MRI nanoplatform (2016) Nano Lett., 16, pp. 2248-2253
Li, Y., Chen, H., Xu, J., Yadav, N.N., Chan, K.W., Luo, L., McMahon, M.T., Liu, G., CEST theranostics: label-free MR imaging of anticancer drugs (2016) Oncotarget, 7, pp. 6369-6378
Liang, Y., Bar-Shir, A., Song, X., Gilad, A.A., Walczak, P., Bulte, J.W., Label-free imaging of gelatin-containing hydrogel scaffolds (2015) Biomaterials, 42, pp. 144-150
Ling, W., Regatte, R.R., Navon, G., Jerschow, A., Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) (2008) Proc. Natl. Acad. Sci. U. S. A., 105, pp. 2266-2270
Liu, G., Song, X., Chan, K.W., McMahon, M.T., Nuts and bolts of chemical exchange saturation transfer MRI (2013) NMR Biomed., 26, pp. 810-828
Liu, H., Jablonska, A., Li, Y., Cao, S., Liu, D., Chen, H., Van Zijl, P.C., Liu, G., Label-free CEST MRI detection of citicoline-liposome drug delivery in Ischemic stroke (2016) Theranostics, 6, pp. 1588-1600
Loftsson, T., Excipient pharmacokinetics and profiling (2015) Int. J. Pharm., 480, pp. 48-54
Longo, D.L., Dastru, W., Digilio, G., Keupp, J., Langereis, S., Lanzardo, S., Prestigio, S., Aime, S., Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: in vivo studies in mice at 7 T (2011) Magn. Reson. Med., 65, pp. 202-211
Longo, D.L., Busato, A., Lanzardo, S., Antico, F., Aime, S., Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent (2013) Magn. Reson. Med., 70, pp. 859-864
Longo, D.L., Di Gregorio, E., Abategiovanni, R., Ceccon, A., Assfalg, M., Molinari, H., Aime, S., Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins’ behaviour (2014) Analyst, 139, pp. 2687-2690
Longo, D.L., Sun, P.Z., Consolino, L., Michelotti, F.C., Uggeri, F., Aime, S., A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol (2014) J. Am. Chem. Soc., 136, pp. 14333-14336
Longo, D.L., Bartoli, A., Consolino, L., Bardini, P., Arena, F., Schwaiger, M., Aime, S., In vivo imaging of tumor metabolism and acidosis by combining PET and MRI-CEST pH imaging (2016) Cancer Res., 76, pp. 6463-6470
Longo, D.L., Michelotti, F., Consolino, L., Bardini, P., Digilio, G., Xiao, G., Sun, P.Z., Aime, S., In vitro and in vivo assessment of nonionic iodinated radiographic molecules as chemical exchange saturation transfer magnetic resonance imaging tumor perfusion agents (2016) Invest. Radiol., 51, pp. 155-162
Longo, D.L., Cutrin, J.C., Michelotti, F., Irrera, P., Aime, S., Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (2017) NMR Biomed.
McMahon, M.T., Gilad, A.A., DeLiso, M.A., Berman, S.M., Bulte, J.W., van Zijl, P.C., New multicolor polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI (2008) Magn. Reson. Med., 60, pp. 803-812
Morana, G., Cugini, C., Scatto, G., Zanato, R., Fusaro, M., Dorigo, A., Use of contrast agents in oncological imaging: magnetic resonance imaging (2013) Cancer Imaging, 13, pp. 350-359
Nanni, P., de Giovanni, C., Lollini, P.L., Nicoletti, G., Prodi, G., TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin. Exp. Metastasis, 1, pp. 373-380
Narayan, P., Overview of drug product development (2011) Curr. Protoc. Pharmacol., pp. 1-29. , (Chapter 7, Unit 7 3)
Nasrallah, F.A., Pages, G., Kuchel, P.W., Golay, X., Chuang, K.H., Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI (2013) J. Cereb. Blood Flow Metab., 33, pp. 1270-1278
Rivlin, M., Navon, G., Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors (2016) Sci. Rep., 6, p. 32648
Rivlin, M., Horev, J., Tsarfaty, I., Navon, G., Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI (2013) Sci. Rep., 3, p. 3045
Rivlin, M., Tsarfaty, I., Navon, G., Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3-O-methyl-D-glucose (2014) Magn. Reson. Med., 72, pp. 1375-1380
Rutten, A., Prokop, M., Contrast agents in X-ray computed tomography and its applications in oncology (2007) Anticancer Agents Med. Chem., 7, pp. 307-316
Sherry, A.D., Caravan, P., Lenkinski, R.E., Primer on gadolinium chemistry (2009) J. Magn. Reson. Imaging, 30, pp. 1240-1248
Shinar, H., Battistel, M.D., Mandler, M., Lichaa, F., Freedberg, D.I., Navon, G., Sialo-CEST: chemical exchange saturation transfer NMR of oligo- and poly-sialic acids and the assignment of their hydroxyl groups using selective- and HSQC-TOCSY (2014) Carbohydr. Res., 389, pp. 165-173
Sun, P.Z., Longo, D.L., Hu, W., Xiao, G., Wu, R., Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH (2014) Phys. Med. Biol., 59, pp. 4493-4504
Terreno, E., Stancanello, J., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M., Kok, M.B., Aime, S., Methods for an improved detection of the MRI-CEST effect (2009) Contrast Media Mol. Imaging, 4, pp. 237-247
Vinogradov, E., Sherry, A.D., Lenkinski, R.E., CEST: from basic principles to applications, challenges and opportunities (2013) J. Magn. Reson., 229, pp. 155-172
Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Rajkumar, V., Johnson, S.P., Richardson, S., Golay, X., In vivo imaging of glucose uptake and metabolism in tumors (2013) Nat. Med., 19, pp. 1067-1072
Wening, K., Breitkreutz, J., Oral drug delivery in personalized medicine: unmet needs and novel approaches (2011) Int. J. Pharm., 404, pp. 1-9
Xu, X., Chan, K.W., Knutsson, L., Artemov, D., Xu, J., Liu, G., Kato, Y., van Zijl, P.C., Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer (2015) Magn. Reson. Med., 74, pp. 1556-1563
Yang, X., Song, X., Li, Y., Liu, G., Ray Banerjee, S., Pomper, M.G., McMahon, M.T., Salicylic acid and analogues as diaCEST MRI contrast agents with highly shifted exchangeable proton frequencies (2013) Angew. Chem. Int. Ed. Engl., 52, pp. 8116-8119
Zaiss, M., Kunz, P., Goerke, S., Radbruch, A., Bachert, P., MR imaging of protein folding in vitro employing nuclear-Overhauser-mediated saturation transfer (2013) NMR Biomed., 26, pp. 1815-1822
van Zijl, P.C., Yadav, N.N., Chemical exchange saturation transfer (CEST): what is in a name and what isn't? (2011) Magn. Reson. Med., 65, pp. 927-948
van Zijl, P.C., Jones, C.K., Ren, J., Malloy, C.R., Sherry, A.D., MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST) (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 4359-4364
Int J Pharm (ISSN: 0378-5173, 1873-3476), 2017; 525(1): 275-281.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.862, 5-year impact factor: 4.229
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018360809&doi=10.1016%2fj.ijpharm.2017.04.040&partnerID=40&md5=4da5e65d7c67d41ef103cc0be4be6173
Keywords: Cest, Chemical Exchange Saturation Transfer, Excipients, Imaging, Tumor, 2 Pyrrolidinone, Ascorbic Acid, Meglumine, N Acetylglucosamine, Sucrose, Contrast Medium, Proton, Animal Cell, Animal Experiment, Animal Model, Article, Breast Cancer, Cancer Cell, Cancer Model, Continuous Infusion, Controlled Study, Female, In Vitro Study, In Vivo Study, Melanoma, Molecular Imaging, Mouse, Nonhuman, Nuclear Magnetic Resonance Imaging, Nuclear Magnetic Resonance Scanner, Priority Journal, Proton Nuclear Magnetic Resonance, Single Drug Dose, Tumor Volume, Tumor Xenograft, Algorithm, Bagg Albino Mouse, Chemistry, Diagnostic Imaging, Drug Screening, Neoplasm, Inbred Balb C, Xenograft Model Antitumor Assays,
Affiliations:
*** IBB - CNR ***
Istituto di Biostrutture e Bioimmagini (IBB), Consiglio Nazionale delle Ricerche (CNR), Via Nizza 52, Torino, 10126, Italy
Dipartimento di Biotecnologie Molecolari e Scienze per la Salute, Università degli Studi di Torino, Via Nizza 52, Torino, 10126, Italy
MSD Belgium, Lynx Binnenhof 5, Brussels, 1200, Belgium
References:
Abrantes, C.G., Duarte, D., Reis, C.P., An overview of pharmaceutical excipients: safe or not safe? (2016) J. Pharm. Sci., 105, pp. 2019-202
Aime, S., Botta, M., Terreno, E., Gd(III)-based contrast agents for MRI (2005) Adv. Inorg. Chem., 57, pp. 173-237
Aime, S., Calabi, L., Biondi, L., De Miranda, M., Ghelli, S., Paleari, L., Rebaudengo, C., Terreno, E., Iopamidol: exploring the potential use of a well-established x-ray contrast agent for MRI (2005) Magn. Reson. Med., 53, pp. 830-834
Anemone, A., Consolino, L., Longo, D.L., MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (2017) Eur. Radiol., 27, pp. 2170-2179
Bar-Shir, A., Liu, G., Chan, K.W., Oskolkov, N., Song, X., Yadav, N.N., Walczak, P., Gilad, A.A., Human protamine-1 as an MRI reporter gene based on chemical exchange (2014) ACS Chem. Biol., 9, pp. 134-138
Bar-Shir, A., Liang, Y., Chan, K.W., Gilad, A.A., Bulte, J.W., Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging (2015) Chem. Commun. (Camb), 51, pp. 4869-4871
Cai, K., Singh, A., Poptani, H., Li, W., Yang, S., Lu, Y., Hariharan, H., Reddy, R., CEST signal at 2 ppm (CEST@2 ppm) from Z-spectral fitting correlates with creatine distribution in brain tumor (2015) NMR Biomed., 28, pp. 1-8
Casas, M., Aguilar-de-Leyva, A., Caraballo, I., Towards a rational basis for selection of excipients: excipient efficiency for controlled release (2015) Int. J. Pharm., 494, pp. 288-295
Chan, K.W., McMahon, M.T., Kato, Y., Liu, G., Bulte, J.W., Bhujwalla, Z.M., Artemov, D., van Zijl, P.C., Natural D-glucose as a biodegradable MRI contrast agent for detecting cancer (2012) Magn. Reson. Med., 68, pp. 1764-1773
Chen, L.Q., Randtke, E.A., Jones, K.M., Moon, B.F., Howison, C.M., Pagel, M.D., Evaluations of tumor acidosis within in vivo tumor models using parametric maps generated with AcidoCEST MRI (2015) Mol. Imaging Biol.
Geraldes, C.F., Laurent, S., Classification and basic properties of contrast agents for magnetic resonance imaging (2009) Contrast Media Mol. Imaging, 4, pp. 1-23
Haris, M., Nanga, R.P., Singh, A., Cai, K., Kogan, F., Hariharan, H., Reddy, R., Exchange rates of creatine kinase metabolites: feasibility of imaging creatine by chemical exchange saturation transfer MRI (2012) NMR Biomed., 25, pp. 1305-1309
Heeg, J.F., Born, G.S., Kessler, W.V., Shaw, S.M., Lange, W.E., Absorption, distribution, and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate (1977) J. Pharm. Sci., 66, pp. 96-99
Jin, T., Nicholls, F.J., Crum, W.R., Ghuman, H., Badylak, S.F., Modo, M., Diamagnetic chemical exchange saturation transfer (diaCEST) affords magnetic resonance imaging of extracellular matrix hydrogel implantation in a rat model of stroke (2017) Biomaterials, 113, pp. 176-190
Jones, K.M., Randtke, E.A., Howison, C.M., Cardenas-Rodriguez, J., Sime, P.J., Kottmann, M.R., Pagel, M.D., Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI (2015) Mol. Imaging Biol., 17, pp. 177-184
Lesniak, W.G., Oskolkov, N., Song, X., Lal, B., Yang, X., Pomper, M., Laterra, J., McMahon, M.T., Salicylic acid conjugated dendrimers are a tunable, high performance CEST MRI nanoplatform (2016) Nano Lett., 16, pp. 2248-2253
Li, Y., Chen, H., Xu, J., Yadav, N.N., Chan, K.W., Luo, L., McMahon, M.T., Liu, G., CEST theranostics: label-free MR imaging of anticancer drugs (2016) Oncotarget, 7, pp. 6369-6378
Liang, Y., Bar-Shir, A., Song, X., Gilad, A.A., Walczak, P., Bulte, J.W., Label-free imaging of gelatin-containing hydrogel scaffolds (2015) Biomaterials, 42, pp. 144-150
Ling, W., Regatte, R.R., Navon, G., Jerschow, A., Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST) (2008) Proc. Natl. Acad. Sci. U. S. A., 105, pp. 2266-2270
Liu, G., Song, X., Chan, K.W., McMahon, M.T., Nuts and bolts of chemical exchange saturation transfer MRI (2013) NMR Biomed., 26, pp. 810-828
Liu, H., Jablonska, A., Li, Y., Cao, S., Liu, D., Chen, H., Van Zijl, P.C., Liu, G., Label-free CEST MRI detection of citicoline-liposome drug delivery in Ischemic stroke (2016) Theranostics, 6, pp. 1588-1600
Loftsson, T., Excipient pharmacokinetics and profiling (2015) Int. J. Pharm., 480, pp. 48-54
Longo, D.L., Dastru, W., Digilio, G., Keupp, J., Langereis, S., Lanzardo, S., Prestigio, S., Aime, S., Iopamidol as a responsive MRI-chemical exchange saturation transfer contrast agent for pH mapping of kidneys: in vivo studies in mice at 7 T (2011) Magn. Reson. Med., 65, pp. 202-211
Longo, D.L., Busato, A., Lanzardo, S., Antico, F., Aime, S., Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent (2013) Magn. Reson. Med., 70, pp. 859-864
Longo, D.L., Di Gregorio, E., Abategiovanni, R., Ceccon, A., Assfalg, M., Molinari, H., Aime, S., Chemical exchange saturation transfer (CEST): an efficient tool for detecting molecular information on proteins’ behaviour (2014) Analyst, 139, pp. 2687-2690
Longo, D.L., Sun, P.Z., Consolino, L., Michelotti, F.C., Uggeri, F., Aime, S., A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol (2014) J. Am. Chem. Soc., 136, pp. 14333-14336
Longo, D.L., Bartoli, A., Consolino, L., Bardini, P., Arena, F., Schwaiger, M., Aime, S., In vivo imaging of tumor metabolism and acidosis by combining PET and MRI-CEST pH imaging (2016) Cancer Res., 76, pp. 6463-6470
Longo, D.L., Michelotti, F., Consolino, L., Bardini, P., Digilio, G., Xiao, G., Sun, P.Z., Aime, S., In vitro and in vivo assessment of nonionic iodinated radiographic molecules as chemical exchange saturation transfer magnetic resonance imaging tumor perfusion agents (2016) Invest. Radiol., 51, pp. 155-162
Longo, D.L., Cutrin, J.C., Michelotti, F., Irrera, P., Aime, S., Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (2017) NMR Biomed.
McMahon, M.T., Gilad, A.A., DeLiso, M.A., Berman, S.M., Bulte, J.W., van Zijl, P.C., New multicolor polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI (2008) Magn. Reson. Med., 60, pp. 803-812
Morana, G., Cugini, C., Scatto, G., Zanato, R., Fusaro, M., Dorigo, A., Use of contrast agents in oncological imaging: magnetic resonance imaging (2013) Cancer Imaging, 13, pp. 350-359
Nanni, P., de Giovanni, C., Lollini, P.L., Nicoletti, G., Prodi, G., TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma (1983) Clin. Exp. Metastasis, 1, pp. 373-380
Narayan, P., Overview of drug product development (2011) Curr. Protoc. Pharmacol., pp. 1-29. , (Chapter 7, Unit 7 3)
Nasrallah, F.A., Pages, G., Kuchel, P.W., Golay, X., Chuang, K.H., Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI (2013) J. Cereb. Blood Flow Metab., 33, pp. 1270-1278
Rivlin, M., Navon, G., Glucosamine and N-acetyl glucosamine as new CEST MRI agents for molecular imaging of tumors (2016) Sci. Rep., 6, p. 32648
Rivlin, M., Horev, J., Tsarfaty, I., Navon, G., Molecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI (2013) Sci. Rep., 3, p. 3045
Rivlin, M., Tsarfaty, I., Navon, G., Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3-O-methyl-D-glucose (2014) Magn. Reson. Med., 72, pp. 1375-1380
Rutten, A., Prokop, M., Contrast agents in X-ray computed tomography and its applications in oncology (2007) Anticancer Agents Med. Chem., 7, pp. 307-316
Sherry, A.D., Caravan, P., Lenkinski, R.E., Primer on gadolinium chemistry (2009) J. Magn. Reson. Imaging, 30, pp. 1240-1248
Shinar, H., Battistel, M.D., Mandler, M., Lichaa, F., Freedberg, D.I., Navon, G., Sialo-CEST: chemical exchange saturation transfer NMR of oligo- and poly-sialic acids and the assignment of their hydroxyl groups using selective- and HSQC-TOCSY (2014) Carbohydr. Res., 389, pp. 165-173
Sun, P.Z., Longo, D.L., Hu, W., Xiao, G., Wu, R., Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH (2014) Phys. Med. Biol., 59, pp. 4493-4504
Terreno, E., Stancanello, J., Longo, D., Castelli, D.D., Milone, L., Sanders, H.M., Kok, M.B., Aime, S., Methods for an improved detection of the MRI-CEST effect (2009) Contrast Media Mol. Imaging, 4, pp. 237-247
Vinogradov, E., Sherry, A.D., Lenkinski, R.E., CEST: from basic principles to applications, challenges and opportunities (2013) J. Magn. Reson., 229, pp. 155-172
Walker-Samuel, S., Ramasawmy, R., Torrealdea, F., Rega, M., Rajkumar, V., Johnson, S.P., Richardson, S., Golay, X., In vivo imaging of glucose uptake and metabolism in tumors (2013) Nat. Med., 19, pp. 1067-1072
Wening, K., Breitkreutz, J., Oral drug delivery in personalized medicine: unmet needs and novel approaches (2011) Int. J. Pharm., 404, pp. 1-9
Xu, X., Chan, K.W., Knutsson, L., Artemov, D., Xu, J., Liu, G., Kato, Y., van Zijl, P.C., Dynamic glucose enhanced (DGE) MRI for combined imaging of blood-brain barrier break down and increased blood volume in brain cancer (2015) Magn. Reson. Med., 74, pp. 1556-1563
Yang, X., Song, X., Li, Y., Liu, G., Ray Banerjee, S., Pomper, M.G., McMahon, M.T., Salicylic acid and analogues as diaCEST MRI contrast agents with highly shifted exchangeable proton frequencies (2013) Angew. Chem. Int. Ed. Engl., 52, pp. 8116-8119
Zaiss, M., Kunz, P., Goerke, S., Radbruch, A., Bachert, P., MR imaging of protein folding in vitro employing nuclear-Overhauser-mediated saturation transfer (2013) NMR Biomed., 26, pp. 1815-1822
van Zijl, P.C., Yadav, N.N., Chemical exchange saturation transfer (CEST): what is in a name and what isn't? (2011) Magn. Reson. Med., 65, pp. 927-948
van Zijl, P.C., Jones, C.K., Ren, J., Malloy, C.R., Sherry, A.D., MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST) (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 4359-4364
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-D-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers). All the investigated molecules showed remarkable CEST contrast upon i.v. administration in the range 1–3 ppm according to the type of mobile proton groups. A marked increase of CEST contrast was observed in tumor regions up to 30 min post injection. The combination of marked tumor contrast enhancement and lack of toxicity make these molecules potential candidates for the diagnosis of tumors within the MRI-CEST approach. © 2017 Elsevier B.V.
Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of molecules possessing exchangeable protons with water. Many molecules, employed as excipients for the formulation of finished drug products, are endowed with hydroxyl, amine or amide protons, thus can be exploitable as MRI-CEST contrast agents. Their high safety profiles allow them to be injected at very high doses. Here we investigated the MRI-CEST properties of several excipients (ascorbic acid, sucrose, N-acetyl-D-glucosamine, meglumine and 2-pyrrolidone) and tested them as tumor-detecting agents in two different murine tumor models (breast and melanoma cancers). All the investigated molecules showed remarkable CEST contrast upon i.v. administration in the range 1–3 ppm according to the type of mobile proton groups. A marked increase of CEST contrast was observed in tumor regions up to 30 min post injection. The combination of marked tumor contrast enhancement and lack of toxicity make these molecules potential candidates for the diagnosis of tumors within the MRI-CEST approach. © 2017 Elsevier B.V.
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
No results. |
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
Other filter: ([btitle,keywords] "Chemical Exchange Sa ...
Anemone A, Capozza M, Arena F, Zullino S, Bardini P, Terreno E, Longo DL, Aime S
* In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model (54 views)
Nmr Biomed (ISSN: 0952-3480linking), 2021 Aug 22; N/D: e4602-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (18 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
View Export to BibTeX Export to EndNote
Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (20 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Longo DL, Irrera P, Consolino L, Sun PZ, Mcmahon MT
* Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept (36 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 241-256.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (9 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K
* Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla (126 views)
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
Impact Factor: 2.983
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Arena F, Capozza M, Longo DL
* Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH (129 views)
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
View Export to BibTeX Export to EndNote
Kujawa A, Kim M, Demetriou E, Anemone A, Livio Longo D, Zaiss M, Golay X
* Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging (23 views)
J Magn Reson (ISSN: 1090-7807linking), 2019 Mar; 300: 120-134.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (265 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
* Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging (293 views)
J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Longo DL, Aime S
* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (215 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 2017 Jul 07; 79(3): 1553-1558.
Impact Factor: 4.082
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (166 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S
* Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (290 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2017; 30(7): N/D-N/D.
Impact Factor: 3.031
View Export to BibTeX Export to EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (262 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
View Export to BibTeX Export to EndNote
Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (409 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (331 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
View Export to BibTeX Export to EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (320 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
View Export to BibTeX Export to EndNote
Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (281 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (281 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
Impact Factor: 1.56
View Export to BibTeX Export to EndNote
Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (358 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
View Export to BibTeX Export to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (580 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
View Export to BibTeX Export to EndNote
* In vitro and in vivo comparison of MRI chemical exchange saturation transfer (CEST) properties between native glucose and 3-O-Methyl-D-glucose in a murine tumor model (54 views)
Nmr Biomed (ISSN: 0952-3480linking), 2021 Aug 22; N/D: e4602-N/D.
Impact Factor:
View Export to BibTeX Export to EndNote
Consolino L, Irrera P, Romdhane F, Anemone A, Longo DL
* Investigating plasma volume expanders as novel macromolecular MRI-CEST contrast agents for tumor contrast-enhanced imaging (18 views)
Magn Reson Med (ISSN: 0740-3194linking, 1522-2594electronic), 2021 Aug; 86(2): 995-1007.
Impact Factor: 3.635
View Export to BibTeX Export to EndNote
Kim H, Wu Y, Villano D, Longo DL, Mcmahon MT, Sun PZ
* Analysis Protocol for the Quantification of Renal pH Using Chemical Exchange Saturation Transfer (CEST) MRI (20 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 667-688.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Longo DL, Irrera P, Consolino L, Sun PZ, Mcmahon MT
* Renal pH Imaging Using Chemical Exchange Saturation Transfer (CEST) MRI: Basic Concept (36 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 241-256.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Pavuluri KD, Consolino L, Longo DL, Irrera P, Sun PZ, Mcmahon MT
* Renal pH Mapping Using Chemical Exchange Saturation Transfer (CEST) MRI: Experimental Protocol (9 views)
Methods Mol Biol (ISSN: 1064-3745linking, 1940-6029electronic), 2021; 2216: 455-471.
Impact Factor: 1.17
View Export to BibTeX Export to EndNote
Zaiss M, Anemone A, Goerke S, Longo DL, Herz K, Pohmann R, Aime S, Rivlin M, Navon G, Golay X, Scheffler K
* Quantification of hydroxyl exchange of D-Glucose at physiological conditions for optimization of glucoCEST MRI at 3, 7 and 9. 4 Tesla (126 views)
Nmr Biomed (ISSN: 0952-3480linking, 1099-1492electronic), 2019 Sep; 32(9): e4113-e4113.
Impact Factor: 2.983
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Arena F, Capozza M, Longo DL
* Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH (129 views)
Cancer Metastasis Rev (ISSN: 0167-7659linking), 2019 Jun; 38(1-2): 25-49.
Impact Factor: 6.667
View Export to BibTeX Export to EndNote
Kujawa A, Kim M, Demetriou E, Anemone A, Livio Longo D, Zaiss M, Golay X
* Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer (CEST) imaging (23 views)
J Magn Reson (ISSN: 1090-7807linking), 2019 Mar; 300: 120-134.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Goerke S, Breitling J, Zaiss M, Windschuh J, Kunz P, Schuenke P, Paech D, Longo DL, Klika KD, Ladd ME, Bachert P
* Dual-frequency irradiation CEST-MRI of endogenous bulk mobile proteins (265 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2018 Jun; 31(6): e3920-N/D.
Impact Factor: 2.872
View Export to BibTeX Export to EndNote
Arena F, Irrera P, Consolino L, Colombo Serra S, Zaiss M, Longo DL
* Flip-angle based ratiometric approach for pulsed CEST-MRI pH imaging (293 views)
J Magn Reson (ISSN: 1090-7807, 1090-7807linking), 2017 Dec 11; 287: 1-9.
Impact Factor: 2.586
View Export to BibTeX Export to EndNote
Longo DL, Aime S
* A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol (215 views)
Magn Reson Med (ISSN: 0740-3194, 1522-2594electronic, 0740-3194linking), 2017 Jul 07; 79(3): 1553-1558.
Impact Factor: 4.082
View Export to BibTeX Export to EndNote
Anemone A, Consolino L, Longo DL
* MRI-CEST assessment of tumour perfusion using X-ray iodinated agents: comparison with a conventional Gd-based agent (166 views)
Eur Radiol (ISSN: 0938-7994, 1432-1084electronic, 0938-7994linking), 2017; 27(5): 2170-2179.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Longo DL, Cutrin JC, Michelotti F, Irrera P, Aime S
* Noninvasive evaluation of renal pH homeostasis after ischemia reperfusion injury by CEST-MRI (290 views)
Nmr Biomed (ISSN: 0952-3480, 1099-1492electronic, 0952-3480linking), 2017; 30(7): N/D-N/D.
Impact Factor: 3.031
View Export to BibTeX Export to EndNote
Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S
* In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents (262 views)
Invest Radiol (ISSN: 0020-9996, 1536-0210, 1536-0210electronic), 2015 Oct 12; 51(3): 155-162.
Impact Factor: 4.887
View Export to BibTeX Export to EndNote
Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (409 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
View Export to BibTeX Export to EndNote
Terreno E, Boffa C, Menchise V, Fedeli F, Carrera C, Castelli DD, Digilio G, Aime S
* Gadolinium-doped LipoCEST agents: A potential novel class of dual 1H-MRI probes (331 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2011 Apr 28; 47(16): 4667-4669.
Impact Factor: 6.169
View Export to BibTeX Export to EndNote
Russo M, Tedesco I, Iacomino G, Palumbo R, Galano G, Russo GL
* Dietary phytochemicals in chemoprevention of cancer (320 views)
Curr Med Chem (ISSN: 1568-0134), 2005; 5(1): 61-72.
Impact Factor: 3.715
View Export to BibTeX Export to EndNote
Tabbì G, Fry SC, Bonomo RP
ESR study of the non-enzymic scission of xyloglucan by an ascorbate-H2O2-copper system: The involvement of the hydroxyl radical and the degradation of ascorbate (281 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Apr; 84(3-4): 179-187.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
Gurrieri S, Miceli L, Lanza CM, Tomaselli F, Bonomo RP, Rizzarelli E
Chemical characterization of Sicilian prickly pear (Opuntia ficus indica) and perspectives for the storage of its juice (281 views)
J Agric Food Chem (ISSN: 0021-8561), 2000 Nov; 48(11): 5424-5431.
Impact Factor: 1.56
View Export to BibTeX Export to EndNote
Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC
Determination of selectivity of reactive nitrogen oxide species for various substrates (358 views)
Method Enzymol (ISSN: 0076-6879, 1557-7988electronic, 0076-6879linking), 1996; 268: 120-130.
Impact Factor: 2.435
View Export to BibTeX Export to EndNote
Testino G, Leone S, Fagoonee S, Del Bas JM, Rodriguez B, Puiggros F, Marine S, Rodriguez MA, Morina D, Armengol L, Caimari A, Arola L, Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-gentilucci U, Cavallo MG, Morini S, Nelson JE, Roth CL, Wilson LA, Yates KP, Aouizerat B, Morgan-stevenson V, Whalen E, Hoofnagle A, Mason M, Gersuk V, Yeh MM, Kowdley KV, Lee SM, Jun DW, Cho YK, Jang KS, Kucukazman M, Ata N, Dal K, Yeniova AO, Kefeli A, Basyigit S, Aktas B, Akin KO, Agladioglu K, Ure OS, Topal F, Nazligul Y, Beyan E, Ertugrul DT, Catena C, Cosma C, Camozzi V, Plebani M, Ermani M, Sechi LA, Fallo F, Goto Y, Ray MB, Mendenhall CL, French SW, Gartside PS
Serum vitamin A deficiency and increased intrahepatic expression of cytokeratin antigen in alcoholic liver disease (580 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 1988 Sep; 83120693611123109(5): 1019-1026.
Impact Factor: 0.913
View Export to BibTeX Export to EndNote
21 Records (21 excluding Abstracts).
Total impact factor: 59.851 (59.851 excluding Abstracts).
Total 5 year impact factor: 68.016 (68.016 excluding Abstracts).
Total impact factor: 59.851 (59.851 excluding Abstracts).
Total 5 year impact factor: 68.016 (68.016 excluding Abstracts).
372 views. Last view on Wednesday 10 August 2022, 22:43:33
ibb.cnr.it