Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome (269 views)
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
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Paper type: Journal Article,
Impact factor: 3.508, 5-year impact factor: 4.297
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052805272&doi=10.3389%2ffneur.2018.00728&partnerID=40&md5=cc540862e662a3b94f72f4c8b4e7e944
Keywords: Mt-Atp8, Ammonia, Metabolic Encephalopathy, Mitochondria, Valproate, Cytochrome C Oxidase, Lactic Acid, Succinate Dehydrogenase, Valproic Acid, Aged, Article, Brain Cortex Atrophy, Brain Disease, Case Report, Clinical Article, Deterioration, Disease Severity, Dna Sequence, Drowsiness, Drug Dose Titration, Drug Withdrawal, Electroencephalogram, Electron Transport, Enzyme Activity, Epilepsy, Female, Follow Up, Gaze Paralysis, Gene Deletion, Gene Mutation, Genetic Association, Genetic Variability, Human, Human Tissue, Lactate Blood Level, Leukoencephalopathy, Limb Weakness, Mitochondrial Genome, Mt Atp8 Gene, Muscle Biopsy, Muscle Strength, Neurologic Examination, Nuclear Magnetic Resonance Spectroscopy, Single Nucleotide Polymorphism, Treatment Duration, Walking Difficulty,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Universita degli Studi di Napoli Federico II, Napoli, Italy.
Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
References:
Galimberti, C.A., Diegoli, M., Sartori, I., Uggetti, C., Brega, A., Tartara, A., Brain pseudo-atrophy and mental regression on valproate and a mitochondrial DNA mutation (2006) Neurology, 67, pp. 1715-171
Nesti, C., Meschini, M.C., Meunier, B., Sacchini, M., Doccini, S., Romano, A., Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy (2015) Hum Mol Genet, 24, pp. 3248-3256
Tomson, T., Battino, D., Perucca, E., Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug (2016) Lancet Neurol, 15, pp. 210-218
Verrotti, A., Trotta, D., Morgese, G., Chiarelli, F., Valproate-induced hyperammonemic encephalopathy (2002) Metab Brain Dis, 17, pp. 367-373
Gerstner, T., Buesing, D., Longin, E., Bendl, C., Wenzel, D., Scheid, B., Valproic acid induced encephalopathy-19 new cases in Germany from 1994 to 2003-a side effect associated to VPA-therapy not only in young children (2006) Seizure, 15, pp. 443-448
Lewis, C., Deshpande, A., Tesar, G.E., Dale, R., Valproate-induced hyperammonemic encephalopathy: a brief review (2012) Curr Med Res Opin, 28, pp. 1039-1042
Baganz, I., Dross, P.E., Valproic acid-induced hyperammoncmic encephalopathy: MR appearance (1994) Am J Neuroradiol, 15, pp. 1779-1781
Ziyeh, S., Thiel, T., Spreer, J., Klisch, J., Schumacher, M., Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy (2002) Epilepsia, 43, pp. 1101-1105
Guerrini, R., Belmonte, A., Canapicchi, R., Casalini, C., Perucca, E., Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment (1998) Epilepsia, 39, pp. 27-32
Mock, C.M., Schwetschenau, K.H., Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy (2012) Am J Health Syst Pharm, 69, pp. 35-39
Senior, A.E., Nadanaciva, S., Weber, J., The molecular mechanism of ATP synthesis by F1F0-ATP synthase (2002) Biochim Biophys Acta, 1553, pp. 188-211
Dautant, A., Meier, T., Hahn, A., Tribouillard-Tanvier, D., di Rago, J.P., Kucharczyk, R., ATP Synthase Diseases of Mitochondrial Genetic Origin (2018) Front Physiol, 9, p. 329
Hroudova, J., Fisar, Z., Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers (2010) Neuro Endocrinol Lett, 31, pp. 336-342
Luis, P.B., Ruiter, J.P., Aires, C.C., Soveral, G., de Almeida, I.T., Duran, M., Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007) Biochim Biophys Acta, 1767, pp. 1126-1133
Lam, C.W., Lau, C.H., Williams, J.C., Chan, Y.W., Wong, L.J., Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy (1997) Eur J Pediatr, 156, pp. 562-564
Chaudhry, N., Patidar, Y., Puri, V., Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate (2013) J Pediatr Neurosci, 8, pp. 135-137
Bianco, A., Martínez-Romero, I., Bisceglia, L., D'Agruma, L., Favia, P., Ruiz-Pesini, E., Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers (2016) Brain, 139, pp. 1-3
Front Neurol (ISSN: 1664-2295linking, 1664-2295print), 2018 Aug 30; 9(AUG): 728-728.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.508, 5-year impact factor: 4.297
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052805272&doi=10.3389%2ffneur.2018.00728&partnerID=40&md5=cc540862e662a3b94f72f4c8b4e7e944
Keywords: Mt-Atp8, Ammonia, Metabolic Encephalopathy, Mitochondria, Valproate, Cytochrome C Oxidase, Lactic Acid, Succinate Dehydrogenase, Valproic Acid, Aged, Article, Brain Cortex Atrophy, Brain Disease, Case Report, Clinical Article, Deterioration, Disease Severity, Dna Sequence, Drowsiness, Drug Dose Titration, Drug Withdrawal, Electroencephalogram, Electron Transport, Enzyme Activity, Epilepsy, Female, Follow Up, Gaze Paralysis, Gene Deletion, Gene Mutation, Genetic Association, Genetic Variability, Human, Human Tissue, Lactate Blood Level, Leukoencephalopathy, Limb Weakness, Mitochondrial Genome, Mt Atp8 Gene, Muscle Biopsy, Muscle Strength, Neurologic Examination, Nuclear Magnetic Resonance Spectroscopy, Single Nucleotide Polymorphism, Treatment Duration, Walking Difficulty,
Affiliations:
*** IBB - CNR ***
Department of Neurosciences and Reproductive and Odontostomatological Sciences, Universita degli Studi di Napoli Federico II, Napoli, Italy.
Molecular Medicine, IRCCS Fondazione Stella Maris, Pisa, Italy.
Institute of Biostructure and Bioimaging, National Research Council, Naples, Italy.
References:
Galimberti, C.A., Diegoli, M., Sartori, I., Uggetti, C., Brega, A., Tartara, A., Brain pseudo-atrophy and mental regression on valproate and a mitochondrial DNA mutation (2006) Neurology, 67, pp. 1715-171
Nesti, C., Meschini, M.C., Meunier, B., Sacchini, M., Doccini, S., Romano, A., Additive effect of nuclear and mitochondrial mutations in a patient with mitochondrial encephalomyopathy (2015) Hum Mol Genet, 24, pp. 3248-3256
Tomson, T., Battino, D., Perucca, E., Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug (2016) Lancet Neurol, 15, pp. 210-218
Verrotti, A., Trotta, D., Morgese, G., Chiarelli, F., Valproate-induced hyperammonemic encephalopathy (2002) Metab Brain Dis, 17, pp. 367-373
Gerstner, T., Buesing, D., Longin, E., Bendl, C., Wenzel, D., Scheid, B., Valproic acid induced encephalopathy-19 new cases in Germany from 1994 to 2003-a side effect associated to VPA-therapy not only in young children (2006) Seizure, 15, pp. 443-448
Lewis, C., Deshpande, A., Tesar, G.E., Dale, R., Valproate-induced hyperammonemic encephalopathy: a brief review (2012) Curr Med Res Opin, 28, pp. 1039-1042
Baganz, I., Dross, P.E., Valproic acid-induced hyperammoncmic encephalopathy: MR appearance (1994) Am J Neuroradiol, 15, pp. 1779-1781
Ziyeh, S., Thiel, T., Spreer, J., Klisch, J., Schumacher, M., Valproate-induced encephalopathy: assessment with MR imaging and 1H MR spectroscopy (2002) Epilepsia, 43, pp. 1101-1105
Guerrini, R., Belmonte, A., Canapicchi, R., Casalini, C., Perucca, E., Reversible pseudoatrophy of the brain and mental deterioration associated with valproate treatment (1998) Epilepsia, 39, pp. 27-32
Mock, C.M., Schwetschenau, K.H., Levocarnitine for valproic-acid-induced hyperammonemic encephalopathy (2012) Am J Health Syst Pharm, 69, pp. 35-39
Senior, A.E., Nadanaciva, S., Weber, J., The molecular mechanism of ATP synthesis by F1F0-ATP synthase (2002) Biochim Biophys Acta, 1553, pp. 188-211
Dautant, A., Meier, T., Hahn, A., Tribouillard-Tanvier, D., di Rago, J.P., Kucharczyk, R., ATP Synthase Diseases of Mitochondrial Genetic Origin (2018) Front Physiol, 9, p. 329
Hroudova, J., Fisar, Z., Activities of respiratory chain complexes and citrate synthase influenced by pharmacologically different antidepressants and mood stabilizers (2010) Neuro Endocrinol Lett, 31, pp. 336-342
Luis, P.B., Ruiter, J.P., Aires, C.C., Soveral, G., de Almeida, I.T., Duran, M., Valproic acid metabolites inhibit dihydrolipoyl dehydrogenase activity leading to impaired 2-oxoglutarate-driven oxidative phosphorylation (2007) Biochim Biophys Acta, 1767, pp. 1126-1133
Lam, C.W., Lau, C.H., Williams, J.C., Chan, Y.W., Wong, L.J., Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) triggered by valproate therapy (1997) Eur J Pediatr, 156, pp. 562-564
Chaudhry, N., Patidar, Y., Puri, V., Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes unveiled by valproate (2013) J Pediatr Neurosci, 8, pp. 135-137
Bianco, A., Martínez-Romero, I., Bisceglia, L., D'Agruma, L., Favia, P., Ruiz-Pesini, E., Mitochondrial DNA copy number differentiates the Leber's hereditary optic neuropathy affected individuals from the unaffected mutation carriers (2016) Brain, 139, pp. 1-3
Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome
Introduction: There are several reported cases of patients developing motor and cognitive neurological impairment under treatment with valproic acid (VPA). We describe a woman who developed a subacute encephalopathy after VPA intake, harboring a mitochondrial DNA variant, previously described as causing VPA sensitivity in one pediatric patient. Material and Methods: A 65-year old woman developed a progressive, severe neurological deterioration after a 3 month treatment with valproate sodium, 800 mg daily. Magnetic resonance spectroscopy (MRS), muscle histochemical analysis and assay of mitochondrial enzymatic activities, and mitochondrial DNA sequencing were performed. Results: Neurological examination showed drowsiness, vertical gaze palsy, inability to either stand or walk, diffuse weakness, increased tendon reflexes. Blood lactate was increased, EEG showed diffuse theta and delta activity, MRI subcortical atrophy and leukoencephalopathy, MRS marked reduction of the NAA spectrum, with a small signal compatible with presence of lactate. Muscle biopsy evidenced presence of ragged red fibers (20%) and reduced COX reactivity. Assay of the muscle enzymatic activities showed multiple deficiencies of the electron transport chain and reduced ATP production. The mt.8393C > T variant in the MT-ATP8 gene was found in homoplasmy. The patient considerably improved after valproate withdrawal. Conclusion: The variant we found has been reported both as a polymorphism and, in a single patient, as related to the valproate-induced encephalopathy. The present case is the first bearing this mutation in homoplasmy. In case of neurological symptoms after starting VPA therapy, once hyperammonemia and liver failure have been ruled out, mtDNA abnormalities should be considered. © 2018 De Michele, Sorrentino, Nesti, Rubegni, Ruggiero, Peluso, Antenora, Quarantelli, Filla, De Michele and Santorelli.
Introduction: There are several reported cases of patients developing motor and cognitive neurological impairment under treatment with valproic acid (VPA). We describe a woman who developed a subacute encephalopathy after VPA intake, harboring a mitochondrial DNA variant, previously described as causing VPA sensitivity in one pediatric patient. Material and Methods: A 65-year old woman developed a progressive, severe neurological deterioration after a 3 month treatment with valproate sodium, 800 mg daily. Magnetic resonance spectroscopy (MRS), muscle histochemical analysis and assay of mitochondrial enzymatic activities, and mitochondrial DNA sequencing were performed. Results: Neurological examination showed drowsiness, vertical gaze palsy, inability to either stand or walk, diffuse weakness, increased tendon reflexes. Blood lactate was increased, EEG showed diffuse theta and delta activity, MRI subcortical atrophy and leukoencephalopathy, MRS marked reduction of the NAA spectrum, with a small signal compatible with presence of lactate. Muscle biopsy evidenced presence of ragged red fibers (20%) and reduced COX reactivity. Assay of the muscle enzymatic activities showed multiple deficiencies of the electron transport chain and reduced ATP production. The mt.8393C > T variant in the MT-ATP8 gene was found in homoplasmy. The patient considerably improved after valproate withdrawal. Conclusion: The variant we found has been reported both as a polymorphism and, in a single patient, as related to the valproate-induced encephalopathy. The present case is the first bearing this mutation in homoplasmy. In case of neurological symptoms after starting VPA therapy, once hyperammonemia and liver failure have been ruled out, mtDNA abnormalities should be considered. © 2018 De Michele, Sorrentino, Nesti, Rubegni, Ruggiero, Peluso, Antenora, Quarantelli, Filla, De Michele and Santorelli.
Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome
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Reversible Valproate-Induced Subacute Encephalopathy Associated With a MT-ATP8 Variant in the Mitochondrial Genome
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (461 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (407 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
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Impact Factor: 4.092
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
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Impact Factor: 6.051
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (438 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1171 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2008 Dec; 33(12): 2444-2471.
Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
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Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (560 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (506 views)
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Impact Factor: 4.447
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (335 views)
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Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
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Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (420 views)
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Impact Factor: 2.478
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
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Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (527 views)
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Impact Factor: 3.324
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
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Impact Factor: 5.359
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
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Impact Factor: 3.72
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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* Targeting Mitochondrial Therapy in the Regulation of HPV Infection and HPV-Related Cancers (6 views)
Pathogens, 2023 Mar; 12(3): 402-417.
Impact Factor: 4.531
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De Rosa V, Iommelli F, Terlizzi C, Leggiero E, Camerlingo R, Altobelli GG, Fonti R, Pastore L, Del Vecchio S
* Non-Canonical Role of PDK1 as a Negative Regulator of Apoptosis through Macromolecular Complexes Assembly at the ER-Mitochondria Interface in Oncogene-Driven NSCLC (16 views)
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Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O , #rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N
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Impact Factor: 17.956
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Negri R, Trinchese G, Carbone F, Caprio MG, Stanzione G, Di Scala C, Micillo T, Perna F, Tarotto L, Gelzo M, Cavaliere G, Spagnuolo MI, Corso G, Mattace Raso G, Matarese G, Mollica MP, Greco L, Iorio R
* Randomised Clinical Trial: Calorie Restriction Regimen with Tomato Juice Supplementation Ameliorates Oxidative Stress and Preserves a Proper Immune Surveillance Modulating Mitochondrial Bioenergetics of T-Lymphocytes in Obese Children Affected by Non-Alcoholic Fatty Liver Disease (NAFLD) (112 views) (PDF 85 views)
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Impact Factor: 5.688
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Lama A, Annunziata C, Coretti L, Pirozzi C, Di Guida F, Nitrato Izzo A, Cristiano C, Mollica MP, Chiariotti L, Pelagalli A, Lembo F, Meli R, Mattace Raso G
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Impact Factor: 5.078
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Barone R, Alaimo S, Messina M, Pulvirenti A, Bastin J, Group MIMIC-A, F , Frye RE, Rizzo (mimic-ag A, Fiumara R, Meli C, Gulisano M, Maugeri F, Prato A, Russo G, Tabbì G
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Impact Factor: 2.857
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
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Impact Factor: 3.098
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Cavallari E, Carrera C, Aime S, Reineri F
* (13) C MR Hyperpolarization of Lactate by Using ParaHydrogen and Metabolic Transformation in Vitro (251 views)
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Impact Factor: 5.16
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Simoni E, Caporaso R, Bergamini C, Fiori J, Fato R, Miszta P, Filipek S, Caraci F, Giuffrida ML, Andrisano V, Minarini A, Bartolini M, Rosini M
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Impact Factor: 3.746
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Magri A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V
* Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes (366 views)
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Impact Factor: 4.932
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Ciccarelli M, Sorriento D, Coscioni E, Iaccarino G, Santulli G
* Adrenergic Receptors (261 views)
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Impact Factor: 0
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De Rosa V, Iommelli F, Monti M, Fonti R, Votta G, Stoppelli MP, Del Vecchio S
* Reversal of Warburg Effect and Reactivation of Oxidative Phosphorylation by Differential Inhibition of EGFR Signaling Pathways in Non-Small Cell Lung Cancer (653 views)
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Impact Factor: 8.738
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Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M
* The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities (462 views)
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Impact Factor: 2.876
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Sorriento D, Del Giudice C, Bertamino A, Ciccarelli M, Gomez-Monterrey I, Campiglia P, Novellino E, Illario M, Trimarco B, De Luca N, Iaccarino G
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Impact Factor: 5.569
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Hangen E, Féraud O, Lachkar S, Mou H, Doti N, Fimia GM, Lam N-V, Zhu C, Godin I, Muller K, Chatzi A, Nuebel E, Ciccosanti F, Flamant S, Bénit P, Perfettini J-L, Sauvat A, Bennaceur-Griscelli A, Ser-Le Roux K, Gonin P, Tokatlidis K, Rustin P, Piacentini M, Ruvo M, Blomgren K, Kroemer G, Modjtahedi N
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Impact Factor: 13.958
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Gargiulo S, Petretta MP, Greco A, Panico M, Larobina M, Gramanzini M, Schiattarella GG, Esposito G, Petretta M, Brunetti A, Cuocolo A
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Impact Factor: 1.878
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Oppermann S, Schrader FC, Elsasser K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C
* Novel N-Phenyl-Substituted Thiazolidinediones Protect Neural Cells against Glutamate- and tBid-Induced Toxicity (578 views)
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Impact Factor: 3.972
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
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Impact Factor: 3.447
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Sorriento D, Ciccarelli M, Santulli G, Illario M, Trimarco B, Iaccarino G
* Trafficking GRK2: Cellular and Metabolic consequences of GRK2 subcellular localization (251 views)
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Impact Factor: 2.256
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Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C
* Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress (562 views)
Cell Death & (ISSN: 2041-4889, 2041-4889electronic), 2014 Jan 16; 5(1): e993-e993.
Impact Factor: 5.014
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (373 views)
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Impact Factor: 6.834
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Dathan NA, Alterio V, Troiano E, Vullo D, Ludwig M, De Simone G, Supuran CT, Monti SM
* Biochemical Characterization Of The Chloroplastic β-Carbonic Anhydrase From Flaveria Bidentis (l. ) "kuntze" (449 views)
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Impact Factor: 2.332
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Sorriento D, Pascale AV, Finelli R, Carillo AL, Annunziata R, Trimarco B, Iaccarino G
* Targeting mitochondria as therapeutic strategy for metabolic disorders (571 views)
Sci World J The Scientific World Journal (ISSN: 1537-744x), 2014; 2014: N/D-N/D.
Impact Factor: 1.219
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Perrino C, Schiattarella GG, Sannino A, Pironti G, Petretta MP, Cannavo A, Gargiulo G, Ilardi F, Magliulo F, Franzone A, Carotenuto G, Serino F, Altobelli GG, Cimini V, Cuocolo A, Lombardi A, Goglia F, Indolfi C, Trimarco B, Esposito G
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Impact Factor: 2.882
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Dolga AM, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C
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Impact Factor: 4.6
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Ciccarelli M, Sorriento D, Franco A, Fusco A, Del Giudice C, Annunziata R, Cipolletta E, Monti MG, Dorn GW, Trimarco B, Iaccarino G
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Arterioscler Thromb Vasc Biol Arteriosclerosis Thrombosis And Vascular Biology (ISSN: 1079-5642, 1049-8834), 2013; 33(10): 2415-2424.
Impact Factor: 5.533
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Sorriento D, Fusco A, Ciccarelli M, Rungi A, Anastasio A, Carillo A, Dorn II GW, Trimarco B, Iaccarino G
* Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages (385 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 2013; 587(21): 3487-3494.
Impact Factor: 3.341
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Forestier A, Douki T, Sauvaigo S, De Rosa V, Demeilliers C, Rachidi W
* Alzheimer's disease-associated neurotoxic peptide amyloid-beta impairs base excision repair in human neuroblastoma cells (460 views)
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Impact Factor: 2.464
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Calabrese V, Cornelius C, Dinkova-Kostova AT, Iavicoli I, Di Paola R, Koverech A, Cuzzocrea S, Rizzarelli E, Calabrese EJ
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Impact Factor: 3.733
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Russo Krauss I, Sica F, Mattia CA, Merlino A
* Increasing the X-ray diffraction power of protein crystals by dehydration: the case of bovine serum albumin and a survey of literature data (461 views)
Int J Mol Sc (ISSN: 1422-0067, 1661-6596, 1422-0067electronic), 2012 Mar; 13(3): 3782-3800.
Impact Factor: 2.464
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Fusco A, Santulli G, Sorriento D, Cipolletta E, Garbi C, Dorn GW, Trimarco B, Feliciello A, Iaccarino G
* Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis (407 views)
Cell Signal (ISSN: 0898-6568), 2012; 24(2): 468-475.
Impact Factor: 4.304
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Corona C, Frazzini V, Silvestri E, Lattanzio R, La Sorda R, Piantelli M, Canzoniero LM, Ciavardelli D, Rizzarelli E, Sensi SL
* Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice (553 views)
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Impact Factor: 4.092
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Perrino C, Feliciello A, Schiattarella GG, Esposito G, Guerriero R, Zaccaro L, Del Gatto A, Saviano M, Garbi C, Carangi R, Di Lorenzo E, Donato G, Indolfi C, Avvedimento VE, Chiariello M
* AKAP121 downregulation impairs protective cAMP signals, promotes mitochondrial dysfunction, and increases oxidative stress (433 views)
Cardiovascular Research (ISSN: 0008-6363), 2010 Oct; 88(1): 101-110.
Impact Factor: 6.051
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Del Vecchio S, Zannetti A, Fonti R, Iommelli F, Lettieri A, Salvatore M
* Molecular imaging of drug resistance in cancer (438 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Mar; 21(1): 31-36.
Impact Factor: 0.268
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Calabrese V, Cornelius C, Mancuso C, Pennisi G, Calafato S, Bellia F, Bates TE, Giuffrida Stella AM, Schapira T, Dinkova Kostova AT, Rizzarelli E
* Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity (1171 views)
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Impact Factor: 2.26
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Zannetti A, Iommelli F, Fonti R, Papaccioli A, Sommella J, Lettieri A, Pirozzi G, Bianco R, Tortora G, Salvatore M, Del Vecchio S
* Gefitinib induction of in vivo detectable signals by Bcl-2/Bcl-xL modulation of inositol trisphosphate receptor type (537 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2008 Aug 15; 14(16): 5209-5219.
Impact Factor: 6.488
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Supuran CT, Di Fiore A, De Simone G
* Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity (560 views)
Expert Opin Emerg Drugsexpert Opinion On Emerging Drugs (ISSN: 1472-8214), 2008 Jun; 13(2): 383-392.
Impact Factor: 3.08
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Atlante A, Amadoro G, Bobba A, de Bari L, Corsetti V, Pappalardo G, Marra E, Calissano P, Passarella S
* A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator (506 views)
Bba-Gen Subjects (ISSN: 0005-2728, 0006-3002print, 0006-3002linking), 2008; 1777(10): 1289-1300.
Impact Factor: 4.447
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Vitale RM, Pedone C, Amodeo P, Antel J, Wurl M, Scozzafava A, Supuran CT, De Simone G
* Molecular modeling study for the binding of zonisamide and topiramate to the human mitochondrial carbonic anhydrase isoform VA (335 views)
Bioorg Med Chem (ISSN: 0968-0896, 1464-3391, 1464-3391electronic), 2007 Jun 15; 15(12): 4152-4158.
Impact Factor: 2.662
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Galdiero S, Galdiero M, Pedone C
* Beta-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly And Interaction With Lipids (438 views)
Curr Protein Pept Sci (ISSN: 1389-2037, 1389-2037linking), 2007 Feb; 8(1): 63-82.
Impact Factor: 3.259
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Calabrese V, Colombrita C, Guagliano E, Sapienza M, Ravagna A, Cardile V, Scapagnini G, Santoro AM, Mangiameli A, Butterfield DA, Giuffrida Stella AM, Rizzarelli E
* Protective effect of carnosine during nitrosative stress in astroglial cell cultures (379 views)
Neurochemical Research (ISSN: 0364-3190, 1573-6903), 2005 Jun; 30(6-7): 797-807.
Impact Factor: 2.187
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De Simone G, Di Fiore A, Menchise V, Pedone C, Antel J, Casini A, Scozzafava A, Wurl M, Supuran CT
* Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies (420 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2005 May 2; 15(9): 2315-2320.
Impact Factor: 2.478
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De Capua A, Del Gatto A, Zaccaro L, Saviano G, Carlucci A, Livigni A, Gedressi C, Tancredi T, Pedone C, Saviano M
* A synthetic peptide reproducing the mitochondrial targeting motif of AKAP121: A conformational study (460 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2004; 76(6): 459-466.
Impact Factor: 2.863
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Saviano M, Zaccaro L, Benedetti E, Pedone C, Del Gatto A, Feliciello A, Affaiatati A, Avvedimento EV
* Development of peptides able to modulate the interaction of AKAP121 with mitochondria (418 views)
Peptide Revolution, 2004; N/D: N/D-N/D.
Impact Factor: 4.659
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Del Vecchio S, Zannetti A, Aloj L, Caracò C, Ciarmiello A, Salvatore M
* Inhibition of early Tc-99m-MIBI uptake by Bcl-2 anti-apoptotic protein overexpression in untreated breast carcinoma (527 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2003 Jun; 30(6): 879-887.
Impact Factor: 3.324
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Cardone L, de Cristofaro T, Affaitati A, Garbi C, Ginsberg MD, Saviano M, Varrone S, Rubin CS, Gottesman ME, Avvedimento EV, Feliciello A
* A-kinase anchor protein 84/121 are targeted to mitochondria and mitotic spindles by overlapping amino-terminal motifs (622 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2002 Jul 12; 320(3): 663-675.
Impact Factor: 5.359
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Russo M, Palumbo R, Tedesco I, Mazzarella G, Russo P, Iacomino G, Russo GL
Quercetin and anti-CD95(Fas/Apo1) enhance apoptosis in HPB-ALL cell line (402 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468electronic), 1999 Dec 3; 462(3): 322-328.
Impact Factor: 3.72
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Bonomo RP, De Flora A, Rizzarelli E, Santoro AM, Tabbì G, Tonetti M
Copper(II) complexes encapsulated in human red blood cells (587 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 1995 Sep; 59(4): 773-784.
Impact Factor: 1.342
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48 Records (43 excluding Abstracts).
Total impact factor: 198.999 (180.474 excluding Abstracts).
Total 5 year impact factor: 176.812 (156.694 excluding Abstracts).
Total impact factor: 198.999 (180.474 excluding Abstracts).
Total 5 year impact factor: 176.812 (156.694 excluding Abstracts).
269 views. Last view on Saturday 14 January 2023, 18:26:16
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