Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (318 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052152815&doi=10.3390%2fijms19082350&partnerID=40&md5=3bc1b1918c145a097648efae4b175ea3
Keywords: Cancer Metastasis, Cell Adhesion, Fibronectin, Integrins, Neutrophil Extracellular Traps, Alphavbeta5 Integrin, Deoxyribonuclease I, Rgd Binding Integrin, Unclassified Drug, Very Late Activation Antigen 5, Vitronectin Receptor, Article, Cell Adhesion Assay, Cell Membrane, Confocal Microscopy, Controlled Study, Dna Degradation, Fluorescence Activated Cell Sorting, Fluorescence Microscopy, Human, Human Cell, Protein Expression, Tumor Cell, Western Blotting,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80131 Naples, Italy. marcello.monti@unina.it.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. viviana.derosa@ibb.cnr.it.
Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", 80145 Naples, Italy. m.carriero@istitutotumori.na.it.
Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80145 Naples, Italy. cr.terlizzi88@gmail.com.
Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy. stefania.belli@igb.cnr.it.
References:
Not available.
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052152815&doi=10.3390%2fijms19082350&partnerID=40&md5=3bc1b1918c145a097648efae4b175ea3
Keywords: Cancer Metastasis, Cell Adhesion, Fibronectin, Integrins, Neutrophil Extracellular Traps, Alphavbeta5 Integrin, Deoxyribonuclease I, Rgd Binding Integrin, Unclassified Drug, Very Late Activation Antigen 5, Vitronectin Receptor, Article, Cell Adhesion Assay, Cell Membrane, Confocal Microscopy, Controlled Study, Dna Degradation, Fluorescence Activated Cell Sorting, Fluorescence Microscopy, Human, Human Cell, Protein Expression, Tumor Cell, Western Blotting,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80131 Naples, Italy. marcello.monti@unina.it.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. viviana.derosa@ibb.cnr.it.
Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", 80145 Naples, Italy. m.carriero@istitutotumori.na.it.
Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80145 Naples, Italy. cr.terlizzi88@gmail.com.
Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy. stefania.belli@igb.cnr.it.
References:
Not available.
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis. We found that high levels of α5β1, αvβ3 and αvβ5 enhance cell adhesion to NETs, whereas low expression of α5β1 prevents cell attachment to NETs. Excess of cyclic RGD peptide inhibited cell adhesion to NETs by competing with fibronectin within NETs. The maximal reduction of such adhesion was similar to that obtained by DNase 1 treatment causing DNA degradation. Our findings indicate that NETs from neutrophil-like cells may be used as a substrate for large screening of the adhesion properties of cancer cells expressing a variety of RGD-binding integrins. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis. We found that high levels of α5β1, αvβ3 and αvβ5 enhance cell adhesion to NETs, whereas low expression of α5β1 prevents cell attachment to NETs. Excess of cyclic RGD peptide inhibited cell adhesion to NETs by competing with fibronectin within NETs. The maximal reduction of such adhesion was similar to that obtained by DNase 1 treatment causing DNA degradation. Our findings indicate that NETs from neutrophil-like cells may be used as a substrate for large screening of the adhesion properties of cancer cells expressing a variety of RGD-binding integrins. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (729 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (548 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (540 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (394 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (312 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (843 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (705 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (688 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (618 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
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Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (389 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (421 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (569 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
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Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (987 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (488 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (470 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (587 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
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Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (503 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
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Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (416 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
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Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (830 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (662 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (689 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (470 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Klain M, Maurea S, Lastoria S, Cuocolo A, Colao A, Salvatore M
Technetium-99m-tetrofosmin imaging of differentiated mixed thyroid cancer (322 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Dec; 36(12): 2248-2251.
Impact Factor: 3.491
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36 Records (35 excluding Abstracts).
Total impact factor: 137.126 (133.892 excluding Abstracts).
Total 5 year impact factor: 151.798 (148.096 excluding Abstracts).
Total impact factor: 137.126 (133.892 excluding Abstracts).
Total 5 year impact factor: 151.798 (148.096 excluding Abstracts).
318 views. Last view on Wednesday 29 November 2023, 9:50:16
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