Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (268 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052152815&doi=10.3390%2fijms19082350&partnerID=40&md5=3bc1b1918c145a097648efae4b175ea3
Keywords: Cancer Metastasis, Cell Adhesion, Fibronectin, Integrins, Neutrophil Extracellular Traps, Alphavbeta5 Integrin, Deoxyribonuclease I, Rgd Binding Integrin, Unclassified Drug, Very Late Activation Antigen 5, Vitronectin Receptor, Article, Cell Adhesion Assay, Cell Membrane, Confocal Microscopy, Controlled Study, Dna Degradation, Fluorescence Activated Cell Sorting, Fluorescence Microscopy, Human, Human Cell, Protein Expression, Tumor Cell, Western Blotting,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80131 Naples, Italy. marcello.monti@unina.it.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. viviana.derosa@ibb.cnr.it.
Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", 80145 Naples, Italy. m.carriero@istitutotumori.na.it.
Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80145 Naples, Italy. cr.terlizzi88@gmail.com.
Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy. stefania.belli@igb.cnr.it.
References:
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D.S., Weinrauch, Y., Zychlinsky, A., Neutrophil extracellular traps kill bacteria (2004) Science, 303, pp. 1532-153
Papayannopoulos, V., Metzler, K.D., Hakkim, A., Zychlinsky, A., Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010) J. Cell Biol., 191, pp. 677-691
Branzk, N., Papayannopoulos, V., Molecular mechanisms regulating netosis in infection and disease (2013) Semin. Immunopathol., 35, pp. 513-530
Neumann, A., Vollger, L., Berends, E.T., Molhoek, E.M., Stapels, D.A., Midon, M., Friaes, A., Gallo, R.L., Novel role of the antimicrobial peptide ll-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases (2014) J. Innate Immun., 6, pp. 860-868
de Oliveira, S., Rosowski, E.E., Huttenlocher, A., Neutrophil migration in infection and wound repair: Going forward in reverse (2016) Nat. Rev. Immunol., 16, pp. 378-391
Mayadas, T.N., Cullere, X., Lowell, C.A., The multifaceted functions of neutrophils (2014) Annu. Rev. Pathol., 9, pp. 181-218
Delgado-Rizo, V., Martinez-Guzman, M.A., Iniguez-Gutierrez, L., Garcia-Orozco, A., Alvarado-Navarro, A., Fafutis-Morris, M., Neutrophil extracellular traps and its implications in inflammation: An overview (2017) Front. Immunol., 8, p. 81
Urban, C.F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., Brinkmann, V., Zychlinsky, A., Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against candida albicans (2009) Plos Pathog, 5
Fuchs, T.A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Zychlinsky, A., Novel cell death program leads to neutrophil extracellular traps (2007) J. Cell Biol., 176, pp. 231-241
Wang, Y., Wysocka, J., Sayegh, J., Lee, Y.H., Perlin, J.R., Leonelli, L., Sonbuchner, L.S., Dou, Y., Human pad4 regulates histone arginine methylation levels via demethylimination (2004) Science, 306, pp. 279-283
Keshari, R.S., Jyoti, A., Dubey, M., Kothari, N., Kohli, M., Bogra, J., Barthwal, M.K., Dikshit, M., Cytokines induced neutrophil extracellular traps formation: Implication for the inflammatory disease condition (2012) Plos ONE, 7
Metzler, K.D., Fuchs, T.A., Nauseef, W.M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V., Zychlinsky, A., Myeloperoxidase is required for neutrophil extracellular trap formation: Implications for innate immunity (2011) Blood, 117, pp. 953-959
Kolaczkowska, E., Kubes, P., Neutrophil recruitment and function in health and inflammation (2013) Nat. Rev. Immunol., 13, pp. 159-175
Monti, M., Iommelli, F., de Rosa, V., Carriero, M.V., Miceli, R., Camerlingo, R., Di Minno, G., Del Vecchio, S., Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (2017) Plos ONE, 12
Martinod, K., Wagner, D.D., Thrombosis: Tangled up in nets (2014) Blood, 123, pp. 2768-2776
Demers, M., Krause, D.S., Schatzberg, D., Martinod, K., Voorhees, J.R., Fuchs, T.A., Scadden, D.T., Wagner, D.D., Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis (2012) Proc. Natl. Acad. Sci. USA, 109, pp. 13076-13081
Demers, M., Wagner, D.D., Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression (2013) Oncoimmunology, 2
Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Ferri, L., Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis (2013) J. Clin. Investig.
Park, J., Wysocki, R.W., Amoozgar, Z., Maiorino, L., Fein, M.R., Jorns, J., Schott, A.F., Won, N.H., Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) Sci. Transl. Med., 8, p. 361
Avraamides, C.J., Garmy-Susini, B., Varner, J.A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat. Rev. Cancer, 8, pp. 604-617
Plow, E.F., Haas, T.A., Zhang, L., Loftus, J., Smith, J.W., Ligand binding to integrins (2000) J. Biol. Chem., 275, pp. 21785-21788
Tohme, S., Yazdani, H.O., Al-Khafaji, A.B., Chidi, A.P., Loughran, P., Mowen, K., Wang, Y., Tsung, A., Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress (2016) Cancer Res, 76, pp. 1367-1380
Najmeh, S., Cools-Lartigue, J., Giannias, B., Spicer, J., Ferri, L.E., Simplified human neutrophil extracellular traps (Nets) isolation and handling (2015) J. Vis. Exp., 16
Young, R.L., Malcolm, K.C., Kret, J.E., Caceres, S.M., Poch, K.R., Nichols, D.P., Taylor-Cousar, J.L., Vasil, M.L., Neutrophil extracellular trap (Net)-mediated killing of pseudomonas aeruginosa: Evidence of acquired resistance within the cf airway, independent of cftr (2011) Plos ONE, 6
Carrigan, S.O., Weppler, A.L., Issekutz, A.C., Stadnyk, A.W., Neutrophil differentiated hl-60 cells model mac-1 (Cd11b/cd18)-independent neutrophil transepithelial migration (2005) Immunology, 115, pp. 108-117
Chiaradonna, F., Fontana, L., Iavarone, C., Carriero, M.V., Scholz, G., Barone, M.V., Stoppelli, M.P., Urokinase receptor-dependent and-independent p56/59(Hck) activation state is a molecular switch between myelomonocytic cell motility and adherence (1999) EMBO J, 18, pp. 3013-3023
Millius, A., Weiner, O.D., Chemotaxis in neutrophil-like hl-60 cells (2009) Methods Mol. Biol., 571, pp. 167-177
Zannetti, A., Del Vecchio, S., Iommelli, F., Del Gatto, A., de Luca, S., Zaccaro, L., Papaccioli, A., Speranza, A., Imaging of alpha(V)beta(3) expression by a bifunctional chimeric rgd peptide not cross-reacting with alpha(v)beta(5) (2009) Clin. Cancer Res., 15, pp. 5224-5233
Yousif, A.M., Ingangi, V., Merlino, F., Brancaccio, D., Minopoli, M., Bellavita, R., Novellino, E., Grieco, P., Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration (2018) Eur. J. Med. Chem., 143, pp. 348-360
de Rosa, V., Iommelli, F., Monti, M., Fonti, R., Votta, G., Stoppelli, M.P., Del Vecchio, S., Reversal of warburg effect and reactivation of oxidative phosphorylation by differential inhibition of egfr signaling pathways in non-small cell lung cancer (2015) Clin. Cancer Res., 21, pp. 5110-5120
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052152815&doi=10.3390%2fijms19082350&partnerID=40&md5=3bc1b1918c145a097648efae4b175ea3
Keywords: Cancer Metastasis, Cell Adhesion, Fibronectin, Integrins, Neutrophil Extracellular Traps, Alphavbeta5 Integrin, Deoxyribonuclease I, Rgd Binding Integrin, Unclassified Drug, Very Late Activation Antigen 5, Vitronectin Receptor, Article, Cell Adhesion Assay, Cell Membrane, Confocal Microscopy, Controlled Study, Dna Degradation, Fluorescence Activated Cell Sorting, Fluorescence Microscopy, Human, Human Cell, Protein Expression, Tumor Cell, Western Blotting,
Affiliations:
*** IBB - CNR ***
Dipartimento di Medicina Clinica e Chirurgia, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80131 Naples, Italy. marcello.monti@unina.it.
Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. viviana.derosa@ibb.cnr.it.
Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori "Fondazione G. Pascale", 80145 Naples, Italy. m.carriero@istitutotumori.na.it.
Dipartimento di Scienze Biomediche Avanzate, Universita degli Studi di Napoli "Federico II", Via S. Pansini 5, 80145 Naples, Italy. cr.terlizzi88@gmail.com.
Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy. stefania.belli@igb.cnr.it.
References:
Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D.S., Weinrauch, Y., Zychlinsky, A., Neutrophil extracellular traps kill bacteria (2004) Science, 303, pp. 1532-153
Papayannopoulos, V., Metzler, K.D., Hakkim, A., Zychlinsky, A., Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps (2010) J. Cell Biol., 191, pp. 677-691
Branzk, N., Papayannopoulos, V., Molecular mechanisms regulating netosis in infection and disease (2013) Semin. Immunopathol., 35, pp. 513-530
Neumann, A., Vollger, L., Berends, E.T., Molhoek, E.M., Stapels, D.A., Midon, M., Friaes, A., Gallo, R.L., Novel role of the antimicrobial peptide ll-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases (2014) J. Innate Immun., 6, pp. 860-868
de Oliveira, S., Rosowski, E.E., Huttenlocher, A., Neutrophil migration in infection and wound repair: Going forward in reverse (2016) Nat. Rev. Immunol., 16, pp. 378-391
Mayadas, T.N., Cullere, X., Lowell, C.A., The multifaceted functions of neutrophils (2014) Annu. Rev. Pathol., 9, pp. 181-218
Delgado-Rizo, V., Martinez-Guzman, M.A., Iniguez-Gutierrez, L., Garcia-Orozco, A., Alvarado-Navarro, A., Fafutis-Morris, M., Neutrophil extracellular traps and its implications in inflammation: An overview (2017) Front. Immunol., 8, p. 81
Urban, C.F., Ermert, D., Schmid, M., Abu-Abed, U., Goosmann, C., Nacken, W., Brinkmann, V., Zychlinsky, A., Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against candida albicans (2009) Plos Pathog, 5
Fuchs, T.A., Abed, U., Goosmann, C., Hurwitz, R., Schulze, I., Wahn, V., Weinrauch, Y., Zychlinsky, A., Novel cell death program leads to neutrophil extracellular traps (2007) J. Cell Biol., 176, pp. 231-241
Wang, Y., Wysocka, J., Sayegh, J., Lee, Y.H., Perlin, J.R., Leonelli, L., Sonbuchner, L.S., Dou, Y., Human pad4 regulates histone arginine methylation levels via demethylimination (2004) Science, 306, pp. 279-283
Keshari, R.S., Jyoti, A., Dubey, M., Kothari, N., Kohli, M., Bogra, J., Barthwal, M.K., Dikshit, M., Cytokines induced neutrophil extracellular traps formation: Implication for the inflammatory disease condition (2012) Plos ONE, 7
Metzler, K.D., Fuchs, T.A., Nauseef, W.M., Reumaux, D., Roesler, J., Schulze, I., Wahn, V., Zychlinsky, A., Myeloperoxidase is required for neutrophil extracellular trap formation: Implications for innate immunity (2011) Blood, 117, pp. 953-959
Kolaczkowska, E., Kubes, P., Neutrophil recruitment and function in health and inflammation (2013) Nat. Rev. Immunol., 13, pp. 159-175
Monti, M., Iommelli, F., de Rosa, V., Carriero, M.V., Miceli, R., Camerlingo, R., Di Minno, G., Del Vecchio, S., Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (2017) Plos ONE, 12
Martinod, K., Wagner, D.D., Thrombosis: Tangled up in nets (2014) Blood, 123, pp. 2768-2776
Demers, M., Krause, D.S., Schatzberg, D., Martinod, K., Voorhees, J.R., Fuchs, T.A., Scadden, D.T., Wagner, D.D., Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis (2012) Proc. Natl. Acad. Sci. USA, 109, pp. 13076-13081
Demers, M., Wagner, D.D., Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression (2013) Oncoimmunology, 2
Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Ferri, L., Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis (2013) J. Clin. Investig.
Park, J., Wysocki, R.W., Amoozgar, Z., Maiorino, L., Fein, M.R., Jorns, J., Schott, A.F., Won, N.H., Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps (2016) Sci. Transl. Med., 8, p. 361
Avraamides, C.J., Garmy-Susini, B., Varner, J.A., Integrins in angiogenesis and lymphangiogenesis (2008) Nat. Rev. Cancer, 8, pp. 604-617
Plow, E.F., Haas, T.A., Zhang, L., Loftus, J., Smith, J.W., Ligand binding to integrins (2000) J. Biol. Chem., 275, pp. 21785-21788
Tohme, S., Yazdani, H.O., Al-Khafaji, A.B., Chidi, A.P., Loughran, P., Mowen, K., Wang, Y., Tsung, A., Neutrophil extracellular traps promote the development and progression of liver metastases after surgical stress (2016) Cancer Res, 76, pp. 1367-1380
Najmeh, S., Cools-Lartigue, J., Giannias, B., Spicer, J., Ferri, L.E., Simplified human neutrophil extracellular traps (Nets) isolation and handling (2015) J. Vis. Exp., 16
Young, R.L., Malcolm, K.C., Kret, J.E., Caceres, S.M., Poch, K.R., Nichols, D.P., Taylor-Cousar, J.L., Vasil, M.L., Neutrophil extracellular trap (Net)-mediated killing of pseudomonas aeruginosa: Evidence of acquired resistance within the cf airway, independent of cftr (2011) Plos ONE, 6
Carrigan, S.O., Weppler, A.L., Issekutz, A.C., Stadnyk, A.W., Neutrophil differentiated hl-60 cells model mac-1 (Cd11b/cd18)-independent neutrophil transepithelial migration (2005) Immunology, 115, pp. 108-117
Chiaradonna, F., Fontana, L., Iavarone, C., Carriero, M.V., Scholz, G., Barone, M.V., Stoppelli, M.P., Urokinase receptor-dependent and-independent p56/59(Hck) activation state is a molecular switch between myelomonocytic cell motility and adherence (1999) EMBO J, 18, pp. 3013-3023
Millius, A., Weiner, O.D., Chemotaxis in neutrophil-like hl-60 cells (2009) Methods Mol. Biol., 571, pp. 167-177
Zannetti, A., Del Vecchio, S., Iommelli, F., Del Gatto, A., de Luca, S., Zaccaro, L., Papaccioli, A., Speranza, A., Imaging of alpha(V)beta(3) expression by a bifunctional chimeric rgd peptide not cross-reacting with alpha(v)beta(5) (2009) Clin. Cancer Res., 15, pp. 5224-5233
Yousif, A.M., Ingangi, V., Merlino, F., Brancaccio, D., Minopoli, M., Bellavita, R., Novellino, E., Grieco, P., Urokinase receptor derived peptides as potent inhibitors of the formyl peptide receptor type 1-triggered cell migration (2018) Eur. J. Med. Chem., 143, pp. 348-360
de Rosa, V., Iommelli, F., Monti, M., Fonti, R., Votta, G., Stoppelli, M.P., Del Vecchio, S., Reversal of warburg effect and reactivation of oxidative phosphorylation by differential inhibition of egfr signaling pathways in non-small cell lung cancer (2015) Clin. Cancer Res., 21, pp. 5110-5120
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis. We found that high levels of α5β1, αvβ3 and αvβ5 enhance cell adhesion to NETs, whereas low expression of α5β1 prevents cell attachment to NETs. Excess of cyclic RGD peptide inhibited cell adhesion to NETs by competing with fibronectin within NETs. The maximal reduction of such adhesion was similar to that obtained by DNase 1 treatment causing DNA degradation. Our findings indicate that NETs from neutrophil-like cells may be used as a substrate for large screening of the adhesion properties of cancer cells expressing a variety of RGD-binding integrins. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Neutrophil extracellular traps (NETs), in addition to their function as a host defense mechanism, play a relevant role in thrombus formation and metastatic dissemination of cancer cells. Here we screened different cancer cell lines endogenously expressing a variety of integrins for their ability to bind to NETs. To this end, we used NETs isolated from neutrophil-like cells as a substrate for adhesion assays of HT1080, U-87 MG, H1975, DU 145, PC-3 and A-431 cells. Levels of α5, αIIb, αv, β1, β3 and β5 chains were determined by western blot analysis in all cell lines and levels of whole integrins on the plasma membrane were assessed by fluorescence-activated cell sorting (FACS) analysis. We found that high levels of α5β1, αvβ3 and αvβ5 enhance cell adhesion to NETs, whereas low expression of α5β1 prevents cell attachment to NETs. Excess of cyclic RGD peptide inhibited cell adhesion to NETs by competing with fibronectin within NETs. The maximal reduction of such adhesion was similar to that obtained by DNase 1 treatment causing DNA degradation. Our findings indicate that NETs from neutrophil-like cells may be used as a substrate for large screening of the adhesion properties of cancer cells expressing a variety of RGD-binding integrins. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins
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Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
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Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (383 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
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Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (307 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
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Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
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Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
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Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
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De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (400 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
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Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (542 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
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Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
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Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
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Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (460 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (410 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (729 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
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Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (569 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
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Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (635 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
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Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (449 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
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Klain M, Maurea S, Lastoria S, Cuocolo A, Colao A, Salvatore M
Technetium-99m-tetrofosmin imaging of differentiated mixed thyroid cancer (283 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Dec; 36(12): 2248-2251.
Impact Factor: 3.491
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* Selective Targeting of αvβ5 Integrin in HepG2 Cell Line by RGDechi15D Peptide (108 views)
Molecules (ISSN: 1420-3049linking, 1420-3049electronic), 2020 Sep 19; 25(18): N/D-N/D.
Impact Factor: 3.267
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Mcnitt DH, Choi SJ, Allen JL, Hames RA, Weed SA, Van De Water L, Berisio R, Lukomski S
* Adaptation of the group A Streptococcus adhesin Scl1 to bind fibronectin type III repeats within wound-associated extracellular matrix: implications for cancer therapy (202 views)
Mol Microbiol (ISSN: 0950-382xlinking), 2019 May 30; N/D: N/D-N/D.
Impact Factor: 3.816
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Mcnitt DH, De Water LV, Marasco D, Berisio R, Lukomski S
* Streptococcal Collagen-like Protein 1 Binds Wound Fibronectin: Implications in Pathogen Targeting (236 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2019; 26: 1933-1945.
Impact Factor: 3.9
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Mcnitt DH, Choi SJ, Keene DR, Van De Water L, Squeglia F, Berisio R, Lukomski S
* Surface-exposed loops and an acidic patch in the Scl1 protein of group A Streptococcus enable Scl1 binding to wound-associated fibronectin (281 views)
J Biol Chem, 2018; N/D: N/D-N/D.
Impact Factor: 4.12
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Comegna D, Zannetti A, Del Gatto A, De Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L
* Chemical Modification for Proteolytic Stabilization of the Selective alphavbeta3 Integrin RGDechi Peptide: in Vitro and in Vivo Activities on Malignant Melanoma Cells (934 views) (PDF 204 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2017 Dec 14; 60(23): 9874-9884.
Impact Factor: 6.253
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Fusella F, Secli L, Busso E, Krepelova A, Moiso E, Rocca S, Conti L, Annaratone L, Rubinetto C, Mello-grand M, Singh V, Chiorino G, Silengo L, Altruda F, Turco E, Morotti A, Oliviero S, Castellano I, Cavallo F, Provero P, Tarone G, Brancaccio M
* The IKK/NF-kappaB signaling pathway requires Morgana to drive breast cancer metastasis (187 views)
Nat Commun (ISSN: 2041-1723, 2041-1723electronic, 2041-1723linking), 2017 Nov 21; 8(1): 1636-1636.
Impact Factor: 12.353
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Dennehy R, RomanoM, Ruggiero A, Mohamed YF, Dignam SL, Mujica Troncoso C, Callaghan M, Valvano MA, Berisio R, Mcclean S
* The Burkholderia cenocepacia peptidoglycan-associated lipoprotein is involved in epithelial cell attachment and elicitation of inflammation (294 views)
Cell Microbiol (ISSN: 1462-5814), 2017 May; 19(5): e12691-e12691.
Impact Factor: 4.41
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Monti M, Iommelli F, De Rosa V, Carriero MV, Miceli R, Camerlingo R, Di Minno G, Del Vecchio S
* Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (392 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2017 Feb; 12(2): 1-15.
Impact Factor: 2.766
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Roviello GN, Iannitti R, Roviello V, Palumbo R, Simonyan H, Vicidomini C
* Synthesis and biological evaluation of a novel Amadori compound (406 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2017 Feb; 49(2): 327-335.
Impact Factor: 2.906
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Lukomski S, Bachert B, Squeglia F, Berisio R
* Collagen-like proteins of pathogenic streptococci (241 views)
Mol Microbiol (ISSN: 0950-382x), 2017; 103: 919-930.
Impact Factor: 3.816
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Pizzanelli S, Forte C, Pinzino C, Magrì A, La Mendola D
* Copper(ii) complexes with peptides based on the second cell binding site of fibronectin: metal coordination and ligand exchange kinetics (354 views)
Phys Chem Chem Phys (ISSN: 1463-9076, 1463-3907, 1463-9084electronic), 2016 Feb 7; 18(5): 3982-3994.
Impact Factor: 4.123
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Montefusco S, Esposito R, D'Andrea L, Monti MC, Dunne C, Dolan B, Tosco A, Marzullo L, Clyne M
* Copper promotes TFF1-mediated Helicobacter pylori colonization (635 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2013 Nov 13; 8(11): e79455-e79455.
Impact Factor: 3.534
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Madonna S, Scarponi C, Doti N, Carbone T, Cavani A, Scognamiglio PL, Marasco D, Albanesi C
* Therapeutical potential of a peptide mimicking the SOCS1 kinase inhibitory region in skin immune responses (616 views)
Eur J Immunol (ISSN: 0014-2980), 2013 Jul; 43(7): 1883-1895.
Impact Factor: 4.518
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Pisano M, De Paola I, Nieddu V, Sassu I, Cossu S, Galleri G, Del Gatto A, Budroni M, Cossu A, Saviano M, Palmieri G, Zaccaro L, Rozzo C
* In vitro activity of the alphavbeta3 integrin antagonist RGDechi-hCit on malignant melanoma cells (447 views)
Anticancer Res (ISSN: 0250-7005, 0250-0700, 1791-7530electronic), 2013 Mar; 33(3): 871-879.
Impact Factor: 1.045
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Magrì A, D'Alessandro F, Di Stefano DA, Campagna T, Pappalardo G, Impellizzeri G, La Mendola D
* Copper(ii) Coordination Properties Of The Integrin Ligand Sequence Phsrn And Its New Beta-Cyclodextrin Conjugates (488 views)
Journal Of Inorganic Biochemistry, 2012 Sep; 113: 15-24.
Impact Factor: 3.444
View Export to BibTeX Export to EndNote
Accardo A, Salsano G, Morisco A, Aurilio M, Parisi A, Maione F, Cicala C, Tesauro D, Aloj L, De Rosa G, Morelli G
* Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: A potential theranostic agent (383 views)
Int J Nanomed (ISSN: 1176-9114, 1178-2013, 1178-2013electronic), 2012; 7: 2007-2017.
Impact Factor: 3.463
View Export to BibTeX Export to EndNote
Satriano C, Fragalà ME, Forte G, Santoro AM, La Mendola D, Kasemo B
* Surface adsorption of fibronectin-derived peptide fragments: The influence of electrostatics and hydrophobicity for endothelial cells adhesion (307 views)
Soft Matter (ISSN: 1744-683x), 2012; 8(1): 53-56.
Impact Factor: 3.909
View Export to BibTeX Export to EndNote
Perrone-filardi P, Dellegrottaglie S, Rudd JH, Costanzo P, Marciano C, Vassallo E, Marsico F, Ruggiero D, Petretta MP, Chiariello M, Cuocolo A
* Molecular imaging of atherosclerosis in translational medicine (756 views)
Eur J Nucl Med (ISSN: 1619-7089, 1619-7070, 0340-6997), 2011 May; 38(5): 969-975.
Impact Factor: 4.991
View Export to BibTeX Export to EndNote
Guarnieri D, De Capua A, Ventre M, Borzacchiello A, Pedone C, Marasco D, Ruvo M, Netti PA
* Covalently immobilized RGD gradient on PEG hydrogel scaffold influences cell migration parameters (656 views)
Acta Biomaterialia (ISSN: 1878-7568, 1742-7061), 2010 Jul; 6(7): 2532-2539.
Impact Factor: 4.824
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment (504 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 243-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Del Vecchio S, Zannetti A, Iommelli F, Lettieri A, Brunetti A, Salvatore M
* Molecular imaging of tumor microenvironment: Challenges and perspectives (597 views)
Q J Nucl Med Mol Im (ISSN: 1824-4785, 1824-4478, 1824-4785linking), 2010 Jun; 54(3): 249-258.
Impact Factor: 1.724
View Export to BibTeX Export to EndNote
Monfregola L, Saviano M, De Luca S
* Synthesis and Characterization of a Selective Alpha(v)Beta(3) Receptor Cyclic Peptide Antagonist Functionalized with a Chelating Group for Metal Labelling (378 views)
Int J Pept Res Ther (ISSN: 1573-3149, 0929-5666), 2010 Mar; 16(1): 1-5.
Impact Factor: 1.034
View Export to BibTeX Export to EndNote
De Simone G, Supuran CT
* Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target (400 views)
Bba-Gen Subjects (ISSN: 1570-9639, 0006-3002, 0925-4439), 2010 Feb; 1804(2): 404-409.
Impact Factor: 2.773
View Export to BibTeX Export to EndNote
Satriano C, Messina GM, Marino C, Aiello I, Conte E, La Mendola D, Distefano DA, D'Alessandro F, Pappalardo G, Impellizzeri G
* Surface immobilization of fibronectin-derived PHSRN peptide on functionalized polymer films - Effects on fibroblast spreading (542 views)
J Colloid Interface Sci (ISSN: 1095-7103electronic, 0021-9797linking), 2010 Jan 15; 341(2): 232-239.
Impact Factor: 3.068
View Export to BibTeX Export to EndNote
Zannetti A, Del Vecchio S, Iommelli F, Del Gatto A, De Luca S, Zaccaro L, Papaccioli A, Sommella J, Panico M, Speranza A, Grieco P, Novellino E, Saviano M, Pedone C, Salvatore M
* Imaging of αvβ3 expression by a bifunctional chimeric RGD peptide not cross-reacting with α vβ5 (928 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 2009 Sep 15; 15(16): 5224-5233.
Impact Factor: 6.747
View Export to BibTeX Export to EndNote
Mancini M, Greco A, Speranza A, Salvatore M
* Ultrasound molecular imaging by targeted microbubble contrast agents (442 views)
Minerva Biotecnol (ISSN: 1120-4826), 2009 Jun; 21(2): 97-110.
Impact Factor: 0.268
View Export to BibTeX Export to EndNote
Gioia M, Monaco S, Van Den Steen PE, Sbardella D, Grasso G, Marini S, Overall CM, Opdenakker G, Coletta M
* The Collagen Binding Domain of Gelatinase A Modulates Degradation of Collagen IV by Gelatinase (460 views)
J Mol Biol (ISSN: 0022-2836, 1089-8638, 1089-8638electronic), 2009; 386(2): 419-434.
Impact Factor: 3.871
View Export to BibTeX Export to EndNote
Hilvo M, Baranauskiene L, Salzano AM, Scaloni A, Matulis D, Innocenti A, Scozzafava A, Monti SM, Di Fiore A, De Simone G, Lindfors M, Janis J, Valjakka J, Pastorekova S, Pastorek J, Kulomaa MS, Nordlund HR, Supuran CT, Parkkila S
* Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes (460 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2008 Oct 10; 283(41): 27799-27809.
Impact Factor: 5.52
View Export to BibTeX Export to EndNote
Castiglione M, Calafiore M, Costa L, Sortino MA, Nicoletti F, Copani A
* Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice (490 views)
Neuropharm (ISSN: 0028-3908, 1873-7064electronic, 0028-3908linking), 2008 Sep; 55(4): 560-567.
Impact Factor: 3.383
View Export to BibTeX Export to EndNote
Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (410 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Del Gatto A, Zaccaro L, Grieco P, Novellino E, Zannetti A, Del Vecchio S, Iommelli F, Salvatore M, Pedone C, Saviano M
* Novel And Selective Alpha (v) Beta3 Receptor Peptide Antagonist: Design, Synthesis, And Biological Behavior (729 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2006 Jun 1; 49(11): 3416-3420.
Impact Factor: 5.115
View Export to BibTeX Export to EndNote
Calafiore M, Battaglia G, Zappal A, Trovato-Salinaro E, Caraci F, Caruso M, Vancheri C, Sortino MA, Nicoletti F, Copani A
* Progenitor cells from the adult mouse brain acquire a neuronal phenotype in response to β-amyloid (569 views)
Neurobiol Aging (ISSN: 0197-4580, 1558-1497electronic, 0197-4580linking), 2006; 27(4): 606-613.
Impact Factor: 5.599
View Export to BibTeX Export to EndNote
Vacatello M, D'Auria G, Falcigno L, Dettin M, Gambaretto R, Di Bello C, Paolillo L
* Conformational Analysis Of Novel Heparin Binding Peptides (635 views)
Biomaterials (ISSN: 0142-9612, 1878-5905electronic, 0142-9612linking), 2005 Jun; 26(16): 3207-3214.
Impact Factor: 4.698
View Export to BibTeX Export to EndNote
Carriero MV, Del Vecchio S, Franco P, Potena MI, Chiaradonna F, Botti G, Stoppelli MP, Salvatore M
Vitronectin binding to urokinase receptor in human breast cancer (449 views)
Clin Cancer Res (ISSN: 1078-0432, 1078-0432linking, 1078-0432print), 1997 Sep; 3(8): 1299-1308.
Impact Factor: 3.419
View Export to BibTeX Export to EndNote
Klain M, Maurea S, Lastoria S, Cuocolo A, Colao A, Salvatore M
Technetium-99m-tetrofosmin imaging of differentiated mixed thyroid cancer (283 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 1995 Dec; 36(12): 2248-2251.
Impact Factor: 3.491
View Export to BibTeX Export to EndNote
36 Records (35 excluding Abstracts).
Total impact factor: 137.126 (133.892 excluding Abstracts).
Total 5 year impact factor: 151.798 (148.096 excluding Abstracts).
Total impact factor: 137.126 (133.892 excluding Abstracts).
Total 5 year impact factor: 151.798 (148.096 excluding Abstracts).
268 views. Last view on Thursday 04 May 2023, 13:01:38
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