Sam Domains in Multiple Diseases (488 views)
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020; 27(3): 450-476.
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Paper type: Journal Article, Review,
Impact factor: 3.469, 5-year impact factor: 4.961
Url: Not available.
Keywords: Sam Domains, Diseases, Drug-Discovery, Protein-Protein Interactions, Structural Biology, Therapeutic Routes, Peptides, Sterile Alpha Motif, Drug Discovery,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council (CNR), Via Mezzocannone 16, 80134 Naples. Italy.
Cirpeb, InterUniversity Research Centre on Bioactive Peptides, University of Naples "Federico II", Via Mezzocannone, 16, 80134 Naples, Italy.
References:
Not available.
Curr Med Chem (ISSN: 0929-8673linking, 1875-533xelectronic), 2020; 27(3): 450-476.
Export to BibTeX Export to EndNote
Paper type: Journal Article, Review,
Impact factor: 3.469, 5-year impact factor: 4.961
Url: Not available.
Keywords: Sam Domains, Diseases, Drug-Discovery, Protein-Protein Interactions, Structural Biology, Therapeutic Routes, Peptides, Sterile Alpha Motif, Drug Discovery,
Affiliations:
*** IBB - CNR ***
Institute of Biostructures and Bioimaging, National Research Council (CNR), Via Mezzocannone 16, 80134 Naples. Italy.
Cirpeb, InterUniversity Research Centre on Bioactive Peptides, University of Naples "Federico II", Via Mezzocannone, 16, 80134 Naples, Italy.
References:
Not available.
Sam Domains in Multiple Diseases
BACKGROUND: The sterile alpha motif (Sam) domain is a small helical protein module able to undergo homo- and hetero-oligomerization as well as polymerization thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable targets for the development of new potential therapeutic routes. This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and progression. METHODS: This review was build up by looking throughout the literature for: a) the structural properties of Sam domains, b) interactions mediated by a Sam module, c) presence of a Sam domain in proteins relevant for a specific disease. RESULTS: Sam domains appear crucial in many diseases including but not limited to cataracts, cancer, renal disorders. Often pathologies are linked to mutations directly positioned in the Sam domains that alter its stability and/or affect interactions that are crucial for proper protein functions. In only a few diseases the Sam motif plays a kind of "side role" and cooperates to the pathological event by enhancing the action of a different protein domain. CONCLUSION: Considering the many roles of the Sam domain into a significant variety of diseases, more efforts and novel drug discovery campaigns need to be engaged to find out small molecules and/or peptides targeting Sam domains. Such compounds may represent the pillars on which to build novel therapeutic strategies to cure different pathologies.
BACKGROUND: The sterile alpha motif (Sam) domain is a small helical protein module able to undergo homo- and hetero-oligomerization as well as polymerization thus forming different types of protein architectures. A few Sam domains are involved in pathological processes and consequently, they represent valuable targets for the development of new potential therapeutic routes. This study intends to collect state-of-the-art knowledge on the different modes by which Sam domains can favor disease onset and progression. METHODS: This review was build up by looking throughout the literature for: a) the structural properties of Sam domains, b) interactions mediated by a Sam module, c) presence of a Sam domain in proteins relevant for a specific disease. RESULTS: Sam domains appear crucial in many diseases including but not limited to cataracts, cancer, renal disorders. Often pathologies are linked to mutations directly positioned in the Sam domains that alter its stability and/or affect interactions that are crucial for proper protein functions. In only a few diseases the Sam motif plays a kind of "side role" and cooperates to the pathological event by enhancing the action of a different protein domain. CONCLUSION: Considering the many roles of the Sam domain into a significant variety of diseases, more efforts and novel drug discovery campaigns need to be engaged to find out small molecules and/or peptides targeting Sam domains. Such compounds may represent the pillars on which to build novel therapeutic strategies to cure different pathologies.
Sam Domains in Multiple Diseases
Sam Domains in Multiple Diseases
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View Export to BibTeX Export to EndNote
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Impact Factor: 3.578
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View Export to BibTeX Export to EndNote
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View Export to BibTeX Export to EndNote
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Impact Factor: 2.473
View Export to BibTeX Export to EndNote
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Impact Factor: 1.807
View Export to BibTeX Export to EndNote
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Impact Factor: 2.347
View Export to BibTeX Export to EndNote
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Impact Factor: 2.648
View Export to BibTeX Export to EndNote
Ruvo M, Marasco D, Viparelli F, Tornatore L, Sandomenico A, Doti N, Pedone C, Benedetti E, Monti SM
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Impact Factor: 1.654
View Export to BibTeX Export to EndNote
Vergara A, Lorber B, Sauter C, Giege R, Zagari A
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Impact Factor: 1.925
View Export to BibTeX Export to EndNote
29 Records (27 excluding Abstracts).
Total impact factor: 92.904 (88.016 excluding Abstracts).
Total 5 year impact factor: 100.109 (94.625 excluding Abstracts).
Total impact factor: 92.904 (88.016 excluding Abstracts).
Total 5 year impact factor: 100.109 (94.625 excluding Abstracts).
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