Combined HAT/EZH2 modulation leads to cancer-selective cell death(455 views) Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Keywords: Acetylation, Apoptosis, Cancer, Epigenetics, Methylation, Antineoplastic Agent, Caspase, Mc 2884, Transcription Factor Ezh2, Unclassified Drug, Acute Myeloid Leukemia, Animal Experiment, Animal Model, Antineoplastic Activity, Antiproliferative Activity, Article, Cancer Cell, Cell Cycle, Cell Death, Cell Growth, Cell Migration, Cell Proliferation, Colon Carcinoma, Controlled Study, Cytotoxicity, Drug Effect, Drug Efficacy, Drug Mechanism, Drug Response, Drug Structure, Human, Human Cell, Mouse, Nonhuman, Tumor Volume, Tumor Xenograft,
Affiliations: *** IBB - CNR ***
Dipartimento di Medicina di Precisione, Universita degli Studi della Campania Luigi Vanvitelli, Napoli 80138, Italy., Department of Molecular Biology, Radboud University, HB Nijmegen 6500, The Netherlands., IRCCS SDN, Napoli 80143, Italy., Dipartimento di Chimica e Tecnologie del Farmaco 'Sapienza' Universita, Roma 00185, Italy., Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Universita della Campania 'Luigi Vanvitelli', Caserta 81100, Italy., Ospedale Umberto I, Nocera Inferiore 84014, Italy., Istituto di Genetica e Biofisica, Napoli 80131, Italy., Centro Nacional de Analisis Genomico, Barcelona, Spain., Istituto di Biostrutture e Bioimmagini, Napoli, Italy., Department of Hematology, University of Groningen and University Medical Center Groningen, RB Groningen 9700, The Netherlands., European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom., Max Planck Institute for Molecular Genetics, Berlin, Germany., Institute Gustave Roussy, Equipe labellisee Ligue Nationale contre le Cancer (LNCC), Universtite Paris-Saclay, INSERM U1170, Paris, France., Dipartimento di Farmacia, Universita di Napoli 'Federico II', Napoli 80131, Italy., Dipartimento di Farmacia, Universita degli Studi di Salerno, Fisciano I-84084, Italy., Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Roma 00185, Italy.,
IRCCS SDN, Napoli, 80143, Italy
References: Not available.
Combined HAT/EZH2 modulation leads to cancer-selective cell death