Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (166 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.579, 5-year impact factor: 2.217
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002263489&doi=10.1016%2fj.microc.2016.09.016&partnerID=40&md5=67f5e08a9f1f1007f1ad29b982ca1467
Keywords: Actin, Colloidal Hydrodynamic Size, Confocal Microscopy, Fluorescein-Labelled Peptide, Peptidomimetics, Plasmonics,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, 95125, Italy
Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, Pisa, 56126, Italy
Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council (CNR), Via Paolo Gaifami 18, Catania, Italy
References:
Di Pietro, P., Strano, G., Zuccarello, L., Satriano, C., Gold and silver nanoparticles for applications in theranostics (2016) Curr. Top. Med. Chem., 16 (27), pp. 3069-310
Parnsamut, C., Brimson, S., Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-alpha production via MAPK pathway in leukemic cell lines (2015) Genet. Mol. Res., 14, pp. 3650-3668
Zhang, P., Hu, C., Ran, W., Meng, J., Yin, Q., Li, Y., Recent progress in light-triggered nanotheranostics for cancer treatment (2016) Theranostics, 6, pp. 948-968
Hornos Carneiro, M.F., Barbosa, F., Jr., Gold nanoparticles: a critical review of therapeutic applications and toxicological aspects (2016) J. Toxicol. Environ. Health B Crit. Rev., 19, pp. 129-148
Pan, Y., Wu, Q., Qin, L., Cai, J., Du, B., Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway (2014) Biomed. Res. Int., 2014, p. 418624
Vallee, B.L., Riordan, J.F., Organogenesis and angiogenin (1997) Cell. Mol. Life Sci., 53, pp. 803-815
Shapiro, R., Strydom, D.J., Olson, K.A., Vallee, B.L., Isolation of angiogenin from normal human plasma (1987) Biochemistry, 26, pp. 5141-5146
Chung, S., Dwabe, S., Elshimali, Y., Sukhija, H., Aroh, C., Vadgama, J.V., Identification of novel biomarkers for metastatic colorectal cancer using angiogenesis-antibody array and intracellular signaling array (2015) PLoS One, 10
La Mendola, D., Giacomelli, C., Rizzarelli, E., Intracellular bioinorganic chemistry and cross talk among different-omics (2016) Curr. Top. Med. Chem., 16 (27), pp. 3103-3130
Nilsson, U.W., Abrahamsson, A., Dabrosin, C., Angiogenin regulation by estradiol in breast tissue: tamoxifen inhibits angiogenin nuclear translocation and antiangiogenin therapy reduces breast cancer growth in vivo (2010) Clin. Cancer Res., 16, pp. 3659-3669
Soncin, F., Guitton, J.D., Cartwright, T., Badet, J., Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells (1997) Biochem. Biophys. Res. Commun., 236, pp. 604-610
Bartczak, D., Muskens, O.L., Sanchez-Elsner, T., Kanaras, A.G., Millar, T.M., Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles (2013) ACS Nano, 7, pp. 5628-5636
Roma-Rodrigues, C., Heuer-Jungemann, A., Fernandes, A.R., Kanaras, A.G., Baptista, P.V., Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo (2016) Int. J. Nanomedicine, 11, pp. 2633-2639
Hruby, V.J., Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors (2016) Biopolymers
La Mendola, D., Magri, A., Campagna, T., Campitiello, M.A., Raiola, L., Isernia, C., Hansson, O., Rizzarelli, E., A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (2010) Chemistry, 16, pp. 6212-6223
Moore, G.J., Designing peptide mimetics (1994) Trends Pharmacol. Sci., 15, pp. 124-129
Forte, G., Travaglia, A., Magri, A., Satriano, C., La Mendola, D., Adsorption of NGF and BDNF derived peptides on gold surfaces (2014) Phys. Chem. Chem. Phys., 16, pp. 1536-1544
Skaper, S.D., Peptide mimetics of neurotrophins and their receptors (2011) Curr. Pharm. Des., 17, pp. 2704-2718
Gho, Y.S., Chae, C.B., Anti-angiogenin activity of the peptides complementary to the receptor-binding site of angiogenin (1997) J. Biol. Chem., 272, pp. 24294-24299
Hatzi, E., Badet, J., Expression of receptors for human angiogenin in vascular smooth muscle cells (1999) Eur. J. Biochem., 260, pp. 825-832
Hu, G.F., Chang, S.I., Riordan, J.F., Vallee, B.L., An angiogenin-binding protein from endothelial cells (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 2227-2231
Hallahan, T.W., Shapiro, R., Vallee, B.L., Dual site model for the organogenic activity of angiogenin (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 2222-2226
Giacomelli, C., Trincavelli, M.L., Satriano, C., Hansson, O., La Mendola, D., Rizzarelli, E., Martini, C., Copper (II) ions modulate angiogenin activity in human endothelial cells (2015) Int. J. Biochem. Cell Biol., 60, pp. 185-196
La Mendola, D., Arnesano, F., Hansson, O., Giacomelli, C., Calo, V., Mangini, V., Magri, A., Rizzarelli, E., Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (2016) Metallomics, 8, pp. 118-124
Crabtree, B., Holloway, D.E., Baker, M.D., Acharya, K.R., Subramanian, V., Biological and structural features of murine angiogenin-4, an angiogenic protein (2007) Biochemistry, 46, pp. 2431-2443
Hu, G.F., Riordan, J.F., Vallee, B.L., A putative angiogenin receptor in angiogenin-responsive human endothelial cells (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 2204-2209
Hu, G.F., Strydom, D.J., Fett, J.W., Riordan, J.F., Vallee, B.L., Actin is a binding protein for angiogenin (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 1217-1221
Hu, G., Riordan, J.F., Vallee, B.L., Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 12096-12100
Pyatibratov, M.G., Tolkatchev, D., Plamondon, J., Xu, P., Ni, F., Kostyukova, A.S., Binding of human angiogenin inhibits actin polymerization (2010) Arch. Biochem. Biophys., 495, pp. 74-81
Magri, A., Munzone, A., Peana, M., Medici, S., Zoroddu, M.A., Hansson, O., Satriano, C., La Mendola, D., Coordination environment of Cu(II) ions bound to N-terminal peptide fragments of angiogenin protein (2016) Int. J. Mol. Sci., 17
Gauci, S., van Breukelen, B., Lemeer, S.M., Krijgsveld, J., Heck, A.J., A versatile peptide pI calculator for phosphorylated and N-terminal acetylated peptides experimentally tested using peptide isoelectric focusing (2008) Proteomics, 8, pp. 4898-4906
Turkevich, J., Stevenson, P.C., Hillier, J., A study of the nucleation and growth processes in the synthesis of colloidal gold (1951) Discuss. Faraday Soc., 11, pp. 55-75
Liu, X., Atwater, M., Wang, J., Huo, Q., Extinction coefficient of gold nanoparticles with different sizes and different capping ligands (2007) Colloids Surf. B: Biointerfaces, 58, pp. 3-7
Piella, J., Bastús, N.G., Puntes, V., Size-controlled synthesis of sub-10-nanometer citrate-stabilized gold nanoparticles and related optical properties (2016) Chem. Mater., 28, pp. 1066-1075
Harpaz, Y., Gerstein, M., Chothia, C., Volume changes on protein folding (1994) Structure, 2, pp. 641-649
Hackley, V.A., Clogston, J.D., Measuring the hydrodynamic size of nanoparticles in aqueous media using batch-mode dynamic light scattering (2011) Methods Mol. Biol., 697, pp. 35-52
Tomaszewska, E., Soliwoda, K., Kadziola, K., Tkacz-Szczesna, B., Celichowski, G., Cichomski, M., Szmaja, W., Grobelny, J., Detection limits of DLS and UV–Vis spectroscopy in characterization of polydisperse nanoparticles colloids (2013) J. Nanomater., 2013, pp. 313081-313090
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 2.579, 5-year impact factor: 2.217
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85002263489&doi=10.1016%2fj.microc.2016.09.016&partnerID=40&md5=67f5e08a9f1f1007f1ad29b982ca1467
Keywords: Actin, Colloidal Hydrodynamic Size, Confocal Microscopy, Fluorescein-Labelled Peptide, Peptidomimetics, Plasmonics,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, Catania, 95125, Italy
Department of Pharmacy, University of Pisa, Via Bonanno Pisano 6, Pisa, 56126, Italy
Institute of Biostructure and Bioimaging (IBB) of the Italian National Research Council (CNR), Via Paolo Gaifami 18, Catania, Italy
References:
Di Pietro, P., Strano, G., Zuccarello, L., Satriano, C., Gold and silver nanoparticles for applications in theranostics (2016) Curr. Top. Med. Chem., 16 (27), pp. 3069-310
Parnsamut, C., Brimson, S., Effects of silver nanoparticles and gold nanoparticles on IL-2, IL-6, and TNF-alpha production via MAPK pathway in leukemic cell lines (2015) Genet. Mol. Res., 14, pp. 3650-3668
Zhang, P., Hu, C., Ran, W., Meng, J., Yin, Q., Li, Y., Recent progress in light-triggered nanotheranostics for cancer treatment (2016) Theranostics, 6, pp. 948-968
Hornos Carneiro, M.F., Barbosa, F., Jr., Gold nanoparticles: a critical review of therapeutic applications and toxicological aspects (2016) J. Toxicol. Environ. Health B Crit. Rev., 19, pp. 129-148
Pan, Y., Wu, Q., Qin, L., Cai, J., Du, B., Gold nanoparticles inhibit VEGF165-induced migration and tube formation of endothelial cells via the Akt pathway (2014) Biomed. Res. Int., 2014, p. 418624
Vallee, B.L., Riordan, J.F., Organogenesis and angiogenin (1997) Cell. Mol. Life Sci., 53, pp. 803-815
Shapiro, R., Strydom, D.J., Olson, K.A., Vallee, B.L., Isolation of angiogenin from normal human plasma (1987) Biochemistry, 26, pp. 5141-5146
Chung, S., Dwabe, S., Elshimali, Y., Sukhija, H., Aroh, C., Vadgama, J.V., Identification of novel biomarkers for metastatic colorectal cancer using angiogenesis-antibody array and intracellular signaling array (2015) PLoS One, 10
La Mendola, D., Giacomelli, C., Rizzarelli, E., Intracellular bioinorganic chemistry and cross talk among different-omics (2016) Curr. Top. Med. Chem., 16 (27), pp. 3103-3130
Nilsson, U.W., Abrahamsson, A., Dabrosin, C., Angiogenin regulation by estradiol in breast tissue: tamoxifen inhibits angiogenin nuclear translocation and antiangiogenin therapy reduces breast cancer growth in vivo (2010) Clin. Cancer Res., 16, pp. 3659-3669
Soncin, F., Guitton, J.D., Cartwright, T., Badet, J., Interaction of human angiogenin with copper modulates angiogenin binding to endothelial cells (1997) Biochem. Biophys. Res. Commun., 236, pp. 604-610
Bartczak, D., Muskens, O.L., Sanchez-Elsner, T., Kanaras, A.G., Millar, T.M., Manipulation of in vitro angiogenesis using peptide-coated gold nanoparticles (2013) ACS Nano, 7, pp. 5628-5636
Roma-Rodrigues, C., Heuer-Jungemann, A., Fernandes, A.R., Kanaras, A.G., Baptista, P.V., Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo (2016) Int. J. Nanomedicine, 11, pp. 2633-2639
Hruby, V.J., Design of cyclic peptides with biological activities from biologically active peptides: the case of peptide modulators of melanocortin receptors (2016) Biopolymers
La Mendola, D., Magri, A., Campagna, T., Campitiello, M.A., Raiola, L., Isernia, C., Hansson, O., Rizzarelli, E., A doppel alpha-helix peptide fragment mimics the copper(II) interactions with the whole protein (2010) Chemistry, 16, pp. 6212-6223
Moore, G.J., Designing peptide mimetics (1994) Trends Pharmacol. Sci., 15, pp. 124-129
Forte, G., Travaglia, A., Magri, A., Satriano, C., La Mendola, D., Adsorption of NGF and BDNF derived peptides on gold surfaces (2014) Phys. Chem. Chem. Phys., 16, pp. 1536-1544
Skaper, S.D., Peptide mimetics of neurotrophins and their receptors (2011) Curr. Pharm. Des., 17, pp. 2704-2718
Gho, Y.S., Chae, C.B., Anti-angiogenin activity of the peptides complementary to the receptor-binding site of angiogenin (1997) J. Biol. Chem., 272, pp. 24294-24299
Hatzi, E., Badet, J., Expression of receptors for human angiogenin in vascular smooth muscle cells (1999) Eur. J. Biochem., 260, pp. 825-832
Hu, G.F., Chang, S.I., Riordan, J.F., Vallee, B.L., An angiogenin-binding protein from endothelial cells (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 2227-2231
Hallahan, T.W., Shapiro, R., Vallee, B.L., Dual site model for the organogenic activity of angiogenin (1991) Proc. Natl. Acad. Sci. U. S. A., 88, pp. 2222-2226
Giacomelli, C., Trincavelli, M.L., Satriano, C., Hansson, O., La Mendola, D., Rizzarelli, E., Martini, C., Copper (II) ions modulate angiogenin activity in human endothelial cells (2015) Int. J. Biochem. Cell Biol., 60, pp. 185-196
La Mendola, D., Arnesano, F., Hansson, O., Giacomelli, C., Calo, V., Mangini, V., Magri, A., Rizzarelli, E., Copper binding to naturally occurring, lactam form of angiogenin differs from that to recombinant protein, affecting their activity (2016) Metallomics, 8, pp. 118-124
Crabtree, B., Holloway, D.E., Baker, M.D., Acharya, K.R., Subramanian, V., Biological and structural features of murine angiogenin-4, an angiogenic protein (2007) Biochemistry, 46, pp. 2431-2443
Hu, G.F., Riordan, J.F., Vallee, B.L., A putative angiogenin receptor in angiogenin-responsive human endothelial cells (1997) Proc. Natl. Acad. Sci. U. S. A., 94, pp. 2204-2209
Hu, G.F., Strydom, D.J., Fett, J.W., Riordan, J.F., Vallee, B.L., Actin is a binding protein for angiogenin (1993) Proc. Natl. Acad. Sci. U. S. A., 90, pp. 1217-1221
Hu, G., Riordan, J.F., Vallee, B.L., Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities (1994) Proc. Natl. Acad. Sci. U. S. A., 91, pp. 12096-12100
Pyatibratov, M.G., Tolkatchev, D., Plamondon, J., Xu, P., Ni, F., Kostyukova, A.S., Binding of human angiogenin inhibits actin polymerization (2010) Arch. Biochem. Biophys., 495, pp. 74-81
Magri, A., Munzone, A., Peana, M., Medici, S., Zoroddu, M.A., Hansson, O., Satriano, C., La Mendola, D., Coordination environment of Cu(II) ions bound to N-terminal peptide fragments of angiogenin protein (2016) Int. J. Mol. Sci., 17
Gauci, S., van Breukelen, B., Lemeer, S.M., Krijgsveld, J., Heck, A.J., A versatile peptide pI calculator for phosphorylated and N-terminal acetylated peptides experimentally tested using peptide isoelectric focusing (2008) Proteomics, 8, pp. 4898-4906
Turkevich, J., Stevenson, P.C., Hillier, J., A study of the nucleation and growth processes in the synthesis of colloidal gold (1951) Discuss. Faraday Soc., 11, pp. 55-75
Liu, X., Atwater, M., Wang, J., Huo, Q., Extinction coefficient of gold nanoparticles with different sizes and different capping ligands (2007) Colloids Surf. B: Biointerfaces, 58, pp. 3-7
Piella, J., Bastús, N.G., Puntes, V., Size-controlled synthesis of sub-10-nanometer citrate-stabilized gold nanoparticles and related optical properties (2016) Chem. Mater., 28, pp. 1066-1075
Harpaz, Y., Gerstein, M., Chothia, C., Volume changes on protein folding (1994) Structure, 2, pp. 641-649
Hackley, V.A., Clogston, J.D., Measuring the hydrodynamic size of nanoparticles in aqueous media using batch-mode dynamic light scattering (2011) Methods Mol. Biol., 697, pp. 35-52
Tomaszewska, E., Soliwoda, K., Kadziola, K., Tkacz-Szczesna, B., Celichowski, G., Cichomski, M., Szmaja, W., Grobelny, J., Detection limits of DLS and UV–Vis spectroscopy in characterization of polydisperse nanoparticles colloids (2013) J. Nanomater., 2013, pp. 313081-313090
Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications
Gold nanoparticles (AuNPs) have unique anti-angiogenic properties and have been applied in a variety of cancers studies. ‘Naked’ gold nanoparticles directly bound to angiogenic factors have been demonstrated to inhibit growth factor-mediated signalling in vitro and vascular endothelial growth factor-induced angiogenesis in vivo. Angiogenin (Ang) is a protein physiologically constituent the human plasma but also a pathological marker of different cancer types. Herein, the peptide Ang60–68, encompassing the putative cellular binding site of the protein Ang, has been synthesized and characterized in the interaction with spherical AuNPs of 12 nm of diameter. The Ang mimicking activity of the peptide was assessed in terms of cell cytoskeleton rearrangements visualized by staining of actin, which is an important target of the whole protein. The hybrid assemblies obtained by physical adsorption of the peptide molecules at the surface of the gold nanoparticles were scrutinised by UV–visible spectroscopy, to characterize with titration experiments the changes in the plasmonic properties of AuNPs as well as the peptide spectral features. The latter were obtained by using the fluorescent analogous peptide, Fam-Ang59–68, incorporating the carboxyfluorescein (Fam) moiety, through an amidic bond of the N-terminal residue. The hydrodynamic size of the peptide-Au systems were determined by dynamic light scattering (DLS) analyses. Proof-of work experiments with human neuroblastoma cells line demonstrated the non-toxicity of the Ang-mimicking peptide functionalised gold nanoparticles. Moreover, laser scanning confocal microscopy (LSM) experiments showed the localization of the peptide-nanoparticles at the cell membrane and their sub-cellular distribution. These data reveal a promising new platform for imaging and therapeutic activities in cancer therapy. © 2016 Elsevier B.V.
Gold nanoparticles (AuNPs) have unique anti-angiogenic properties and have been applied in a variety of cancers studies. ‘Naked’ gold nanoparticles directly bound to angiogenic factors have been demonstrated to inhibit growth factor-mediated signalling in vitro and vascular endothelial growth factor-induced angiogenesis in vivo. Angiogenin (Ang) is a protein physiologically constituent the human plasma but also a pathological marker of different cancer types. Herein, the peptide Ang60–68, encompassing the putative cellular binding site of the protein Ang, has been synthesized and characterized in the interaction with spherical AuNPs of 12 nm of diameter. The Ang mimicking activity of the peptide was assessed in terms of cell cytoskeleton rearrangements visualized by staining of actin, which is an important target of the whole protein. The hybrid assemblies obtained by physical adsorption of the peptide molecules at the surface of the gold nanoparticles were scrutinised by UV–visible spectroscopy, to characterize with titration experiments the changes in the plasmonic properties of AuNPs as well as the peptide spectral features. The latter were obtained by using the fluorescent analogous peptide, Fam-Ang59–68, incorporating the carboxyfluorescein (Fam) moiety, through an amidic bond of the N-terminal residue. The hydrodynamic size of the peptide-Au systems were determined by dynamic light scattering (DLS) analyses. Proof-of work experiments with human neuroblastoma cells line demonstrated the non-toxicity of the Ang-mimicking peptide functionalised gold nanoparticles. Moreover, laser scanning confocal microscopy (LSM) experiments showed the localization of the peptide-nanoparticles at the cell membrane and their sub-cellular distribution. These data reveal a promising new platform for imaging and therapeutic activities in cancer therapy. © 2016 Elsevier B.V.
Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications
Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications
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Scognamiglio PL, Morelli G, Marasco D
* Synthetic and structural routes for the rational conversion of peptides into small molecules (472 views)
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
Impact Factor: 3.221
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Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
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Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
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Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
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Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (373 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
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Satriano C, Sfrazzetto GT, Amato ME, Ballistreri FP, Copani A, Giuffrida ML, Grasso G, Pappalardo A, Rizzarelli E, Tomaselli GA, Toscano RM
* A ratiometric naphthalimide sensor for live cell imaging of copper(i) (455 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013 Jun 21; 49(49): 5565-5567.
Impact Factor: 6.718
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Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (552 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
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Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (429 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
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Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
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Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (445 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
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Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
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Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
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Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (457 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
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Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (502 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
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Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
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Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
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Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
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Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (410 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
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Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
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* Structure-Activity Relationship Investigations of Novel Constrained Chimeric Peptidomimetics of SOCS3 Protein Targeting JAK2 (13 views)
Pharmaceuticals (ISSN: 1424-8247linking), 2022 Apr 9; 15(4): N/D-N/D.
Impact Factor: 5.68
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La Manna S, Lopez-sanz L, Bernal S, Fortuna S, Mercurio FA, Leone M, Gomez-guerrero C, Marasco D
* Cyclic mimetics of kinase-inhibitory region of Suppressors of Cytokine Signaling 1: Progress toward novel anti-inflammatory therapeutics (22 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2021 Oct 5; 221: 113547-113547.
Impact Factor: 5.572
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La Manna S, Lopez-sanz L, Mercurio FA, Fortuna S, Leone M, Gomez-guerrero C, Marasco D
* Chimeric Peptidomimetics of SOCS 3 Able to Interact with JAK2 as Anti-inflammatory Compounds (55 views)
Acs Med Chem Lett (ISSN: 1948-5875linking), 2020 May 14; 11(5): 615-623.
Impact Factor: 3.975
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Di Natale C, La Manna S, Avitabile C, Florio D, Morelli G, Netti PA, Marasco D
* Engineered β-hairpin scaffolds from human prion protein regions: Structural and functional investigations of aggregates (58 views)
Bioorg Chem (ISSN: 0045-2068linking, 1090-2120electronic), 2020 Mar; 96: 103594-103594.
Impact Factor: 4.831
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Monti M, De Rosa V, Iommelli F, Carriero MV, Terlizzi C, Camerlingo R, Belli S, Fonti R, Di Minno G, Del Vecchio S
* Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins (264 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2018 Aug 9; 19(8): N/D-N/D.
Impact Factor: 3.687
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Giaquinto M, Micco A, Aliberti A, Bobeico E, La Ferrara V, Ruvo M, Ricciardi A, Cusano A
* Optimization Strategies for Responsivity Control of Microgel Assisted Lab-On-Fiber Optrodes (375 views) (PDF 218 views)
Sensors (ISSN: 1424-8220linking, 1424-3210, 1424-8220electronic), 2018 Apr 6; 18(4): N/D-N/D.
Impact Factor: 2.677
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La Manna S, Lopez-sanz L, Leone M, Brandi P, Scognamiglio PL, Morelli G, Novellino E, Gomez-guerrero C, Marasco D
* Structure-activity studies of peptidomimetics based on kinase-inhibitory region of suppressors of cytokine signaling (397 views)
Biopolymers (ISSN: 0006-3525, 0006-6352, 0006-3525print), 2017 Nov 20; N/D: N/D-N/D.
Impact Factor: 1.99
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Skiba J, Bernas T, Trzybinski D, Wozniak K, Ferraro G, Marasco D, Merlino A, Shafikov MZ, Czerwieniec R, Kowalski K
* Mitochondria Targeting with Luminescent Rhenium(I) Complexes (316 views)
Molecules (ISSN: 1420-3049, 1420-3049electronic, 1420-3049linking), 2017 May 15; 22(5): N/D-N/D.
Impact Factor: 3.098
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Monti M, Iommelli F, De Rosa V, Carriero MV, Miceli R, Camerlingo R, Di Minno G, Del Vecchio S
* Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells (386 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2017 Feb; 12(2): 1-15.
Impact Factor: 2.766
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Sinopoli A, Giuffrida A, Tomasello MF, Giuffrida ML, Leone M, Attanasio F, Caraci F, De Bona P, Naletova I, Saviano M, Copani A, Pappalardo G, Rizzarelli E
* Ac-LPFFD-Th: A Trehalose-Conjugated Peptidomimetic as a Strong Suppressor of Amyloid-beta Oligomer Formation and Cytotoxicity (453 views)
Chembiochem (ISSN: 1439-4227, 1439-7633, 1439-4227linking), 2016 Aug 17; 17(16): 1541-1549.
Impact Factor: 2.847
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Celentano V, Diana D, Di Salvo C, De Rosa L, Romanelli A, Fattorusso R, D'Andrea LD
* 1, 2, 3-Triazole Bridge as Conformational Constrain in beta-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions (442 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2016 Apr 11; 22(16): 5534-5537.
Impact Factor: 5.317
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Giaquinto M, Micco A, Aliberti A, Ricciardi A, Ruvo M, Cutolo A, Cusano A
* Microgel photonics and lab on fiber technology for advanced label-free fiber optic nanoprobes (209 views)
Proc Spie Int Soc Opt Eng (ISSN: 0277-786x9781510602199), 2016; 9916: N/D-N/D.
Impact Factor: 0.958
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Trusso Sfrazzetto G, Satriano C, Tomaselli GA, Rizzarelli E
* Synthetic fluorescent probes to map metallostasis and intracellular fate of zinc and copper (330 views)
Coord Chem Rev (ISSN: 0010-8545), 2016; 311: 125-167.
Impact Factor: 13.324
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Giacomelli C, Trincavelli ML, Satriano C, Hansson O, La Mendola D, Rizzarelli E, Martini C
* Copper (II) ions modulate Angiogenin activity in human endothelial cells (422 views)
Int J Biochem Cell B (ISSN: 1357-2725), 2015 Mar; 60: 185-196.
Impact Factor: 3.905
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Smaldone G, Diana D, Pollegioni L, Di Gaetano S, Fattorusso R, Pedone E
* Insight into conformational modification of alpha-synuclein in the presence of neuronal whole cells and of their isolated membranes (434 views)
Febs Lett (ISSN: 0014-5793, 0014-5793print, 1873-3468), 2015 Feb 18; 589(7): 798-804.
Impact Factor: 3.519
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Rizzitelli S, Giustetto P, Cutrin JC, Delli Castelli D, Boffa C, Ruzza M, Menchise V, Molinari F, Aime S, Terreno E
* Sonosensitive theranostic liposomes for preclinical in vivo MRI-guided visualization of doxorubicin release stimulated by pulsed low intensity non-focused ultrasound (470 views)
J Control Release (ISSN: 0168-3659), 2015 Jan 24; 202: 21-30.
Impact Factor: 7.441
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Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L
* Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics (490 views)
Org Lett (ISSN: 1523-7060, 1523-7052, 1523-7052electronic), 2015; 17(3): 640-643.
Impact Factor: 6.732
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Scognamiglio PL, Morelli G, Marasco D
* Synthetic and structural routes for the rational conversion of peptides into small molecules (472 views)
Methods Mol Biol (ISSN: 1064-3745, 1940-6029electronic, 1064-3745linking), 2015; 1268: 159-193.
Impact Factor: 3.221
View Export to BibTeX Export to EndNote
Altieri F, Di Stadio CS, Severino V, Sandomenico A, Minopoli G, Miselli G, Di Maro A, Ruvo M, Chambery A, Quagliariello V, Masullo M, Rippa E, Arcari P
* Anti-amyloidogenic property of human gastrokine (527 views)
Biochimie (ISSN: 0300-9084, 1638-6183, 0300-9084linking), 2014 Nov; 106C: 91-100.
Impact Factor: 2.963
View Export to BibTeX Export to EndNote
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (454 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Tomasello MF, Sinopoli A, Attanasio F, Giuffrida ML, Campagna T, Milardi D, Pappalardo G
* Molecular and cytotoxic properties of hIAPP17-29 and rIAPP17-29 fragments: A comparative study with the respective full-length parent polypeptides (1043 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2014 Jun 23; 81: 442-455.
Impact Factor: 3.447
View Export to BibTeX Export to EndNote
Giuffrida ML, Rizzarelli E, Tomaselli GA, Satriano C, Trusso Sfrazzetto G
* A novel fully water-soluble Cu(i) probe for fluorescence live cell imaging (373 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2014; 50(69): 9835-9838.
Impact Factor: 6.834
View Export to BibTeX Export to EndNote
Satriano C, Sfrazzetto GT, Amato ME, Ballistreri FP, Copani A, Giuffrida ML, Grasso G, Pappalardo A, Rizzarelli E, Tomaselli GA, Toscano RM
* A ratiometric naphthalimide sensor for live cell imaging of copper(i) (455 views)
Chem Commun (ISSN: 1359-7345, 1364-548x, 1364-548xelectronic), 2013 Jun 21; 49(49): 5565-5567.
Impact Factor: 6.718
View Export to BibTeX Export to EndNote
Scudiero O, Galdiero S, Nigro E, Del Vecchio L, Di Noto R, Cantisani M, Colavita I, Galdiero M, Cassiman JJ, Daniele A, Pedone C, Salvatore F
* Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines (552 views)
Antimicrob Agents Ch (ISSN: 1098-6596, 0066-4804), 2013 Apr; 57(4): 1701-1708.
Impact Factor: 4.451
View Export to BibTeX Export to EndNote
Grasso G, Spoto G
* Plasmonics for the study of metal ion-protein interactions (429 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Feb; 405(6): 1833-1843.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Scalia M, Satriano C, Greca R, Stella AM, Rizzarelli E, Spina-Purrello V
* PARP-1 inhibitors DPQ and PJ-34 negatively modulate proinflammatory commitment of human glioblastoma cells (422 views)
Neurochemical Research (ISSN: 1573-6903, 0364-3190), 2013 Jan; 38(1): 50-58.
Impact Factor: 2.551
View Export to BibTeX Export to EndNote
Smaldone G, Falanga A, Capasso D, Guarnieri D, Correale S, Galdiero M, Netti PA, Zollo M, Galdiero S, Di Gaetano S, Pedone E
* gH625 is a viral derived peptide for effective delivery of intrinsically disordered proteins (445 views)
Int J Nanomed (ISSN: 1178-2013, 1176-9114, 1178-2013electronic), 2013; 8: 2555-2565.
Impact Factor: 4.195
View Export to BibTeX Export to EndNote
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Cirillo G, Colangelo AM, Bianco MR, Cavaliere C, Zaccaro L, Sarmientos P, Alberghina L, Papa M
* BB14, a Nerve Growth Factor (NGF)-like peptide shown to be effective in reducing reactive astrogliosis and restoring synaptic homeostasis in a rat model of peripheral nerve injury (402 views)
Biotechnology Advances (ISSN: 0734-9750), 2012 Jan; 30(1): 223-232.
Impact Factor: 9.599
View Export to BibTeX Export to EndNote
Tarallo R, Accardo A, Falanga A, Guarnieri D, Vitiello G, Netti P, D'Errico G, Morelli G, Galdiero S
* Clickable functionalization of liposomes with the gH625 peptide from herpes simplex virus type i for intracellular drug delivery (457 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2011 Nov 4; 17(45): 12659-12668.
Impact Factor: 5.925
View Export to BibTeX Export to EndNote
Monfregola L, De Luca S
* Synthetic strategy for side chain mono-N-alkylation of Fmoc-amino acids promoted by molecular sieves (502 views)
Amino Acids (ISSN: 0939-4451, 1438-2199, 1438-2199electronic), 2011 Oct; 41(4): 981-990.
Impact Factor: 3.248
View Export to BibTeX Export to EndNote
Palmieri C, Falcone C, Iaccino E, Tuccillo FM, Gaspari M, Trimboli F, De Laurentiis A, Luberto L, Pontoriero M, Pisano A, Vecchio E, Fierro O, Panico M, Larobina M, Gargiulo S, Costa N, Dal Piaz F, Schiavone M, Arra C, Giudice A, Palma G, Barbieri A, Quinto I, Scala G
* In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder (597 views)
Blood (ISSN: 0006-4971, 0006-6497, 0390-6078), 2010 Jul 15; 116(2): 226-238.
Impact Factor: 10.558
View Export to BibTeX Export to EndNote
Alfieri A, Pasanisi F, Salzano S, Esposito L, Martone D, Tafuri D, Daniele A, Contaldo F, Sacchetti L, Zagari A, Buono P
* Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy (395 views)
Gene (ISSN: 0378-1119), 2010 Jun 1; 457(1-2): 35-41.
Impact Factor: 2.266
View Export to BibTeX Export to EndNote
Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A
* HMGA1 protein is a novel target of the ATM kinase (482 views)
European Journal Of Cancer (ISSN: 0959-8049), 2008 Nov; 44(17): 2668-2679.
Impact Factor: 4.475
View Export to BibTeX Export to EndNote
Guarnieri D, Borzacchiello A, De Capua A, Ruvo M, Netti P
* Engineering of covalently immobilized gradients of RGD peptides on hydrogel scaffolds: Effect on cell behaviour (410 views)
Macromol Sympos (ISSN: 1022-1360), 2008; 266(1): 36-40.
Impact Factor: 0
View Export to BibTeX Export to EndNote
Formaggio F, Bonchio M, Crisma M, Peggion C, Mezzato S, Polese A, Barazza A, Antonello S, Maran F, Broxterman QB, Kaptein B, Kamphuis J, Vitale RM, Saviano M, Benedetti E, Toniolo C
* Nitroxyl peptides as catalysts of enantioselective oxidations (489 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2002; 8(1): [d]84-93.
Impact Factor: 4.238
View Export to BibTeX Export to EndNote
36 Records (34 excluding Abstracts).
Total impact factor: 164.4 (160.208 excluding Abstracts).
Total 5 year impact factor: 159.711 (155.162 excluding Abstracts).
Total impact factor: 164.4 (160.208 excluding Abstracts).
Total 5 year impact factor: 159.711 (155.162 excluding Abstracts).
166 views. Last view on Thursday 23 February 2023, 21:58:02
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