Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (370 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054150381&doi=10.3390%2fijms19102896&partnerID=40&md5=a6e4dcf4844b7b5ce7e96e29f33c6e2d
Keywords: Artificial Enzymes, Catalytic Activity, Functional Biomaterials, Gold Nanoparticles, Immobilization Strategies, Peroxidases, Carbon, Citrate Sodium, Heme, Hydrogen, Iron, Platinum, Silver, Thioctic Acid, Biomedicine, Biotechnology, Catalysis, Conjugation, Crystallization, Cyclic Potentiometry, Electrochemical Analysis, Electrospray Mass Spectrometry, Enzyme Activity, Enzyme Immobilization, Inductively Coupled Plasma Mass Spectrometry, Kinetic Parameters, Nonhuman, Oxidation Reduction Reaction, Physical Chemistry, Reversed Phase High Performance Liquid Chromatography, Transmission Electron Microscopy, Ultraviolet Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. gerardo.zambrano@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. emmanuel.ruggiero@basf.com., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. anna.malafronte@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. marco.chino@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. ornella.maglio@unina.it., Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy. ornella.maglio@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. vincenzo.pavone@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. flavia.nastri@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. alombard@unina.it.,
BASF SE, Dept. Material Physics, Carl-Bosch-Strasse 38, Ludwigshafen, 67056, Germany
References:
Not available.
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054150381&doi=10.3390%2fijms19102896&partnerID=40&md5=a6e4dcf4844b7b5ce7e96e29f33c6e2d
Keywords: Artificial Enzymes, Catalytic Activity, Functional Biomaterials, Gold Nanoparticles, Immobilization Strategies, Peroxidases, Carbon, Citrate Sodium, Heme, Hydrogen, Iron, Platinum, Silver, Thioctic Acid, Biomedicine, Biotechnology, Catalysis, Conjugation, Crystallization, Cyclic Potentiometry, Electrochemical Analysis, Electrospray Mass Spectrometry, Enzyme Activity, Enzyme Immobilization, Inductively Coupled Plasma Mass Spectrometry, Kinetic Parameters, Nonhuman, Oxidation Reduction Reaction, Physical Chemistry, Reversed Phase High Performance Liquid Chromatography, Transmission Electron Microscopy, Ultraviolet Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. gerardo.zambrano@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. emmanuel.ruggiero@basf.com., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. anna.malafronte@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. marco.chino@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. ornella.maglio@unina.it., Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy. ornella.maglio@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. vincenzo.pavone@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. flavia.nastri@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. alombard@unina.it.,
BASF SE, Dept. Material Physics, Carl-Bosch-Strasse 38, Ludwigshafen, 67056, Germany
References:
Not available.
Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
Many efforts are continuously devoted to the construction of hybrid biomaterials for specific applications, by immobilizing enzymes on different types of surfaces and/or nanomaterials. In addition, advances in computational, molecular and structural biology have led to a variety of strategies for designing and engineering artificial enzymes with defined catalytic properties. Here, we report the conjugation of an artificial heme enzyme (MIMO) with lipoic acid (LA) as a building block for the development of gold-based biomaterials. We show that the artificial MIMO@LA can be successfully conjugated to gold nanoparticles or immobilized onto gold electrode surfaces, displaying quasi-reversible redox properties and peroxidase activity. The results of this work open interesting perspectives toward the development of new totally-synthetic catalytic biomaterials for application in biotechnology and biomedicine, expanding the range of the biomolecular component aside from traditional native enzymes. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Many efforts are continuously devoted to the construction of hybrid biomaterials for specific applications, by immobilizing enzymes on different types of surfaces and/or nanomaterials. In addition, advances in computational, molecular and structural biology have led to a variety of strategies for designing and engineering artificial enzymes with defined catalytic properties. Here, we report the conjugation of an artificial heme enzyme (MIMO) with lipoic acid (LA) as a building block for the development of gold-based biomaterials. We show that the artificial MIMO@LA can be successfully conjugated to gold nanoparticles or immobilized onto gold electrode surfaces, displaying quasi-reversible redox properties and peroxidase activity. The results of this work open interesting perspectives toward the development of new totally-synthetic catalytic biomaterials for application in biotechnology and biomedicine, expanding the range of the biomolecular component aside from traditional native enzymes. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
Other filter: ([btitle,keywords] "Artificial Enzymes" ...
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View Export to BibTeX Export to EndNote
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International Journal Of Molecular Sciences, 2020; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Truppo E, Langella E, Vullo D, Supuran CT, Monti SM
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J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic), 2019 Dec; 34(1): 1506-1510.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
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J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
View Export to BibTeX Export to EndNote
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* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (186 views)
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Impact Factor: 2.579
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Vecchio G
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View Export to BibTeX Export to EndNote
Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
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View Export to BibTeX Export to EndNote
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Nat Nanotechnol (ISSN: 1748-3387), 2015; 10(4): 285-285.
Impact Factor: 35.267
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
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Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (645 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (391 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Zanoli LM, D'Agata R, Spoto G
* Functionalized gold nanoparticles for ultrasensitive DNA detection (436 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2012 Feb; 402(5): 1759-1771.
Impact Factor: 3.659
View Export to BibTeX Export to EndNote
D'Urso L, Grasso G, Messina E, Bongiorno C, Scuderi V, Scalese S, Puglisi O, Spoto G, Compagnini G
* The Role of Linear Carbon Chains in the Aggregation of Copper, Silver, and Gold Nanoparticles (523 views)
J Phys Chem C (ISSN: 1932-7447), 2010 Jan 21; 114(2): 907-915.
Impact Factor: 4.524
View Export to BibTeX Export to EndNote
Hilvo M, De Simone G, Supuran CT, Parkkila S
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Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
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Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (447 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Bonomo RP, Cennamo G, Purrello R, Santoro AM, Zappala R
* Comparison Of Three Fungal Laccases From Rigidoporus Lignosus And Pleurotus Ostreatus: Correlation Between Conformation Changes And Catalytic Activity (321 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Jan 1; 83(1): 67-75.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
17 Records (17 excluding Abstracts).
Total impact factor: 90.499 (90.499 excluding Abstracts).
Total 5 year impact factor: 91.122 (91.122 excluding Abstracts).
Total impact factor: 90.499 (90.499 excluding Abstracts).
Total 5 year impact factor: 91.122 (91.122 excluding Abstracts).
370 views. Last view on Friday 08 September 2023, 8:07:05
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