Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials (242 views)
Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054150381&doi=10.3390%2fijms19102896&partnerID=40&md5=a6e4dcf4844b7b5ce7e96e29f33c6e2d
Keywords: Artificial Enzymes, Catalytic Activity, Functional Biomaterials, Gold Nanoparticles, Immobilization Strategies, Peroxidases, Carbon, Citrate Sodium, Heme, Hydrogen, Iron, Platinum, Silver, Thioctic Acid, Biomedicine, Biotechnology, Catalysis, Conjugation, Crystallization, Cyclic Potentiometry, Electrochemical Analysis, Electrospray Mass Spectrometry, Enzyme Activity, Enzyme Immobilization, Inductively Coupled Plasma Mass Spectrometry, Kinetic Parameters, Nonhuman, Oxidation Reduction Reaction, Physical Chemistry, Reversed Phase High Performance Liquid Chromatography, Transmission Electron Microscopy, Ultraviolet Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. gerardo.zambrano@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. emmanuel.ruggiero@basf.com., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. anna.malafronte@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. marco.chino@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. ornella.maglio@unina.it., Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy. ornella.maglio@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. vincenzo.pavone@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. flavia.nastri@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. alombard@unina.it.,
BASF SE, Dept. Material Physics, Carl-Bosch-Strasse 38, Ludwigshafen, 67056, Germany
References:
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Int J Mol Sc (ISSN: 1422-0067electronic, 1422-0067linking, 1661-6596), 2018 Sep 24; 19(10): N/D-N/D.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 3.687, 5-year impact factor: 2.617
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054150381&doi=10.3390%2fijms19102896&partnerID=40&md5=a6e4dcf4844b7b5ce7e96e29f33c6e2d
Keywords: Artificial Enzymes, Catalytic Activity, Functional Biomaterials, Gold Nanoparticles, Immobilization Strategies, Peroxidases, Carbon, Citrate Sodium, Heme, Hydrogen, Iron, Platinum, Silver, Thioctic Acid, Biomedicine, Biotechnology, Catalysis, Conjugation, Crystallization, Cyclic Potentiometry, Electrochemical Analysis, Electrospray Mass Spectrometry, Enzyme Activity, Enzyme Immobilization, Inductively Coupled Plasma Mass Spectrometry, Kinetic Parameters, Nonhuman, Oxidation Reduction Reaction, Physical Chemistry, Reversed Phase High Performance Liquid Chromatography, Transmission Electron Microscopy, Ultraviolet Spectrophotometry,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. gerardo.zambrano@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. emmanuel.ruggiero@basf.com., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. anna.malafronte@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. marco.chino@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. ornella.maglio@unina.it., Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134 Napoli, Italy. ornella.maglio@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. vincenzo.pavone@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. flavia.nastri@unina.it., Department of Chemical Sciences, University of Napoli "Federico II" Via Cintia, 80126 Napoli, Italy. alombard@unina.it.,
BASF SE, Dept. Material Physics, Carl-Bosch-Strasse 38, Ludwigshafen, 67056, Germany
References:
Nastri, F., Chino, M., Maglio, O., Bhagi-Damodaran, A., Lu, Y., Lombardi, A., Design and engineering of artificial oxygen-activating metalloenzymes (2016) Chem. Soc. Rev., 45, pp. 5020-505
Grayson, K.J., Anderson, J.L.R., The ascent of man (Made oxidoreductases) (2018) Curr. Opin. Struct. Biol., 51, pp. 149-155
Hyster, T.K., Ward, T.R., Genetic optimization of metalloenzymes: Enhancing enzymes for non-natural reactions (2016) Angew. Chem. Int. Ed., 55, pp. 7344-7357
Schwizer, F., Okamoto, Y., Heinisch, T., Gu, Y., Pellizzoni, M.M., Lebrun, V., Reuter, R., Ward, T.R., Artificial metalloenzymes: Reaction scope and optimization strategies (2017) Chem. Rev., 118, pp. 142-231
Lewis, J.C., Artificial metalloenzymes and metallopeptide catalysts for organic synthesis (2013) ACS Catal, 3, pp. 2954-2975
Mocny, C.S., Pecoraro, V.L., De novo protein design as a methodology for synthetic bioinorganic chemistry (2015) Acc. Chem. Res., 48, pp. 2388-2396
Yu, F., Cangelosi, V.M., Zastrow, M.L., Tegoni, M., Plegaria, J.S., Tebo, A.G., Mocny, C.S., Pecoraro, V.L., Protein design: Toward functional metalloenzymes (2014) Chem. Rev., 114, pp. 3495-3578
Jeschek, M., Panke, S., Ward, T.R., Artificial metalloenzymes on the verge of new-to-nature metabolism (2018) Trends Biotechnol, 36, pp. 60-72
Petrik, I.D., Liu, J., Lu, Y., Metalloenzyme design and engineering through strategic modifications of native protein scaffolds (2014) Curr. Opin. Chem. Biol., 19, pp. 67-75
Yu, Y., Hu, C., Xia, L., Wang, J., Artificial metalloenzyme design with unnatural amino acids and non-native cofactors (2018) ACS Catal, 8, pp. 1851-1863
Jeschek, M., Reuter, R., Heinisch, T., Trindler, C., Klehr, J., Panke, S., Ward, T.R., Directed evolution of artificial metalloenzymes for in vivo metathesis (2016) Nature, 537, pp. 661-665
Chino, M., Leone, L., Zambrano, G., Pirro, F., D’Alonzo, D., Firpo, V., Aref, D., Nastri, F., Oxidation catalysis by iron and manganese porphyrins within enzyme-like cages (2018) Biopolymers
Yu, Y., Cui, C., Liu, X., Petrik, I.D., Wang, J., Lu, Y., A designed metalloenzyme achieving the catalytic rate of a native enzyme (2015) J. Am. Chem. Soc., 137, pp. 11570-11573
Oohora, K., Meichin, H., Kihira, Y., Sugimoto, H., Shiro, Y., Hayashi, T., Manganese(V) porphycene complex responsible for inert c–h bond hydroxylation in a myoglobin matrix (2017) J. Am. Chem. Soc., 139, pp. 18460-18463
Dydio, P., Key, H.M., Nazarenko, A., Rha, J.Y., Seyedkazemi, V., Clark, D.S., Hartwig, J.F., An artificial metalloenzyme with the kinetics of native enzymes (2016) Science, 354, pp. 102-106
Key, H.M., Dydio, P., Clark, D.S., Hartwig, J.F., Abiological catalysis by artificial haem proteins containing noble metals in place of iron (2016) Nature, 534, pp. 534-537
Arnold, F.H., Directed evolution: Bringing new chemistry to life (2017) Angew. Chem. Int. Ed, 56, pp. 2-8
Hammer, S.C., Kubik, G., Watkins, E., Huang, S., Minges, H., Arnold, F.H., Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis (2017) Science, 358, pp. 215-218
Kan, S.B.J., Lewis, R.D., Chen, K., Arnold, F.H., Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life (2016) Science, 354, pp. 1048-1051
Kan, S.B.J., Huang, X., Gumulya, Y., Chen, K., Arnold, F.H., Genetically programmed chiral organoborane synthesis (2017) Nature, 552, pp. 132-136
Chen, K., Huang, X., Kan, S.B.J., Zhang, R.K., Arnold, F.H., Enzymatic construction of highly strained carbocycles (2018) Science, 360, pp. 71-75
Caserta, G., Chino, M., Firpo, V., Zambrano, G., Leone, L., D’Alonzo, D., Nastri, F., Lombardi, A., Enhancement of peroxidase activity in the artificial Mimochrome VI catalysts through rational design (2018) Chembiochem
Watkins, D.W., Jenkins, J.M.X., Grayson, K.J., Wood, N., Steventon, J.W., Vay, K.K.L., Goodwin, M.I., Crump, M.P., Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme (2017) Nat. Commun., 8
Bilal, M., Iqbalb, H.M.N., Guoa, S., Hua, H., Wanga, W., Zhang, X., State-of-the-art protein engineering approaches using biological macromolecules: A review from immobilization to implementation view point (2018) Int. J. Biol. Macromol., 108, pp. 893-901
Sheldon, R.A., van Pelt, S., Enzyme immobilisation in biocatalysis: Why, what and how (2013) Chem. Soc. Rev., 42, pp. 6223-6235
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Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
Many efforts are continuously devoted to the construction of hybrid biomaterials for specific applications, by immobilizing enzymes on different types of surfaces and/or nanomaterials. In addition, advances in computational, molecular and structural biology have led to a variety of strategies for designing and engineering artificial enzymes with defined catalytic properties. Here, we report the conjugation of an artificial heme enzyme (MIMO) with lipoic acid (LA) as a building block for the development of gold-based biomaterials. We show that the artificial MIMO@LA can be successfully conjugated to gold nanoparticles or immobilized onto gold electrode surfaces, displaying quasi-reversible redox properties and peroxidase activity. The results of this work open interesting perspectives toward the development of new totally-synthetic catalytic biomaterials for application in biotechnology and biomedicine, expanding the range of the biomolecular component aside from traditional native enzymes. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Many efforts are continuously devoted to the construction of hybrid biomaterials for specific applications, by immobilizing enzymes on different types of surfaces and/or nanomaterials. In addition, advances in computational, molecular and structural biology have led to a variety of strategies for designing and engineering artificial enzymes with defined catalytic properties. Here, we report the conjugation of an artificial heme enzyme (MIMO) with lipoic acid (LA) as a building block for the development of gold-based biomaterials. We show that the artificial MIMO@LA can be successfully conjugated to gold nanoparticles or immobilized onto gold electrode surfaces, displaying quasi-reversible redox properties and peroxidase activity. The results of this work open interesting perspectives toward the development of new totally-synthetic catalytic biomaterials for application in biotechnology and biomedicine, expanding the range of the biomolecular component aside from traditional native enzymes. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
Artificial Heme Enzymes for the Construction of Gold-Based Biomaterials
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Impact Factor: 4.927
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Santoro AM, D’urso A, Cunsolo A, Milardi D, Purrello R, Sbardella D, Tundo GR, Diana D, Fattorusso R, Di Dato A, Paladino A, Persico M, Coletta M, Fattorusso C
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Impact Factor: 0
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De Simone G, Di Fiore A, Truppo E, Langella E, Vullo D, Supuran CT, Monti SM
* Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach (222 views)
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Impact Factor: 4.027
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Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (164 views)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
View Export to BibTeX Export to EndNote
Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (166 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Impact Factor: 2.579
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
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Impact Factor: 5.16
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Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
* An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (447 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 22; 13(17): 4859-4868.
Impact Factor: 3.559
View Export to BibTeX Export to EndNote
Merlino A, Caterino M, Russo Krauss I, Vergara A
* Missing gold atoms in lysozyme crystals used to grow gold nanoparticles (310 views)
Nat Nanotechnol (ISSN: 1748-3387), 2015; 10(4): 285-285.
Impact Factor: 35.267
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (360 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
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Impact Factor: 4.58
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Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (385 views)
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Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Zanoli LM, D'Agata R, Spoto G
* Functionalized gold nanoparticles for ultrasensitive DNA detection (341 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2012 Feb; 402(5): 1759-1771.
Impact Factor: 3.659
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D'Urso L, Grasso G, Messina E, Bongiorno C, Scuderi V, Scalese S, Puglisi O, Spoto G, Compagnini G
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Impact Factor: 4.524
View Export to BibTeX Export to EndNote
Hilvo M, De Simone G, Supuran CT, Parkkila S
* Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV (289 views)
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Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (479 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
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Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Bonomo RP, Cennamo G, Purrello R, Santoro AM, Zappala R
* Comparison Of Three Fungal Laccases From Rigidoporus Lignosus And Pleurotus Ostreatus: Correlation Between Conformation Changes And Catalytic Activity (319 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Jan 1; 83(1): 67-75.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
* Synthesis, Characterization, and Study of Catalytic Activity of Chiral Cu(II) and Ni(II) Salen Complexes in the α-Amino Acid C-α Alkylation Reaction (5 views)
Molecules, 2023 Jan 25; 28: 1180-1196.
Impact Factor: 4.927
View Export to BibTeX Export to EndNote
Santoro AM, D’urso A, Cunsolo A, Milardi D, Purrello R, Sbardella D, Tundo GR, Diana D, Fattorusso R, Di Dato A, Paladino A, Persico M, Coletta M, Fattorusso C
Cooperative binding of the cationic porphyrin tris-t4 enhances catalytic activity of 20s proteasome unveiling a complex distribution of functional states (21 views)
International Journal Of Molecular Sciences, 2020; N/D: N/D-N/D.
Impact Factor: 0
View Export to BibTeX Export to EndNote
De Simone G, Di Fiore A, Truppo E, Langella E, Vullo D, Supuran CT, Monti SM
* Exploration of the residues modulating the catalytic features of human carbonic anhydrase XIII by a site-specific mutagenesis approach (222 views)
J Enzym Inhib Med Ch (ISSN: 1475-6366linking, 1475-6374electronic), 2019 Dec; 34(1): 1506-1510.
Impact Factor: 4.027
View Export to BibTeX Export to EndNote
Caporale A, Monti A, Selis F, Sandomenico A, Tonon G, Ruvo M, Doti N
* A comparative analysis of catalytic activity and stability of microbial transglutaminase in controlled denaturing conditions (164 views)
J Biotechnol (ISSN: 0168-1656linking), 2019 Aug 20; 302: 48-57.
Impact Factor: 3.163
View Export to BibTeX Export to EndNote
Satriano C, Munzone A, Cucci LM, Giacomelli C, Trincavelli ML, Martini C, Rizzarelli E, La Mendola D
* Angiogenin-mimetic peptide functionalised gold nanoparticles for cancer therapy applications (166 views)
Microchemical Journal (ISSN: 0026-265x), 2018; 136: 157-163.
Impact Factor: 2.579
View Export to BibTeX Export to EndNote
Oliveri V, Bellia F, Vecchio G
* Cyclodextrin Nanoparticles Bearing 8-Hydroxyquinoline Ligands as Multifunctional Biomaterials (752 views)
Chemistry (ISSN: 0947-6539, 1521-3765, 1521-3765electronic), 2017; 23(18): 4442-4449.
Impact Factor: 5.16
View Export to BibTeX Export to EndNote
Vitale R, Lista L, Cerrone C, Caserta G, Chino M, Maglio O, Nastri F, Pavone V, Lombardi A
* An artificial heme-enzyme with enhanced catalytic activity: evolution, functional screening and structural characterization (447 views)
Org Biomol Chem (ISSN: 1477-0520, 1477-0539, 1477-0539electronic), 2015 Apr 22; 13(17): 4859-4868.
Impact Factor: 3.559
View Export to BibTeX Export to EndNote
Merlino A, Caterino M, Russo Krauss I, Vergara A
* Missing gold atoms in lysozyme crystals used to grow gold nanoparticles (310 views)
Nat Nanotechnol (ISSN: 1748-3387), 2015; 10(4): 285-285.
Impact Factor: 35.267
View Export to BibTeX Export to EndNote
D'Agata R, Spoto G
* Surface plasmon resonance imaging for nucleic acid detection (360 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2013 Jan; 405(2-3): 573-584.
Impact Factor: 3.578
View Export to BibTeX Export to EndNote
Scarí G, Porta F, Fascio U, Avvakumova S, Dal Santo V, De Simone M, Saviano M, Leone M, Del Gatto A, Pedone C, Zaccaro L
* Gold nanoparticles capped by a GC-containing peptide functionalized with an RGD motif for integrin targeting (561 views)
Bioconjug Chem (ISSN: 1520-4812, 1043-1802, 1520-4812electronic), 2012 Mar 21; 23(3): 340-349.
Impact Factor: 4.58
View Export to BibTeX Export to EndNote
Truppo E, Supuran CT, Sandomenico A, Vullo D, Innocenti A, Di Fiore A, Alterio V, De Simone G, Monti SM
* Carbonic anhydrase VII is S-glutathionylated without loss of catalytic activity and affinity for sulfonamide inhibitors (385 views)
Bioorg Med Chem Lett Bioorganic And Medicinal Chemistry Letters (ISSN: 0960-894x), 2012 Feb 15; 22(4): 1560-1564.
Impact Factor: 2.338
View Export to BibTeX Export to EndNote
Zanoli LM, D'Agata R, Spoto G
* Functionalized gold nanoparticles for ultrasensitive DNA detection (341 views)
Anal Bioanal Chem (ISSN: 1618-2642), 2012 Feb; 402(5): 1759-1771.
Impact Factor: 3.659
View Export to BibTeX Export to EndNote
D'Urso L, Grasso G, Messina E, Bongiorno C, Scuderi V, Scalese S, Puglisi O, Spoto G, Compagnini G
* The Role of Linear Carbon Chains in the Aggregation of Copper, Silver, and Gold Nanoparticles (521 views)
J Phys Chem C (ISSN: 1932-7447), 2010 Jan 21; 114(2): 907-915.
Impact Factor: 4.524
View Export to BibTeX Export to EndNote
Hilvo M, De Simone G, Supuran CT, Parkkila S
* Advances in the Inhibitory and Structural Investigations on Carbonic Anhydrase Isozymes XIII and XV (289 views)
Drug Des Of Zinc Enzyme Inhibitors (ISSN: 9780-4702, 9780-470275009), 2009; N/D: 273-283.
Impact Factor: 1.156
View Export to BibTeX Export to EndNote
Hilvo M, Innocenti A, Monti SM, De Simone G, Supuran CT, Parkkila S
* Recent advances in research on the most novel carbonic anhydrases, CA XIII and XV (479 views)
Curr Pharm Des Current Pharmaceutical Design (ISSN: 1381-6128, 1873-4286), 2008; 14(7): 672-678.
Impact Factor: 4.399
View Export to BibTeX Export to EndNote
Merlino A, Mazzarella L, Carannante A, Di Fiore A, Di Donato A, Notomista E, Sica F
* The importance of dynamic effects on the enzyme activity: X-ray structure and molecular dynamics of onconase mutants (441 views)
Jbc Papers (ISSN: 0021-9258, 1083-351x, 0021-9258linking), 2005 May 6; 280(18): 17953-17960.
Impact Factor: 5.854
View Export to BibTeX Export to EndNote
Bonomo RP, Cennamo G, Purrello R, Santoro AM, Zappala R
* Comparison Of Three Fungal Laccases From Rigidoporus Lignosus And Pleurotus Ostreatus: Correlation Between Conformation Changes And Catalytic Activity (319 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2001 Jan 1; 83(1): 67-75.
Impact Factor: 1.729
View Export to BibTeX Export to EndNote
17 Records (17 excluding Abstracts).
Total impact factor: 90.499 (90.499 excluding Abstracts).
Total 5 year impact factor: 91.122 (91.122 excluding Abstracts).
Total impact factor: 90.499 (90.499 excluding Abstracts).
Total 5 year impact factor: 91.122 (91.122 excluding Abstracts).
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