Management of primary biliary cholangitis prior to obeticholic acid availability (309 views)
Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Dec; 109(6): 410-417.
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*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it., Department of Medical Sciences, University of Turin, Turin, Italy., Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Turin, Italy., Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy.,
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Hepatology (ISSN: 1827-1669electronic, 0026-4806linking), 2018 Dec; 109(6): 410-417.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0.913, 5-year impact factor: 0.843
Url: Not available.
Keywords: Not available.
Affiliations:
*** IBB - CNR ***
Department of Medical Sciences, University of Turin, Turin, Italy - marilena.durazzo@unito.it., Department of Medical Sciences, University of Turin, Turin, Italy., Institute for Biostructures and Bioimages (CNR) c/o Molecular Biotechnology Center, Turin, Italy., Unit of Gastroenterology, Molinette-SGAS Hospital, Turin, Italy.,
References:
Not available.
Management of primary biliary cholangitis prior to obeticholic acid availability
BACKGROUND: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease with unknown etiology. The prognosis of patients affected by PBC is heterogeneous, with a relevant improvement achieved after the introduction of ursodeoxycolic acid (UDCA). Since in the last years obeticholic acid (OCA) has been approved for the combined treatment of PBC, in patient non-responders to UDCA or as monotherapy in those intolerant to UDCA, we evaluated the response to UDCA in a cohort of patients with PBC managed in a specialistic setting. METHODS: We included 38 UCDA-treated non-cirrhotic, early-PBC patients. Data were retrieved from documents compiled during the annual follow-up. The response to therapy was assessed comparing the parameters of our cohort with the inclusion criteria of the POISE Trial and the Paris I and Paris II criteria. RESULTS: The cohort included 34/38 female patients and the average age was 65.34+/-10.69 years. Over 50% of the patients were affected by at least one disease associated to PBC. Using the POISE criteria and the Paris I and Paris II criteria, we identified 5, 2 and 5 non-responders, respectively. All patients with severe fibrosis had a biochemical response to UDCA according to the three different criteria applied. No side effect was reported. CONCLUSIONS: We confirm that UDCA is a safe and effective treatment in patients with PBC. Non-responder patients represent 13% of our population, with high risk of disease progression and complications. In this context, further therapy using OCA should be considered.
BACKGROUND: Primary biliary cholangitis (PBC) is an autoimmune cholestatic liver disease with unknown etiology. The prognosis of patients affected by PBC is heterogeneous, with a relevant improvement achieved after the introduction of ursodeoxycolic acid (UDCA). Since in the last years obeticholic acid (OCA) has been approved for the combined treatment of PBC, in patient non-responders to UDCA or as monotherapy in those intolerant to UDCA, we evaluated the response to UDCA in a cohort of patients with PBC managed in a specialistic setting. METHODS: We included 38 UCDA-treated non-cirrhotic, early-PBC patients. Data were retrieved from documents compiled during the annual follow-up. The response to therapy was assessed comparing the parameters of our cohort with the inclusion criteria of the POISE Trial and the Paris I and Paris II criteria. RESULTS: The cohort included 34/38 female patients and the average age was 65.34+/-10.69 years. Over 50% of the patients were affected by at least one disease associated to PBC. Using the POISE criteria and the Paris I and Paris II criteria, we identified 5, 2 and 5 non-responders, respectively. All patients with severe fibrosis had a biochemical response to UDCA according to the three different criteria applied. No side effect was reported. CONCLUSIONS: We confirm that UDCA is a safe and effective treatment in patients with PBC. Non-responder patients represent 13% of our population, with high risk of disease progression and complications. In this context, further therapy using OCA should be considered.
Management of primary biliary cholangitis prior to obeticholic acid availability
Management of primary biliary cholangitis prior to obeticholic acid availability
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Akgül Ö, Lucarini E, Mannelli LDC, Ghelardini C, D'Xambrosio K, Buonanno M, Monti SM, De Simone G, Angeli A, Supuran CT, Carta F
* Sultam based Carbonic Anhydrase VII inhibitors for the management of neuropathic pain (105 views)
Eur J Med Chem (ISSN: 0223-5234linking, 1768-3254, 1768-3254electronic), 2022 Jan 5; 227: 113956-113956.
Impact Factor: 7.088
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Fatima N, Baqri SSR, Alsulimani A, Fagoonee S, Slama P, Kesari KK, Roychoudhury S, Haque S
* Phytochemicals from Indian Ethnomedicines: Promising Prospects for the Management of Oxidative Stress and Cancer (81 views)
Antioxidants (ISSN: 2076-3921linking), 2021 Oct 13; 10 (10 ): N/D-N/D.
Impact Factor:
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Ribaldone DG, Imperatore N, Le Grazie M, Furfaro F, Balestrieri P, De Blasio F, Fagoonee S, Mosso E, Boano V, Reggio D, Sarli E, Castiglione F, Milla M, Vecchi M, Saracco GM, Salizzoni M, Romagnoli R, Fiorino G, Astegiano M
* Inflammatory bowel disease course in liver transplant versus non-liver transplant patients for primary sclerosing cholangitis: LIVIBD, an IG-IBD study (106 views)
Dig Liver Dis (ISSN: 1590-8658linking), 2021 Jun; 53(6): 712-716.
Impact Factor: 3.57
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Mainenti PP, Castiglione F, Rispo A, Laccetti E, Guarino S, Romeo V, Testa A, Pace L, Maurea S
* MR-enterography in Crohn's disease: what MRE mural parameters are associated to one-year therapeutic management outcome? (304 views)
Br J Radiol (ISSN: 0007-1285linking, 1748-880xelectronic), 2021 Feb 1; 94(1118): 20200844-20200844.
Impact Factor: 2.196
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Abenavoli L, Procopio AC, Fagoonee S, Pellicano R, Carbone M, Luzza F, Invernizzi P
* Primary Biliary Cholangitis and Bile Acid Farnesoid X Receptor Agonists (199 views)
Diseases (ISSN: 2079-9721linking), 2020 Jun 10; 8 (2 ): N/D-N/D.
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Di Serafino M, Gioioso M, Severino R, Esposito F, Vezzali N, Ferro F, Pelliccia P, Caprio MG, Iorio R, Vallone G
* Ultrasound findings in paediatric cholestasis: how to image the patient and what to look for (290 views) (PDF 112 views)
J Ultrasound (ISSN: 1876-7931linking, 1876-7931electronic), 2020 Mar; 23(1): 1-12.
Impact Factor: 1.547
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Pisconti S, Della Vittoria Scarpati G, Buonerba C, Messinese S, Carella R, Di Marzo M, Di Lorenzo G, Lazzari G, Perri F, Solla R
* Management of Ewing Sarcoma Family of Tumors: A Short Description of a Rare Primitive Uterine pPNET and Literature Review (147 views)
Oncotargets Ther (ISSN: 1178-6930linking), 2020 Feb 14; 13: 1179-1184.
Impact Factor: 3.337
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Melillo E, Palmiero G, Ferro A, Mocavero PE, Monda V, Ascione L
* Diagnosis and Management of Left Atrium Appendage Thrombosis in Atrial Fibrillation Patients Undergoing Cardioversion (364 views)
Medicina (ISSN: 1010-660xlinking, 1648-9144electronic), 2019 Aug 21; 55(9): N/D-N/D.
Impact Factor: 1.467
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Perri F, Della Vittoria Scarpati G, Caponigro F, Ionna F, Longo F, Buonopane S, Muto P, Di Marzo M, Pisconti S, Solla R
* Management of recurrent nasopharyngeal carcinoma: current perspectives (275 views)
Oncotargets Ther (ISSN: 1178-6930linking), 2019 Feb 26; 12: 1583-1591.
Impact Factor: 2.272
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Perri F, Ionna F, Muto P, Marzo MD, Caponigro F, Longo F, Vittoria Scarpati GD, Lorenzo GD, Giuliano M, Solla R
* Genetics and management of locally advanced carcinomas of the head and neck: role of altered fractionation radiotherapy (303 views)
Future Sci Oa (ISSN: 2056-5623linking), 2018 Oct 26; 5(1): FSO347-FSO347.
Impact Factor: 0
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Durazzo M, Ponzo E, Bonetto S, Fagoonee S, Pellicano R
* Liver diseases in the elderly (448 views)
Hepatology (ISSN: 0026-4806linking, 1827-1669electronic), 2018 Oct 11; 110(1): 35-51.
Impact Factor: 2.863
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Clemente G, Giorgini M, Mancini M, Gallo M, Amd-associazione Medici Diabetologi ‘diabetes Cancer’ worki
* Diabetologists and Oncologists attitudes towards treating diabetes in the oncologic patient: Insights from an exploratory survey (365 views)
Diabetes Res Clin Pract (ISSN: 0168-8227linking), 2018 Sep; 143: 420-427.
Impact Factor: 3.639
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Ribaldone DG, Mazzucco D, Fagoonee S, Crocella L, Lavagna A, Fracchia M, Caviglia GP, Simondi D, Rocca R, Astegiano M
* Management of Helicobacter pylori in Piedmont, Italy (273 views)
Minerva Gastroenterol Dietol (ISSN: 1827-1642electronic, 1121-421xlinking), 2018 Sep; 64(3): 235-250.
Impact Factor: 1.29
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Castello F, Costabile G, Bresciania L, Tassottia M, Naviglio D, Luongo D, Ciciola P, Vitale M, Vetrani C, Galaverna G, Brighenti F, Giacco R, Del Rio D, Mena P
* Bioavailability and pharmacokinetic profile of grape pomace phenolic compounds in humans (447 views) (PDF 172 views)
Arch Bioch Bioph (ISSN: 0003-9861linking), 2018 May 15; 646: 1-9.
Impact Factor: 3.165
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Corrias G, Huicochea Castellanos S, Merkow R, Langan R, Balachandran V, Ragucci M, Carollo G, Mancini M, Saba L, Mannelli L
* Does Second Reader Opinion Affect Patient Management in Pancreatic Ductal Adenocarcinoma? (594 views)
Acad Radiol (ISSN: 1076-6332, 1878-4046electronic, 1076-6332linking), 2018; 25(7): 825-832.
Impact Factor: 2.128
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Mazziotti G, Formenti AM, Panarotto MB, Arvat E, Chiti A, Cuocolo A, Dottorini ME, Durante C, Agate L, Filetti S, Felicetti F, Filice A, Pace L, Pellegrino T, Rodari M, Salvatori M, Tranfaglia C, Versari A, Viola D, Frara S, Berruti A, Giustina A, Giubbini R
* Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience (553 views)
Endocrine (ISSN: 1355-008x, 1355-008xlinking), 2017 Nov 06; 59(1): 90-101.
Impact Factor: 3.179
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Mishra CB, Kumari S, Angeli A, Monti SM, Buonanno M, Tiwari M, Supuran CT
* Discovery of Benzenesulfonamides with Potent Human Carbonic Anhydrase Inhibitory and Effective Anticonvulsant Action: Design, Synthesis, and Pharmacological Assessment (1075 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2017 Mar 23; 60(6): 2456-2469.
Impact Factor: 6.253
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Esposito C, Escolino M, Lopez M, Farina A, Cerulo M, Savanelli A, La Manna A, Caprio MG, Settimi A, Varlet F
* Surgical Management of Pediatric Vesicoureteral Reflux: A Comparative Study Between Endoscopic, Laparoscopic, and Open Surgery (284 views) (PDF 190 views)
Journal Of Laparoendoscopic & Advanced Surgical Techniques, 2016 Oct; 26: 1-7.
Impact Factor: 1.297
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Acampa W, Gaemperli O, Gimelli A, Knaapen P, Schindler TH, Verberne HJ, Zellweger MJ
* Role of risk stratification by SPECT, PET, and hybrid imaging in guiding management of stable patients with ischaemic heart disease: expert panel of the EANM cardiovascular committee and EACVI (625 views) (PDF 248 views)
Eur Heart J-Card Img (ISSN: 2047-2404, 2047-2412, 2047-2404linking), 2015 Apr 22; Epub: jev093-jev093.
Impact Factor: 4.293
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Moccia M, Pappata S, Erro R, Picillo M, Vitale C, Amboni M, Longo K, Palladino R, Barone P, Pellecchia MT
* Uric Acid Relates To Dopamine Transporter Availability In Parkinson'S Disease (854 views)
Acta Neurol Scand (ISSN: 0001-6314, 1600-0404), 2015; 131(2): 127-131.
Impact Factor: 2.559
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Moccia M, Pappata S, Picillo M, Erro R, Coda ARD, Longo K, Vitale C, Amboni M, Brunetti A, Capo G, Salvatore M, Barone P, Pellecchia MT
* Dopamine transporter availability in motor subtypes of de novo drug-naïve Parkinson's disease (1167 views)
J Neurol (ISSN: 0340-5354, 1432-1459, 0340-5354print), 2014 Nov; 261(11): 2112-2118.
Impact Factor: 3.377
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Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G
* Cancer-selective targeting of the NF-kappaB survival pathway with GADD45beta/MKK7 inhibitors (760 views)
Cancer Cell (ISSN: 1535-6108), 2014 Oct 13; 26(4): 495-508.
Impact Factor: 23.523
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Moccia M, Erro R, Montella S, Carotenuto A, Pappata S, Orefice G
* Diagnostic challenges of Parkinsonism occurring in multiple sclerosis (389 views)
Acta Neurol Belg (ISSN: 0300-9009), 2014 Oct 12; 115(3): 513-515.
Impact Factor: 0.894
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Paladini D, Quarantelli M, Sglavo G, Pastore G, Cavallaro A, D'Armiento MR, Salvatore M, Nappi C
* Accuracy of neurosonography and MRI in clinical management of fetuses referred with central nervous system abnormalities (449 views)
Ultrasound Obst Gyn (ISSN: 0960-7692, 1469-0705), 2014 Aug; 44(2): 188-196.
Impact Factor: 3.853
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Perri F, Dell'Oca I, Muto P, Schiavone C, Aversa C, Fulciniti F, Solla R, Scarpati GD, Buonerba C, Di Lorenzo G, Caponigro F
* Optimal management of a patient with recurrent nasopharyngeal carcinoma (379 views)
World Journal Of Clinical Cases (ISSN: 2307-8960), 2014; 2(7): 297-300.
Impact Factor: 0.895
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Napolitano S, Troiani T, Morgillo F, Ciardiello F, Belli G, Cioffi L, Sirignano C, Martinelli E
* Predictive Biomarkers To Anti-Egfr Inhibitors Treatment In The Management Of Metastatic Colorectal Cancer (334 views) (PDF 39 views)
Journal Of Carcinogenesis & Mutagenesis, 2014; N/D: 2157-2518.
Impact Factor: 3.445
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Bellia F, Oliveri V, Rizzarelli E, Vecchio G
* New derivative of carnosine for nanoparticle assemblies (578 views)
Eur J Med Chem (ISSN: 1768-3254, 0223-5234, 1768-3254electronic), 2013 Dec; 70: 225-232.
Impact Factor: 3.432
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Paladini D, Quarantelli M, Sglavo G, Pastore G, Cavallaro A, D'Armiento, Salvatore M, Nappi C
* The Role Of Mri In The Clinical Management Of Foetuses With Central Nervous System Abnormalities In A Tertiary Referral Center (414 views)
Ultrasound Obstet Gynecol John Wiley And Sons Ltd, 2013 Nov 1; N/D: 1002/uog-1002/uog.
Impact Factor: 5.694
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Clerico M, De Mercanti S, Versino E, Piazza F, Gned D, Brescia Morra V, Lanzillo R, Amato L, Quarantelli M, Ghezzi A, Bianchi A, Baroncini D, Salemi G, Realmuto S, Ferro MT, Vitetta F, Donghia M, Paolicelli D, Trojano M, Durelli L
* Management of multiple sclerosis patients after the 24th Natalizumab course: the Ty-STOP study (361 views)
Mult Scler (ISSN: 1352-4585, 1477-0970, 1352-4585linking), 2013 Oct; 19(11): N/D-N/D.
Impact Factor: 4.863
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Acampa W, Petretta MP, Daniele S, Perrone-Filardi P, Petretta M, Cuocolo A
* Myocardial perfusion imaging after coronary revascularization: A clinical appraisal (692 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2013 Sep; 40(8): 1275-1282.
Impact Factor: 5.217
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Stecca G, Baffo I, Galiano G, Clemente F
* Design of a holonic remote monitoring and diagnosis system for fleet management (294 views)
Measurement (ISSN: 0263-2241), 2013 Jul; 46(6): 1947-1956.
Impact Factor: 1.526
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Gramanzini M, Di Girolamo N, Gargiulo S, Greco A, Cocchia N, Delogu M, Rosapane I, Liuzzi R, Selleri P, Brunetti A
* Assessment Of Dual-Energy X-Ray Absorptiometry For Use In Evaluating The Effects Of Dietary And Environmental Management On Hermann'S Tortoises (testudo Hermanni) (861 views)
Am J Vet Res (ISSN: 0002-9645, 0002-2964), 2013 Jun; 74(6): 918-924.
Impact Factor: 1.214
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Clemente F, Faiella G, Stecca G, Romano M, Bifulco P, Rutoli G, Cesarelli M
* Process modeling of devices management in Home Care (355 views)
2013 E Health And Bioengineering Conference, 2013; N/D: N/D-N/D.
Impact Factor: 0
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Erro R, Pappata S, Amboni M, Vicidomini C, Longo K, Santangelo G, Picillo M, Vitale C, Moccia M, Giordano F, Brunetti A, Pellecchia MT, Salvatore M, Barone P
* Anxiety is associated with striatal dopamine transporter availability in newly diagnosed untreated Parkinson's disease patients (833 views)
Parkinsonism Relat D (ISSN: 1873-5126, 1353-8020, 1873-5126electronic), 2012 Nov; 18(9): 1034-1038.
Impact Factor: 3.274
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Vassallo M, Giuseppe M, Quarantelli M, Pastore G, Paladini D
* Choroid plexus carcinoma: Prenatal characterization by 3-dimensional sonography and magnetic resonance imaging perinatal management, and natural history (503 views)
J Ultrasound Med (ISSN: 0278-4297, 1550-9613, 0278-4297linking), 2012 Feb; 31(2): 337-340.
Impact Factor: 1.402
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Magliulo M, Cella L, Pacelli R
* Novel technique radio frequency identification (RFID) based to manage patient flow in a radiotherapy department (379 views)
Proc Ieee Embs Int Conf Biomed Health Informatics (ISSN: 9781-4577, 9781-457721779), 2012; N/D: 972-975.
Impact Factor: 0.41
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Varrone A, Halldin C
Molecular imaging of the dopamine transporter (666 views)
J Nucl Med (ISSN: 0161-5505, 1535-5667, 1535-5667electronic), 2010 Sep 1; 51(9): 1331-1334.
Impact Factor: 7.022
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Kapucu OL, Nobili F, Varrone A, Booij J, Vander Borght T, Nagren K, Darcourt J, Tatsch K, Van Laere KJ
* EANM procedure guideline for brain perfusion SPECT using Tc-99m-labelled radiopharmaceuticals, version (911 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2093-2102.
Impact Factor: 4.531
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Varrone A, Asenbaum S, Vander Borght T, Booij J, Nobili F, Någren K, Darcourt J, Kapucu OL, Tatsch K, Bartenstein P, Van Laere K
* EANM procedure guidelines for PET brain imaging using [18F]FDG, version (1342 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2009 Dec; 36(12): 2103-2110.
Impact Factor: 4.531
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Galloro G, Napolitano V, Magno L, Diamantis G, Nardone G, Bruno M, Mollica C, Persico G
* Diagnosis and therapeutic management of cystic dystrophy of the duodenal wall in heterotopic pancreas. A case report and revision of the literature (1469 views)
Jop (ISSN: 1590-8577, 1590-0857), 2008 Nov 03; 9(6): 725-732.
Impact Factor: 0
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Savastano M, Hovsto A, Pharow P, Blobel B
* Identity-Management Factors In E-Health And Telemedicine Applications (437 views)
Journal Of Telemedicine And Telecare, 2008; 14: 386-388.
Impact Factor: 1.736
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Sirignano C, Quarantelli M, Soscia E, Soscia F, Ccamera L, Salvatore M
* Ruolo Delle Tecniche Di Imaging Nella Stadiazione E Nel Management Del Nodulo Polmonare Solitario (373 views)
La Radiologia Medica, 2008; 113: 283-283.
Impact Factor: 1.368
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Bischof Delaloye A, Carrio I, Cuocolo A, Knapp W, Gourtsoyiannis N, Mccall I, Reiser M, Silberman B
* White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging (553 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Sep; 34(8): 1147-1151.
Impact Factor: 4.101
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Cuocolo A, Milcinski M, Bischof Delaloye A
* Syllabus for postgraduate specialisation in Nuclear Medicine: 2006/07 update (804 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2007 Mar; 34(3): 433-436.
Impact Factor: 4.101
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Cuocolo A, Acampa W, Varrone A, Salvatore M
* Highlights of the Annual Congress of the European Association of Nuclear Medicine, Istanbul, 2005: The incremental value of nuclear medicine for patient management and care (805 views)
Eur J Nucl Med (ISSN: 1619-7070, 1619-7089, 0340-6997), 2006 Mar; 33(3): 360-381.
Impact Factor: 4.041
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Argenone A, Pepe A, Martin G, Conson M, Solla R, Farella A, Cella L, Salzano G, Pacelli R Salvatore M
* Radioteraphy in the management of primary orbital lymphoma: report on 43 cases (349 views)
Tumori (ISSN: 0300-8916, 0300-8916print, 0300-8916linking), 2006; 4: S103-S103.
Impact Factor: 0.701
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Slavazza P, Fonti R, Ferraro M, Biasuzzi C, Gilardoni L
* Towards a knowledge ecosystem (329 views)
Lecture Notes In Computer Science (ISSN: 0302-974335404636319783540463634, 0302-974335402975459783540297543), 2006; 4248LNAI: 366-380.
Impact Factor: 0.302
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Marino M, Rossi M, Ruvo M, Fassina G
* Novel molecular targets for systemic lupus erythematosus (509 views)
Curr Drug Targets (ISSN: 1389-4501), 2002 Jun; 3(3): 223-228.
Impact Factor: 3.597
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Fassina G, Ruvo M, Palombo G, Verdoliva A, Marino M
* Novel ligands for the affinity-chromatographic purification of antibodies (1590 views)
J Biochem Biophys Methods (ISSN: 0165-022x, 0165-022xlinking), 2001 Oct 30; 49(1-3): 481-490.
Impact Factor: 1.218
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53 Records (47 excluding Abstracts).
Total impact factor: 162.073 (149.037 excluding Abstracts).
Total 5 year impact factor: 153.879 (140.122 excluding Abstracts).
Total impact factor: 162.073 (149.037 excluding Abstracts).
Total 5 year impact factor: 153.879 (140.122 excluding Abstracts).
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