"dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents (374 views)
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
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Paper type: Journal Article,
Impact factor: 0, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037865210&doi=10.1021%2facsbiomaterials.7b00547&partnerID=40&md5=7fd37b83067d714cc9deb55d9773d19a
Keywords: Amphiphilic Amino Acid, Anticancer Agents, Antiproliferative Activity, Nanoaggregates, Ru(iii) Complexes, Biocompatibility, Cell Culture, Chlorine Compounds, Cytotoxicity, Dynamic Light Scattering, Neutron Scattering, Ruthenium, Anti-Cancer Agents, Anti-Proliferative Activities, Anticancer Treatment, Cellular Internalization, Efficient Protections, Systemic Toxicities, Ruthenium Compounds, 2 Dioleoyl 3 Trimethylammoniopropane, Ruthenium Complex, Water, 3t3-L1 Cell Line, Antineoplastic Activity, Article, Biological Activity, C6 Cell Line (glioma), Controlled Study, Drug Delivery System, Drug Formulation, Female, Hacat Cell Line, Hela Cell Line, Human, Human Cell, Hydrophilicity, In Vitro Study, Lipophilicity, Mcf-7 Cell Line, Nonhuman, Photon Correlation Spectroscopy, Priority Journal, Ultraviolet Spectroscopy,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Via Cintia 21, Napoli, 80126, Italy
CNR, Istituto di Biostrutture e Bioimmagini, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano 49, Napoli, 80131, Italy
ISIS Facility Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, United Kingdom
CSGI, Consorzio Interuniversitario per Lo Sviluppo Dei Sistemi A Grande Interfase, Via della Lastruccia 3, Sesto Fiorentino, (Florence), 50019, Italy
Istituto per l'Endocrinologia e l'Oncologia Gaetano Salvatore, Consiglio Nazionale Delle Ricerche (CNR), Via Pansini 5, Napoli, 80131, Italy
References:
Rademaker-Lakhai, J.M., Van Den Bongard, D., Pluim, D., Beijnen, J.H., Schellens, J.H.M., A phase i and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent (2004) Clin. Cancer Res., 10 (11), pp. 3717-372
Hartinger, C.G., Jakupec, M.A., Zorbas-Seifried, S., Groessl, M., Egger, A., Berger, W., Zorbas, H., Keppler, B.K., KP1019, a new redox-active anticancer agent-preclinical development and results of a clinical phase i study in tumor patients (2008) Chem. Biodiversity, 5 (10), pp. 2140-2155
Lentz, F., Drescher, A., Lindauer, A., Henke, M., Hilger, R.A., Hartinger, C.G., Scheulen, M.E., Jaehde, U., Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase i dose-escalation study (2009) Anti-Cancer Drugs, 20 (2), pp. 97-103
Leijen, S., Burgers, S.A., Baas, P., Pluim, D., Tibben, M., Van Werkhoven, E., Alessio, E., Schellens, J.H.M., Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy (2015) Invest. New Drugs, 33 (1), pp. 201-214
Bergamo, A., Sava, G., Ruthenium anticancer compounds: Myths and realities of the emerging metal-based drugs (2011) Dalton Trans., 40 (31), pp. 7817-7823
Bergamo, A., Gaiddon, C., Schellens, J.H., Beijnen, J.H., Sava, G., Approaching tumour therapy beyond platinum drugs: Status of the art and perspectives of ruthenium drug candidates (2012) J. Inorg. Biochem., 106 (1), pp. 90-99
Bacac, M., Hotze, A.C.G., Van Der Schilden, K., Haasnoot, J.G., Pacor, S., Alessio, E., Sava, G., Reedijk, J., The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity: An NMR evaluation (2004) J. Inorg. Biochem., 98 (2), pp. 402-412
Alessio, E., Thirty years of the drug candidate NAMI-A and the myths in the field of ruthenium anticancer compounds: A personal perspective (2017) Eur. J. Inorg. Chem., 2017 (12), pp. 1549-1560
Wheate, N.J., Walker, S., Craig, G.E., Oun, R., The status of platinum anticancer drugs in the clinic and in clinical trials (2010) Dalton Trans., 39 (35), pp. 8113-8127
Simeone, L., Mangiapia, G., Irace, C., Di Pascale, A., Colonna, A., Ortona, O., De Napoli, L., Paduano, L., Nucleolipid nanovectors as molecular carriers for potential applications in drug delivery (2011) Mol. BioSyst., 7 (11), pp. 3075-3086
Mangiapia, G., D'Errico, G., Simeone, L., Irace, C., Radulescu, A., Di Pascale, A., Colonna, A., Paduano, L., Ruthenium-based complex nanocarriers for cancer therapy (2012) Biomaterials, 33 (14), pp. 3770-3782
Mangiapia, G., Vitiello, G., Irace, C., Santamaria, R., Colonna, A., Angelico, R., Radulescu, A., Paduano, L., Anticancer cationic ruthenium nanovectors: From rational molecular design to cellular uptake and bioactivity (2013) Biomacromolecules, 14 (8), pp. 2549-2560
Montesarchio, D., Mangiapia, G., Vitiello, G., Musumeci, D., Irace, C., Santamaria, R., D'Errico, G., Paduano, L., A new design for nucleolipid-based Ru(III) complexes as anticancer agents (2013) Dalton Trans., 42 (48), pp. 16697-16708
Vitiello, G., Luchini, A., D'Errico, G., Santamaria, R., Capuozzo, A., Irace, C., Montesarchio, D., Paduano, L., Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex (2015) J. Mater. Chem. B, 3 (15), pp. 3011-3023
Riccardi, C., Musumeci, D., Irace, C., Paduano, L., Montesarchio, D., Ru (III) complexes for anticancer therapy: The importance of being nucleolipidic (2017) Eur. J. Org. Chem., 2017 (7), pp. 1100-1119
Luchini, A., Vitiello, G., Rossi, F., Ruiz De Ballesteros, O., Radulescu, A., D'Errico, G., Montesarchio, D., Paduano, L., Developing functionalized Fe3O4-Au nanoparticles: A physico-chemical insight (2015) Phys. Chem. Chem. Phys., 17 (8), pp. 6087-6097
Luchini, A., Irace, C., Santamaria, R., Montesarchio, D., Heenan, R.K., Szekely, N., Flori, A., Paduano, L., Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: Defining the structure and probing in vivo applications (2016) Nanoscale, 8 (19), pp. 10078-10086
Stolnik, S., Illum, L., Davis, S.S., Long circulating microparticulate drug carriers (1995) Adv. Drug Delivery Rev., 16 (23), pp. 195-214
Nishiyama, N., Kataoka, K., Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery (2006) Pharmacol. Ther., 112 (3), pp. 630-648
Stenzel, M.H., RAFT polymerization: An avenue to functional polymeric micelles for drug delivery (2008) Chem. Commun., 44 (30), pp. 3486-3503
Rösler, A., Vandermeulen, G.W.M., Klok, H.A., Advanced drug delivery devices via self-assembly of amphiphilic block copolymers (2001) Adv. Drug Delivery Rev., 53 (1), pp. 95-108
Lomakin, A., Teplow, D.B., Benedek, G.B., Quasielastic light scattering for protein assembly studies (2005) Amyloid Proteins: Methods and Protocols, 299, pp. 153-174. , Sigurdsson, E. M. Humana Press: Totowa, NJ
Zhang, H., Annunziata, O., Effect of macromolecular polydispersity on diffusion coefficients measured by Rayleigh interferometry (2008) J. Phys. Chem. B, 112 (12), pp. 3633-3643
Heenan, R.K., Penfold, J., King, S.M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr., 30 (6), pp. 1140-1147
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., Intercalibration of small-angle X-ray and neutron scattering data (1988) J. Appl. Crystallogr., 21 (6), pp. 629-638
Bartlett, P., Ottewill, R.H., A neutron scattering study of the structure of a bimodal colloidal crystal (1992) J. Chem. Phys., 96 (4), pp. 3306-3318
Hoyle, C.E., Bowman, C.N., Thiol-ene click chemistry (2010) Angew. Chem., Int. Ed., 49 (9), pp. 1540-1573
Carpino, L.A., 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive (1993) J. Am. Chem. Soc., 115 (10), pp. 4397-4398
Alessio, E., Balducci, G., Lutman, A., Mestroni, G., Calligaris, M., Attia, W.M., Synthesis and characterization of two new classes of ruthenium(III)-sulfoxide complexes with nitrogen donor ligands (L) (1993) Inorg. Chim. Acta, 203 (2), pp. 205-217. , Na[trans-RuCl4(R2SO)(L)] and mer, cis-RuCl3(R2SO)(R2SO)(L). the crystal structure of Na[trans-RuCl4(DMSO)(NH3)] · 2DMSO, Na[trans-RuCl4(DMSO)(Im)] · H2O, Me2CO (Im = imidazole) and mer, cis-RuCl3(DMSO)(DMSO)(NH3)
Musumeci, D., Rozza, L., Merlino, A., Paduano, L., Marzo, T., Massai, L., Messori, L., Montesarchio, D., Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (2015) Dalton Trans., 44 (31), pp. 13914-13925
Berghausen, J., Zipfel, J., Lindner, P., Richtering, W., Influence of water-soluble polymers on the shear-induced structure formation in lyotropic lamellar phases (2001) J. Phys. Chem. B, 105 (45), pp. 11081-11088
Santamaria, R., Bevilacqua, M.A., Maffettone, C., Irace, C., Iovine, B., Colonna, A., Induction of H-ferritin synthesis by oxalomalate is regulated at both the transcriptional and post-transcriptional levels (2006) Biochim. Biophys. Acta, Mol. Cell Res., 1763 (8), pp. 815-822
Miniaci, M.C., Irace, C., Capuozzo, A., Piccolo, M., Di Pascale, A., Russo, A., Lippiello, P., Santamaria, R., Cysteine prevents the reduction in keratin synthesis induced by iron deficiency in human keratinocytes (2016) J. Cell. Biochem., 117 (2), pp. 402-412
Irace, C., Misso, G., Capuozzo, A., Piccolo, M., Riccardi, C., Luchini, A., Caraglia, M., Santamaria, R., Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: Insights into their mode of action (2017) Sci. Rep., 7, pp. 45236-45249
Masters, J.R., HeLa cells 50 years on: The good, the bad and the ugly (2002) Nat. Rev. Cancer, 2 (4), pp. 315-319
Grobben, B., De Deyn, P.P., Slegers, H., Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion (2002) Cell Tissue Res., 310 (3), pp. 257-270
Dragutan, I., Dragutan, V., Demonceau, A., The expanding chemistry of the ruthenium complexes (2015) Molecules, 20 (9), pp. 17244-17274
Abid, M., Shamsi, F., Azam, A., Ruthenium complexes: An emerging ground to the development of metallopharmaceuticals for cancer therapy (2016) Mini-Rev. Med. Chem., 16 (10), pp. 772-786
Ravera, M., Baracco, S., Cassino, C., Zanello, P., Osella, D., Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl4(DMSO)(Im)], NAMI-A (2004) Dalton Trans., (15), pp. 2347-2351
Zheng, K., Wu, Q., Wang, C., Tan, W., Mei, W., Ruthenium(II) complexes as potential apoptosis inducers in chemotherapy (2017) Anticancer Agents Med. Chem., 17 (1), pp. 29-39
Acs Biomater Sci Eng (ISSN: 2373-9878), 2018; 4(1): 163-174.
Export to BibTeX Export to EndNote
Paper type: Journal Article,
Impact factor: 0, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85037865210&doi=10.1021%2facsbiomaterials.7b00547&partnerID=40&md5=7fd37b83067d714cc9deb55d9773d19a
Keywords: Amphiphilic Amino Acid, Anticancer Agents, Antiproliferative Activity, Nanoaggregates, Ru(iii) Complexes, Biocompatibility, Cell Culture, Chlorine Compounds, Cytotoxicity, Dynamic Light Scattering, Neutron Scattering, Ruthenium, Anti-Cancer Agents, Anti-Proliferative Activities, Anticancer Treatment, Cellular Internalization, Efficient Protections, Systemic Toxicities, Ruthenium Compounds, 2 Dioleoyl 3 Trimethylammoniopropane, Ruthenium Complex, Water, 3t3-L1 Cell Line, Antineoplastic Activity, Article, Biological Activity, C6 Cell Line (glioma), Controlled Study, Drug Delivery System, Drug Formulation, Female, Hacat Cell Line, Hela Cell Line, Human, Human Cell, Hydrophilicity, In Vitro Study, Lipophilicity, Mcf-7 Cell Line, Nonhuman, Photon Correlation Spectroscopy, Priority Journal, Ultraviolet Spectroscopy,
Affiliations:
*** IBB - CNR ***
Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Via Cintia 21, Napoli, 80126, Italy
CNR, Istituto di Biostrutture e Bioimmagini, Via Mezzocannone 16, Napoli, 80134, Italy
Dipartimento di Farmacia, Università di Napoli Federico II, Via D. Montesano 49, Napoli, 80131, Italy
ISIS Facility Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, United Kingdom
CSGI, Consorzio Interuniversitario per Lo Sviluppo Dei Sistemi A Grande Interfase, Via della Lastruccia 3, Sesto Fiorentino, (Florence), 50019, Italy
Istituto per l'Endocrinologia e l'Oncologia Gaetano Salvatore, Consiglio Nazionale Delle Ricerche (CNR), Via Pansini 5, Napoli, 80131, Italy
References:
Rademaker-Lakhai, J.M., Van Den Bongard, D., Pluim, D., Beijnen, J.H., Schellens, J.H.M., A phase i and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent (2004) Clin. Cancer Res., 10 (11), pp. 3717-372
Hartinger, C.G., Jakupec, M.A., Zorbas-Seifried, S., Groessl, M., Egger, A., Berger, W., Zorbas, H., Keppler, B.K., KP1019, a new redox-active anticancer agent-preclinical development and results of a clinical phase i study in tumor patients (2008) Chem. Biodiversity, 5 (10), pp. 2140-2155
Lentz, F., Drescher, A., Lindauer, A., Henke, M., Hilger, R.A., Hartinger, C.G., Scheulen, M.E., Jaehde, U., Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase i dose-escalation study (2009) Anti-Cancer Drugs, 20 (2), pp. 97-103
Leijen, S., Burgers, S.A., Baas, P., Pluim, D., Tibben, M., Van Werkhoven, E., Alessio, E., Schellens, J.H.M., Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy (2015) Invest. New Drugs, 33 (1), pp. 201-214
Bergamo, A., Sava, G., Ruthenium anticancer compounds: Myths and realities of the emerging metal-based drugs (2011) Dalton Trans., 40 (31), pp. 7817-7823
Bergamo, A., Gaiddon, C., Schellens, J.H., Beijnen, J.H., Sava, G., Approaching tumour therapy beyond platinum drugs: Status of the art and perspectives of ruthenium drug candidates (2012) J. Inorg. Biochem., 106 (1), pp. 90-99
Bacac, M., Hotze, A.C.G., Van Der Schilden, K., Haasnoot, J.G., Pacor, S., Alessio, E., Sava, G., Reedijk, J., The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity: An NMR evaluation (2004) J. Inorg. Biochem., 98 (2), pp. 402-412
Alessio, E., Thirty years of the drug candidate NAMI-A and the myths in the field of ruthenium anticancer compounds: A personal perspective (2017) Eur. J. Inorg. Chem., 2017 (12), pp. 1549-1560
Wheate, N.J., Walker, S., Craig, G.E., Oun, R., The status of platinum anticancer drugs in the clinic and in clinical trials (2010) Dalton Trans., 39 (35), pp. 8113-8127
Simeone, L., Mangiapia, G., Irace, C., Di Pascale, A., Colonna, A., Ortona, O., De Napoli, L., Paduano, L., Nucleolipid nanovectors as molecular carriers for potential applications in drug delivery (2011) Mol. BioSyst., 7 (11), pp. 3075-3086
Mangiapia, G., D'Errico, G., Simeone, L., Irace, C., Radulescu, A., Di Pascale, A., Colonna, A., Paduano, L., Ruthenium-based complex nanocarriers for cancer therapy (2012) Biomaterials, 33 (14), pp. 3770-3782
Mangiapia, G., Vitiello, G., Irace, C., Santamaria, R., Colonna, A., Angelico, R., Radulescu, A., Paduano, L., Anticancer cationic ruthenium nanovectors: From rational molecular design to cellular uptake and bioactivity (2013) Biomacromolecules, 14 (8), pp. 2549-2560
Montesarchio, D., Mangiapia, G., Vitiello, G., Musumeci, D., Irace, C., Santamaria, R., D'Errico, G., Paduano, L., A new design for nucleolipid-based Ru(III) complexes as anticancer agents (2013) Dalton Trans., 42 (48), pp. 16697-16708
Vitiello, G., Luchini, A., D'Errico, G., Santamaria, R., Capuozzo, A., Irace, C., Montesarchio, D., Paduano, L., Cationic liposomes as efficient nanocarriers for the drug delivery of an anticancer cholesterol-based ruthenium complex (2015) J. Mater. Chem. B, 3 (15), pp. 3011-3023
Riccardi, C., Musumeci, D., Irace, C., Paduano, L., Montesarchio, D., Ru (III) complexes for anticancer therapy: The importance of being nucleolipidic (2017) Eur. J. Org. Chem., 2017 (7), pp. 1100-1119
Luchini, A., Vitiello, G., Rossi, F., Ruiz De Ballesteros, O., Radulescu, A., D'Errico, G., Montesarchio, D., Paduano, L., Developing functionalized Fe3O4-Au nanoparticles: A physico-chemical insight (2015) Phys. Chem. Chem. Phys., 17 (8), pp. 6087-6097
Luchini, A., Irace, C., Santamaria, R., Montesarchio, D., Heenan, R.K., Szekely, N., Flori, A., Paduano, L., Phosphocholine-decorated superparamagnetic iron oxide nanoparticles: Defining the structure and probing in vivo applications (2016) Nanoscale, 8 (19), pp. 10078-10086
Stolnik, S., Illum, L., Davis, S.S., Long circulating microparticulate drug carriers (1995) Adv. Drug Delivery Rev., 16 (23), pp. 195-214
Nishiyama, N., Kataoka, K., Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery (2006) Pharmacol. Ther., 112 (3), pp. 630-648
Stenzel, M.H., RAFT polymerization: An avenue to functional polymeric micelles for drug delivery (2008) Chem. Commun., 44 (30), pp. 3486-3503
Rösler, A., Vandermeulen, G.W.M., Klok, H.A., Advanced drug delivery devices via self-assembly of amphiphilic block copolymers (2001) Adv. Drug Delivery Rev., 53 (1), pp. 95-108
Lomakin, A., Teplow, D.B., Benedek, G.B., Quasielastic light scattering for protein assembly studies (2005) Amyloid Proteins: Methods and Protocols, 299, pp. 153-174. , Sigurdsson, E. M. Humana Press: Totowa, NJ
Zhang, H., Annunziata, O., Effect of macromolecular polydispersity on diffusion coefficients measured by Rayleigh interferometry (2008) J. Phys. Chem. B, 112 (12), pp. 3633-3643
Heenan, R.K., Penfold, J., King, S.M., SANS at pulsed neutron sources: Present and future prospects (1997) J. Appl. Crystallogr., 30 (6), pp. 1140-1147
Russell, T.P., Lin, J.S., Spooner, S., Wignall, G.D., Intercalibration of small-angle X-ray and neutron scattering data (1988) J. Appl. Crystallogr., 21 (6), pp. 629-638
Bartlett, P., Ottewill, R.H., A neutron scattering study of the structure of a bimodal colloidal crystal (1992) J. Chem. Phys., 96 (4), pp. 3306-3318
Hoyle, C.E., Bowman, C.N., Thiol-ene click chemistry (2010) Angew. Chem., Int. Ed., 49 (9), pp. 1540-1573
Carpino, L.A., 1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive (1993) J. Am. Chem. Soc., 115 (10), pp. 4397-4398
Alessio, E., Balducci, G., Lutman, A., Mestroni, G., Calligaris, M., Attia, W.M., Synthesis and characterization of two new classes of ruthenium(III)-sulfoxide complexes with nitrogen donor ligands (L) (1993) Inorg. Chim. Acta, 203 (2), pp. 205-217. , Na[trans-RuCl4(R2SO)(L)] and mer, cis-RuCl3(R2SO)(R2SO)(L). the crystal structure of Na[trans-RuCl4(DMSO)(NH3)] · 2DMSO, Na[trans-RuCl4(DMSO)(Im)] · H2O, Me2CO (Im = imidazole) and mer, cis-RuCl3(DMSO)(DMSO)(NH3)
Musumeci, D., Rozza, L., Merlino, A., Paduano, L., Marzo, T., Massai, L., Messori, L., Montesarchio, D., Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (2015) Dalton Trans., 44 (31), pp. 13914-13925
Berghausen, J., Zipfel, J., Lindner, P., Richtering, W., Influence of water-soluble polymers on the shear-induced structure formation in lyotropic lamellar phases (2001) J. Phys. Chem. B, 105 (45), pp. 11081-11088
Santamaria, R., Bevilacqua, M.A., Maffettone, C., Irace, C., Iovine, B., Colonna, A., Induction of H-ferritin synthesis by oxalomalate is regulated at both the transcriptional and post-transcriptional levels (2006) Biochim. Biophys. Acta, Mol. Cell Res., 1763 (8), pp. 815-822
Miniaci, M.C., Irace, C., Capuozzo, A., Piccolo, M., Di Pascale, A., Russo, A., Lippiello, P., Santamaria, R., Cysteine prevents the reduction in keratin synthesis induced by iron deficiency in human keratinocytes (2016) J. Cell. Biochem., 117 (2), pp. 402-412
Irace, C., Misso, G., Capuozzo, A., Piccolo, M., Riccardi, C., Luchini, A., Caraglia, M., Santamaria, R., Antiproliferative effects of ruthenium-based nucleolipidic nanoaggregates in human models of breast cancer in vitro: Insights into their mode of action (2017) Sci. Rep., 7, pp. 45236-45249
Masters, J.R., HeLa cells 50 years on: The good, the bad and the ugly (2002) Nat. Rev. Cancer, 2 (4), pp. 315-319
Grobben, B., De Deyn, P.P., Slegers, H., Rat C6 glioma as experimental model system for the study of glioblastoma growth and invasion (2002) Cell Tissue Res., 310 (3), pp. 257-270
Dragutan, I., Dragutan, V., Demonceau, A., The expanding chemistry of the ruthenium complexes (2015) Molecules, 20 (9), pp. 17244-17274
Abid, M., Shamsi, F., Azam, A., Ruthenium complexes: An emerging ground to the development of metallopharmaceuticals for cancer therapy (2016) Mini-Rev. Med. Chem., 16 (10), pp. 772-786
Ravera, M., Baracco, S., Cassino, C., Zanello, P., Osella, D., Appraisal of the redox behaviour of the antimetastatic ruthenium(III) complex [ImH][RuCl4(DMSO)(Im)], NAMI-A (2004) Dalton Trans., (15), pp. 2347-2351
Zheng, K., Wu, Q., Wang, C., Tan, W., Mei, W., Ruthenium(II) complexes as potential apoptosis inducers in chemotherapy (2017) Anticancer Agents Med. Chem., 17 (1), pp. 29-39
"dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents
In the search for more efficient anticancer treatments, Ru(III) complexes have attracted much interest among metal-based candidate drugs, showing marked antitumor and antimetastatic activity associated with lower systemic toxicity. Remarkable examples are the Ru(III) complexes NAMI-A and KP1019, which have reached advanced clinical evaluation. In order to improve the in vivo stability of Ru(III)-based drugs, as well as their cellular uptake and effectiveness, a new approach has been proposed by our research group, based on the incorporation of the active, NAMI-A-like Ru(III) complex into highly functionalized nucleolipidic structures, i.e., hybrid molecules containing a nucleoside or nucleotide central core derivatized with a lipid chain, ensuring both efficient protection against extracellular degradation and high cellular internalization of the metal. Aiming at expanding the chemical diversity of available amphiphilic Ru(III) complexes, we here selected a trifunctional α-amino acid to replace the nucleosidic core of previously prepared nucleolipid-based Ru(III) complexes. The amino acidic scaffold, linked to the Ru(III) complex, is decorated with both hydrophilic and lipophilic moieties, conferring high propensity to form stable aggregates in water, which is required to obtain a suitable nanocarrier for the drug delivery. Following this approach, a novel compound, indicated here as compound I, was successfully prepared and characterized, then studied in coformulation with the biocompatible cationic lipid 1,2-dioleyl-3-trimethylammoniumpropane chloride (DOTAP) by dynamic light scattering (DLS), small angle neutron scattering (SANS), and UV-vis analysis. Evaluated in vitro on a panel of human and nonhuman cell lines, it showed good antiproliferative activity on cancer cells, with IC50 values in the μM range, and no relevant cytotoxicity on the healthy cells used as control. © 2017 American Chemical Society.
In the search for more efficient anticancer treatments, Ru(III) complexes have attracted much interest among metal-based candidate drugs, showing marked antitumor and antimetastatic activity associated with lower systemic toxicity. Remarkable examples are the Ru(III) complexes NAMI-A and KP1019, which have reached advanced clinical evaluation. In order to improve the in vivo stability of Ru(III)-based drugs, as well as their cellular uptake and effectiveness, a new approach has been proposed by our research group, based on the incorporation of the active, NAMI-A-like Ru(III) complex into highly functionalized nucleolipidic structures, i.e., hybrid molecules containing a nucleoside or nucleotide central core derivatized with a lipid chain, ensuring both efficient protection against extracellular degradation and high cellular internalization of the metal. Aiming at expanding the chemical diversity of available amphiphilic Ru(III) complexes, we here selected a trifunctional α-amino acid to replace the nucleosidic core of previously prepared nucleolipid-based Ru(III) complexes. The amino acidic scaffold, linked to the Ru(III) complex, is decorated with both hydrophilic and lipophilic moieties, conferring high propensity to form stable aggregates in water, which is required to obtain a suitable nanocarrier for the drug delivery. Following this approach, a novel compound, indicated here as compound I, was successfully prepared and characterized, then studied in coformulation with the biocompatible cationic lipid 1,2-dioleyl-3-trimethylammoniumpropane chloride (DOTAP) by dynamic light scattering (DLS), small angle neutron scattering (SANS), and UV-vis analysis. Evaluated in vitro on a panel of human and nonhuman cell lines, it showed good antiproliferative activity on cancer cells, with IC50 values in the μM range, and no relevant cytotoxicity on the healthy cells used as control. © 2017 American Chemical Society.
"dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents
| ▼ Targeted Drug Delivery by integrin avb3 antagonist |
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"dressing up" an Old Drug: An Aminoacyl Lipid for the Functionalization of Ru(III)-Based Anticancer Agents
Other filter: ([btitle,keywords] "Amphiphilic Amino Ac ...
Platella C, Capasso D, Riccardi C, Musumeci D, Dellagreca M, Montesarchio D
* Natural compounds from Juncus plants interacting with telomeric and oncogene G-quadruplex structures as potential anticancer agents (134 views)
Org Biomol Chem (ISSN: 1477-0520linking, 1477-0539electronic), 2021 Nov 8; N/D: N/D-N/D.
Impact Factor: 3.876
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Riccardi C, Napolitano E, Platella C, Musumeci D, Melone MAB, Montesarchio D
* Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics (114 views)
Med Res Rev (ISSN: 0198-6325linking, 1098-1128electronic), 2021 Jan; 41(1): 464-506.
Impact Factor: 9.3
View Export to BibTeX Export to EndNote
Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (183 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (280 views)
Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
View Export to BibTeX Export to EndNote
Capasso D, Borbone N, Terracciano M, Di Gaetano S, Piccialli V
* Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells (206 views)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jul 29; 18(8): N/D-N/D.
Impact Factor: 4.379
View Export to BibTeX Export to EndNote
Quassinti L, Gianfranceschi G, Cipiciani A, Caporale A, Ruvo M, Bramucci M
* AcGly-Phe-Asn(OH) and AcGly-Phe-Asn(NH(2)) tripeptides selectively affect the proliferation rate of MDA-MB 231 and HuDe cells (213 views)
Mol Biol Rep (ISSN: 0301-4851linking), 2020 May; 47(5): 4009-4014.
Impact Factor: 1.402
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (409 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print, 1873-3344), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Fusco S, Capasso D, Centore R, Di Gaetano S, Parisi E
* A new biologically active molecular scaffold: crystal structure of 7-(3-hydroxyphenyl)-4-methyl-2H-[1, 2, 4]triazolo[3, 2-c][1, 2, 4]triazole and selective antiproliferative activity of three isomeric triazolo-triazoles (221 views)
Acta Crystallogr C Struct Chem (ISSN: 2053-2296linking), 2019 Oct 1; 75(Pt10): 1398-1404.
Impact Factor: 0.93
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (545 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (458 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (443 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (724 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
View Export to BibTeX Export to EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (1122 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (431 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
Accardo A, Del Zoppo L, Morelli G, Condorelli D, Barresi V, Musso N, Spampinato G, Bellia F, Tabbì G, Rizzarelli E
* Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration (275 views)
Med Chem Comm, 2016 Sep; 7: 2364-2367.
Impact Factor: 2.319
View Export to BibTeX Export to EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (941 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
View Export to BibTeX Export to EndNote
Mügge C, Marzo T, Massai L, Hildebrandt J, Ferraro G, Rivera-Fuentes P, Metzler-Nolte N, Merlino A, Messori L, Weigand W
* Platinum(II) Complexes with O, S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding (504 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2015; 54(17): 8560-8570.
Impact Factor: 4.82
View Export to BibTeX Export to EndNote
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (676 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (1252 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (731 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (612 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (392 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
* Natural compounds from Juncus plants interacting with telomeric and oncogene G-quadruplex structures as potential anticancer agents (134 views)
Org Biomol Chem (ISSN: 1477-0520linking, 1477-0539electronic), 2021 Nov 8; N/D: N/D-N/D.
Impact Factor: 3.876
View Export to BibTeX Export to EndNote
Riccardi C, Napolitano E, Platella C, Musumeci D, Melone MAB, Montesarchio D
* Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics (114 views)
Med Res Rev (ISSN: 0198-6325linking, 1098-1128electronic), 2021 Jan; 41(1): 464-506.
Impact Factor: 9.3
View Export to BibTeX Export to EndNote
Ogloblina AM, Iaccarino N, Capasso D, Di Gaetano S, Garzarella EU, Dolinnaya NG, Yakubovskaya MG, Pagano B, Amato J, Randazzo A
* Toward G-Quadruplex-Based Anticancer Agents: Biophysical and Biological Studies of Novel AS1411 Derivatives (183 views)
Int J Mol Sc (ISSN: 1422-0067linking, 1422-0067electronic, 1661-6596), 2020 Oct 21; 21(20): N/D-N/D.
Impact Factor: 4.556
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Coppola A, Platella C, Montesarchio D, Di Gaetano S, Roviello GN, Musumeci D
* Synthesis, Antiproliferative Activity, and DNA Binding Studies of Nucleoamino Acid-Containing Pt(II) Complexes (280 views)
Pharmaceuticals (ISSN: 1424-8247linking, 1424-8247print), 2020 Sep 30; 13(10): 284-284.
Impact Factor: 4.421
View Export to BibTeX Export to EndNote
Capasso D, Borbone N, Terracciano M, Di Gaetano S, Piccialli V
* Antiproliferative Activity of Mycalin A and Its Analogues on Human Skin Melanoma and Human Cervical Cancer Cells (206 views)
Mar Drugs (ISSN: 1660-3397linking), 2020 Jul 29; 18(8): N/D-N/D.
Impact Factor: 4.379
View Export to BibTeX Export to EndNote
Quassinti L, Gianfranceschi G, Cipiciani A, Caporale A, Ruvo M, Bramucci M
* AcGly-Phe-Asn(OH) and AcGly-Phe-Asn(NH(2)) tripeptides selectively affect the proliferation rate of MDA-MB 231 and HuDe cells (213 views)
Mol Biol Rep (ISSN: 0301-4851linking), 2020 May; 47(5): 4009-4014.
Impact Factor: 1.402
View Export to BibTeX Export to EndNote
Riccardi C, Capasso D, Rozza GM, Platella C, Montesarchio D, Di Gaetano S, Marzo T, Pratesi A, Messori L, Roviello GN, Musumeci D
* Synthesis, DNA binding studies, and antiproliferative activity of novel Pt(II)- complexes with an L-alanyl-based ligand (409 views)
J Chem Res (ISSN: 0162-0134linking, 0162-0134print, 1873-3344), 2020 Feb; 203: 110868-110868.
Impact Factor: 3.224
View Export to BibTeX Export to EndNote
Fusco S, Capasso D, Centore R, Di Gaetano S, Parisi E
* A new biologically active molecular scaffold: crystal structure of 7-(3-hydroxyphenyl)-4-methyl-2H-[1, 2, 4]triazolo[3, 2-c][1, 2, 4]triazole and selective antiproliferative activity of three isomeric triazolo-triazoles (221 views)
Acta Crystallogr C Struct Chem (ISSN: 2053-2296linking), 2019 Oct 1; 75(Pt10): 1398-1404.
Impact Factor: 0.93
View Export to BibTeX Export to EndNote
Carella A, Roviello V, Iannitti R, Palumbo R, La Manna S, Marasco D, Trifuoggi M, Diana R, Roviello GN
* Evaluating the biological properties of synthetic 4-nitrophenyl functionalized benzofuran derivatives with telomeric DNA binding and antiproliferative activities (545 views)
Int J Biol Macromol (ISSN: 0141-8130linking, 1879-0003electronic), 2019 Jan; 121: 77-88.
Impact Factor: 4.784
View Export to BibTeX Export to EndNote
Petraglia F, Singh AA, Carafa V, Nebbioso A, Conte M, Scisciola L, Valente S, Baldi A, Mandoli A, Petrizzi VB, Ingenito C, De Falco S, Cicatiello V, Apicella I, Janssen-megens EM, Kim B, Yi G, Logie C, Heath S, Ruvo M, Wierenga ATJ, Flicek P, Yaspo ML, Della Valle V, Bernard O, Tomassi S, Novellino E, Feoli A, Sbardella G, Gut I, Vellenga E, Stunnenberg HG, Mai A, Martens JHA, Altucci L
* Combined HAT/EZH2 modulation leads to cancer-selective cell death (458 views)
Oncotarget (ISSN: 1949-2553electronic, 1949-2553linking), 2018 May 22; 9(39): 25630-25646.
Impact Factor: 5.008
View Export to BibTeX Export to EndNote
Bonaccorso C, Grasso G, Musso N, Barresi V, Condorelli DF, La Mendola D, Rizzarelli E
* Water soluble glucose derivative of thiocarbohydrazone acts as ionophore with cytotoxic effects on tumor cells (443 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 1873-3344electronic), 2018; 182: 92-102.
Impact Factor: 3.317
View Export to BibTeX Export to EndNote
Oliveri V, Lanza V, Milardi D, Viale M, Maric I, Sgarlata C, Vecchio G
* Amino- and chloro-8-hydroxyquinolines and their copper complexes as proteasome inhibitors and antiproliferative agents (724 views)
Metallomics (ISSN: 1756-5901, 1756-591x), 2017 Oct 18; 9(10): 1439-1446.
Impact Factor: 4.069
View Export to BibTeX Export to EndNote
Tomasello MF, Nardon C, Lanza V, Di Natale G, Pettenuzzo N, Salmaso S, Milardi D, Caliceti P, Pappalardo G, Fregona D
* New comprehensive studies of a gold(III) Dithiocarbamate complex with proven anticancer properties: Aqueous dissolution with cyclodextrins, pharmacokinetics and upstream inhibition of the ubiquitin-proteasome pathway (1122 views)
Eur J Med Chem (ISSN: 0223-5234, 1768-3254, 0223-5234linking), 2017 Jun 19; 138: 115-127.
Impact Factor: 4.816
View Export to BibTeX Export to EndNote
Cucciolito ME, Trinchillo M, Iannitti R, Palumbo R, Tesauro D, Tuzi A, Ruffo F, D'Amora A
* Sugar-Incorporated N-Heterocyclic-Carbene-Containing Gold(I) Complexes: Synthesis, Characterization, and Cytotoxic Evaluation (431 views)
Eur J Inorg Chem (ISSN: 1434-1948, 1099-0682e), 2017; 2017(42): 4855-4961.
Impact Factor: 2.507
View Export to BibTeX Export to EndNote
Accardo A, Del Zoppo L, Morelli G, Condorelli D, Barresi V, Musso N, Spampinato G, Bellia F, Tabbì G, Rizzarelli E
* Liposome antibody-ionophore conjugate antiproliferative activity increases by cellular metallostasis alteration (275 views)
Med Chem Comm, 2016 Sep; 7: 2364-2367.
Impact Factor: 2.319
View Export to BibTeX Export to EndNote
Musumeci D, Rozza L, Merlino A, Paduano L, Marzo T, Massai L, Messori L, Montesarchio D
* Interaction of anticancer Ru(III) complexes with single stranded and duplex DNA model systems (941 views)
Dalton T (ISSN: 1477-9226, 1477-9234, 1477-9226linking), 2015; 44(31): 13914-13925.
Impact Factor: 4.177
View Export to BibTeX Export to EndNote
Mügge C, Marzo T, Massai L, Hildebrandt J, Ferraro G, Rivera-Fuentes P, Metzler-Nolte N, Merlino A, Messori L, Weigand W
* Platinum(II) Complexes with O, S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding (504 views)
Inorg Chem (ISSN: 0020-1669, 1520-510x, 0020-1669linking), 2015; 54(17): 8560-8570.
Impact Factor: 4.82
View Export to BibTeX Export to EndNote
Capasso D, De Paola I, Liguoro A, Del Gatto A, Di Gaetano S, Guarnieri D, Saviano M, Zaccaro L
* Rgdechi-Hcit: Alpha V Beta 3 Selective Pro-Apoptotic Peptide As Potential Carrier For Drug Delivery Into Melanoma Metastatic Cells (676 views)
Plosone (ISSN: 1932-6203, 1932-6203electronic, 1932-6203linking), 2014 Sep 23; 9(9): e106441-e106441.
Impact Factor: 3.234
View Export to BibTeX Export to EndNote
Rai M, Kon K, Ingle A, Duran N, Galdiero S, Galdiero M
* Broad-spectrum bioactivities of silver nanoparticles: the emerging trends and future prospects (1252 views)
Appl Microbiol Biot (ISSN: 0175-7598), 2014 Mar; 98(5): 1951-1961.
Impact Factor: 3.337
View Export to BibTeX Export to EndNote
Tedesco I, Russo M, Bilotto S, Spagnuolo C, Scognamiglio A, Palumbo R, Nappo A, Iacomino G, Moio L, Russo GL
* Dealcoholated red wine induces autophagic and apoptotic cell death in an osteosarcoma cell line (731 views)
Food Chem Toxicol (ISSN: 0278-6915), 2013; 60: 377-384.
Impact Factor: 2.61
View Export to BibTeX Export to EndNote
Leese MP, Jourdan FL, Gaukroger K, Mahon MF, Newman SP, Foster PA, Stengel C, Regis-Lydi S, Ferrandis E, Di Fiore A, De Simone G, Supuran CT, Purohit A, Reed MJ, Potter BVL
* Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents (612 views)
J Med Chem (ISSN: 0022-2623, 1520-4804, 0022-2623print), 2008 Mar 13; 51(5): 1295-1308.
Impact Factor: 4.898
View Export to BibTeX Export to EndNote
Messere A, Fabbri E, Borgatti M, Gambari R, Di Blasio B, Pedone C, Romanelli A
* Antiproliferative activity of Pt(II) and Pd(II) phosphine complexes with thymine and thymidine (392 views)
J Chem Res (ISSN: 0162-0134, 1873-3344, 0162-0134print), 2007 Feb; 101(2): 254-260.
Impact Factor: 3.663
View Export to BibTeX Export to EndNote
22 Records (21 excluding Abstracts).
Total impact factor: 85.647 (82.413 excluding Abstracts).
Total 5 year impact factor: 65.718 (62.016 excluding Abstracts).
Total impact factor: 85.647 (82.413 excluding Abstracts).
Total 5 year impact factor: 65.718 (62.016 excluding Abstracts).
374 views. Last view on Tuesday 10 December 2024, 10:14:16
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