Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics (273 views)
Cancers (ISSN: 2072-6694, 2072-6694linking), 2017; 9(12): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 5.326, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038959130&doi=10.3390%2fcancers9120174&partnerID=40&md5=7cdfd2a980ead599f5539dff890aa416
Keywords: Cancer Biomarkers, Dna Aptamers, Fluorescence Sensing, Fluorescently-Labelled Aptamers, Label-Free Aptamers, Tumour Diagnosis, Angiogenin, Elastase, Lysozyme, Microrna, Mucin, Nanoparticle, Pegaptanib, Platelet Derived Growth Factor, Protein Tyrosine Kinase, Quantum Dot, Single Walled Nanotube, Small Interfering Rna, Thrombin, Tumor Marker, Unclassified Drug, Vasculotropin, Binding Kinetics, Cancer Cell, Cancer Diagnosis, Cancer Research, Clinical Assessment, Diagnostic Imaging, Enzymatic Assay, Fluorescence Analysis, Fluorescence Resonance Energy Transfer, Intraoperative Period, Molecular Recognition, Next Generation Sequencing, Non Invasive Procedure, Nuclear Magnetic Resonance Spectroscopy, Protein Secondary Structure, Review, Signal Processing, Systematic Evolution Of Ligands By Exponential Enrichment Aptamer Technique, X Ray Crystallography,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia 21, Napoli, 80126, Italy
CNR, Istituto di Biostrutture e Bioimmagini, Via Mezzocannone 16, Napoli, 80134, Italy
CNR, Istituto per l’Endocrinologia e l’Oncologia ‘Gaetano Salvatore,’, Via Pansini 5, Napoli, 80131, Italy
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Cancers (ISSN: 2072-6694, 2072-6694linking), 2017; 9(12): N/D-N/D.
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Paper type: Journal Article,
Impact factor: 5.326, 5-year impact factor: 0
Url: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038959130&doi=10.3390%2fcancers9120174&partnerID=40&md5=7cdfd2a980ead599f5539dff890aa416
Keywords: Cancer Biomarkers, Dna Aptamers, Fluorescence Sensing, Fluorescently-Labelled Aptamers, Label-Free Aptamers, Tumour Diagnosis, Angiogenin, Elastase, Lysozyme, Microrna, Mucin, Nanoparticle, Pegaptanib, Platelet Derived Growth Factor, Protein Tyrosine Kinase, Quantum Dot, Single Walled Nanotube, Small Interfering Rna, Thrombin, Tumor Marker, Unclassified Drug, Vasculotropin, Binding Kinetics, Cancer Cell, Cancer Diagnosis, Cancer Research, Clinical Assessment, Diagnostic Imaging, Enzymatic Assay, Fluorescence Analysis, Fluorescence Resonance Energy Transfer, Intraoperative Period, Molecular Recognition, Next Generation Sequencing, Non Invasive Procedure, Nuclear Magnetic Resonance Spectroscopy, Protein Secondary Structure, Review, Signal Processing, Systematic Evolution Of Ligands By Exponential Enrichment Aptamer Technique, X Ray Crystallography,
Affiliations:
*** IBB - CNR ***
Department of Chemical Sciences, University of Napoli Federico II, Via Cintia 21, Napoli, 80126, Italy
CNR, Istituto di Biostrutture e Bioimmagini, Via Mezzocannone 16, Napoli, 80134, Italy
CNR, Istituto per l’Endocrinologia e l’Oncologia ‘Gaetano Salvatore,’, Via Pansini 5, Napoli, 80131, Italy
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Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics
Among the various advantages of aptamers over antibodies, remarkable is their ability to tolerate a large number of chemical modifications within their backbone or at the termini without losing significant activity. Indeed, aptamers can be easily equipped with a wide variety of reporter groups or coupled to different carriers, nanoparticles, or other biomolecules, thus producing valuable molecular recognition tools effective for diagnostic and therapeutic purposes. This review reports an updated overview on fluorescent DNA aptamers, designed to recognize significant cancer biomarkers both in soluble or membrane-bound form. In many examples, the aptamer secondary structure switches induced by target recognition are suitably translated in a detectable fluorescent signal using either fluorescently-labelled or label-free aptamers. The fluorescence emission changes, producing an enhancement (“signal-on”) or a quenching (“signal-off”) effect, directly reflect the extent of the binding, thereby allowing for quantitative determination of the target in bioanalytical assays. Furthermore, several aptamers conjugated to fluorescent probes proved to be effective for applications in tumour diagnosis and intraoperative surgery, producing tumour-type specific, non-invasive in vivo imaging tools for cancer pre- and post-treatment assessment. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Among the various advantages of aptamers over antibodies, remarkable is their ability to tolerate a large number of chemical modifications within their backbone or at the termini without losing significant activity. Indeed, aptamers can be easily equipped with a wide variety of reporter groups or coupled to different carriers, nanoparticles, or other biomolecules, thus producing valuable molecular recognition tools effective for diagnostic and therapeutic purposes. This review reports an updated overview on fluorescent DNA aptamers, designed to recognize significant cancer biomarkers both in soluble or membrane-bound form. In many examples, the aptamer secondary structure switches induced by target recognition are suitably translated in a detectable fluorescent signal using either fluorescently-labelled or label-free aptamers. The fluorescence emission changes, producing an enhancement (“signal-on”) or a quenching (“signal-off”) effect, directly reflect the extent of the binding, thereby allowing for quantitative determination of the target in bioanalytical assays. Furthermore, several aptamers conjugated to fluorescent probes proved to be effective for applications in tumour diagnosis and intraoperative surgery, producing tumour-type specific, non-invasive in vivo imaging tools for cancer pre- and post-treatment assessment. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics
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Fluorescence sensing using DNA Aptamers in cancer research and clinical diagnostics
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Sandomenico A, Ruvo M
* Targeting Nodal and Cripto-1: perspectives inside dual potential theranostic cancer biomarkers (270 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Sep 11; N/D: N/D-N/D.
Impact Factor: 4.63
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Pica A, Russo Krauss I, Parente V, Tateishi-karimata H, Nagatoishi S, Tsumoto K, Sugimoto N, Sica F
* Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers (210 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2016 Nov 28; N/D: N/D-N/D.
Impact Factor: 10.162
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* Targeting Nodal and Cripto-1: perspectives inside dual potential theranostic cancer biomarkers (270 views)
Curr Med Chem (ISSN: 1875-533xelectronic, 0929-8673linking), 2018 Sep 11; N/D: N/D-N/D.
Impact Factor: 4.63
View Export to BibTeX Export to EndNote
Pica A, Russo Krauss I, Parente V, Tateishi-karimata H, Nagatoishi S, Tsumoto K, Sugimoto N, Sica F
* Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers (210 views)
Nucleic Acids Res (ISSN: 0305-1048, 1362-4962), 2016 Nov 28; N/D: N/D-N/D.
Impact Factor: 10.162
View Export to BibTeX Export to EndNote
2 Records (2 excluding Abstracts).
Total impact factor: 14.792 (14.792 excluding Abstracts).
Total 5 year impact factor: 14.299 (14.299 excluding Abstracts).
Total impact factor: 14.792 (14.792 excluding Abstracts).
Total 5 year impact factor: 14.299 (14.299 excluding Abstracts).
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